Kakaretso ea Cycloastragenol
Cycloastragenol (CAG) e tsejoang hape e le T-65 ke tlhaho ea tetracyclic triterpenoid e fumanoeng ho Astragalus astragalus semela. E ile ea sibolloa la pele neng Astragalus astragalus extract e ne e ntse e hlahlojoa bakeng sa metsoako ea eona e sebetsang e nang le thepa e thibelang botsofali.
Cycloastragenol e ka boela ea tsoa ho Astragaloside IV ka ts'ebetso ea hydrolysis. Astragaloside IV ke sesebelisoa se ka sehloohong se sebetsang ho Astragalus astragalus setlama. Le ha Cycloastragenol le Astragaloside IV li tšoana ka sebopeho sa tsona sa lik'hemik'hale, cycloastragenol e bobebe boima ba limolek'hule ho feta Astragaloside IV. Ka hona, Cycloastragenol e sebetsa hantle haholo ka lebaka la bioavailability e phahameng mme ka hona e na le metabolism e phahameng ea cycloastragenol. Metabolism e phahameng ea cycloastragenol e tsejoa ka maleng a methapo ea methapo ka tsela e sa tsamaeeng hantle.
Setlama sa astragalus se 'nile sa sebelisoa e le moriana oa setso oa China ka makholo a lilemo mme se ntse se sebelisoa le kajeno. Semela sa Astragalus se sebelisitsoe ka lebaka la litlamorao tsa sona tse ntle ho kenyelletsa anti-baktheria, anti-inflammatory hape le bokhoni ba ho matlafatsa boits'ireletso ba mmele.
CAG e bonts'oa e le motsoako o khahlanong le botsofali o matlafatsang ts'ebetso ea enzyme telomerase le pholiso ea maqeba. Hajoale ke kompone e kholo e tsejoang ho hlohlelletsa telomerase bathong, ka hona ke tebello e kholo ea tlatsetso bakeng sa nts'etsopele e tsoelang pele.
Cycloastragenol e tsejoa e le activator ea telomerase, e phethang karolo ea ho eketsa bolelele ba li-telomere. Li-telomere ke likatiba tse sireletsang tse entsoeng ka ho pheta-pheta ha nucleotide qetellong ea chromosome. Li-telomere tsena lia khutsufala kamora karohano e ngoe le e ngoe ea sele e hlahisang senescence ea sele le ho senyeha. Ho feta moo, li-telomere li ka khutsufatsoa ke khatello ea maikutlo.
Khutsufatso ena e fetelletseng ea li-telomere e amahanngoa le botsofali, lefu le mathata a mang a amanang le ag. Ka lehlohonolo, enzyme ea telomerase e khona ho eketsa bolelele ba li-telomere tsena.
Leha ho se lithuto tse pharalletseng ho paka bokhoni ba cycloastragenol ho lelefatsa bophelo ba motho, ke setsi se ts'episang ho thibela botsofali. Ho netefalitsoe hore e felisa matšoao a botsofali ho kenyeletsoa mela e metle le masosong. CAG e kanna ea theola le ts'oso ea ho ba le mathata a holofatsang a kang a Parkinson, Alzheimer's, le lera la mahlo.
Leha e le ngata cycloastragenol melemo ea bophelo bo botle, ho na le ngongoreho ea hore e ka lebisa ho mofets'e kapa ea eketsa mofetše. Leha ho le joalo, lithuto tse ling tse entsoeng ka lithuto tsa liphoofolo li tlaleha melemo ea cycloastragenol ntle le ts'oaetso ea mofets'e.
Cycloastragenol phofo e rekisoang e fumaneha habonolo inthaneteng mme e ka rekoa ho barekisi ba bangata ba tsebahalang ba cycloastragenol.
Leha, melemo e mengata ea bophelo ba cycloastragenol e bonts'itsoe, e ntse e le setho se secha tlasa lithuto. Ntle le moo, litla-morao tsa cycloastragenol ha li hlake hantle, ka hona li lokela ho sebelisoa ka hloko.
Cycloastragenol ke eng?
Cycloastragenol
Cycloastragenol ke motsoako oa triterpenoid saponin o tsoang motso oa setlama sa Astragalus. Astragalus astragalus semela se sebelisitsoe litlhare tsa setso tsa China (TCM) ka lilemo tse fetang 2000 mme se ntse se sebelisoa litokisetsong tsa litlama.
Setlama sa astragalus se tsebahala ka bokhoni ba sona ba ho ntlafatsa boits'ireletso ba mmele, ho sireletsa tse phelang, ho sebetsa joaloka diuretic hape bophelo bo bong thepa e kang anti-hypersensitivity, antibacterial, Khahlanong le botsofali le melemo e khahlano le khatello ea maikutlo.
Cycloastragenol eo hangata e tsejoang e le TA-65 empa e boetse e bitsoa Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin, le Astramembrangenin. Cycloastragenol tlatsetsa e tsejoa haholo joalo ka moemeli oa ho tsofala, leha ho le joalo, melemo e meng ea bophelo bo botle ba cycloastragenol e kenyelletsa ho matlafatsa boits'ireletso ba mmele, anti-inflammatory le anti-oxidative.
Cycloastragenol le Astragaloside IV
Ka bobeli cycloastragenol le Astragaloside IV li hlaha ka tlhaho ho semela sa astragalus. Astragaloside IV ke sesebelisoa sa mantlha se sebetsang ho astragalus membranaceus, leha ho le joalo, e hlaha ka bongata motsotso motso. Ts'ebetso ea ho ntša li-saponin tsena, cycloastragenol le astragaloside IV, hangata e ba thata ka lebaka la boemo bo phahameng ba tlhoekiso e hlokahalang.
Ka bobeli cycloastragenol le astragaloside IV li tsoa setlama sa astragalus, cycloastragenol e ka fumaneha le ho astragaloside IV ka ts'ebetso ea hydrolysis.
Metsoako ena e 'meli e na le sebopeho sa lik'hemik'hale se ts'oanang, leha ho le joalo, cycloastragenol e bobebe boima ba limolek'hule ho feta astragaloside IV hape e fumaneha haholoanyane.
Mokhoa oa Ketso ea Cycloastragenol
i. Ts'ebetso ea Telomerase
Li-telomere li pheta-pheta li-nucleotide pheletsong ea li-chromosome tse tatileng 'me li tlameletsoe ke sehlopha se itseng sa liprotheine. Li-Telomere ka tlhaho lia khutsufala ka karohano e ngoe le e ngoe ea sele. Telomerase, moetso oa ribonucleoprotein o nang le li-enzyme tsa catalytic reverse transcriptase (TERT) le karolo ea telomerase RNA (TERC) e lelefatsa li-telomere. Kaha karolo ea bohlokoa ea li-telomere ke ho sireletsa li-chromosome hore li se ke tsa kopana le ho senyeha, lisele hangata li amohela li-telomere tse khuts'oane haholo joaloka DNA e senyehileng.
Liphello tsa ts'ebetso ea cycloastragenol telomerase e lelefatsa li-telomere tse hlahisang litlamorao.
Ii. E ntlafatsa metabolism ea lipid
Lipids ka tlhaho li sebetsa joalo ka lebenkele la matla 'meleng ea rona. Leha ho le joalo, lipids tse ngata haholo li ka ba kotsi bophelong ba rona.
Cycloastragenol e khothalletsa metabolism e nang le lipid e phetseng hantle ka mefuta e fapaneng ea lipid metabolism biomarkers.
Ntlha ea pele, ka litekanyo tse tlase, CAG e fokotsa marotholi a cytoplasmic lipid ho li-adipocyte tsa 3T3-L1. Taba ea bobeli, ha e sebelisoa ka litekanyetso tse phahameng, CAG e sitisa phapang ea li-preadipocyte tsa 3T3-L1. Kamora nako, CAG e ka baka tšubuhlellano ea calcium ho li-preadipocyte tsa 3T3-L1.
Kaha khalsiamo e phahameng ea lisele e ka thibela phapang ea li-adipocyte, CAG e tlisa tekano lipid metabolism ka ho hlohlelletsa phallo ea calcium.
Iii. Ketsahalo ea antioxidant
Ho imeloa kelellong ke sesosa sa mafu a mangata hape le senescence ea sele. Ho imeloa kelellong ho tlisoang ke oksijene ho etsahala ha 'mele o na le li-radical tse ngata tse sa lefelloeng.
Cycloastragenol e bonts'a litšobotsi tse khahlanong le oxidative ka ho matlafatsa matla a antioxidant. Ketsahalo ena ea antioxidant e amana le sehlopha sa hydroxyl se fumanehang ho CAG.
Ho feta moo, khatello ea mali ke sesosa se ka sehloohong sa ho khutsufatsa li-telomere, ka hona tšireletso ea CAG telomere e tsoa mesebetsing ea antioxidant le telomerase activation.
Iv. Ketso e khahlano le ho ruruha
Le ha ho ruruha e le mokhoa oa tlhaho oo 'mele o loantšang tšoaetso kapa kotsi, ho ruruha ho sa foleng ho kotsi. Ho ruruha ho sa foleng ho amahanngoa le mathata a mangata a kang pneumonia, lefu la tsoekere, mathata a pelo le methapo le ramatiki.
Cycloastragenol phofo e bontša thepa e khahlanong le ho ruruha. Melemo e khahlano le ho ruruha ea cycloastragenol e teng ka mekhoa e fapaneng ho kenyelletsa ho thibela ho ata ha lymphocyte le ho ntlafatsa phosphorylation ea AMP-activated protein kinase (AMPK).
Melemo ea Cycloastragenol
i.Cycloastragenol le boits'ireletso ba mmele
Cycloastragenol e ka thusa ho ntlafatsa boits'ireletso ba mmele ka ho matlafatsa ho ata ha T lymphocyte. Bokhoni ba cycloastragenol supplement ho kenya tšebetsong telomerase bo e nolofalletsa ho hlasimolla tokiso ea DNA ha e ntse e etella pele kholo le bolelele ba telomere.
Ii.Cycloastragenol le Anti-botsofali
Cycloastragenol anti-botsofali thepa ke tsona thahasello ea mantlha ea lipatlisiso tse ngata kajeno. CAG ho bonts'itsoe hore e liehisa ho tsofala bathong le ho fokotsa matšoao a botsofali a kang makhopo le mela e metle. Ts'ebetso ea anti-botsofali ea cycloastragenol e fihlelleha ka mekhoa e mene e fapaneng. Mekhoa ea anti-botsofali ea cycloastragenol e kenyelletsa;
- Ho loantša khatello ea mali
Ho imeloa kelellong ho tlholehang ho etsahala ka tlhaho ha ho na le ho se leka-lekane lipakeng tsa mahlaseli a kotsi le antioxidant 'meleng. Haeba e sa laoloe, khatello ea mali e ka potlakisa ho tsofala hape e lebise maemong a sa foleng a kang mofetše, lefu la pelo le lefu la tsoekere.
Tlhaloso ea cycloastragenol astragalus ke motsoako o tsoileng matsoho oa antioxidant hape e ntlafatsa bokhoni ba li-antioxidants tse teng ka tlhaho. Sena se thusa ho liehisa botsofali hape ho thibela ho ba le mathata a amanang le lilemo.
- Cycloastragenol e sebetsa e le sesebelisoa sa telomerase
Joalokaha ho boletsoe karolong e kaholimo mabapi le ts'ebetso ea ts'ebetso, cycloastragenol e thusa ho lelefatsa li-telomere. Sena se bapala karolo ea bohlokoa ho netefatsa tsoelo-pele ea karohano ea lisele ka hona ho liehisa botsofali. Sena se boetse se thusa ho boloka litho tsa 'mele li sebetsa hantle.
- Cycloastragenol e fana ka tšireletso mahlaseling a UV
Ha motho a pepesehela khanya ea letsatsi nako e telele lisele tsa 'mele li ka senyeha' me ka lebaka leo li hloleha ho sebetsa hantle. Sena se fella ka mofuta oa botsofe ba pele ho nako bo bitsoang ho tsofala.
Cycloastragenol phofo ea thusa kaha e bonts'oa ho sireletsa letlalo liphellong tse mpe tsa mahlaseli a UV.
- Cycloastragenol e thibela protein glycation
Glycation ke ts'ebetso eo ka eona tsoekere e kang tsoekere kapa fructose e hokelang lipid kapa protheine. Glycation ke e 'ngoe ea li-biomarker tsa lefu la tsoekere mme e amahanngoa le botsofali le mathata a mang.
Tlatsetso ea cycloastragenol e thusa ho thibela botsofali ka lebaka la glycation ka ho thibela sebopeho sa lihlahisoa tsa glycation.
Iii.Melemo e meng e ka bang teng ea bophelo bo botle ba Cycloastragenol:
- Kalafo ea mofets'e oa cycloastragenol
Phekolo ea kankere ea cycloastragenol e bonts'oa ke bokhoni ba eona ba ho senya lisele tse nang le mofetše, ho ntlafatsa boits'ireletso ba mmele le ho e sireletsa liketsong tse kotsi tsa chemotherapy.
Phuputsong ea batho ba nang le mofetše oa matsoele, kankere ea cycloastragenol kalafo e bontšitsoe ke bokhoni ba eona ba ho fokotsa lefu ka 40%.
- E ka sireletsa pelo khahlanong le tšenyo
Cycloastragenol e ka fana ka tšireletso khahlanong le ho se sebetse ha pelo.
Phuputsong ea likhoto tse nang le tšenyo ea pelo e bakoang, cycloastragenol supplementation e fumanoe ho ntlafatsa ho se sebetse ha pelo ka ho khothaletsa ho itšireletsa liseleng tsa myocardial le ho hatella lipolelo tsa matrix metalloproteinase-2 (MMP-2) le MMP-9.
- Molemo le ho Feta boroko bo
Ho ipapisitsoe le litlhahlobo tsa cycloastragenol, ho ka etsahala ntlafatsa boleng ba boroko. Leha ho le joalo, ho tla hlokahala lithuto tsa bongaka ho fana ka bopaki bo tiileng ka bokhoni ba eona ba ho ntlafatsa boroko.
- E ka thusa ho loants'a khatello ea maikutlo
Telomere e khutsufalitsoeng e fumanoe ho batho ba nang le mathata a ho tepella maikutlo joalo ka mathata a maikutlo le mafu a kang Alzheimer's.
Phuputsong ea litoeba tekong ea ho sesa e qobelloang, tlatsetso ea cycloastragenol e tsamaisoang matsatsi a 7 e fumanoe e fokotsa ho hloleha ha bona. E bonts'itsoe ho kenya ts'ebetsong telomerase ka methapo ea kutlo le liseleng tsa PC1, e hlalosang bokhoni ba eona ba ho loants'a khatello ea maikutlo.
- E ka potlakisa pholiso ea leqeba
Pholiso ea maqeba ke bothata bo boholo ho bakuli ba nang le lefu la tsoekere. Ts'ebetso ena ea pholiso ea maqeba e etsahala ka letoto la mesebetsi. Mesebetsi ena ke; ts'ebetso ea ho ruruha, ho koala, ho khutlisa epithelium, ho aha bocha mme qetellong taolo ea lisele tsa stem Lisele tsena tsa epithelial stem li bohlokoa ho foleng ha leqeba la lefu la tsoekere.
Ho bonts'itsoe hore ho senyeha ha telomere ho ama hampe pholiso ea leqeba. Mona ke moo phofo ea cycloastragenol e kenang ho lokisa li-telomere tse khutsufalitsoeng le ho ntlafatsa ho ata le ho sisinyeha ha lisele tsa bakoang. Sena le sona se thusa ho lokisa leqeba ka potlako.
- Ntlafatsa bophelo ba moriri
Litlhahlobo tsa cycloastragenol tsa basebelisi ba motho li bonts'a hore cycloastragenol e kanna ea thusa ho thibela ho lahleheloa ke moriri, ea khothaletsa kholo ea moriri le ho ntlafatsa mmala oa moriri.
Melemo e meng ea cycloastragenol astragalus e ntšitsoeng ke;
- E fana ka ts'ebetso e khahlanong le vaerase khahlano le lisele tsa CD4 tsa motho.
- Ho matlafatsa matla.
- E ntlafatsa bophelo bo botle ba letlalo.
- E ka ntlafatsa pono.
Tekanyetso e tloaelehileng ea Cycloastragenol
Tekanyetso cycloastragenol litekanyetso li behoa e ka bang 10 mg ka letsatsi. Leha ho le joalo, kaha sena se secha tlatsetsa litekanyo tsa eona li tla itšetleha haholo ka ts'ebeliso, lilemo le maemo a bongaka a mantlha.
Tekanyo ena e tloaelehileng ea cycloastragenol e lokela ho eketsoa ho batho ba tsofetseng ba fetang lilemo tse 60 ho fihlela bophahamo bo lekaneng ba telomere le ho liehisa botsofali.
Na Cycloastragenol e bolokehile?
Cycloastragenol phofo hangata e nkuoa e bolokehile maemong a itseng a litekanyetso. Leha ho le joalo, kaha e ncha tlatsetsa litla-morao tse ka bang teng tsa cycloastragenol ha li e-so tsejoe.
Litlhahlobo tse 'maloa tsa cycloastragenol mabapi le melemo e boletsoeng ea cycloastragenol ha li felle ka ho lekana ho netefatsa hore li sebelisoa ka nepo.
Ntle le moo, ho na le lipelaelo tsa hore cycloastragenol supplement e ka potlakisa mofetše ka ho khothaletsa kholo ea lihlahala. Ena ke khopolo-taba e inahaneloang e ipapisitseng le taba ea hore mokhoa o ka sehloohong oa ts'ebetso ea cycloastragenol ke ka bolelele ba telomere. Kahoo ho nahanoa hore e tla ntlafatsa kholo ea lisele tsa mofetše.
Ka hona ho bohlokoa hore u qobe ho fa bakuli ba mofets'e cycloastragenol ho fihlela tlhaiso-leseling e fumanehang mabapi le monahano ona le ho qoba chefo efe kapa efe e sa tsejoeng ea cycloastragenol.
Re ka fumana cycloastragenol e molemohali hokae?
hantle, cycloastragenol phofo e rekisoang e fumaneha habonolo inthaneteng le mabenkeleng a fapaneng a phepo e nepahetseng. Leha ho le joalo, kamehla etsa lipatlisiso bakeng sa phofo ea cycloastragenol e rekisoang ho tsoa ho barekisi ba cycloastragenol ba amohelehang le ba tummeng ho netefatsa hore o fumana cycloastragenol e hloekisitsoeng haholo.
Liphuputso tse ling
Cycloastragenol phofo e bonts'itsoe hore e na le litlamorao tse ngata tse ntle ebile e le thepa ea anti-botsofali ea cycloastragenol. Ts'ebetso ea cycloastragenol telomerase ke mokhoa o ka sehloohong oa ketso o tla eketsa telomere. Tsena li bontšitsoe mefuteng e mengata ea liphoofolo le tse 'maloa invitro lithuto.
Liteko tsa bongaka tsa cycloastragenol astragalus tse hlahisang phello ea ho lelefatsa telomere li fokola haholo kahoo lithuto tse ling tse ngata tse fanang ka bopaki bo tiileng lia hlokahala.
Phello e ka bang teng ea TA-65 ho ntlafatseng ho se sebetse ha pelo e tebile haholo hobane lithuto tse fokolang li teng ho ts'ehetsa ketso ena ea TA-65.
Ho ithuta metabolism ea cycloastragenol ka lintlha ho tla ntlafatsa le tlhaiso-leseling e fumanehang le ho pepesa chefo ea cycloastragenol e ka bang teng ka lebaka la ho bokellana ho fetelletseng.
Lithuto tse ling tsa ho lekola katleho ea tlatsetso ea cycloastragenol melemo e boletsoeng. Litla-morao tsa cycloastragenol ha li tsejoe. Ka hona, lipatlisiso li lokela ho lebisoa ho lekanyeng se ka etsahalang litla-morao tsa cycloastragenol hammoho le litšebelisano le meriana e meng.
Ho utloisisa melemo ea bophelo ba cycloastragenol, e tla thusa ho lekola mekhoa e tlisoang ke liketso tsena tsa CAG.
Ntle le moo, litekanyo tse loketseng tsa cycloastragenol li hloka lithuto tse ling ho lekola litekanyetso tse khothalletsoang bakeng sa lihlopha tse fapaneng tsa lilemo. Bafani ba cycloastragenol ba fapaneng ba laetse litekanyo tse fapaneng tse lokelang ho lumellanoa ka lipatlisiso.
References
- Yuan Yao le Maria Luz Fernandez (2017). "Liphello tse Molemo tsa Selemo sa Telomerase Activator (TA-65) Khahlanong le Mafu a sa Foleng". Phepo ea EC 6.5: 176-183.
- Wang, J., Wu, M.-L., Cao, S.-P., Cai, H., Zhao, Z.-M., & Pina, Y.-H. (2018). Cycloastragenol e ntlafatsa tšenyo ea pelo ea liteko ho likhoto ka ho khothaletsa autophagy ea myocardial ka ho thibela ho saena ha AKT1-RPS6KB1. Biomedicine & Pharmacotherapy, 107, 1074-1081. doi: 10.1016 / j.biopha.2018.08.016
- Letsatsi, C., Jiang, M., Zhang, L., Yang, J., Zhang, G., Du, B.,… Yao, J. (2017). Cycloastragenol e sebetsana le khatello ea ts'ebetso le keketseho ho concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacology le Immunotoxicology, 39 (3), 131-139. doi: 10.1080 / 08923973.2017.1300170.
- Ip F, C, F, Ng Y, P, An H, J, Dai Y, Pang H, H, Hu Y, Q, Chin A, C, Harley C, B, Wong Y, H, Ip N, Y: Cycloastragenol Ke Sebetsa se Matla sa Telomerase ho Lisele tsa Neuronal: Litlamorao tsa Tsamaiso ea Ho Tepella Maikutlong. Li-Neurosignals 2014; 22: 52-63. doi: 10.1159 / 000365290.
- Yu, Yongjie & Zhou, Limin & Yang, Yajun & Liu, Yuyu. (2018). Cycloastragenol: Mokhethoa ea monate oa lipale tsa mafu a amanang le lilemo (Tlhahlobo). Meriana ea liteko le ea kalafo. 16. 10.3892 / etm.2018.6501 (Khatisitsoeng)
- CYCLOASTRAGENOL POWDER (78574-94-4)