α-ketoglutaric

Phcoker e na le bokhoni ba tlhahiso ea bongata le phepelo ea Calcium 2-oxoglutarate le Alpha-Ketoglutaric Acid tlasa boemo ba cGMP.

Ke mabitso afe a mang a alpha-ketgoglutaric acide e tsejoang ke?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alfa-Cétoglutarate Categate Cate ea Khauta, Alpha-Cétoglutarate d'Arginine, Alpha , Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha KG, Alpha KG, Alpha KG -Ketoglutarate, K'halsiamo Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoganateic Asiti.

Alpha-Ketoglutaric acid ke eng?

Alpha-ketoglutaric (AKG) ke asiti ea manyolo e bohlokoa moetong o nepahetseng oa metabolism ea liamino acid tsohle tsa bohlokoa le phetisetso ea matla a sele ho potoloho ea acid ea citric. Ke selelekela sa asiti ea glutamic, amino acid eo e seng ea bohlokoa e amehang ho protheine ea mantlha le taolo ea maemo a tsoekere ea mali. Hammoho le L-glutamate, AKG e ka fokotsa maemo a ammonia a entsoeng bokong, mesifa le liphio, hape e thusa ho leka-lekanya k'hemistri ea naetrojene ea 'mele le ho thibela naetrojene e fetelletseng liseleng tsa' mele le maro. Batho ba nang le liprotheine tse phahameng, tšoaetso ea baktheria, kapa dysbiosis ea masapo ba ka rua molemo ho tlatsetso ea AKG ho thusa ho leka-lekanya maemo a ammonia le ho sireletsa lisele.

Batho ba bang ba nka alpha-ketoglutarate ho ntlafatsa ts'ebetso ea baatlelete. Barekisi ba liatleletiki tse tlatsetsang phepong ba re alpha-ketoglutaric acid e ka ba tlatsetso ea bohlokoa lijong tse nepahetseng le koetlisong ea moatlelete ea batlang ts'ebetso e phahameng. Ba theha kopo ena lithutong tse bonts'ang ammonia e eketsehileng 'meleng e ka kopana le alpha-ketoglutarate ho fokotsa mathata a amanang le ammonia e ngata (chefo ea ammonia). Empa, ho fihlela joale, lithuto feela tse bontšang alpha-ketoglutarate li ka fokotsa chefo ea ammonia li entsoe ho bakuli ba hemodialysis.

Bafani ba tlhokomelo ea bophelo bo botle ka linako tse ling ba fana ka alpha-ketoglutarate ka methapo (ka IV) bakeng sa ho thibela ho lemala pelong ho bakoang ke mathata a phallo ea mali nakong ea ts'ebetso ea pelo le ho thibela ho senyeha ha mesifa kamora ho buuoa kapa ho sithabela.

Mekhoa ea ts'ebetso ea alpha-Ketoglutaric acid

Mekhoa e nepahetseng ea ketso bakeng sa α-Ketoglutarate ha e so hlakisoe. Liketso tse ling tsa α-Ketoglutarate li kenyelletsa ho sebetsa lipotong tsa Krebs e le lipakeng, liphetoho tsa phetoho nakong ea metabolism ea amino acid, ho etsa asiti ea glutamic ka ho kopanya le ammonia, le ho fokotsa naetrojene ka ho kopanya le eona. Mabapi le liketso tsa α-Ketoglutarate le ammonia, ho etsoa tlhahiso ea hore α-Ketoglutarate e ka thusa bakuli ba nang le propionic academia ba nang le maemo a phahameng a ammonia le maemo a tlase a glutamine / glutamate maling a bona. Hobane glutamate / glutamine e sa feleng e hlahisoa ho tsoa ho α-Ketoglutarate, bakuli ba propionic acidemia ba senyehile tlhahiso ea α-Ketoglutarate le tlatsetso ea α-Ketoglutarate e lokela ho ntlafatsa boemo ba bakuli bana. Liphuputso tse ling tse 'maloa tsa liteko li boetse li bontšitse hore tsamaiso ea α-Ketoglutarate phepong ea malapa e fuoeng bakuli ba kamora' ts'ebetso e thusitse ho fokotsa ho fokotseha ha protheine ea mesifa e atisang ho bonoa kamora ho buuoa. Ts'ebetso ena e fokotsehileng ea mesifa e nahanoa hore e bakoa ke maemo a tlase haholo a α-Ketoglutarate.

Tlatsetso ea alpha ketoglutaric acid (AKG) - Melemo ea alpha ketoglutaric acid ke efe?

Alpha-Ketoglutarate (AKG) joalo ka Tlatsetso ea Ts'ebetso ea Athletic
Alpha ketoglutaric acid, kapa Alpha-ketoglutarate ke sehlahisoa sa mitochondria mme e bapala karolo ea bohlokoa phetohong ea lijo hore e be matla. Hape ke mohloli oa glutamine le glutamate. Ka mesifa, glutamine le glutamate li thibela ho senyeha ha protheine le ho eketsa protheine.

Alpha-ketoglutarate e ntlafatsa sebopeho sa masapo. E laola ts'ebetsong ea collagen mohlomong ka ho eketsa palo ea limolek'hule tse fumanehang bakeng sa ho qaptjoa. Collagen ke karolo ea bohlokoa ea masapo a masapo.

Alpha-ketoglutarate e hlohlelletsa tlhahiso ea insulin e ts'oanang le kholo-1 le kholo ea kholo. Tsena ke lihormone ka bobeli tse laolang phetolo ea masapo le sebopeho sa lisele tse ncha tsa masapo.

alpha ketoglutaric acid e rua molemo botsofaling
Boithuto bo bontšitse hore AKG e ka khona ho sebetsana le maemo a mangata ha e nkuoa joalo ka ha e laetsoe.

Leha ho le joalo, ho na le lipontšo tse ling tsa hore Alpha-Ketoglutarate (AKG) e kanna ea thusa ka thepa e thibelang botsofali.

Phuputso e 'ngoe e kholo e entsoeng ho Buck Institute for Research on Aging hammoho le Ponce de Leon Health e fumane bophelo bo ntlafetseng ka 60% thutong ea bona ea mammalia.

α-ketoglutaric
AKG e holisa nako ea bophelo ba batho ba baholo ba C. elegans. (A) AKG e eketsa nako ea bophelo ea liboko tsa batho ba baholo. (B) Karolo ea karabelo ea lethal dose ea phello ea AKG ho phela nako e telele.
Ntle le moo, Ponce De Lon Health (PDL) e hlahisitse tlaleho ea liteko, tlaleho e bonts'ang hore kamora halofo ea selemo, lilemo tsa mmele oa lithuto li fokotsehile ka karolelano ea lilemo tse 8.5 kamora ho nka alpha-ketoglutarate (AKG) e fumanehang k'hamphaning.

Metsoako e meng, joalo ka rapamycin ea lithethefatsi e seng e tsofetse le metformin ea kalafo ea lefu la tsoekere, e bonts'itse litlamorao tse tšoanang litekong tsa toeba. Empa AKG ka tlhaho e entsoe ke litoeba le 'mele ea rona,' me e se e ntse e nkuoa e bolokehile hore e ka jeoa ke balaoli.

Lintho tseo re hlokang ho li ela hloko ke hore alpha e hloekileng ea ketoglutaric e na le asiti haholo ebile ha ho bonolo ho e ja. Lisebelisoa tse matlafatsang 'marakeng li eketsoa ka arginine-α-ketoglutarate (AAKG), eo karolo ea eona ea mantlha e leng arginine, ha e sebelisoang ke Ponce De Lon Health ke α-ketoglutarate calcium.

Alpha-ketoglutarate le eona e na le thepa e matlafatsang sesole sa 'mele
AKG e boetse e bitsoa motsoako oa phepo ea 'mele' me e bapala karolo ea bohlokoa ho metabolism ea 'mele ea mmele. Ho se ho tsebahala hore AKG ke mohloli oa bohlokoa oa glutamine le glutamate, e hlalosoang e le homologue ea glutamine ebile e tsoa ho eona. 'Meleng, e fetoloa glutamine. Glutamine e ka eketsa litekanyo tsa lisele tse tšoeu tsa mali (macrophages le neutrophils) .AKG joalo ka ha glutamine homologue e na le thepa e matlafatsang 'mele, e ka boloka tšitiso ea mala, ea eketsa lisele tsa' mele ea ho itšireletsa mafung le tšebetso ea li-neutrophils le phagocytosis, ea fokotsa phetoho ea baktheria vivo.

Tlhaloso:

  1. Aussel C, Coudray-Lucas C, Lasnier E, le al. Alpha-Ketoglutarate e nka li-fibroblast tsa batho. Cell Biol Int 1996; 20: 359-63.
  2. Wernerman J, Hammarqvist F, Vinnars E. Alpha-ketoglutarate le mesifa ea kamora ho sebetsa. Lancet1990; 335: 701-3.
  3. Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine le alpha-ketoglutarate li thibela ho fokotseha ha mokokotlo oa mesifa ea glutamine le tšusumetso ea protheine kamora ho nka sebaka sa letheka. Metabolism 1995; 44: 1215-22.
  4. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E.Alpha-ketoglutarate e boloka protheine le glutamine ea mahala mesifa ea masapo kamora ho buuoa. Phekolo ea 1991; 109: 28-36.
  5. Zhang W, Qu J, Liu GH, le al. Epigenome ea botsofali le nchafatso ea eona [J]. Tlhatlhobo ea Tlhaho Biology ea Cell ea Molecular, 2020, 21 (3).
  6. Litsela TW, Anderson RM. Alpha-Ketoglutarate, Metabolite e Laolang Botsofali ho Litoeba [J]. Cell Metabolism, 2020.
  7. Alpha-Ketoglutarate, Metabolite e sa Feleng, e Atolosa Bophelo ba Motho 'me e hatella ho fokola ha litoeba tsa botsofali. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, CD ea Wiley, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.