Nicotinamide riboside (NR) le nicotinamide riboside (Chloride)

Nicotinamide riboside (NR) chloride ke mofuta o nang le chlorine oa nicotinamide riboside (NR).

1.Nicotinamide Riboside (NR) ke eng?

NR ke mofuta oa vithamine B3 kapa niacin. Motsoako ona o ile oa sibolloa lilemong tsa bo-1940 e le kholo ea H. ntaramane. Qalong ea 21st lekholo la lilemo, lithuto tse ngata li ka paka hore NR ke selelekela sa NAD +. 'Meleng oa motho, phepo ena e theola maemo a k'holeseterole, e fokotsa menyetla ea mafu a pelo, e matlafatsa tšebetso ea boko le ho fokotsa ramatiki.

Nicotinamide riboside (NR) ke pyridine-nucleoside, e sebetsang e le selelekela sa NAD + (Nicotinamide adenine dinucleotide). NAD + e matlafatsa mesebetsi e mengata ea likokoana-hloko ho kenyeletsa ho lokisoa ha DNA, ho hlahisa matla a lisele, ho beha pina ea 'mele ea circadian le tse ling. Ka bomalimabe, limolek'hule tsena ka tlhaho lia fokotseha ka ho hlaka.

2.Nicotinamide Riboside (NR) Chloride ke eng?

Nicotinamide Riboside (NR) chloride (NIAGEN) ke tsoa ho NR le chlorine. Motsoako o eketsa maemo a NAD + mme o kenya tšebetsong SIRT1 le SIRT3. E khutlisetsa botsofali ka ho matlafatsa metabolism ea oxidative le ho loants'a li-comorbidities tse amanang le lijo.

Naheng ea Amerika, nicotinamide riboside chloride ka kakaretso e tsejoa e le e bolokehileng. Ka hona, ke sesebelisoa sa lijo se lumelloang se ka sebelisoang liprotheine tse sisinyehang, metsi a vithamine, marenene le tse ling tse amanang le tsona tlatsana.

3.fihlela qeto e

Botho bo ntse bo loants'a botsofali ka ho lebisa letlalo. Ka nako e 'ngoe, e tlameha ebe u kile ua kopana le tse ling Khahlanong le botsofali kerime bakeng sa ho hlatsoa masoba a sefahleho a tebileng, letlalo le tetemang le bosootho. Leha ho le joalo, kalafo tsena ha li fetohe ebile ke tsa nakoana. Mokhoa o netefalitsoeng oa ho tsofala ka bokhabane ke ka ho theha liphetoho tsa tlhaho ka mor'a senescence le ho sebetsana le sesosa sa motso.

Ho tloha ka nako eo bafuputsi ba thehile khokahano lipakeng tsa maemo a tlase a NAD + le mafu a amanang le lilemo. Ts'ibollo ena e matla ebile tšisinyeho ea kakao lefapheng la bongaka ka ho eketsa monyetla oa ho khutlisa botsofali. Ka lebaka lena, nicotinamide riboside chloride phofo e kile ea etela hangata litsing tsa lipatlisiso tsa bongaka ka lebaka la matla a eona a ho phethola oache ea tlhaho.

The lik'hemik'hale ga tlhaloso ea Nicotinamide Riboside (chloride) phofo

Name Product Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Lebitso la lik'hemik'hale NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; K'holeseterole ea Nicotinamide; 3-Carbamoyl-1- (β-D-ribofuranosyl) kloride ea pyridinium; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
Nomoro ea CAS 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
Smile C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Molecular Formula C11H15ClN2O5
Boima ba 'mele 290.7002
Masapo a monoisotopic 290.066949 g / mol
Melting Point N / A
Color o mosoeu
Setsi sa polokelo -20 ° C Freezer
kopo lisebelisoa tsa tlatsetso ea lijo, tšimo ea litlama

Nicotinamide riboside chloride

Ho tseba Melemo ea Nicotinamide riboside (NR), Melemo ea Nicotinamide Riboside Chloride ke efe?

Melemo ea nicotinamide riboside chloride vs nicotinamide riboside ea tšoana hobane ka bobeli ba sebetsa ho kenya liprotheine tsa NAD le sirtuin 1.

Metabolism e phetseng hantle bakeng sa ho laola botenya

Liphuputso tse ngata li pakile katleho ea nicotinamide riboside chloride ho fokotsa boima ba 'mele. Basebelisi ba ka lahleheloa ke 10% ea mafura a 'mele ea bona ntle le khatello ea takatso kapa koetliso ea' mele.

Ho noa moriana ho thusa ho theola k'holeseterole ea LDL ha o ntse o phahamisa maemo a k'holeseterole e ntle. Sena se etsahala ha se thibela ts'ebetso ea li-enzyme tse ikarabellang bakeng sa ho qaptjoa ha triglycerides. Ka lebaka leo, tlhahiso ea lipoprotein tse nang le letsoalo le tlase e fokotseha.

Nicotinamide riboside chloride e thusa bakuli ba nonneng haholo ba nang le lefu la tsoekere. Tlatsetso e matlafatsa metabolism ka ho ntlafatsa ho hloka mamello ha tsoekere

neuroprotection

Ha maemo a NAD a theohela tlase hantle, sistimi ea hau ea methapo ea kutlo le bophelo bo botle ba kelello li ka ba kotsing. Nka, mohlala, bakuli ba nang le lefu la Alzheimer ba bonts'a khatello e tlase ea NAD + le ho se sebetse ha mitochondria.

Har'a tšebeliso ea bongaka ea nicotinamide riboside chloride, taolo ea methapo ea methapo ea botsofali e ka holimo ho lenane. Moriana ona o sebetsa khahlano le tšenyo ea 'mele, lefu la ischemic, ho ruruha ha methapo le lefu la neuronal.

Tlatsetso ea ho tsofala

E 'ngoe ea lintlha tsa bohlokoa tsa tšebeliso ea Nicotinamide riboside chloride e kenyelletsa ho khothaletsa bophelo bo botle botsofali. Motsoako ona o lebisa keketsehong ea tlhahiso ea NAD, e phethang karolo ea bohlokoa ka seleng. Mohlala, e phahamisa matla a sele kahara mesifa, sebete le liphio. Ntle le moo, Nicotinamide riboside chloride e thibela senescence ka ho eketsa ho potoloha ha mali lithong tsena tsa bohlokoa.

Ho lokisa DNA

Nicotinamide riboside chloride e ruisa litlolo tsa lefutso ka ho lokisa DNA ea khale le e senyehileng. Haeba khatello ea NAD e oela, deoxyribonucleic acid e lemetseng e ka baka mefuta ea oksijene e sebetsang, e lebisang khatellong ea mali le ts'oaetso ea mofets'e.

Nicotinamide riboside chloride

Nicotinamide Riboside Chloride e ka Fetoha Botsofali Joang?

Nakong ea botsofali, 'mele o ba le liphetoho tse ling tsa' mele ha mesebetsi ea lisele e khutlela morao. Mohlala, 'mele o tlosa liprotheine tsa NAD + le SIRT1 ho feta kamoo o ka ikamahanyang ka teng. Maemo a tlase a li-coenzymes tsena a potlakisa senate ha a ntse a baka likotsi tse amanang le lilemo tse kenyeletsang lefu la tsoekere, mafu a pelo le methapo le botenya.

Ho tsamaisa nicotinamide riboside chloride e thusa sesole sa 'mele ka ho matlafatsa methapo ea mali, joalo ka li-lymphocyte le leucocyte. Motsoako ona o hlophisa tšebetso ea NAD +, ka hona, e phahamisa maemo a liprotheine tsa SIRT1. Ka lebaka leo, SIRT1 e fokotsa botsofali ba methapo ka ho eketsa phallo ea mali masapong a masapo, tsamaiso ea pelo le methapo ea methapo.

Ntle le moo, nicotinamide riboside chloride supplement e khutlisa botsofali ka ho hlahisa NAD + e eketsehileng ho thusa ho lokisa DNA ka har'a sebopeho sa lisele. Phello ena e thibela khatello ea mali

Phuputso e fumanehang e boetse e tiisa hore nicotinamide riboside chloride e bala ho fokotseha ha masapo, phokotso ea tlhahiso ea meokho le fundus hypopigmentation. Maemo ana kaofela a namme har'a batho ba tsofetseng.

Bahlahisi ba NAD⁺: Nicotinamide Riboside Chloride vs Nicotinamide Mononucleotide

Ho na le li-precursors tsa NAD + tse fetang tse hlano empa hajoale, re ka lebisa tlhokomelo ea rona ho nicotinamide riboside chloride vs nicotinamide mononucleotide (NMN).

Metsoako ena e 'meli e eketsa maemo a NAD +' meleng ho ntlafatsa ts'ebetso ea lisele le ho fokotsa ho senola.

Se arohanyang batho bana ba babeli ke hore NMN ha se mofuta oa vithamine B3. K'hemik'hale ha e phunyeletse ka seleng ho fihlela e fetohela nicotinamide riboside. Lebaka ke hore boholo ba limolek'hule li kholo ho feta ba nicotinamide riboside chloride phofo. Ka lebaka la thepa ena, bioavailability ea NMN le menyetla ea eona ea ho kenya tšebetsong maemo a NAD + e bile lesapo la likhang sebakeng sa lipatlisiso.

Ho ea ka Dr. Sinclair, setsebi sa liphatsa tsa lefutso Univesithing ea Harvard, bokhoni ba NMN bo ke ke ba bapisoa. O ipolela ho sebelisa sena tlatsetsa, e etsang hore a ikutloe a le mocha a bile a nchafale. Sinclair e lekana le katleho ea NMN le ho matha ka treadmill. Rasaense eo o hlokometse hore e ntlafatsa tsamaiso ea mali, e khothaletsa mamello ea mesifa le metabolism e sebetsang hantle.

Ka lehlakoreng le leng, Nicotinamide riboside chloride e nkuoa ka kotloloho ke sele. Molek'hule ke mofuta o mong oa vithamine B3. E tla eketsa maemo a NAD + ka ho feta 60% 'meleng oa motho. Ho fapana le ba bangata Lits'oants'o tsa NAD, tse lenaneng la lioache tsa FDA, nicotinamide riboside (NR) chloride e lethathamong la lihlahisoa tsa lijo tsa GRAS (Tse Amoheloang ka Kakaretso e le Tse Sireletsehileng).

Hobaneng u sa nke phofo ea NAD ka kotloloho? Nicotinamide Riboside Chloride vs Nicotinamide Adenine Dinucleotide (NAD)

Kaha mohopolo oa rona o mabapi le ho phahamisa NAD 'meleng, mohlomong o ntse o botsa hore na hobaneng ho ngangisana ka nicotinamide riboside chloride. Ha ua lokela ho fana ka taolo NAD ka kotloloho ho sistimi ea hau ho fapana le ho ba le bothata ba ho sebelisa li-intermediate tse kang NIAGEN, NR, kapa NMN? E re ke u hlalosetse ka nicotinamide riboside chloride vs nicotinamide adenine dinucleotide.

Lebaka le ka sehloohong leo ka lona u sa lokelang ho nka NAD ka kotloloho ke hore biomarker ha e khone ho kena seleng.

Motsoako oa ho sebelisa nicotinamide riboside chloride vs nicotinamide adenine dinucleotide ke hore ea pele e ka kenella ho lera la plasmic. Sekhahla sa eona sa ho monya se phahame haholo ka ts'ebetso ea tšilo ea lijo, ho kena maling, mme qetellong ho ea bokong.

Nicotinamide riboside chloride

Tekanyo ea Nicotinamide riboside (NR) ea Chloride: U ka e sebelisa joang?

Ka 2016, nicotinamide riboside chloride supplement e hapile boemo ba GRAS. Selemo pele ho moo, FDA e ne e e amohetse e le mohloli oa niacin le sesebelisoa sa phepo ka lethal dose la 180mg letsatsi le letsatsi.

Hajoale, litekanyetso tse phahameng tsa laesense ea nicotinamide riboside chloride ho 300mg ka letsatsi. Leha ho le joalo, litekong tse ling tsa batho, bafo ba ne ba ka noa 2000mg ea sethethefatsi. U lokela ho hlokomela hore ho feta tekanyetso ea 500mg ho kanna ha lebisa ho litlamorao tse ke keng tsa mamelloa tsa nicotinamide riboside.

Tekanyo ea niacin e sebetsa feela ho bophelo bo botle batho ba baholo, ho kenyeletsoa basali ba lebeletseng le bo-mme ba anyesang.

Litla-morao tsa Nicotinamide Riboside Chloride Side: Na ho Sireletsehile ho Sebelisa Tlatsetso ea Nicotinamide Riboside Chloride?

Nicotinamide riboside chloride phofo e sireletsehile 'me e na le boemo bo chachehetseng ka mohono ba lintho tsa GRAS. Taba ena ha e bolele hore kompone ha e na matšoao a bohloko. Ntle le moo, metsi ke bophelo empa a boetse a hulanya litšisinyeho tse mpe ha o a sebelisa hampe. Ho loants'a litla-morao, netefatsa hore litekanyetso tsa hau tsa Nicotinamide riboside chloride li tlase ka hohle kamoo ho ka khonehang.

Tse ling tsa liphetoho tse bohloko li kenyelletsa;

  • Mathata a ferekane
  • Nausea
  • Ho otla
  • Letšollo
  • Liketso tsa letlalo tse kang ho phatloha le ho eketseha ha matetetso

Ntle le litla-morao tsa nicotinamide riboside chloride, o kanna oa ba le ona boima ba 'mele. Leha ho le joalo, sephetho sena ke tlhohonolofatso ho ipata haholo haeba o nonne haholo, o nonne haholo, kapa o leka ho boloka boima ba 'mele bo lekane.

Moo u ka rekang (NR) Nicotinamide Riboside Chloride ka bongata?

U ka etsa nicotinamide riboside chloride e reka lebenkeleng la inthanete. Hore na o batla phofo ea sehlahisoa sa meriana ka bongata kapa tlatsetso ea sehlopha sa lijo, etsa bonnete ba hore o batla morekisi oa 'nete. Ntho e ntle ka ho fetisisa ea ho reka ke hore u ka bapisa litheko mme u hlahlobe maikutlo a bareki ba nako ea nnete. Leha ho le joalo, o kanna oa oela bakeng sa maiketsetso.

Re cha e tšepahalang mme lihlahisoa tsohle tsa rona li latela mehato ea taolo ea boleng. Re sebetsana le lik'hemik'hale tse fapaneng mme tlatsana le motsoako. Iteanye le rona bakeng sa otara ea hau le khotheishene e mosa.

References
    1. Conze, D., Brenner, C., & Kruger, CL (2019). Ts'ireletseho le Metabolism ea Tsamaiso ea Nako e Telele ea NIAGEN (Nicotinamide Riboside Chloride) ka Teko ea Kliniki e laoloang ka nako e telele, e nang le mahlo a mabeli, e laoloang ke batho ba baholo. Lipuo tsa Scientific.
    2. Bogan, KL & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, le Nicotinamide Riboside: Tlhatlhobo ea Limolek'hule ea NAD + ea pele ho livithamini ho Phepo ea Batho. Tlhahlobo ea selemo le selemo ea phepo e nepahetseng.
    3. Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside - Boemo ba Hajoale ba Lipatlisiso le Ts'ebeliso ea Bongaka.
    4. Moferefere, D., Castenimiller, J., et al. (2019). Polokeho ea Nicotinamide Riboside Chloride e le Buka ea Lijo e Tsamaeang le Molaoana (EU) 2015/2283 le Bioavailability ea Nicotinamide e tsoang Mohloling ona, ho Context of Directive 2002/46 / EC. Tlaleho ea EFSA.
    5. Elhassan, YS le al. (2019). Nicotinamide Riboside e Eketsa Mokokotlo oa Batho ba Tsofetseng NAD + Metabolome mme e Khothaletsa Li-signature tsa Transcriptomic le Anti-Inflammatory. Litlaleho tsa Cell.
    6. Aman, Y., Qiu, Y., Tao, J., & Fang, EF (2018). Phekolo ea Monyetla oa ho matlafatsa NAD + ho Botsofali le Mafu a Amanang le Lilemo. Meriana ea Phetolelo ea Botsofali.
    7. Tala NICOTINAMIDE MONONUCLEOTIDE (NMN) phofo (1094-61-7)
    8. Tala LORCASERIN HCL phofo (846589-98-8)

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