Lithethefatsi tsa morao-rao tsa ho tsofala: Nicotinamide Mononucleotide (NMN)

Na u shoele u beha khahlanong le botsofali? Ha ho pelaelo hore lithethefatsi tse khahlanong le botsofali ke khetho e ka tšeptjoang ka ho fetisisa ea ho fetola nako ea hau ea tlhaho. Sheba lintlha tse bohlokoa tsa Nicotinamide Mononucleotide (NMN), karolo ea eona ho senescence, le mokhoa oa ho fumana phekolo.

Selelekela

Ho tsofala ho ke ke ha qojoa. Leha ho le joalo, ho na le menyetla ea ho fetola mokhoa oa ho tsofala Nicotinamide Mononucleotide. Tšoara lipere tsa hau hobane ke tla u fa boitsebiso bo felletseng mabapi le kamoo boselamose bo sebetsang ka har'a lisele tsa motho.

Moriri o moputsoa o tšoana le bohlale!

Tumelo ena ke mohlomong ntho e molemo ka ho fetisisa eo u tla bua ka eona e kholo. Leha ho le joalo, pososelo ea hau e tla phela hakhutšoane ha o qala ho hlokomela litlhaka hohle letlalo la hao. Ho feta moo, botsofali bo ama likarolo tsa 'mele le tsebo ea kutloisiso.

Ha re e tobeng. The Khahlanong le botsofali litlolo tsa sefahleho le ho buuoa ka litlolo e bile ntho ea bohlokoa lekholong lena le bohlale la lilemo. Seo u hlokang ho se tseba ke hore lits'ebetso tsena ke tsa nakoana mme li kanna tsa baka litlamorao tse mpe.

Ha e le hantle, u tlameha ho loantša botsofali ka ho utloisisa pele mekhoa ea cellular le ea physiological e bapalang karolo ea maemo a amanang le lilemo. Ka mor'a moo, ho ba bonolo ho fumana mekhoa ea ho loantša senescence. Nicotinamide Mononucleotide e thibelang botsofali e sebetsa ho tsosolosa bocha.

Kaofela ha rōna re batla ho tsofala ka mokhoa o motle, ha ho joalo? Ha e le hantle, bopaki bona bo ka ba bo sa khoneheng ha 'mele oa hau o ntse o fokolisa,' me u qetella u le makenete bakeng sa mefuta eohle ea lipelo tsa pelo, Alzheimer's, ho lahleheloa kelellong, le ho feta.

Mohlolo oa Nicotinamide Mononucleotide (NMN)

Ka hona, taba efe e amanang le Nicotinamide Mononucleotide? E-re ke hlalose.

NMN e teng ka bobeli ba alpha (α) le mofuta oa beta (β). Leha ho le joalo, β-NMN ke foromo e sebetsang ka ho fetisisa. Nucleotide ena e nkiloeng ke karolo e itseng ea ho iphetola hoa ha nicotinamide adenine dinucleotide kapa NAD +.

Sebaka sena ka tlhaho se teng li-avocado, tamati, likomkomere, cabbages, broccoli le nama ea likhomo e tala. Le laborateng, e fumaneha e le nicotinamide mononucleotide phofo e kholo.

Ka foromo ea eona e tala, e khetholla ka nomoro ea CAS, 1094-61-7. Motsoako ona o hlaha karabelong e lipakeng tsa nucleoside, joalo ka nicotinamide riboside le sehlopha sa phosphate.

Liphuputsong tse totobetseng, mosebetsi oa Nicotinamide Mononucleotide ho litoeba o iponahatsa o le o mongata mesebetsing ea lik'hemik'hale tsa lik'hemik'hale, ho laola lefu la Alzheimer, lefu la tsoekere le nang le lilemo, mathata a bakoang ke botenya, le lefu la pelo. Ho sa tsotellehe mesebetsi ena eohle ea phekolo ea metsoako e amanang le Nicotinamide Mononucleotide, ntho e fumanoang ka ho fetisisa ke ho kenya letsoho mesebetsing e khahlanong le botsofali.

'Mele oa motho, NMN ke mohloli o matla oa matla ka har'a lisele. Ha u ntse u hōla, matla a cellular a fokotseha ka lebaka la maemo a tlaase a nicotinamide mononucleotide le ho fokotseha ha morao ho NAD +. Ho tsamaisa NMN ho tla fetola mokhoa ona le ho lefella bofokoli boo.

(1) NMN e makatsa joang?

Lithethefatsi tsena tse thibelang botsofali li tsamaea joalo ka lehalima le tsoang ka maleng ho ea mali. Ka metsotso e seng mekae, li tla be li nketsoe maling. Ka lebaka lena, hoa hlaka hore ho kanna ha se be le tšebetso efe kapa efe ea biochemical e etsahalang tseleng ea limolek'hule.

Lebelo le makatsang le entse bafuputsi ho fihlela qeto ea monyetla oa ho tsamaisa, e nolofalletsang phepelo ea mafura a sele. Mohlala, Imai le metsoalle ea hae ba ikemiselitse ho fumana karabo ka boithuto ba hae ba morao-rao bo phatlalalitsoeng ka Pherekhong 7, 2019.

Ka botsofali, 'mele o sebelisa NAD + ho feta kamoo o ka o etsang. Leha o sebelisa nicotinamide mononucleotide haholo, ts'ebetso ena e ntse e tla ba tšenyo ea nako ha feela ho se molek'hule e thusang ho e tsamaisa. Tsoela pele ho phetla ho utulla mopalami ea makatsang ea tla rarolla mathata a 90% a botsofali.

(2) Mekhoa ea Motheo ea Nicotinamide Mononucleotide

(3) Mekhoa ea Nicotinamide Mononucleotide

lebitso Product	Phororo e khōlō ea Nicotinamide Mononucleotide (NMN)
CAS che.	1094-61-7
Tlhahiso ea mohlolo	C11H15N2O8P
Boima ba 'mele	334.221 g / mol
Ponahalo	Phosente e tšoeu ea kristale
Ho hloeka	> 98%
Solubility	Metsi a tsitsitseng
Storage mocheso	-20 ° C
mabitso a mang	· Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate· Β-nicotinamide mononucleotide· Beta-NMN· Nicotinamide ribonucleotide· 3-(Aminocarbonyl) -1-(5-O-phosphonato-beta-D- ribofuranosyl)pyridinium· Nicotinamide ribonucleoside 5'-phosphate

Nicotinamide Mononucleotide le NAD +

ka bobeli Nicotinamide Mononucleotide le NAD + ke li-biomarker tsa bohlokoa tse hlahisoang ke oli.

NMN ke mohokahanyi oa phetoho ea limela tsa Nicotinamide adenine dinucleotide (NAD +). Ntho e sebetsa e le karoloana ea li-enzyme tse khethehileng tse kang nicotinamide mononucleotide adenylyltransferase, e fetolelang NAD + 'meleng oa motho. Ka lebaka la ho silafala, karolo ena e fetoha ho nicotinamide. Ka mor'a moo, e na le tšusumetso e 'ngoe e thusang nicotinamide phosphoribosyltransferase (NAMPT) e etsang NMN.

Limolek'hule tsena tse peli lia kopana hoo ho se be teng ha leha e le efe ho bona ho tla ama e mong. Nka, mohlala, ha litekanyetso tsa NMN li oela ka tlase, mohlomong ka lebaka la ts'oaetso, boholo ba NAD + bo tla qetella bo fokotsehile.

Ha u ntse u hōla, mesebetsi e meng ea li-enzymatic e atisa ho ja NAD + ho feta 'mele o ka hlahisa mafura. Theirtuine, NADase, le poly-ADP-ribose polymerase (PARP) ke karolo ea li-enzyme, tse chesang NAD + e lebisang ho eona.

Leha ho le joalo, ho theoha ha lisebelisoa tsa cellular ha hoa lekana. Ka mohlala, nahana ka karabo ea lik'hemik'hale tse amang liphallelo tsa PARP ho lokisa DNA e senyehileng. Hape, li-sireriti li phetha karolo ea bohlokoa ho ntlafatsa metabolism ea cellular.

Le ha ho na le kamano ea bongaka lipakeng tsa li-biomarker tsena tse peli, le ka mohla u ke ke ua kenya NAD + ka kotloloho tsamaisong ena. Ka mokhoa oo ho ka khonehang, litla-morao li ke ke tsa mamelloa. Mohlala, tekanyetso e phahameng e tšoauoa ka mokhathala, ho tšoenyeha le ho hlobaela. Ho feta moo, motsoako ona ha o khone ho kena ka lera la lero la mali.

(1) Mechism of Absorption

The Anti-aging Nicotinamide Mononucleotidee fumaneha e le lithethefatsi tsa molomo. Ho kenngoa ha eona ka leboteng la maru le ka mokhoa oa ho potoloha ho qala ka metsotso e ka bang tharo. Ka 15^th min, kaofela ha eona e tla be e nkiloe. Phuputso e felletseng ea Imai le bafuputsi-'moho le eena e netefatsa hore ho na le protheine e potlakisang sekhahla sena sa ho monya ka potlako.

Ha li hlahisa likaroloana tsena, NMN e fetoha ka NAD + bakeng sa polokelo e bonolo. Mokhoa oa metabolism o ka nka halofo ea hora. Ntho ea mahloriso ea NAD + e jele setsi sa mesifa, tšoeu e tšoeu ea adipose, sebete le cortex. Leha ho le joalo, tsamaiso ea nako e telele ea Nicotinamide Mononucleotide e ile ea phahamisa boemo ba NAD + lithong tse ling tse kang li-brown adipose tissue.

(2) Litsela tsa NMN Biosynthetic

Ka har'a lisele tsa mammalian, ho na le litsela tse tharo tse fapaneng tsa mefuta-futa tse fanang ka chelete e fokolang ea NAD +.

①De Novo Tsela

De Novo ke lentsoe la Lain, le bolelang "ho tloha ts'imolohong." Mona, li-nucleotide li tsoa ho tryptophan kapa nicotinic acid, tse ka sehloohong li tsoa lijong tsa NMN tse ruileng.

Tseleng ena, ho latellana ha mosebetsi oa likokoana-hloko ho lebisa tlhophisong ea nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, mme qetellong ho lebeletsoe haholo NAD +. De Novo e hlahisa ka 15% ea palo ea lisele tsa cellular.

②Tsela ea Salvage

Mona, tsela e khutlisetsa nucleosides maemong ao DNA e theohang teng. E na le karolo ea 80% ea kakaretso ea NAD +, e leng 'mele oa motho o hlokang mesebetsi ea selefouno. Tsela e sebelisa nicotinic acid le nicotinamide ho etsa NAD e hloekileng.

Phootinate phosphoribosyltransferase e potlakisa ho thehoa ha nicotinic acid mononucleotide ho tloha nicotinic acid. Ka mor'a moo, nicotinamide mononucleotide adenylyltransferase 1 e kenyelletsa adenylation ea sehlahisoa se hlahisang nicotinic acid adenine mononucleotide, mme qetellong ho NAD +.

Mosebetsi oa NMN ho motho o ipapisitse le tsela ena.

③Phetolelo ea NR

Nicotinamide Riboside ke moeletsi e mong oa NAD +. Ka holim'a phosphorylation ka pel'a nicotinamide riboside kinase, biomarker e hlahisa NMN pele e e-ba le phetoho e 'ngoe ea enzymatic ho NAD +.

Histori ea NAD + le NMN ho Lipatlisiso

Ho theosa le lilemo, thuto le ts'ebeliso ea meriana ea nicotinamide adenine dinucleotide le pele ho eona e bile khalefo eohle. Leha ho le joalo, o lokela ho hlokomela hore tsena ho loantša botsofali ho tlatsetsa li 'nile tsa tšoaroa haholo ho lipatlisiso ho tloha bohareng ba 1900s.

Ka 1906, litsebi tsa pele li ile tsa bolela hore NAD + e potlakisa lebelo la ho belisa ka tomoso. Ka mor'a moo, litsebi tse ling tsa likokoana-hloko li ile tsa latela se nepahetseng ka ho li beha e le nucleotide.

Ka lipatlisiso tsa hae ho 1937, Conrad Elvehjem o fumane hore nicotinamide le nicotinic ke li-vithamine le li-precurse tsa NAD +. Hamorao, o ile a fumana hore tsena tse peli li ka fokotsa pellagra ho lintja. Lebaka ke hore maemong a nicotinic acid le nicotinamide e ne e le tlase ho batho ba nang le lefu lena.

Ka 1963, sehlopha sa bo-rasaense se ile sa theha hore Nicotinamide Mononucleotide e sebetsa litoeba e tla tsosa li-enzyme tse itšetlehileng ka DNA, tse neng li le bohlokoa ho matlafatseng mesebetsi ea lisele. Lilemo tse peli hamorao, bafuputsi ba bang ba ile ba hlahisa NAD + litsela tsa biochemical tse kenyang tryptophan le nicotinic acid.

Ho tloha ka nako eo, baeloji ba likokoana-hloko ba 'nile ba bontša thahasello ho patlisiso ea NMN le NAD +. Mehleng ena, ho tsepamisa maikutlo ho bohlokoa ho bohlokoa ba tsena lithethefatsi tse khahlanong le botsofali ka nako e telele le ho fokotsa mathata a amanang le lilemo.

Phuputso ea morao-rao ea Lipatlisiso tsa Nicotinamide Mononucleotide Mosebetsing Litulong

Ho na le liphuputso tse ngata tsa mekhoa e metle ea mefuta-futa e bontšang melemo ea kalafo ea Nicotinamide Mononucleotide (1094-61-7).

A re lebiseng tlhokomelo ho tse 'maloa, tse nang le phetoho ea phetoho liphatseng tsa lefutso.

(1) Ho latela Sinclair, NAD + ke Mohloli oa Bocha

Dr. Sinclair le basebetsi-'moho le eena ba phatlalalitse likarolo tse 'maloa tsa lipatlisiso mabapi le monyetla oa nicotinamide mononucleotide le NAD + ho fetola botsofali. Ho ea ka phuputso ea hae ea 2013, Sinclair le sehlopha ba fumane hore litoeba tsa likhoeli tsa 22 tse ntseng li nka NMN ka matsatsi a tšeletseng li bontšitse ntlafatso ea matla a mesifa, metabolism le mamello.

Hamorao ho pampiri ea lipatlisiso ea 2016, sehlopha se tiisitse hore NMN e na le melemo e tšoanang le ea ho ikoetlisa. Ho e-na le ho matha ka treadmill letsatsi le leng le le leng, u ntse u ka ba le liphello tse tšoanang ha u sebelisa lisebelisoa tsa Nicotinamide Mononucleotide ho e-na le hoo.

Ho ea ka ena Harvard Geneticist, the NMN e sebetsa ho batho e itšetlehile ka ho matlafatsa tšollo ea mali ho baatlelete ba hōlileng le ba phahameng.

(2) Mills e fana ka maikutlo a hore NMN e nolofalletsa ho fokotseha ha metso ho litoeba tse tsofetseng

Mabapi le thuto ea 2016, Mills et al. e fumane hore phekolo ea NMN e ne e tla thibela ho fokotseha ha tšebetso ea 'mele le ea immunology ho litoeba tsa khale. Qetellong ea patlisiso ena ea tlatsetso ea NMN, litoeba li ngolisitse keketseho ea polelo ea lisele tsa 'mele tsa ho itšireletsa mafung, ho ata ha lymphocytic, le ho fokotseha ha li-neutrophils.

Pejana, ho 2011, Mills, Yoshino, le Imai ba ne ba sebelisitse mefuta ea litoeba ho netefatsa karolo ea NAD + ho phekola lefu la tsoekere le bakoang ke lijo le lilemo. Thutong e 'ngoe hape ea 2016, o ile a ikopanya le bafuputsi ba bang ba ileng ba tiisa hore tlatsetso ea NMN e ka loants'a khatello ea mali le ho se sebetse ha methapo ea litoeba tse tsofetseng.

(3) Mathata a NMN a Alzheimer (AD) a Murine Models

Ka 2015, Long et al. e batlisitse phello ea NMN ho khaello ea phefumoloho ea mitochondrial ho litoeba tse nang le lefu la Alzheimer's. Sehlopha se hlokometse hore kalafo ea NMN e atlehile ho phekola etiology ea AD, ho kenyeletsoa le OCR e tlase (litefiso tsa ts'ebeliso ea oksijene), ho putlama ha NAD, le ho se tloaelehe ha mitochondria.

Ka 2016, Wang le metsoalle ea hae ba phatlalalitse lipatlisiso tsa bona, ba fihlela qeto ea hore tsena Khahlanong le botsofali lithethefatsi li loantša ts'oaetso ea kelello le neural, e bakoang ke oligomer ea lo-amyloid (Aomer). Protheine ena ea Aβ e na le neurotoxic mme e ikarabella bakeng sa sebopeho sa lejoe bokong ba bakuli ba AD. Wang et al. e phethile ka hore tsamaiso ea NMN ho litoeba e lebisitse ho fokotseheng ha li-oligomers, ka hona ea matlafatsa ts'ebetso ea kutloisiso.

Ka mor'a tlhahlobo ea 2017, Hou le basebetsi-'moho le eena ba ile ba sibolla hore NAD + ea tlatsetso e ile ea theola tlhahiso ea li-oligomere tsa β-amyloid. Selemo hamorao, Yao le sehlopha sa hae ba thehile hore Nicotinamide Mononucleotide e fokotsa ho bokella ha Aβ le tahlehelo ea synaptic ho mehlala ea AD-Tg murine.

(4) NMN le Cardio-ts'ireletso

Ho latela sengoliloeng sa 2014 sa Yamamoto le basebetsi-'moho le eena, NMN e sireletsa pelo khahlanong le likotsi tsa ischemic le repffusion. Pele ho thuto ena, Yamamoto e ne e le karolo ea sehlopha sa 2012, se fumaneng hore NAD + e bala litlolo tse bakiloeng ke ho ja botenya ho litoeba.

Ka 2016, De Picciotto et al. mme bo-ramahlale-'moho le eena ba ithutile ka phello ea tlatsetso ea NMN ts'ebetsong ea methapo ea litoeba tse tsofalang. Ho latela ts'oaetso, nicotinamide mononucleotide e ipakile e sebetsa ho feliseng ho se sebetse ha methapo, khatello ea mali le ho fokotseha ha elastin.

(5) Tlhahlobo ka Tsela e Ncha ea Motsoako oa Motsoako oa Shin-Ichiro Imai

Phuputsong ea morao-rao, sehlopha sa bo-rasaense se etelletsoeng ke Imai se ile sa fumana 'me sa emolla moemeli oa mohlolo oa NMN ka liseleng.

Patlisiso ena ea tlatsetso ea NMN e ile ea fumanoa pele ka January 2019 ho Tlhaho ea Metabolism. Imai o thehile hore protheine e itseng, Slc12a8, e ikarabella bakeng sa phetoho e potlakileng ea NMN ho NAD + le ho e fetisetsa seleng. Enzyme ena e ka sehloohong ho batho ba khale ho e-na le batho ba bacha kapa ba phetseng hantle.

Lithutong tsohle tsa pele ho nako, bo-rasaense ba etsang lipatlisiso ba tla qhala mehato e tsebahalang ea nicotinamide mononucleotide phofo e ngata ka metsing pele ba li fa litoeba.

Melemo ea Nicotinamide Mononucleotide (NMN)

NMN e na le mesebetsi e mengata ea phekolo le liphello tsa meriana 'meleng oa motho. Ka nako e ka tlaase ho lilemo tse leshome, bo-rasaense ba fane ka nako ea bona ho ithuta melemo eohle ea Nicotinamide Mononucleotide ho kenyeletsa le mekhoa e hlalosang botsofali le maloetse a amanang le lilemo.

Ha re hlahlobeng melemo ea setsi sa tsamaiso ea motho.

(1) Ho otlolla Cellular Lifespan

Ho fihlela ho qala ha 21^st lekholo la lilemo, litsebi li ne li e-na le mabaka a lekaneng a ho bolela botsofali e le mokhoa o ke keng oa qojoa. Leha ho le joalo, khopolo ena e fetohile e se nang thuso ka lebaka la ho sibolloa ha sekhahla sa ho loantša botsofali ho tlatsetsa joaloka Nicotinamide Mononucleotide.

NMN e etsahala ka tlhaho lisele tsa motho 'me e ikarabella bakeng sa phetoho ea limela tsa NAD + le tlhahiso ea matla. Ha u ntse u tsofala, lik'hemik'hale tsena tse peli li fokotseha li lebisa tlhophisong ea lisele tsa stem. Hopola hore lihlopha tsena tse sebetsang li hloka peterole e lekaneng bakeng sa ho pheta-pheta, mme ka hona, ho oa ho tla fokotsa nako ea bophelo ea lisele.

Ho tsamaisa lithethefatsi tse atlehang tse khahlanong le botsofali joaloka NMN ho tla fetola mokhoa ona le ho lieha ho tsofala.

(2) Ho tšehetsa Mekhoa ea Matla a Matla a Bocha

Tšimoloho e ka sehloohong ea maloetse a mangata a amanang le botsofali a fokotsehile ho fihlela moemong oa lisele tsa cellular. Ho fokotseha ha tlhahiso ea matla ka har'a lisele ke sesosa se seholo sa matšoao a botsofali.

Ho ba moemeli oa NAD +, NMN e na le karolo e lokelang ho e bapala ho boloka matla a matle a mitochondria ea sele. Botsofali bo tla baka ho fokotseha ha mahlakore a NAD +. Ka lebaka leo, botsofali bo nka nakoana ho lebisa tlhokomelong ea mafu a botsofali.

Ho theoha ha litebelisoa tsa matla a cellular ka hare ho litho tsa bohlokoa tse kang mesifa, methapo ea mali, liphio, sebete, kapa liphakose li sitisa bophelo bo botle ba 'mele le kutloisiso. Ke ka lebaka lena mafu a kang ischemia, maemo a pelo, ho hloleha ha liphio, mathata a ho ba le pelo, le ba bang ba thunya.

Tharollo e phethahetseng ke ka ho tlatselletsa 'mele Mononucleotide ea Nicotinamide le NAD + ka phekolo ea NMN e ka ntle. Lithethefatsi tsena tse thibelang botsofali li fana ka bophelo bo bocha ho lisele tse tsofalang, tse tla beha ponahalo ea bocha.

(3) Ho Ntlafatsa Tsamaiso ea Mali

E 'ngoe ea liphetoho tse etsahalang nakong ea khale ke ho fokotseha ha boleng ba methapo ea mali ka har'a' mele oa mammalian. Ka hona, tsamaiso ea li-circulatory e na le mathata a mangata ha e jara limatlafatsi, oksijene, mocheso kapa ho tlosa litšila lithong. Kaha maemo a ntse a phehella, a mpefala ha nako e ntse e lebisa tlhokomelo ea mafu a nako e telele.

Nicotinamide Mononucleotide e ikarabella ka ho toba bakeng sa tlhahiso ea methapo ea mali. E-re ke hlalose. The compound e etsa NAD +, e leng eona e sebelisang protheine ea sirtuin deacetylase (SIRT1).

Ka lehlakoreng le leng, SIRT1 e fokotsa lihlahisoa tsa lysine tse thusang ho hlahisa li-radicals mahala. Mokhoa ona o loantšana le khatello e ka 'nang ea e-ba teng ea oxidative, reperfusion, kapa lik'hemik'hale. Maemong a tloaelehileng, 'mele ka boeona o tla sebetsana ka katleho le senyemia le maemo a amanang le' ona ka ho sebelisa li-ischemic preconditioning (IPC). IPC e tla nka khato ho susumetsa tlhahiso ea SIRT1.

O ka fana ka tsamaiso ea NMN pele ho ketsahalo e sa tloaelehang kapa nakong ea ponahalo ea eona. Pele ho etsahala, setsi sena se fana ka li-cardio-ts'ireletso ka ho eketsa tlhahiso ea ATP ka glycolysis.

Tabeng ea Ischemia, o ntse o ka sebelisa Nicotinamide Mononucleotide kaha e tla baka acidosis mme e bake ho fokola ha mitochondrial; ka hona, ho netefatsa ts'ireletso ea sistimi ea pelo.

(4) Mamello ea Mamello

U lebelletse eng ha phallo ea mali e fokotseha? Hantle, mmuso o tla lebisa ho lahleheloeng ke mesifa. Ha ho pelaelo hore o tla hlokomela hore batho ba khale ha ba sebetse hantle, mamello e tlase, ha ba khone ho tsamaea ebile ba khathetse haholo ka linako tsohle.

E 'ngoe ea tse sibolotsoeng ke Dr Sinclair e ne e shebile bokhoni ba NMN ho matlafatseng matla a mesifa. Ho latela liphuputso tsa hae tsa 2013 le tsa 2018 tsa morao-rao, litoeba tsa khale tse pepesitsoeng kalafo ea matsatsi a supileng ea NMN li ile tsa phela hantle 'meleng le ho ba mafolofolo joaloka balekane ba bona ba banyane.

Matla a mesifa le mamello ea litoeba tsa khale ka ho fetisisa (likhoeli tse 30) li ne li tšoana le tsa ngoana ea likhoeli li hlano. Mengwaha ena e bapiswa le dilemo tse ka bang 70 le 20 ho batho. Ho tsoa ho liphuputso, o ka fana ka maikutlo a hore mosebetsi oa NMN ho batho ke lefu.

(5) Ho loantša Mathata a Neurodegenerative

Boko bo tšoana le matla a tsamaiso ea hau. Tšobotsi ena e ka 'na ea e-ba lebaka leo ka lona meriana e tla lula e itšetleha ka mesebetsi ea boko ha e phatlalatsa nako ea lefu.

Ho fokotseha ha maemo a NAD + bokong ho sitisa bophelo bo botle ba kelello har'a batho ba hōlileng. Tsamaiso ea NMN e potlakisa tlhahiso ea NAD, kahoo, ho sireletsa mesebetsi ea neural.

Lithuto tse ngata li paka hore Nicotinamide Mononucleotide e thusa ho tseba, ho otloa ke stroke, le ho sitisa tahlehelo ea mohopolo, e atileng le botsofali. Ka kakaretso, sena Khahlanong le botsofali tlatsetso e ikarabella ho tlhokomelo ea li-neuron.

NMN e shebile haholo ho etiology ea boemo bofe kapa bofe ba methapo. Mohlala, Alzheimer's Boloetse bo hlaha ka lebaka la ho fokotseha ha NAD +, sekhahla se tlase sa ts'ebeliso ea oksijene bokong, le ho sa tloaelehang hoa mitochondrial. Ho eketsa palo ea NMN 'meleng ho sebetsana le litlamorao tsena tsohle.

Ho ea ka phuputso e phatlalalitsoeng ka 2012, Nicotinamide Mononucleotide e tla sebetsana ka katleho le tšenyo ea kelello, e atisang ho lebisa ho stroke. Litoeba tsa khale tse neng li le tlasa litekanyetso tsa NMN li ngolisitse ntlafatso e kholo tlhahisong ea NAD + e sa sebetseng. Mefuta ena ea lipatlisiso e ne e sirelelitsoe ka ho fetesisa khahlanong le leqeba la ischemic, lefu la methapo le ho ruruha ha methapo.

(6) Metabolism e ntlafalitsoeng botsofaling

Bafuputsi ba 'maloa ba ithutile le ho paka hore NMN e thusa ho mamellana ha glucose ha ho ntse ho matlafatsa metabolism ea tsoekere holim'a litoeba tsa botsofali ka lijo tse futsanehileng. Phuputso ena e boetse e sebetsa ho batho ba tsofetseng ba hlaolelang lefu la tsoekere ka lebaka la tsoekere e phahameng kapa phepo e mpe. Ho phaella moo, ho ja ho nang le mafura ho lebisa ho insulin ho hanyetsa.

Nicotinamide Mononucleotide e boloka tlhōrō ea tlhahiso ea NAD +, e leng se fokotsang ho ruruha ho amanang le lilemo ha e ntlafatsa ts'ebetsong ea insulin lithong tse mafura.

(7) Phekolo ea lefu la tsoekere

Batho ba nang le lefu la tsoekere la mofuta oa II ba lula ba le khahlanong le insulin. Tšobotsi ena e bakoa ke ho oa ha NAD +. Ka lebaka leo, lisele li ba le khatello ea mali le ho ruruha. Haeba o sa le monyane, 'mele o tla ipha matla ka ho etsa lintho tse ling tse amanang le' mele. Leha ho le joalo, ka botsofali, maemo a NAD + a fokotseha lithong tse tšehetsang bophelo joalo ka mesifa ea masapo, sebete, boko le manyeme.

Lebaka le leng le tlatsetsang lefung la tsoekere ke lijo tse nang le mafura a mangata. Palo e sa tloaelehang ea mafura a khotsofatsang e thibela biosynthesis ea NAD +. Ka sepheo sa ho paka katleho ea Nicotinamide Mononucleotide kalafong ea lefu la tsoekere le bakoang ke lijo, Yoshino le basebetsi-'moho le eena ba ile ba sebelisa litoeba tse peli.

Kamora ho fana ka tekanyetso ea letsatsi le letsatsi ea NMN bakeng sa matsatsi a ka bang 10, litsebi li ile tsa tiisa hore litoeba, tse neng li fuoa lijo tse nang le mafura a mangata, li ile tsa hatisa ho hloka mamello ha insulin. Ka lehlakoreng le leng, litoeba tsa lefu la tsoekere li bontšitse ntlafatso e kholo ho hyperlipidemia.

(8) Ho tsofala botsofaling

Mathata a bophelo bo sa foleng a lula a tsamaisana le botsofali. Ha 'mele o e-ba le liphetoho tse' maloa tsa 'mele, mesebetsi e meng ea cellular e etsahala ho khutlela morao. Nka, mohlala, litekanyetso tsa nicotinamide adenine dinucleotide li fokotseha likarolong tse ngata, tse lebisang ho fokotseha ha tlhahiso ea matla ka mitochondrion ea sele.

Botsofali bo etsa lintho tse sa tšoaneng tse kang ho senya DNA ka lebaka la limolek'hule tse sa lefelloeng, khatello ea li-vascular oxidative le mathata a mang a ho utloisisa. Na ua tseba se etsahalang? Hantle, ho na le protheine ea ho lokisa DNA (PARP1) tsamaisong ea motho. Tabeng ea tšenyo ea DNA, NAD + e tla bula protheine ena ho lokisa sele e amehileng.

Lithuto tse 'maloa li hlahisitse melemo ea nicotinamide mononucleotide botsofaling. Ka mohlala, Mills le basebetsi-'moho le eena ba ile ba sebelisa mekhoa ea litoeba ho batlisisa phello ea ho fokotseha ha 'mele ho bakoang ke lilemo tsa NMN.

Phuputsong eo, bafuputsi ba boletse hore tsamaiso ea nako e telele ea phekolo e lebisitse ho phahama ha liphatsa tsa lefutso tse sebetsaneng le sebete, mesifa ea masapo le mesifa ea adipose. Ho feta moo, liphuputso li tiisitse ho ntlafatsa liphatlalatso tsa 'mele oa' mele, ho eketseha ha lymphocyte, le ts'ebetso ea leukocyte.

Sebaka se seng sa botsofali ke boteng ba mabala a khanyang ka chelete ea mahlo. Boemo bona hammoho le ho senya ha masapo le ho sitoa ho hlahisa meokho ho 'nile ha ithutoa ka ho feletseng ka litoeba. Bo-rasaense ba hlokometse hore litoeba, tse ileng tsa kenngoa kalafo ea NMN ea khoeli ea 12, li ile tsa fetola maemo 'ohle a ka holimo.

Nako e telele ke eona feela lebaka leo ka lona batho ba leng teng reka Monotucleotide ea Nicotinamide.

(9) Kalafo ea Botenya

Bakeng sa ba hōlileng, NMN e ka fokotsa ho fihlela ho 10% ea boima ba 'mele ba pele ntle le ho fumana sebaka se pakeng tsa takatso le kgolo. Mokhoa oa ho kula haholo le lefu la tsoekere o amana. Maemong a tlaase a NAD + a tlisa ho se sebetse ha mitochondrial; ka hona, ho fokotseha ha tlhahiso ea ATP.

Botenya bo fokotsa matla a mitochondria ho hlahisa ATP matla bakeng sa lisele. Hang ha o fana ka Nicotinamide Mononucleotide, meriana eo e tla ntlafatsa ho hloka mamello ha glucose le mesebetsi e meng ea metsoako e amanang le botenya.

Ha ho tluoa ho ntlafatseng phallo ea mali, NMN ea kalafo e feteletseng e sebetsa ka mokhoa o ts'oanang le ho ikoetlisa. Pilisi e le 'ngoe e ka tšoana le ho sebelisa treadmill letsatsi le leng le le leng. Leha ho le joalo, phapang e tla maemong a litaba tsa NAD + lithong tsa 'mele. Le ha Nicotinamide Mononucleotide e eketsa NAD + liseleng tsa sebete le mesifa, boikoetliso bo matlafatsa komporo ka har'a mesifa feela.

Na Nicotinamide Mononucleotide (NMN) e Hlile e Sebetsa Batho?

E kanna eaba ena ke potso ea hajoale e llang ka hloohong ea hau. Leha ho le joalo, lipatlisiso tsohle le lithuto tsa pele ho tlhokomelo tse shebaneng le Nicotinamide mononucleotide le NAD + esale li shebile mefuta ea murine.

Haeba u na le liphallelo mabapi le katleho ea NMN e sebetsang ho batho, ke tsena tsohle tseo u lokelang ho li tseba. Dr. David Sinclair, mofuputsi ea phahameng le setsebi sa liphatsa tsa lefutso Univesithing ea Harvard ke e mong oa ba amohelang NMN.

Sinclair oa lumela hore o nka tlatsetso. Ho fihlela joale, setsebi ha se so tlalehe litla-morao tsa nicotinamide mononucleotide. Ho fapana le moo, o re o ikutloa a le monyane ka kelello e hlaphohileng. Li-hangovers le jet lags joale ke nako e fetileng ho eena. O boetse a tiisa hore ntate oa hae, ea lilemo li ka bang mashome a supileng, le eena o nka tlatsetso.

Ho phaella moo, Dr. Sinclair o sebelisitse phekolo e le nyeoe ea pele ho Brigham le Sepetlele sa Basali. O na le merero ea ho tsoela pele ho hlahlojoa tlatsetso ho batho ba baholo ba phetseng hantle. Le hoja thuto ea hae e le 'ngoe e phethiloe, o sa ntse a tla etsa khatiso ea molao. Sinclair o qalile karolo ea bobeli ea tleliniki ena Tlatsetso ea NMN ho etsa lipatlisiso a 2018.

Litlhahlobo tsa meriana

Thutong ea bongaka e lokelang 1^st Ka June 2020, bafuputsi ba batla ho theha phetoho ea kutloisiso le beta-cell e sebetsang le tlatsetso ea NMN ho batho. Litsebi li tsoa Sekolo sa Bongaka sa Bongaka sa Washington le Keio University School of Medicine e Tokyo.

Tekong ea batho e ileng ea emisa 2016 Keio University, litsebi li ne li batla ho hlahloba polokeho ea NMN ho batho ba baholo ba phetseng hantle. Karolong ea bobeli e tsoelang pele, setsi se le seng, se eteletsoeng ke Shin-Ichiro, se ntse se etsa lipatlisiso ka nako e telele ea tsamaiso ea NMN. Ho feta moo, sehlopha se batla ho hlahloba mekhahlelo e amanang le lefu lena la methapo-hloko, NMN kinetics, le phello ea lithethefatsi ka methapo ea methapole ea methapole.

Phuputsong ea kliniki ea 2017 ea Univesithing ea Washington, litho tsa sehlopha li ne li kenyeletsa basali ba 50 ba lilemo li 55 ho ea ho lilemo tse 75. Sehlopha se ne se behoa litekanyetso tsa letsatsi le letsatsi tsa 250mg ea NMN libeke tse robeli. Le hoja e ne e le batho ba nang le bophelo bo botle, basali bana ba ne ba e-na le likarolo tse phahameng tsa tšelo ea mali, triglyceride le BMI. Thuto ha e e-s'o phethe.

Joalo ka hajoale, ha ho na lingoliloeng tse lumellanang le mosebetsi oa NMN ho batho. Leha ho le joalo, o lokela ho ts'oara hobane ho na le ho phehang mme liteko tsa bongaka li kanna tsa ts'episa.

Kamoo U ka Sebelisang Nicotinamide Mononucleotide (NMN) Bakeng sa Botsofali?

Haeba u batla ho reka nicotinamide mononucleotide, ho na le lintho tse seng kae tseo u lokelang ho li tseba.

U ka nka feela phekolo e le phaello ea lijo hobane e e-s'o fumane tumello ea ho qetela ea FDA hore e be moriana oa ngaka.

Litekanyo tsa litekanyo li pakeng tsa 25mg le 300mg ho itšetlehile ka melemo ea bophelo bo botle eo u batlang ho e finyella. Leha ho le joalo, batho ba bang ba lumela ho nka 1000mg ka letsatsi. Nka, mohlala, Dr. Sinclair o nka 750mg / letsatsi. Ntle ho moo, o tlatsa puso ena ka resveratrol le metformin.

Litekong tsa meriana ea NMN, bafuputsi ba bangata ba ne ba tla beha bafo ba bona ka lebelo la 100mg le 250mg.

Mantsoe a hlalosang molumo

Haeba o batla ho eketsa ts'ebeliso ea bioava ea tlatsetso ena, u lokela ho reka matlapa a Nicotinamide Mononucleotide bakeng sa tsamaiso ea litlhaku. Ho sebelisa lithethefatsi molomong ho fokotsa chelete e kenngoa ka har'a lisele. Lebaka ke hore li kenngoa metabolism le ho silafala ha li feta tšebetsong ea lijo le sebete.

NMN e ikemetseng e kenella ka ho toba maling ntle le litlhapi leha e le life. Tekanyo ea mocheso ea mokhoa ona oa ho pepa e ka ba ka makhetlo a mahlano ho feta tsamaiso ea lentsoe. Tabeng ena, o tla tlameha ho eketsa litekanyetso ho etsa pele ho feta metabolism sebeteng. Ha u re u ntse u etsa lipatlisiso, u ka 'na ua hloka nicotinamide mononucleotide phofo e kholo hore u phethe thuto.

Phello e Ntle ea Nicotinamide Mononucleotide U Lokela ho Tseba

Tloaelehileng li ts'oana le tse bonts'itsoeng ke niacinamide le litla-morao tse ling tsa vithamine B3 komponnicotinamide mononucleotide s. Leha ho le joalo, batho ba bangata ha ba bile le boiphihlelo ho hang. Mohlala, rasaense ea phahameng oa lipatlisiso oa Univesithi ea Harvard o lumela ho nka NMN, empa ha a so ka a bona litlamorao tsa ho kokota.

Ho fihlela joale, hohle Nicotinamide Mononucleotide e fumanehang ho sebetsa litoeba, ha ho boitsebiso bo bonts'ang hore ho na le litla-morao leha e le life ka mehlala ea murine. Ha ho mofuputsi o ngotseng matšoao a mabe ka bobeli nakong e khutšoanyane le ea nako e telele ea tsamaiso ea NMN.

Batho ba bang ba ka 'na ba bona litlaleho tse latelang tse mpe;

• Nausea
• Ho otla
• Sehlōhō
• Mathata a ferekane
• Letšollo
• Liphetoho tsa litlama tse kang ho itchiness, hives, kapa rashes

Maemong a sa tloaelehang, litla-morao tsa nicotinamide mononucleotide li ka ba matla ho isa tekanyong eo u lokelang ho batla tlhahlobo ea bophelo bo botle hang-hang. Ho bua ka tse seng kae, mathata a phefumoloho, ho otla pelo ha pelo, ho hlatsa ka nako e telele, letlalo la mosehla le ho lahleheloa ke takatso ke tse ling tsa matšoao a maholo.

Litlhōlisano

Ho fihlela joale, liteko tsa litliniki li 'nile tsa tsepamisoa ke batho ba baholo ba phetseng hantle nakong ea lilemo tsa 45 ho ea ho lilemo tse 75. Ka lebaka lena, lihlopha tse latelang li lokela ho ba hlokolosi pele li fana ka lisebelisuoa tse khahlanong le botsofali ba NMN.

• Bakhachane le ba anyesang
• Batho ba nang le histori ea hypersensitivity ho NMN
• Bakuli ba noang meriana bakeng sa maloetse a sa foleng

Nka fumana lithethefatsi tse khahlanong le botsofali-Nicotinamide Mononucleotide (NMN) kae?

(1) Lihlahisoa tsa lijo tsa NMN

U ka 'na ua ikitlaetsa ka hore na ke hobane'ng ha u lokela ho reka Nicotinamide Mononucleotide ha u ka e fumana habonolo lijong tse itseng. E-re ke hlalosetse ka bokhutšoanyane hore na ke hobane'ng ha tlatsetso ena e hlokahala.

Ha NAD + e theoha 'meleng ka lebaka la botsofali, lisele li ke ke tsa khona ho loantša phello. Ka nako ena, khetho ea hau e ka 'na ea e-ba ho sebelisa lisebelisoa tsa NMN. Lingaka li tla u khothalletsa hore u nke lijo tse nang le NMN tse kang broccoli, li-mushroom, edamame kapa shrimp. Leha ho le joalo, lijo tsena li tla fana ka tlase ho 5% ea seo 'mele oa hao o se hlokang.

FDA e khothalletsa hore motho leha e le ofe a hloka hoo e batlang e le 560mg ea NMN ka letsatsi. Ha u re u ka fumana setlankane ho broccoli, u tla tlameha ho ja lichelete tsa 1500 tse tšoanang.

(2) Lisebelisoa tsa NMN

The nicotinamide mononucleotide phofo e kholo e fumaneha libakeng tse ngata tsa meriana le lithethefatsi kapa laboratories. Haeba u batla tse ling bakeng sa lipatlisiso tsa hau, u ka etsa lethathamo la bongata, le nang le theko e theko e tlaase le litefiso ho litefiso tsa ho romella.

Ho reka inthaneteng ea NMN ha ho boloke nako ea hau feela empa hape ho fana ka sethala se setle sa ho bapisa litheko tse fapaneng. Haeba u se mofuputsi, u ntse u ka reka Nicotinamide Mononucleotidesupplements bakeng sa tšebeliso ea hau. Pele o etsa odara, etsa bonnete ba hore ke sehlahisoa sa boemo ba lijo.

Summary

Ho utloahala ho sa utloahale ho bolela hore NMN e eketsa nako ea bophelo ea batho. Leha ho le joalo, taba ena e tiile. Lebaka la lefu har'a batho ba tsofetseng ke ka lebaka la maloetse a bakoang ke lilemo tse ngata, tse hlahang ka lebaka la mesebetsi e seng mekae ea cellular.

Theanti-botsofali Nicotinamide Mononucleotide e kenella feela ho ntlafatsa phepelo ea mafura a cellular le ho matlafatsa ts'ebetso ea lisele. E sebetsa ka ho laola NAD +, e atisang ho fokotseha ha re ntse re tsofala.

Ho sebelisa li-creams tsa botsofali, li-moisturizers, li-sunscreens, kapa ho ikoetlisa kamehla ka phepo e nepahetseng ho ka fetola sefahleho sa hao feela. Leha ho le joalo, o hloka ho utloisisa mohloli oa mathata a botsofali ho sebetsana le bona ka bomong. Nicotinamide mononucleotide e fetola ts'ebetso ea ho tsofala ka ho lokisa DNA e senyehileng, ho sireletsa boko, pelo ea pelo, ho ntlafatsa mesebetsi ea mesifa le ho matlafatsa mamello.

Haeba o batla phofo e kholo ea nicotinamide mononucleotide, hlahloba le rona 'me u thabele litekanyetso tsa botsoalle.

References

1. Mills, KF, Yoshino, J., Yoshida, S., le al. (2016). Tlhaloso ea nako e telele ea Nicotinamide Mononucleotide e fokotsa ho ba le mekhoa e fokolang ea mekhoa ea mefuta ea lilemo. Cell Metabolism.
2. Yoshino, J., Mills, KF, Imai, SI, le Yoon, MJ (2011). Nicotinamide Mononucleotide, e leng senotlolo sa NAD + se Akaretsang, se sebetsana le Pathophysiology ea lefu la tsoekere le la lilemo-ngata tse fumanoang ke litoeba. Cell Metabolism.
3. Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., le Sadoshima, J. (2014). Nicotinamide Mononucleotide, ea Bohareng ba NAD + Synthesis, e Sireletsa Pelo ho tloha Ischemia le Reperfusion.
4. Sinclair, DA, Uddin, GM, Youngson, NA, le Morris, MJ (2016). Hlooho ea Hlooho ho Hlooho Ho Bapisoa le Phekolo ea nako e Khuts'oanyane le Nako-pele ea NAD + ea Nicotinamide Mononucleotide (NMN) le Libeke tse tšeletseng tsa ho ikoetlisa Meleng ea Bo-'mè ba Bo-'mè.
5. Imai, S., Yoshino, J., Mills, KF, Grozio, A., le al. (2019) Slc12a8 ke Transotter ea Nicotinamide Mononucleotide. Tlhaho ea Metabolism.
6. De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, le al. (2016). Nicotinamide Mononucleotide e furalla ho se sebetse ha li-Vascular le khatello ea kelello ea likokoana-hloko le litoeba tse tsofetseng.
7. Yao, Z., Gao, Z., Yang, W., le Jia, P. (2017). Nicotinamide Mononucleotide e Thibela JNK Ho Etsa Hore ho Phekoloe Maloetse a Alzheimer.
8. Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Tlatsetso e lekanyetsa litšobotsi tsa Alzheimer ea Key le DNA Litlhaselo Tlokotsing ka New AD Mouse Model ka Khaello ea DNA Repair Repair.
9. RAW NICOTINAMIDE MONONUCLEOTIDE (NMN) MOPU (1094-61-7).