6-Paradol ke eng?

6-paradol ke motsoako o sebetsang o fumanehang haholo peo ea pepere ea Guinea, eo hape e tsejoang ka hore ke Grains of Paradise kapa pepere ea alligator. E fumaneha ka tlhaho ho ginger joalo ka karoloana e nyane hangata e thehiloeng hammoho le 6-gingerol le 6-shogaol.

Batho ba bangata ba tloaetse ho sebelisa litlama bakeng sa melemo e mengata ea bophelo bo botle joalo ka ho chesa likhalori. Ntle le tšibollo ea mafura a 6 a paradol, komporo e na le litlamorao tse fokolang le tse bonolo. Ha ho le joalo, basebelisi ba bangata ba nka hore mafura a 6 a paramente e le mokhoa o sireletsehileng ha o bapisoa le lithethefatsi tse ling tsa pharmacological tse etselitsoeng ho chesa mafura.

Ntle le merero ea eona ea bongaka, 6-paradol e boloka tatso ea eona ea mantlha hore e sebelisoe e le senoko sa ho rata lijo.

 

6-paradol e sebetsa joang 'meleng?

6-paradol e sebetsa tlasa mekhoa e 'meli ho thusa ho chesa mafura:

 

1.Ke eketsa ts'ebetso ea lisele tsa brown adipose

Nama ea adipose e sootho ke linama tse khethehileng tse sebetsanang le 'mele tse hlahisang metabolism. Ho kenella ka mokhoa o le mong oa potoloho ea 6-paradol ho eketsa ts'ebeliso ea matla ka ts'ebetso ea lithane tsa adipose tse sootho ka ho ntlafatsa ts'ebeliso ea glucose ho myotubes ea c-c12.

Sena ka kakaretso se hlalosa 6-paradol thermogenesis Ts'ebetso, e sebetsang haholo bakeng sa phokotso ea mafura a 'mele.

 

2.Ke eketsa ho chesoa ha likhalori

Nama ea adipose e sootho e na le protheine e bitsoang UCP-1 e laolang ho chesoa ha likhalori tsa khalori tsa mocheso oa 'mele. Ts'ebeliso ea khafetsa ea 6-paradol e kenya UCP-1, ka lebaka leo e eketsa lebelo leo ho lona 'mele o chesang mafura a bolokiloeng libakeng tsa ona tsa mafura.

Ho eketseha ha khalori ka lebaka la tšebeliso ea 6-paradol ho bolela hore mmele oa hau o tla fumana matla a mangata ho tsoa liseleng tsa mafura bakeng sa mesebetsi e fapaneng. Ka hona, e fetoha e fokolang haholo mehloling ea kantle ea matla, ka lebaka leo, ea hau takatso ea lijo ea fokotseha.

 

Melemo ea 6-paradol ke efe?

Ho na le le melemo e 6 ea paradol, ho kenyelletsa:

 

1.Regulation ea li-hormone

Batho ba nang le ho se leka-lekane ha li-hormonal ke ba bang ba basebelisi ba batlang melemo ea 6-paradol. Hormonal ho leka-lekana ho etsahala ha ho na le litekanyetso tsa lihormone tse feteletseng kapa tse sa lekaneng mohloling oa mali. Sena se ka baka litlamorao tse mpe hohle 'meleng. Boemong bo joalo, 6-paradol e tsoela 'mele molemo ka ho khutlisa litla-morao tse joalo ka ho tsamaisa katleho ea boemo bo lekanang ba li-hormone.

 

Tšusumetso ea 2.Antitumor

6-paradol le eona e ka ba thuso e makatsang ho batho ba nang le mofetše, ka lebaka la ts'ebetso ea ts'oaetso ea paradol ea 6 le bokhoni ba anti-tumor. Karolo ea tlhaho e ka ntlafatsa ho hlaphoheloa ha mofetše le / kapa ho thibela nts'etsopele ea lihlahala 'meleng oa hau. Kahoo, e ka bapala karolo ea bohlokoa phetisong ea mofets'e le kalafo.

Ketsahalo ea 6-paradol e khahlanong le ho ruruha e etsa 6-paradol tlatsetso khetho ea ho ea batho ba batlang sehlahisoa se fanang ka phytochemical ea tlhaho ea anti-carcinogenic. Lebaka ke hobane tlatsetso e tsoa limeleng tse jeoang. Kahoo, ts'ebetso ea ts'oaetso ea paradol e 6 ha e amane le litlamorao tse mpe tse hlahisoang ke lihlahisoa tse nang le likarolo tsa maiketsetso kapa tse mamellang bobe.

Ho feta moo, lipatlisiso li bonts'a ts'ebeliso ea 6-paradol e ts'ehetsa carcinogeneis ea letlalo le TPA.

 

3.Ko fokotsa khatello ea mali

Hypertension e bontšoa ke ho eketseha ho tsoelang pele ha maemo a khatello ea mali 'meleng. Boemo bo ka laoloa ke mekhoa ea bo-ramahlale le eo e seng ea meriana. Leha ho le joalo, lithethefatsi tse ling tsa khatello ea mali li baka litla-morao tse mpe, li siea 6-paradol e le e 'ngoe ea likhetho tse ntle haholo taolong ea khatello ea mali.

Ho fokotsa boima ba 'mele ke e' ngoe ea maano a sebetsang ka ho fetisisa a ho laola khatello ea mali e phahameng, ke mona ke moo thepa ea 6-paradol e thibelang botenya le thepa ea boima ba 'mele e tlang ho sebetsa. Ka litekanyetso tse nepahetseng tsa paradol tse 6, motho ea nang le khatello ea mali o khona ho lahleheloa ke boima ba 'mele bo tla thusa ho fokotsa khatello ea mali.

6-Paradol

4.Le profid ea lipid e ntlafalitsoeng

Boemo bo phahameng ba lipid bo kotsi bophelong ba hau. Sesebelisoa sa ho chesa mafura a 6 se thusa ho theola maemo a cholesterol ea hau, ka hona ho fokotsa bongata ba mafura 'meleng. Boemo bo ntlafalitsoeng ba lipid ka lebaka la 6-paradol thermogenesis bo fokotsa likotsi tsa hau ho maloetse a fapaneng.

 

5.Ke ntlafalitse bophelo ba kelello

Boithuto bo fapaneng bo bonts'a hore 6-paradol e ka sebetsa e le antioxidant. Bokhoni ba 6-paradol antioxidant bo hlaha ka phokotso ea carbohydrate le lipids oxidation. Ha sekhahla sa oxidation se fokotseha, palo ea li-radicals tsa mahala 'meleng lia fokotseha. Ka ho nahana hore li-radicals tsa mahala li khothaletsa karabelo ea ketane e ka bakang tšenyo e kholo ea lisele tsa boko, 6-paradol antioxidant athari e ntlafatsa bophelo ba kelello.

 

6. Liphello tsa ho haha ​​mmele

Haeba u batla sebopeho se shebahalang hantle 'meleng se phetseng hantle, u ka eketsa melemo ea melemo ea 6-paradol. 6-paradol bodybuilding effect e tla ka lebaka la bokhoni ba komporo ea ho ntlafatsa thermogenesis ka ho chesa khalori e eketsehileng.

Leha ho le joalo, ho bohlokoa ho hlokomela hore melemo ea 6-paradol bodybuild, joalo ka melemo efe kapa efe ea 6-paradol, hase ntho eo u tla e lemoha ka bosiu bo le bong. U hloka ho nka se nepahetseng Tekanyetso ea 6-paradol bolelele ba likhoeli tse itseng.

 

Hobaneng u khetha 6-paradol?

6-paradol ke komporo e 'nileng ea sebelisoa ho batho ba bangata molemong oa melemo e mengata. Ka ho khetha 6-paradol, u khetha ho fumana melemo e 6 ea paradol, ho kenyelletsa ho hlohlona ho ntlafalitsoeng ha lijo, keketseho ea tšebeliso ea matla hammoho le tahlehelo e ntlafalitsoeng ea mafura a mmele.

Leha o ka batla ho nahana ka litlatsetso tse ling bakeng sa melemo e boletsoeng ka holimo, 6-paradol e ntse e le khetho e ntle hobane melemo le mochine o tšehelitsoe ke bopaki ba saense. Bafuputsi ba fapaneng ba kentse komporo lithutong tsa batho mme ba fumane bopaki bo lekaneng bo ts'ehetsang bokhoni ba eona ba ho fana ka melemo.

E 'ngoe hape bakeng sa 6-paradol ha e bapisoa le baphatlalatsi ke hore ha e se khothalletso. Ka hona, ha e phahamise sekhahla sa pelo ea hau, leha e le hore e baka jetter, joalo ka ha ho le joalo ka ba bang ba mafura a mang. Hore na o nka phofo ea 6-paradol, matlapa kapa likhakeletsi, tiiseha hore ha o na ho ba le litlamorao ka lebaka la tlatsetso.

6-Paradol

Ke mang ea ka ruang molemo ho 6-paradol?

Ho na le lihlopha tse fapaneng tsa batho ba ka fumanang melemo ea 6-paradol. Li kenyeletsa:

  • Banna kapa basali ba seng ba le lilemo li 18.
  • Batho ba baholo ba batlang ho tšolla mafura a mangata a 'mele.
  • Mang le mang ea batlang ho eketsa foromo ea bona e tukang ea mafura.
  • Batho ba amehileng ka litlatsetso empa ba ntse ba ikemiselitse ho fihlela lipheo tsa bona tsa ho theola boima ba 'mele.

 

Litlamorao tsa 6-paradol

Ho fihla joale, litlamorao tse 6 tse tlalehiloeng tsa paradol ha li na letho. Ebile, basebelisi ba bang ba 6-paradol ha ho mohla ba nang le litlamorao tsa 6-paradol ho hang. Tsamaiso ea Lijo le Lithethefatsi (FDA) e kenyellelitse 6-paradol ka kakaretso ea bona ea botanicals e sirelelitsoeng haholo.

Leha ho le joalo, ka ho hlokomela hore ke karolo ea lelapa la ginger la Zingiberaceae, komporo ena e ka baka karohano e bonolo pakeng tsa basebelisi ba hanang ho sitoa ke semela. Taba e ts'oanang e sebetsa ho ba boneng ba sa ts'oenyeha ho Cardamom. Ka hona, batho ba joalo ba lokela ho sebelisa tlatsetso ea 6-paradol ka tlhokomeliso.

Ntle le moo, tlaleho ea bongaka e hlahisitsoeng ho Nigerian Journal of Physiological Sciences e bonts'a hore tlatsetso ea li-paradol tse 6 li ka ba kotsi ho basali ba lebelletseng, haholo nakong ea bokhachane ba pele baimana. Leha ho le joalo, bo-ramahlale ha baa ka ba bona litla-morao tsa 6-paradol har'a banna.

 

Tekanyetso ea 6- paradol ke eng?

Joalo ka tlatsetso efe kapa efe e 'ngoe, tekanyetso e nepahetseng ea 6-paradol e thehiloe motheong oa chelete e hlokahalang ho hlahisa sephetho se lakatsehang. Mabapi le sena, litekanyetso tsa letsatsi le letsatsi tsa 6-paradol tse khothalletsoang li pakeng tsa 25 mg ho isa 50mg, ho latela sephetho se lakatsehang.

Bakeng sa li-bodybuilders, litekanyetso tse tloaelehileng tse khothalletsoang tse 6-paradol li tloha ho 40mg ho isa 50mg. Tekanyetso ena e sebetsa ho boholo ba basebelisi ba tlatselletsang ba maiketsetso le bona.

 

Ke nako efe e nepahetseng ea ho sebelisa 6-paradol?

Haeba u ntse u rera ho reka 6-paradol, ho bohlokoa hore o tsebe hore na o tla e sebelisa neng pele ho eona hore o fumane tse ntle ho eona. Jwalo ka tse ding mafura a tlotsang mafura, nako e ntle ea ho sebelisa paradol ea 6 ke hoseng. E nke pele u etsa eng kapa eng hoseng.

Haeba o lokela ho nka tlatsetso ho litekanyetso tse peli ka letsatsi, nako e nepahetseng ea hore a be le tekanyetso ea bobeli ke mots'eare oa mantsiboea. Ntle le moo, u ka nka tekanyetso ena pele u qala lenaneo la hau la mantsiboea.

 

6-Paradol e le Tlatsetso ea Mafura a Burner

Ho chesa mafura ke e 'ngoe ea Melemo ea 6-paradol. Batho ba bangata ba sebelisa litlatsetso tsa 6-paradol bakeng sa ho chesa mafura kapa joalo ka litlatsetso tsa pele ho mosebetsi. Bongata bo bongata ba tlatsetso ea tlholeho bo kenella melemong ea melemo ea 6 ea paradol ea botenya, e tlisoang ke bokhoni ba 6 ba ho chesa mafura.

6-paradol tlatsetso e na le thepa ea ho chesa mafura. Ho ntse ho le joalo, ho fapana le tse ling tahlehelo ea boima ba 'mele, tlatsetso e na le litaba tse tlase tse tlatsetsang. Kahoo, melemo ea ho loants'a botenya ha e kopantsoe le litla-morao tse amanang le litekanyetso tse phahameng tsa mmele.

Boithuto bo fapaneng bo senotse bokhoni ba tlatsetso ea 6-paradol ea ho fetola lisele tsa mafura tse tloaelehileng hore e be lisele tse mafura a sootho.

Ts'ebetso e kholo ea lisele tse mafura a sootho ke ho fetola matla ho tloha ho lijo ho fetoha mocheso oa 'mele. Kahoo, ka lebaka la keketseho ea puisano ea sele, mabenkele a mafura a 'mele a fokotseha, a ntlafatsa bokhoni ba' mele ba ho etsa thermogeneis.

Thermogenesis e bua ka tlhahiso ea mocheso 'meleng. Phepelo e eketsang mafura a tukang joalo ka; 6-paradol e nkoa e le thermogenic. 6-paradol thermogenesis e kenngoe ka har'a lithane tsa adipose e sootho 'me e ka bula mekhoa e mecha bakeng sa taolo ea boima ba 'mele le ho hlokomela boima ba 'mele.

Ts'ebeliso ea 6-paradol e le sejo se tlatsetsang e eketsa phetoho ea mafura a sootho. Litlhapi tsa brown adipose li laola tšebeliso ea matla a 'mele le mafura a' mele. Patlisiso mabapi le kamano lipakeng tsa ts'ebetso ea li-adipose tiske (BAT) le boikoetliso ba 'mele e bontša hore BAT e sireletsa' mele khahlano le ho bokella mafura a 'mele, ka lebaka la ts'ebetso ea ona ea ho hlatsoa matla.

Ho kenella ha paradol ea letsatsi le letsatsi ho eketsa tšebeliso ea matla a 'mele le ho fokotsa mafura a visceral bathong ba motho. E etsa sena ka ts'ebetso ea lisele tsa brown adipose. Patlisiso e fana ka maikutlo a hore tlatsetso e bolokehile hape e sebetsa bakeng sa ho fokotsa mafura a mmele, ka hona e thibela ho bokelloa hoa mafura a visceral.

Boithuto bo sebetsang bo fana ka maikutlo a hore melemo ea tahlehelo ea mafura a 6 paradol e bakoa ke taba ea hore khetla e eketsa litšenyehelo tsa matla a letsatsi le letsatsi. Tekanyetso ea 6-paradol e ka bang 30mg ho 40mg e khothalletsoa tahlehelo ea mafura.

Phuputso e ile ea etsoa ho banna ba leshome le metso e robong ba neng ba fuoa 40mg ea 6-paradol letsatsi le leng le le leng ka libeke tse 'ne. Ka mor'a moo ba beoa kamoreng e batang 'me maoto a bona a behiloe ka holim'a leqhoa bakeng sa lihora tse' maloa. Kamora nako, ba ile ba hlahlojoa bakeng sa ts'ebetso ea lisele tse sootho, tse bonts'ang keketseho, e lebisang ho keketseho ea tšebeliso ea matla.

Ts'ebeliso ea paradol ea 6 bakeng sa tahlehelo ea mafura e netefalitsoe hore e sebetsa. Kahoo, haeba u ntse u leka ho theola boima ba 'mele, phaello ea melemo ea 6-paradol bakeng sa tahlehelo ea mafura. Leha ho le joalo, haeba u batla ho fumana sephetho se nepahetseng sa tahlehelo ea mafura, ho bohlokoa ho 6-paradol phofo, li-capsules kapa litafole e le karolo ea foromo e pharalletseng ea ho chesa mafura.

6-Paradol

U ka reka phofo ea paradol e 6 kae?

Haeba u ikemiselitse ho reka phofo ea 6-paradol, ho na le mabenkele a mangata a fumanehang ka ntle ho marang-rang le lithethefatsi le lijo tseo u ka tšepang hore u tla li reka. Leha ho le joalo, ebang ke marang-rang kapa marang-rang, ho bohlokoa hore u reke sehlahisoa ho tloha Morekisi ea nang le lengolo le tumello. Ho seng joalo, u ka qetella u rekile thepa ea maiketsetso.

 

fihlela qeto e

6-paradol, e leng motsoako o sebetsang pepereng ea Guinean le k'habeche e nyane ho ginger, ke sesebelisoa se sireletsehileng le se phetseng hantle sa mafura. Ho feta moo, ho tloha phello ea antitumor ho isa ho antioxidation le taolo ea li-hormone, ho na le melemo e fetang 6-paradol. Ho molemo le ho feta, ho fapana le maqhubu a mang a chesang, litla-morao tsa 6-paradol li nyane ebile li bonolo. Kahoo, o ka ts'epa ka kholiseho ho 6-paradol tlatsetso bakeng sa tahlehelo e bolokehileng le e sebetsang ea 'mele, hara melemo e meng ea bophelo bo botle.

 

References

Chung, W. Y., Jung, Y. J., Surh, Y. J., Lee, S. S., & Park, K. K. (2001). Antioxidative and antitumor promoting effects of [6]-paradol and its homologs. Patlisiso ea phetoho / liphatsa tsa lefutso le tikoloho ea tikoloho le tikoloho ea tikoloho496(1-2), 199-206.

Gaire, B. P., Kwon, O. W., Park, S. H., Chun, K. H., Kim, S. Y., Shin, D. Y., & Choi, J. W. (2015). Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One10(3), e0120203.

Kim, S. H., & Plutzky, J. (2016). Brown fat and browning for the treatment of obesity and related metabolic disorders. Diabetes & metabolism journal40(1), 12-21.

Sugita, J., Yoneshiro, T., Hatano, T., Aita, S., Ikemoto, T., Uchiwa, H., … & Saito, M. (2013). Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. British Journal of Nutrition110(4), 733-738.

Suresh, K., Manoharan, S., Vijayaanand, M. A., & Sugunadevi, G. (2010). Chemopreventive and antioxidant efficacy of (6)-paradol in 7, 12-dimethylbenz (a) anthracene induced hamster buccal pouch carcinogenesis. Litlaleho tsa Pharmacological62(6), 1178-1185.

Wei, C. K., Tsai, Y. H., Korinek, M., Hung, P. H., El-Shazly, M., Cheng, Y. B., … & Chang, F. R. (2017). 6-paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet-fed mice. Koranta ea Machaba ea saense ea limolek'hule18(1), 168.

TSOALO EA 6-PARADOL POWDER (27113-22-0)

 

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