spermine

Spermine le polyamine

Joale polyamine ke eng? Hona ke hobane’ng ha li le bohlokoa hakaale karolong ea botsofali? Li-polyamine li teng hohle liseleng tse phelang le liseleng. Li tsejoa e le li-amine tsa biogenic e leng metsoako e nang le lihlopha tse fetang tse peli tsa amino. Li-poliamine li hlaha ka tlhaho 'meleng ea rona mme ka bomalimabe, ha re ntse re tsofala maemo ana a fokotseha.

Polyamine e bapala karolo ho:

• Karohano ea lisele le phapang
• Ho ata ha lisele
• DNA le protheine synthesis
• Homeostasis (bokhoni ba 'mele ba ho fetola le ho boloka boemo bo tsitsitseng)
• Le polelo ea liphatsa tsa lefutso (khoutu ea mofuta o sebelisoang ho tsamaisa protheine synthesis)

Ha re sheba mesebetsi eohle ea polyamine, re ka bona hore na ke hobane'ng ha re lokela ho ameha haeba botsofali bo etsa hore maemo a rona a theohe. Metsoako ena ea bohlokoa e bonahala e ameha haholo mekhoeng ea ho hōla ha lisele le ho boloka botsitso ba liphatsa tsa lefutso. Ka hona, li thusa ho liehisa mokhoa oa ho tsofala le ho ntlafatsa bophelo ba rona le bophelo ba rona (boleng ba rona ba bophelo). Ho theoha ha maemo a rona a polyamines ka hona ho re hanela melemo e mengata ea kalafo.

Li-poliamine tse ka sehloohong tse fumanoang liseleng tsa mammalian esita le limela ke spermidine, spermine, le putrescine. Batho le limela ba na le lintho tse ngata tse tšoanang, e 'ngoe ea lintho tseo ke hore ka bobeli re etsa sohle seo re ka se khonang ho etsa bonnete ba hore re phela nako e telele kamoo ho ka khonehang. E 'ngoe ea litsela tseo re ka li finyellang ke ka ho kenngoa ha polyamine le polyamine synthesis. Mokhoa ona o khothalletsa autophagy, e leng mokhoa oa 'mele oa rona oa ho nkela lisele tse senyehileng sebaka ka lisele tse ncha, tse nchafalitsoeng. Joalokaha u ka inahanela, ts'ebetso ena e ka re thusa ho phela bophelo bo bolelele, bo thabileng le bo botle. Spermine ke mohlala oa polyamine e ka thusang ho ntšetsa pele boits'oaro.

Spermine ke eng?

Spermine ke polyamine e hlahang ka tlhaho e hlahang li-eukaryote tsohle, empa ha e fumanehe hangata ho prokaryotes. E bohlokoa bakeng sa kholo ea lisele tsa lisele tse tloaelehileng le tsa neoplastic. Spermine e thehoa ka ho eketsoa ha sehlopha sa aminopropyl ho spermidine ka spermine synthase. Spermine e na le sebopeho sa motheo ka matla, 'me ka tharollo ea metsi ho pH ea fisioloji, lihlopha tsohle tsa eona tsa amino li tla fumanoa e le polycation.

Spermine e ka sebelisoa mefuteng e mengata ea likokoana-hloko e le tlatsetso kapa moemeli oa taolo. E sebelisoa e le co-matrix le DHB bakeng sa MALDI-MS ea sialylated glycans ka mokhoa o fosahetseng oa ion.

spermine tetrahydrochloride phofo ke eng?

Spermine tetrahydrochloride ke polyamine e hlahisang mefuta e fapaneng ea liphello tsa modulatory ho NMDA receptor channel, e sebetsang ka sebaka se itseng se rarahaneng se ka bakang liphello tsa agonist le mohanyetsi. Spermine tetrahydrochloride phofo ke mofuta oa tetrahydrochloride oa Spermine. Spermine tetrahydrochloride powder ke mofuta o mosoeu oa phofo ha setsi sa mahala sa Spermine se le mokelikeli. Melemo ea phofo ea spermine tetrahydrochloride e tšoana le melemo ea Spermine.

Spermine Mechanism ea ketso: E sebetsa joang?

Spermine e tsoa ho spermidine ka spermine synthase. Spermine ke polyamine, cations e nyane ea manyolo e hlokahalang bakeng sa kholo ea lisele tsa eukaryotic. Spermine, hangata e fumanoa ka har'a millimolar concentrations khubung. Spermine e sebetsa ka kotloloho e le mohanyetsi oa mahala, mme e theha mefuta e fapaneng ea li-adducts tse thibelang tšenyo ea oxidative ho DNA. Tšenyo ea oxidative ho DNA ka mefuta ea oksijene e sebetsang ke bothata bo sa feleng boo lisele li lokelang ho itebela khahlanong le bona ho phela. Kahoo, spermine ke motsoako o moholo oa tlhaho oa intracellular o khonang ho sireletsa DNA tlhaselong ea mahala ea radical. Spermine e boetse e ameha taolong ea polelo ea liphatsa tsa lefutso, ho tsitsisa ha chromatin, le ho thibela ho arohana ha DNA ea endonuclease-mediated.

Melemo ea spermine - spermine e sebelisetsoa eng?

Spermine ke polyamine ea tlhaho e nang le lihlopha tse ngata tsa amino. Ho fumanoe hore e phetha karolo ea bohlokoa ho metabolism ea cellular liseleng tsohle tsa eukaryotic. Spermine, e leng polyamine e hlahang ka tlhaho, e sa tsoa hlaha e bonts'a thepa e thibelang botsofali. Li-supplement tsa Spermine tse entsoeng ke Spermine tetrahydrochloride powder li eketsa nako ea bophelo le ho hanyetsa khatello ea kelello, 'me li fokotsa ho hlaha ha mafu a amanang le lilemo le tahlehelo ea bokhoni ba ho tsamaisa likoloi.

Spermine e matlafatsa tahlehelo ea ho boloka mohopolo.
Kamora kalafo ea Spermine, bokhoni ba ho boloka mohopolo bo ile ba ntlafatsoa haholo ho litoeba tsa SAMP8. Spermine tetrahydrochloride phofo e ntlafalitse haholo nako ea nako ea ho hlahloba ntho e ncha.

Spermine e kokobetsa khatello ea oxidative bokong ba litoeba.
Re ile ra lekola phello ea polyamine le rapamycin khatellong ea oxidative. Spermine e fokolitse maemo a MDA bokong ba litoeba tsa SAMP8. Mosebetsi oa SOD o ile oa eketseha ka ho khetheha sehlopheng sa spermine. Liphetho tsena li bontšitse hore phofo ea Spermine tetrahydrochloride e matlafatsa haholo khatello ea oxidative ho SAMP8.

Spermine e eketsa polasetiki ea synaptic le lintlha tsa neurotrophic
Polelo ea lintlha tsa neurotrophic le liprotheine tsa synaptic li ile tsa fumanoa sehlopheng sa spermine. Ntho ea ho hōla ha methapo ea kutlo (NGF), neurotrophic factor (BDNF) e tsoang bokong, postsynaptic density le postsynaptic density ho hlakile hore e ntlafalitsoe sehlopheng sa spermine.

Spermine e lokisa ho se sebetse ha mitochondrial
Joalokaha ho bontšitsoe, polelo ea liprotheine tse amanang le mitochondrion e ntlafalitsoe haholo sehlopheng sa spermine. Ho hlakile hore Spermine e ile ea etsa hore phosphorylation ea DRP 1. Motsoako oa ATP o ne o le tlase sehlopheng sa litoeba tsa SAMP8 ho feta sehlopheng sa spermine.

Spermine e baka autophagy
Ka mor'a phekolo ea Spermine tetrahydrochloride phofo, boemo ba phosphorylation ea AMPK bo ne bo phahame. Boemo ba liprotheine tse amanang le autophagy ho kenyelletsa le bo ile ba eketseha haholo sehlopheng sa spermine.

Spermine e ntlafatsa apoptosis

spermine attenuate ho ruruha
Joalokaha ho bontšitsoe, Ka mor'a phekolo ea spermine, polelo ea liprotheine tsa ho ruruha e ile ea fokotseha haholo. li-supplement tsa spermine tse entsoeng ke Spermine tetrahydrochloride phofo li ka sithabetsa ho ruruha bokong.

Spermine le spermidine

Likahare tsa spermidine le spermine liseleng tsa mammalian li na le likarolo tsa bohlokoa ho protheine le nucleic acid synthesis le sebopeho, ts'ireletso khahlanong le tšenyo ea oxidative, ts'ebetso ea likanale tsa ion, ho ata ha lisele, ho arola le apoptosis.

Spermine ke mofuta o mong oa polyamine. Metsoako ka bobeli e amana. Spermine e tsoa ho Spermidine 'me e bohlokoa bakeng sa metabolism ea lisele ho batho le limela. Ho nka li-supplement tsa spermidine ho netefatsa hore le uena u fumana melemo ea spermine.

Spermine tetrahydrochloride phofo kopo

Spermine tetrahydrochloride phofo e ne e sebelisetsoa ho fokotsa DNA bakeng sa tlhahlobo ea cytometric e tsoang ho lisele tse ncha tsa kankere ea matsoele e leqhoa, lisele tsa polokelo ea masapo, li-renal le thyroid tumors2 le lisele tse khubelu tsa mali tsa khoho. Hona joale Spermine tetrahydrochloride phofo e sebelisitse li-supplement tse khahlanong le botsofali. Reka Spermine tetrahydrochloride phofo inthaneteng.

Moo u ka rekang bongata ba Spermine?

Lefatšeng la sejoale-joale, o ka reka li-supplement tsa Spermine tse entsoeng ke phofo ea Spermine tetrahydrochloride matšelisong a ntlo ea hau inthaneteng. Leha ho le joalo, o tla tlameha ho hlahloba ka ho pharaletseng bakeng sa bafani ba phofo ea boleng bo phahameng ea Spermine tetrahydrochloride. Litlhahlobo tsa bareki ke tsela e 'ngoe ea ho netefatsa melemo ea phofo ea Spermine tetrahydrochloride le ho bokella tlhahisoleseding mabapi le litla-morao tse ka bang teng tsa spermine.

Ho na le phofo e ngata ea spermine tetrahydrochloride e rekisoang 'marakeng. Phcoker joalo ka fektheri ea tlhahiso e fana ka bongata bo bongata ba spermine tetrahydrochloride phofo. Phofo e ntle ka ho fetisisa ea tlatsetso ea spermine e na le bohloeki bo phahameng le bioavailability. Spermine tetrahydrochloride powder wholesale buy e tla fumana theko e ntle.

LBH

Na Spermine Anti botsofali?
Pampiri e phatlalalitsoeng ka 1992 e ile ea fana ka maikutlo a hore spermine le spermidine li sireletsa DNA khahlanong le tšenyo ea free-radical oxidative. Maemo a rona a Spermine a theoha ha re ntse re tsofala, e seng litaba tse monate ho rona kaha re ka lahleheloa ke melemo eo e khahlanong le botsofali le bophelo bo botle. Tekong e 'ngoe, litoeba tse neng li sa khone ho hlahisa spermine le spermidine li ile tsa lahleheloa ke moriri, tsa e-ba le letlalo le sosobaneng, 'me tsa shoa li le monyenyane ho feta litoeba tse tloaelehileng, empa ha ho letho le ileng la hlaha le le kotsi ho litho leha e le life.

Na spermine ke antioxidant?
Ho ea ka liphuputso tse ling, tsamaiso ea spermine e ka eketsa matla a antioxidant sebeteng le spleen 'me e ka ntlafatsa boemo ba antioxidant spleen le sebete tlas'a khatello ea oxidative. Spermine e khethiloe e le antioxidant e matla le e khahlanong le ho ruruha. Motsoako o teng linthong tsohle le lithong tsohle.

spermine e etsa eng ka peō ea botona?
Kaha nako e nepahetseng ea capacitation le karabelo ea acrosome e bohlokoa bakeng sa manyolo a atlehileng, ho khothaletsoa hore karolo ea seminal spermine ke ho thibela capacitation pele ho nako le karabelo ea acrosome.

Peō ea botona e fumanoa hokae?
Spermine ke polyamine, cations e nyane ea manyolo e hlokahalang ka botlalo bakeng sa kholo ea lisele tsa eukaryotic. Spermine, hangata e fumanoa ka har'a li-millimolar tse ka har'a nucleus. Spermine e sebetsa ka kotloloho e le mohanyetsi oa mahala, mme e theha mefuta e fapaneng ea li-adducts tse thibelang tšenyo ea oxidative ho DNA.

Na spermine ke protheine?
Le hoja spermidine e na le karolo ea bohlokoa le e ikhethang e le selelekela sa hypusine phetoho ea ka morao ea phetolelo ea elongation factor eIF5A, e hlokahalang hore protheine ena e sebetse ka har'a protheine synthesis, ha ho karolo e ikhethang ea spermine e fumanoeng ka mokhoa o sa tsitsang.

U boloka motsoako oa spermine joang?
Boloka mocheso oa 2-8 ° C. Litharollo tsa motheo oa mahala oa spermine li na le oxidized habonolo. Litharollo li tsitsitse ka ho fetisisa haeba li lokiselitsoe metsing a khaotsoeng 'me li bolokiloe ka li-aliquots tse leqhoa, tlas'a argon kapa nitrogen gas. spermine tetrahydrochloride phofo ke mofuta o tsitsitseng haholoanyane oa motheo oa mahala oa spermine.

Peō ea botona e tsoa hokae?
Spermine e teng linthong tse ngata tse kenyelletsang liphoofolo, limela, li-fungus tse ling, li-archaea tse ling le libaktheria tse ling. E entsoe ka spermine synthase, aminopropyltransferase e khethehileng haholo. Spermine e tsoa ho spermidine ka spermine synthase.

pH ea spermine ke eng?
Ho netefatsa hore spermine e ne e sebetsa ka bioloji ho pH 7.4 re ile ra leka litlamorao tsa eona ho li-receptor tsa glutamate tse hlahisitsoeng ka mokhoa o fapaneng (GluR3)

Na peo ea botona e molemo bakeng sa letlalo?
Ha e le hantle, ha ho na bopaki leha e le bofe ba saense bo tšehetsang maikutlo a ho beha peō letlalong la hao. Ntle le ho etsa ho fokolang ho thusa 'mele oa hau, ho ka boela ha fella ka ho hanana le mafu le mafu a tšoaetsanoang ka thobalano (STIs).

1.E 'ngoe ea lipolelo tsa melemo ea peō bakeng sa letlalo la sefahleho ke ho phekola maqoqomete. Melemo ea peō bakeng sa botle ho lumeloa hore e tsoa nthong ea spermine. Spermine ke ntho e tsoang ho ntho ea spermidine peōng ea banna, eo ho lumeloang hore e sebetsa e le antioxidant le anti-inflammatory agent. Ntle le peō ea monna, spermine e ka boela ea fumanoa liseleng tsa 'mele oa motho. Ho lumeloa hore spermine e phekola makhopho le ho loantša maqeba a makhopho.

Ka bomalimabe, ha ho na liphetho tsa lipatlisiso tsa saense tse ka pakang melemo ea peō bakeng sa letlalo le nang le makhopho.

2.Claims Melemo ea peō bakeng sa botle ke ho thibela ponahalo ea matšoao a ho tsofala pele ho nako, joalo ka wrinkles kapa mela e metle.Hape, tseko ea melemo ea peō bakeng sa sefahleho sa basali e hlaha hobane peō e na le spermine. Ho lumeloa hore spermine ke antioxidant e khonang ho pata matšoao a botsofali, joalo ka makhopho le mela e metle, ho etsa hore letlalo le shebahale le le le le lenyane. Phuputso e phatlalalitsoeng koranteng ea Nature Cell Biology e re peō ea botona e khona ho fokotsa botsofali ha e sebelisoa ka ho e kenya ka ho toba liseleng tsa letlalo la motho.

Leha ho le joalo, melemo ea peō bakeng sa sefahleho, e sebelisoang ka ho e sebelisa ka ho toba holim'a letlalo, e ntse e sa pakoa. Ke hore, melemo ea peō bakeng sa sefahleho sa basali ho thibela ho tsofala pele ho nako ke tšōmo feela.

Tlhaloso:

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