9-ME-BC ke eng?

9-Me-BC (9-Methyl-β-carboline) e tsejoang hape e le 9-MBC ke sebali sa nootropic sa nalane se tsoang sehlopheng sa β-carboline. Β-Carbolines e tsoa lelapeng le fapaneng haholo la carboline. Sena se bolela hore li hlahisoa ka ho sa feleng 'meleng oa motho hape le litholoana tse ling ka mokhoa o ikhethileng, nama e phehiloeng, mosi oa koae le kofi.

Li-b-Carbolines (BCs) li khetholloa e le neurotoxic, leha ho le joalo, ho sa tsoa sibolloa hore 9-Me-Bc e na le molemo. 9-Me-BC ke dopaminergic neuroprotector e ntlafatsang ts'ebetso ea ts'ebetso ea kelello.

9-Me-BC phofo hammoho le capsule ea 9-Me-BC tlatsetsa foromo ke nootropic e ntle haholo. Kaha ho fapana le li-nootropics tse ling tseo melemo ea tsona e felang kamora lihora tse 'maloa, 9-Me-BC e fana ka litlamorao tse tšoarellang le tse telele.

9-ME-BC phofo- E sebetsa joang?

9-Me-BC e na le nootropic e hantle haholo e bonts'ang mekhoa e mengata ea ketso. Mekhoa e mengata ea tšebetso ea 9-Me-BC e e nolofalletsa ho sebetsa hantle nakong eo e sebetsang.

Ka tlase ke mekhoa ea ts'ebetso ea 9-Me-BC;

  1. E phahamisa boemo ba dopamine bokong ka ho thibela ho senyeha ha dopamine, ho fapana le tse ling tse khothatsang tse kang caffeine e fokotsang dopamine ka lebaka la tokollo le ts'ebeliso e fetelletseng.
  2. 9-Me-BC e hlohlelletsa ts'ebetso ea dopamine, e khetholla hape e sireletsa li-neuron, li-dendrites le li-synapses bokong. Ke ka hona e khonang ho ntlafatsa ho ithuta, memori le ts'ebetso ea kelello
  3. E susumetsa tyrosine hydroxylase (TH) le likarolo tsa eona tsa phetolelo ha e ntse e sebelisana le tyrosine kinases. Li-tyrosine kinases li bapala karolo ea ho fetolela L-tyrosine ho L-Dopa e ikarabellang bakeng sa ho qaptjoa ha dopamine.
  4. 9-Me-BC e thibela monoamine oxidase A le B (MAOA le MAOB) ka hona ho thibela tlhahiso ea metsoako ea neurotoxic joalo ka DOPAC ho tsoa ho dopamine metabolism. Lintho tsena li baka lefu la li-neuron tsa dopaminergic.
  5. 9-Me-BC e ntlafatsa ketane ea phefumoloho ea mitochondrial. E etsa sena ka ho eketsa kapa ho sireletsa NADH dehydrogenase, e sebelisoang ts'ebetsong ea phetisetso ea elektronike bakeng sa tlhahiso ea matla.
  6. 9-Me-BC le eona e ka eketsa lintlha tsa neurotrophic joalo ka Nerve growth factor (NGF), SHH (Sonic Hedgehog Signaling Molecule), Brain-derived neurotrophic factor (BDNF) e ntlafatsang ts'ebetso ea ts'ebeliso ea kelello, ho tsepamisa maikutlo le ho susumetsa.
  7. E susumetsa tšebetso ea methapo ea kutlo ha e ntse e phahamisa kholo ea li-neurone tse ncha. Sena se ntlafatsa mohopolo le ho ithuta le ts'ebetso e akaretsang ea kutloisiso.
  8. Mefuta e khahlanong le ho ruruha. 9-me-BC e etsahala ho loants'a ho ruruha ho sa foleng bokong ka ho fokotsa li-cytokine tsa ho ruruha, tse tsejoang li baka pokello ea microglial eo le eona e sitisang ts'ebetso ea kelello.

Melemo ea 9-ME-BC - Phofo ea 9-ME-BC (Nootropic) e ka u thusa?

9-Me-BC tlatsetsa na le melemo e mengata e fapaneng ea bophelo bo botle. Melemo e fapaneng ea 9-Me-BC e bakoa ke mekhoa e mengata eo e e bontšang.

Ka tlase ke melemo ea 9-Me-BC;

i. E ka ntlafatsa ho ithuta, ho hopola le ho tseba

9-Me-BC e matlafatsa tšebetso ea methapo ea kutlo le ho matlafatsa kholo ea lisele tse ncha tsa methapo ea kutlo. Sena ke senotlolo sa ho ntlafatsa thuto, memori le ts'ebetso e akaretsang ea kutloisiso.

9-Me-BC hape matlafatsa ATP tlhahiso ea matla ka ho matlafatsa ketane ea phefumoloho ea mitochondrial. Kahoo matla a eketsehileng a matlafatsang tšusumetso le tlhokomeliso.

Phuputsong ea likhoto, tlatsetso ea 9-Me-BC e fuoeng matsatsi a 10 e fumanoe e ntlafatsa thuto. Phuputso e tlalehile hore sena se bakiloe ke ho eketseha ha maemo a dopamine hape le ho khothaletsa kholo ea li-synapses le dendrites.

9-Me-BC

Ii. E thusa ho loantša ho ruruha

Ho ruruha ke mokhoa oa tlhaho oo 'mele o loantšang tšoaetso kapa likotsi. Leha ho le joalo, ho ruruha ho sa foleng ho ka ba kotsi 'meleng' me ha amahanngoa le mafu a mangata a kang lefu la tsoekere le mofetše.

Kahoo hoa hlokahala ho thibela ho ruruha hona pele ho ka ba kotsi 'meleng oa hau. Ka lehlohonolo, phofo ea 9-Me-BC e ka thusa ho thibela ho ruruha ho sa foleng. E loantša ho ruruha ka ho fokotsa li-cytokine tse chesang.

Iii. E ka ntlafatsa libido

9-Me-BC motsoako oa nootropic o na le dopaminergic haholo. Metsoako ea Dopaminergic e tsejoa e le ho eketsa maemo a dopamine bokong. Sena le sona se eketsa ts'ebetso ea dopamine e amanang haufi le ho eketseha ha libido.

Iv. E kanna ea ntlafatsa tšebetso ea baatlelete

Bokhoni ba 9-Me-BC ba ho eketsa tlhahiso ea matla le maikutlo le tšusumetso li e etsa mokhethoa ea ka bang teng ho ntlafatseng ts'ebetso ea baatlelete.

Phihlelo ea 9-Me-BC: U ka sebelisa 9-MBC joang?

Tekanyo e khothalletsoang ea 9-Me-BC e nka capsule e le 'ngoe ea 9-Me-BC ka letsatsi. Komiki e le 'ngoe ea 9-Me-BC e lekana le 15 mg ea phofo ea 9-Me-BC.

Ho eletsoa ho nka capsule ea 9-Me-BC hoseng joalo ka ha e tsebahala ho eketsa ho falimeha, ho ba le maikutlo le ho ba le tšusumetso, e leng seo o tla se hloka nakong ea mesebetsi ea letsatsi.

Na ho bolokehile ebile ho molaong ho sebelisa 9-MBC? Likotsi tsa 9-me-bc?

9-MBC e nkuoa e sireletsehile ka kakaretso lijo tse eketsehileng. Ho tsoa phuputsong ea liphoofolo, 9-Me-BC nootropic e tsamaisoang matsatsi a 10 e fumanoe e bolokehile ka botlalo.

Leha ho le joalo, ha ho na data e fumanehang mabapi le ts'ebeliso ea tlatsetso ea 9-Me-BC nako e telele hape le liteko tse fokolang haholo tsa bongaka mabapi le nootropic ena ea 9-Me-BC.

Ka hona ho bohlokoa hore o ele hloko ha o nka nootropic ena ka ho nka khefu lipakeng ho qoba likotsi tse ka bang teng tsa 9-Me-BC.

Tlatsetso ea 9-Me-BC e molaong naheng e ngoe le e ngoe lefats'eng ka bophara. E arotsoe ka mekhahlelo e bile e rekisoa e le tlatsetso ea lijo ka hona e laoloa ka tsela e ts'oanang le lijo ke Tsamaiso ea Lijo le Lithethefatsi.

Ho molaong hore mang kapa mang a reke le ho sebelisa tlatsetso ea 9-Me-BC. Leha ho le joalo, 9-Me-BC e nkuoa e le e bolokehileng ka molao, ho eletsoa hore motho a botse ngaka ea bona pele a e amohela.

Litla-morao tsa 9-Me-BC

Le ha tlatsetso ea 9-Me-BC ka kakaretso e nkuoa e bolokehile, ho na le litla-morao tse kholo tsa 9-Me-Bc tseo u ka bang le tsona;

Photo-sensitivity - ho pepesehela khanya ea letsatsi nako e telele ho lokela ho qojoa ha u sebelisa Tlatsetso ea 9-Me-BC kaha sena se ka baka tšenyo ea DNA ka lebaka la ho pepeseha ha mahlaseli a UV. Haeba u tlameha ho ba tlasa khanya ea letsatsi setlolo se sireletsang letsatsi se tla hlokahala ho qoba litlamorao tse boletsoeng tsa 9-Me-BC.

Dopamine neurotoxicity le eona e ka hlaha; leha ho le joalo, sena se etsahala ha o feta tekanyetso e khothalletsoang ea 9-Me-BC. Ka hona, ho ka qojoa ka ho nka tekanyetso e khothalletsoang ea 9-Me-BC.

Litla-morao tse ling tsa 9-Me-BC tse tlalehiloeng ho tsoa ho basebelisi ba arolelaneng boiphihlelo ba bona ba 9-Me-BC li kenyelletsa ho nyekeloa le pelo. Leha ho le joalo, litlamorao tsena ha li fumanehe hangata 'me li etsahala ha motho a noa setlatse se feteletseng sa 9-Me-BC.

Ke mang ea ka ruang molemo ho 9-me-bc (nootropic)?

Ha e le hantle motho e mong le e mong a ka fumana melemo ho tsoa ho nootropic ea 9-Me-BC. Leha ho le joalo, lihlopha tse ling tsa batho li ka rua molemo ho feta ho 9-Me-BC ho feta tse ling. Basebetsi, baithuti le baatlelete ba ka kotula haholo ho Melemo ea 9-Me-BC.

Ho tloha ha, 9-Me-BC e hlophisitsoe hantle ebile e na le dopaminergic haholo, ke tlatsetso e ntle haholo bakeng sa baithuti ba batlang ho eketsa tlhokomeliso, tšusumetso ea ho ithuta joalo ka ha ba ntse ba ntlafatsa thuto le mohopolo oa bona ho hopola ho feta.

Ho sebetsa ho ka u sithabetsa le ho o qeta, empa ka lehlohonolo 9-Me-BC e fana ka tšusumetso le matla a eketsang bokhoni ba hau mosebetsing. E etsa hore li-neurone li u boloke u tsepamisitse maikutlo hohle.

Basebelisi ba litlhahlobo tsa 9-Me-BC ba na le ts'epo e ntle ntle le litla-morao tse fokolang tse tlalehiloeng Kahoo e ntle tlatsetsa bakeng sa tsohle.

9-Me-BC

9-ME-BC phofo e rekisoang - O ka reka kae 9-ME-BC?

9-Me-BC ea rekisoa e fumaneha habonolo inthaneteng. Leha ho le joalo, ho hloka sekoli se phahameng ho lokela ho netefatsoa hore o tla fumana litholoana tse lebelletsoeng. Nahana ka tlhahlobo ea 9-Me-BC ho tsoa ho basebelisi ho fumana leseli la capsule ea 9-Me-BC e ntle kapa phofo.

Joalo ka tlatsetso e ngoe, ho hotle ho nahana ka likotsi tsa 9-Me-BC tse ka hlahang le ho nka mehato e hlokahalang.

Basebelisi ba bangata ba 9-Me-BC ba e reka ho tsoa ho tumello bafani ba nootropics ea fanang ka 9-Me-BC e rekisoa ka boleng bo holimo haholo.

Ha o nahana ho sebelisa 9-Me-BC reka ho tsoa lik'hamphaning tse fanang ka 9-Me-BC tse rekisoang ka bongata ho thabela litheko tse theotsoeng.

References
  1. Gille G., Gruss M., Schmitt A., Braun K., Enzensperger C., Fleck C. le Appenroth D. (2011) 9-Methyl-b-carboline e ntlafatsa ho ithuta le ho hopola likhoto. Neurodegen. Dis. 8, 195.
  2. Gruss, M., Appenroth, D., Flubacher, A., Enzenperger, C., Bock, J., Fleck, C.,… Braun, K. (2012). Ntlafatso ea ts'oaetso ea 9-Methyl-β-carboline e amahanngoa le maemo a phahameng a hippocampal dopamine le ho ata ha dendritic le synaptic. Tlaleho ea Neurochemistry, 121 (6), 924-931.doi: 10.1111 / j.1471-4159.2012.07713. x.
  3. Hamann, J., Wernicke, C., Lehmann, J., Reichmann, H., Rommelspacher, H., & Gille, G. (2008). 9-Methyl-β-carboline up-e laola ponahalo ea li-neuron tsa dopaminergic tse khethollohileng moetlong oa mantlha oa mesencephalic. Machaba oa Neurochemistry, 52 (4-5), 688-700.doi: 10.1016 / j.neuint.2007.08.018.
  4. Polanski W., Enzenperger C., Reichmann H. le Gille G. (2010) Thepa e ikhethang ea 9-methyl-beta-carboline: ts'usumetso, ts'ireletso le ntlafatso ea li-neuron tsa dopaminergic hammoho le litlamorao tse khahlisang. J. Neurochem. 113, 1659-1675.
  5. Wernicke, C., Hellmann, J., Ziêba, B., Kuter, K., Ossowska, K., Frenzel, M.,… Rommelspacher, H. (2010). 9-Methyl-b-carboline e na le litlamorao tsa mofuta oa phoofolo oa lefu la Parkinson. Litlaleho tsa Pharmacological, 19.
  6. TSOALO 9-METHYL-9H-BETA-CARBOLINE POWDER (2521-07-5)

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