1. Pterostilbene ke eng?

Pterostilbene ke k'hemik'hale ea bohlokoa e hlahisoang ka tlhaho nakong ea bophelo ba limela tse ling e le mokhoa oa ho loants'oa tšoaetso. K'homphieutha ena e tšoana le k'homphieutha e ngoe e tsejoang e le resveratrol 'me e fumaneha habonolo ka foromo ea tlatsetso. Li-supplement tsa Pterostilbene li fumaneha haholo. Sena se bolela hore li ka kenella 'meleng habonolo le kapele ebile ha li nyenyefatsoe nakong ea ho sililoa. Pterostilbene phofo le eona e sebetsa, empa nako ea eona ea bophelo e khuts'oane haholo hobane e tlasa metsotso e 100.

Mehloli ea lijo ea Pterostilbene

Pterostilbene Mehloli ea lijo e kenyelletsa li-blueberries, almonds, cranberries, mulberry, peanse, veine e khubelu, morara o mofubelu, makhasi a morara, makhapetla a sefate sa India se, Red sandalwood, le cocoa. Li-Blueberries, leha ho le joalo, ke mohloli o phahameng ka ho fetisisa oa lijo tsa Pterostilbene, empa palo ea li-blueberries e ntse e le nyane ha e bapisoa le tlatsetso ea Pterostilbene Litaba tsa "bloter" tsa Pterostilbene li lumeloa hore li ka ba 99 ho isa ho 52 li-nanograms ho gram e ngoe le e ngoe ea li-blueberries.

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2.Mochine oa ts'ebetso oa Pterostilbene

Mochine oa ts'ebetso oa Pterostilbene o fapane le oa resveratrol. Pterostilbene komporo ke eona e nang le matla ka ho fetisisa. Melemo e fapaneng ea Pterostilbene phofo e tsamaisana le mochine o fapaneng oa ts'ebetso le. Ketso ea pharmacological ea trans-pterostilbene e kenyelletsa antineoplastic, antioxidant, le anti-inflammatory.

Pterostilbene e bonts'a mesebetsi e sebetsang ea antifungal e matla ho feta makhetlo a leshome ho feta resveratrol. Pterostilbene e boetse e bonts'a litla-morao. Tšireletso ea limela ho tsoa ho likokoana-hloko tse 'maloa e bonahala e le mokhoa oa bohlokoa oa li-stilbenes, ho kenyelletsa le Pterostilbene,' me mesebetsi ena e atoloha ho liphoofolo le bathong.

Pterostilbene e boetse e bonts'a litlamorao tsa anticancer ka methapo e mengata ea limolek'hule. Lipatlisiso li bonts'a liketso tsa Pterostilbene li kenyelletsa mefuta ea tumor suppressor, phetisetso ea lits'oaetso tsa phetisetso ea li-ishara, oncogene, liphatsa tsa lefutso tsa sele, le mefuta ea taolo ea potoloho ea sele.

Lintho tsa antioxidative tsa Pterostilbene li fapane haholo le tsa resveratrol. Ka resveratrol, lihlopha tse tharo tsa hydroxyl li khelosa ROS (mefuta e sebetsang ea oksijene) ka li-lymphoblasts tse se nang mali le mali kaofela ha Pterostilbene, e nang le sehlopha sa 1 hydroxyl le lihlopha tse 2 tsa methoxy li fokotsa ROS ea extracellular. Ts'ebeliso ea lehae ea thepa ea antioxidation e thusa ho sebelisoa ha phofo ea Pterostilbene ho lebisa mefuta ea oksijene e sebetsang, e bakang tšenyo ea lithane nakong ea ts'oaetso e sa foleng.

Ka tlase ho na le mekhoa ea ho sebetsa e buisanang ka lintlha tse ling;

Mochine oa ts'ebetso oa Pterostilbene; Ts'ebetso ea Sirtuin

Pterostilbene e hlohlelletsa tsela ea ho supa ea SIRT1 liseleng tse fanang ka ts'ireletso khahlano le ts'enyo ea cellular, ka hona e e kenya tšebetsong. Mmila ona o eketsa p53 polelo. P53 ke protheine e sireletsang DNA khaellong le e sirelletsang lisele tse khahlanong le liphetoho tse ka bakang mofetše.

SIRT1 e ka u thibela ho senyeha le ho fokola ha lisele, tse tsoelang pele ha u ntse u tsofala.

Liphetoho tse khahlanong le ho Ruruha

Boithuto bo 'maloa bo bonts'itse hore pterostilbene lik'hemik'hale lik'hemik'hale tse tlase tse fokotsang matla tse laoloang ke TNF-alpha (tumor necrosis factor-alpha). Khatello ea kelello ea Oxidative e tlisa ho ruruha; Pterostilbene e thibela li-interleukin-1b le TNF-alpha ka ho fokotsa mefuta ea oksijene e sebetsang.

K'homphieutha ena e boetse e sireletsa khahlanong le khatello ea kelello ka har'a mochine oa mehala o tsejoang ka hore ke ER (endoplasmic reticulum). Phuputsong, ha marang-rang a lisele tsa methapo ea mali a pepesetsoa phofo ea Pterostilbene, maro a tsona ha a ka a arabela matšoao a ts'oaetso, mme ha a ka a bonahala a ferekane.

Mochine oa ts'ebetso oa Pterostilbene; Liphello tsa Khahlano le Kankere

Ho makatsang ke hore, leha a fokotsa khatello ea methapo ea methapo ea methapo ea kutlo (endoplasmic reticulum) ka har'a methapo ea methapo ea mali, Pterostilbene e eketsa khatello ea methapo ea methapo ea kutlo liseleng tsa mofetše oa 'metso. Ka hona, e senya lisele tse nang le mofetše ka mokhoa o ikhethileng 'me e sireletsa khahlanong le khatello ea maikutlo ka liseleng tse phetseng hantle.

Liseleng tsa mofetše tsa mokokotlo kapa bokong (glioma), Pterostilbene e theola Bcl-2 mme e tsosa Bax; liphetoho tsena li eketsa matšoao a "ho ipolaea" ha sele ho etsa hore lisele tsa mokokotlo kapa tsa boko li shoe.

Lisele tsa kankere li sebelisa tsela e tsejoang e le Notch-1, ho itšireletsa liketsong tsa meriana ea chemotherapy, ho kenyelletsa oxaliplatin le fluorouracil. Pterostilbene e thibela Notch-1 e bonts'a li-tumors li utloahala haholo kalafong ka chemotherapy.

Pterostilbene e theola tlhahiso ea likhomphutha tse 'maloa tse khothaletsang mofets'e, ho kenyeletsa MUC1, b-catenin, Sox2, NF-κB, le CD133. Litlamorao tsena li fokotsa ho ruruha 'me li etsa hore ho be thata ho hola lisele tsa mofetše.

neuroprotection

Pterostilbene e khona ho lebisa sebaka sa hippocampus ka mokhoa o ikhethileng bokong. Mona, e matlafatsa CREB (proteni e arolang likarolo tsa cAMP), BDNF (brain-based neurotrophic factor), le MAPK (mitogen-activated protein kinases),

Liprotheine tsena tse tharo li thusa li-neuron ho ngatafala, ho hola le ho arabela hantle tikolohong ea tsona. Li-antidepressants tsa SNRI le tsona li habile litsela tsena.

Pterostilbene e boetse e eketsa protheine e tsejoang e le Nrf2 hippocampus, eo ka lehlakoreng le leng e matlafatsang polelo ea liprotheine tsa antioxidant.

Pterostilbene e thibela 'mele khahlanong le lefu la Alzheimer's ka ho fana ka tšireletso bokong khahlanong le beta-amyloid (Aβ). E etsa sena ka ho kenyelletsa Akt le PI3K, liprotheine tse peli tse tšehetsang kholo ea neuron, mohopolo le ho ithuta.

3. Melemo ea Pterostilbene phofo

Ho tšohloa ka tlase mona ke tse tharo tsa bohlokoa ka ho fetisisa pterostilbene phofo melemo;

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i. Pterostilbene joalo ka nootropics

Ha re ntse re tsofala, mehopolo e mecha ea menahano e ba thata haholo ho e theha, 'me ho ba thata ho e hopola. Ho sitoa ho etsa mesebetsi e tloaelehileng ea kelello ho fokotseha le hona. Li-supplement tsa Pterostilbene li ka thusa ho theha tikoloho e nchafalitsoeng ea neural ka nako efe kapa efe.

Pterostilbene ke nootropic e matla, e thusang boikhathollong ba kelello le ntlafatso ea kelello. E boetse e nkoa khafetsa nakong ea boikoetliso ba pele ho nako ka lebaka la bokhoni ba eona ba ho thusa ho vasodilation ea methapo ea mali. Ka hona, e fana ka litlamorao tse ts'oanang le tsa lisebelisoa tse ling tsa nitric oxide boosting.

Melemo ea Pterostilbene nootropic ho lumeloa hore e ka lebaka la bokhoni ba eona ba ho eketsa maemo a dopamine. Ka litoeba, Pterostilbene e theoletse matšoenyeho le ho ntlafatsa mohopolo. Patlisisong e kenyelletsang litoeba tsa khale, li-tlatsana tsa pterostilbene li phahamisitse maemo a dopamine le temohisiso e ntlafalitsoeng. Hape, ha Pterostilbene e ne e fumaneha ka kelellong ea likhoto, "memory memory" ea bona e ile ea matlafatsoa.

Phuputsong e 'ngoe e amanang le likhoto, Pterostilbene hape e ntlafalitse kholo ea lisele tse ncha hippocampus. Hape, lisele tsa stem tse tsoang bokong ba litoeba tse nyane li ile tsa hola ka potlako ha li pepesetsoa Pterostilbene.

Ho ea ka lithuto tsa sele, pterostilbene phofo e thibela MAO-B (monoamine oxidase B) mme e eketsa dopamine e teng ka har'a masapo a rona a kelello. Ketso ena e ts'oana le lithethefatsi tse phekolang lefu la Parkinson, joalo ka rasagiline, safinamide, le selegiline. Phuputsong, Pterostilbene e boetse e sireletsa li-neurons khahlano le tšenyo e amanang le lefu la AD (lefu la Alzheimer's).

Matla a ho laola matšoenyeho a Pterostilbene ho boetse ho lumeloa hore ke ka lebaka la bokhoni ba eona ba ho thibela monoamine oxidase B. Thutong e itseng, Pterostilbene o bonts'itse ts'ebetso ea ho tšoenyeha ka tekanyo ea litekanyetso tse peli le e le 'ngoe tsa mg / kg. Ts'ebetso ena e tšoenyang ea komporo ena e ne e tšoana le ea diazepam e le 'ngoe le tse peli mg / kg ho EPM.

ii. Pterostilbene le botenya

Phuputso e entsoeng ho lekola bokhoni ba Pterostilbene ho sebetsana le botenya e bonts'itse hore ho na le khokahano e kholo lipakeng tsa tlatsetso ea pterostilbene le taolo ea boima ba 'mele. Bo-ramahlale ba ne ba lumela hore Pterostilbene phofo e na le bokhoni ba ho ama maemo a boima ba mafura ka lebaka la bokhoni ba eona ba ho fokotseha lipogenesis. Lipogeneis ke mohato oa ho theha lisele tse mafura a mangata. Pterostilbene le eona e eketsa mafura a tukang kapa mafura a mangata ka har'a sebete.

Phuputsong e amang batho ba lilemo tse mahareng ba nang le k'holeseterole e ngata, sehlopha sa bankakarolo ba neng ba sa noe lithethefatsi tsa cholesterol ba ile ba theola boima ba 'mele ha ba ntse ba sebelisa litlatsetso tsa pterostilbene. Liphetho tsena li ile tsa makatsa bafuputsi hobane lipatlisiso tsena li ne li sa rereloa ho lekanya tlatsetso ea pterostilbene e le thuso ea ho theola boima ba 'mele.

Lithuto tsa liphoofolo le tsa sele le tsona li bonts'a hore karolo ea pterostilbene e ka thusa ho matlafatsa kutloisiso ea insulin. Seo Pterostilbene e se etsang ke hore e thibela ts'ebetso ea ho fetola tsoekere e le mafura. E boetse e sitisa lisele tsa mafura hore li se ke tsa hola le ho eketseha.

Pterostilbene e boetse e fetola sebopeho sa makhopho ka mpeng mme e thusa ho chesoa ha lijo.

Lirosa tse neng li fepiloe ke Pterostilbene li ne li na le limela tse phetseng hantle hape li matlafalitsoe haholo Akkermansia muciniphila. A. muciniphila ke mofuta oa bacteria o shebahalang o thibela ho ruruha ha maemo a tlase, botenya le lefu la tsoekere. Baktheria ena e fetohile mohopolo o motle oa ho etsa lipatlisiso tsa mahlale morao tjena.

iii. Pterostilbene e Khabisa Nako e telele

Melemo ea ho thibela botsofali ea Pterostilbene e hokahane le lik'hemik'hale tse bioactive tse tsejoang ka hore ke Trans-pterostilbene. K'hemik'hale ena e pakiloe hore e fokotsa ho ruruha, ho fokotseha hoa kelello le ho tsitsisa tsoekere ea mali. Lithutong tsa vivo le tsa vitro li ts'ehetsa litlamorao tsa thibelo le kalafo ea Pterostilbene. K'hemik'hale ena e boetse e sebetsa e le sethibela-caloric thibelo mimetic, e eketsang 'mele ho lokolla li-biochemicals, ho kenyelletsa le adiponectin e liehisang ts'ebetso ea botsofali ha e ntse e khothaletsa pholiso.

Tlatsetso ena e khahlano le ho tsofala e tsebahala ka ho sireletsa khahlanong le mafu a amanang le botsofe, ka ho etsa joalo e lelefatsa bophelo. Ka litoeba, litekanyetso li tlase tsa matšoao ana a k'hemik'hale a theotsoeng mabapi le botsofali. Phuputso e khothalelitse hore ho ja mehloli e mengata ea lijo ea pterostilbene e kang li-blueberries ho ka liehisa mathata a bophelo bo botle a amanang le botsofali, ho kenyelletsa 'dementia' le mofetše.

pterostilbene-phofo-3

4. Pterostilbene le resveratrol

Ha ho na pelaelo ea hore Pterostilbene le resveratrol li amana haufi. Resveratrol e tsejoa haholo e le k'hemik'hale ea bioactive ho veine e khubelu le morara.

Melemo ea bophelo bo botle ba resveratrol e tšoana le ea Pterostilbene mme e kenyelletsa ts'ireletso khahlanong le Alzheimer's, litlamorao tsa anticancer, matlafatso ea mamello, litlamorao tse khahlanong le ho fokola, monyetla oa ho loants'a lefu la tsoekere, le melemo ea pelo.

Pterostilbene e hlile e tšoana le lik'hemik'hale ka tsela e tšoanang, empa liphuputso li se li tlalehiloe hore Pterostilbene e kanna ea ba matla le ho feta ts'ebetsong ea maemo a bophelo bo botle. Pterostilbene e bontšitse bokhoni bo eketsehileng ba ho ntlafatsa ts'ebetso ea kelello, bophelo bo botle ba pelo le maemo a tsoekere.

Bophelo ba halofo ea Pterostilbene le bona bo bokhuts'oane ho feta halofo ea bophelo ba resveratrol. Pterostilbene ha e le hantle e nka makhetlo a mane ho potlakela ho amohela ho tsoa ho tsamaiso ea tšilo ea lijo ho e feta 'meleng ho feta resveratrol. Ka mohopolo, sena se ka etsa hore Pterostilbene e sebetse makhetlo a mangata ho feta resveratrol. Leha ho le joalo, ho hlokahala lithuto tse ling ho netefatsa sena.

Pterostilbene le resveratrol le tsona ka linako tse ling li kopantsoe ho fana ka tlatsetso e kopaneng ka sebopeho sa capsule. Tlatsetso e kopantsoeng e kholoa hore e matla ho feta ha e kopanya melemo ea likhomphutha tse peli.

5. Tlatsetso ea Pterostilbene

Ha ho na pelaelo hore e le hore u ka fumana melemo e lakatsehang ka ho fetisisa ea Pterostilbene, ho khothalletsoa hore u e nke e le tlatsetso ea phofo. Pterostilbene tlatsetso li rekisoa ka lebenkeleng la lijo tsa tlhaho le mabenkeleng a marang-rang a ikhethileng ka tlatsetso ea phepo. U ka fumana baetsi ba pterostilbene marang-rang.

Pterostilbene tlatsetso e fumaneha haholo ka sebopeho sa li-capsules, ka litekanyetso tse fapaneng. U lokela ho bala ka hloko label kapa label 'me u hlokomele palo ea Pterostilbene ho khabisitsoeng ka ngoe pele u e reka. Sena ke sa bohlokoa hobane litekanyetso tse fapaneng li ka bonts'a litlamorao tse fapaneng.

Hape, litekanyetso tse ling tsa tlatsetso ea pterostilbene li ka ba holimo ho feta tse fumanoeng lipatlisiso tsa batho. Litlhare tse tloaelehileng ka ho fetisisa tse fumanehang li pakeng tsa 50 mg le 1,000 mg ka kotloloho e ngoe le e ngoe.

Joalokaha ho boletsoe pejana, li-supplement tsa tlatsetso le tsona lia fumaneha, 'me motsoako o tummeng haholo ke Pterostilbene le resveratrol. Pterostilbene e boetse e kopantsoe le curcumin, tee e tala, astragalus le metsoako e meng ea tlhaho.

U ka fumana litlolo tse sirelelitsoeng ke letsatsi tse nang le Pterostilbene leha sena e le seoelo. Palo ea Pterostilbene e hlokahalang ho o sireletsa hantle khahlanong le lefu la letlalo ha e e-so ithutoe, empa e ka fana ka ts'ireletso e eketsehileng.

6. U ka fumana phofo ea boleng bo phahameng ka ho fetisisa ea Peterostilbene?

Haeba u batla phofo ea boleng bo phahameng ea pterostilbene, joale u sebakeng se nepahetseng. Re baetsi ba moetsi oa pterostilbene ea tummeng, ea nang le tsebo le boiphihlelo China. Re fana ka lihlahisoa tse hloekileng le tse pakiloeng hantle tse lulang li lekoa ke laboratori la mokga oa boraro ho netefatsa bohloeki le polokeho. Kamehla re fana ka litaelo ho pholletsa le US, Europe, Asia le libakeng tse ling tsa lefats'e. Kahoo haeba u batla ho reka pterostilbene phofo ea boleng bo phahameng ka ho fetisisa bo fumanehang, ikopanye le rona feela joale.

References

  1. Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR (2004). "Resveratrol, pterostilbene, le piceatannol a vaccinium monokotsoai". J Agric Chem Chem. 52 (15): 4713-9.
  2. Kapetanovic IM, Muzzio M., Huang Z., Thompson TN, McCormick DL Pharmacokinetics, bioavailability ea molomo, le metabolic profil ea resveratrol le dimethylether analog, pterostilbene, ka likhoto. Chemother. Pharmacol. 2011; 68: 593-601.
  3. Ts'ireletseho ea maiketsetso a maiketsetso e le lijo tse nooang ho latela Molao (EC) No 258/97 ″. Sengoloa sa EFSA. Lekhotla la Ts'ireletso ea Lijo Europe, EFSA Panel mabapi le Lihlahisoa tsa Li-Dietetic, Nutrition le Allergies. 14 (1): 4368
  4. Becker L, Carré V, Poutaraud A, Merdinoglu D, Chaimbault P (2014). "Litekanyetso tsa" MALDI tse kholo tsa pono ea sebaka se ts'oanang sa resveratrol, pterostilbene le viniferin makhasi a morara ". Limolek'hule. 2013 (7): 10587-600.

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