Urolithin phofo

Urolithin A ke eng?

Urolithin A ke motsoako oa metabolite o bakoang ke phetoho ea li-ellagitannins ke libaktheria tsa mala. Ke ea sehlopha sa metsoako ea manyolo e tsejoang ka hore ke benzo-coumarin kapa dibenzo-α-pyrones. Urolithin A e bontšitsoe e le ho hlasimolla mitophagy le ho ntlafatsa bophelo bo botle ba mesifa liphoofolong tsa khale le mefuteng ea botsofe. Ho sa le joalo, ho boetse ho bonts'itsoe hore e tšela tšitiso ea boko ba mali, mme e kanna ea ba le litlamorao tsa ts'ireletso khahlanong le Lefu la Alzheimer's.

Urolithin A phofo ke sehlahisoa sa tlhaho se nang le li-antiproliferative le antioxidant. Urolithin A e thehiloe ke metabolism e tsoang ho li-polyphenol tse fumanoang linate le litholoana tse ling, haholo likharenate. Tse ka pele ho eona - li-ellagic acid le li-ellagitannins - li fumaneha ka tlhaho, ho kenyeletsoa limela tse jeoang, joalo ka likharenate, fragole, tse tala, walnuts, tee le morara oa muscat, hammoho le litholoana tse ngata tsa tropike.

Ho tloha lilemong tsa bo-2000, urolithin A esale e le tlasa lithuto tsa pele mabapi le litlamorao tsa eona tsa bioloji.

Urolithin A e sebetsa joang?

Urolithin A ke urolithin, metabolism ea likokoana-hloko ea motho ea li-ellagic acid tse tsoang lijong (tse kang ellagic acid). Ka metabolism ea mala ea libaktheria, ellagitannin le ellagic acid li lebisa ho sebopeho Li-urolithin tse sebetsang A, B, C le D. Har'a tsona, urolithin A (UA) ke 'mele oa mala o sebetsang ka ho fetesisa le o sebetsang, o ka sebelisoang e le anti e sebetsang. -a chesa le antioxidant.

Lithutong tsa laboratori, ho bonts'itsoe hore urolithin A e hlohlelletsa mitochondria, e leng ho hlaphoheloa ha mitochondria ka boiketsetso. Autophagy ke mokhoa oa ho tlosa mitochondria e senyehileng kamora ho tsoa likotsi kapa khatello ea maikutlo, mme e sebetsa hantle nakong ea botsofali. tlase le tlase. Phello ena e bonoe mefuteng e fapaneng ea liphoofolo (lisele tsa mammalian, litoeba le litlou tsa Caenorhabditis).

Leha ho le joalo, hobane mohloli oa ellagitannin o fapane, sebopeho sa sehlopha ka seng sa baktheria le sona se tla fapana, ka hona ts'ebetso ea phetoho ea urolithin A e fapane haholo bathong, mme batho ba bang ba kanna ba se be le phetoho.

Melemo ea Urolithin A

Urolithin A (UA) ke sejo sa tlhaho, metabolism e tsoang sechabeng sa likokoana-hloko. E na le melemo e fapaneng ea bophelo bo botle, ho kenyelletsa ho fokotsa ho tšoaea ho hlaselang, litlamorao tse khahlanong le mofetše le ho thibela ho bokellana ha lipid.

Joaloka metabolite e sebetsang ka ho fetesisa le e sebetsang ea mala, urolithin A (UA) e ka sebetsa e le anti-inflammatory le antioxidant. E ka boela ea matlafatsa phagocytosis ea mitochondrial liphoofolong tsa khale le mehlala ea botsofe le ho ntlafatsa bophelo bo botle ba mesifa.

Na Urolithin A e ka sebelisoa e le litlatsetso?

Ka 2018, Tsamaiso ea Tsamaiso ea Lijo le Lithethefatsi ea Amerika e khethile urolithin A e le sesebelisoa se bolokehileng lijong kapa lijong tsa tlatsetso ea lijo, ka chelete e ka bang limilimithara tse 250 ho isa ho 1 gram ka nako ea phepelo.

Na ho na le litla-morao tsa Urolithin A?

Boithuto ba polokeho ho batho ba baholo ba bontšitse hore urolithin A e mamelleha hantle. Liphuputsong tsa vivo ha li so tsebe hore na ho na le chefo kapa litlamorao tse itseng tsa ho ja urolitin A.

Hape, polokeho ea nako e telele bakeng sa tlatsetso ea Urolithin A le kharenate ha e tsejoe, leha kalafo ea nako e khuts'oane e ntšitsoeng ka kharenate e bolokehile.

Urolithin B ke eng? Urolithin B phofo?

Urolithin B phofo (CAS NO: 1139-83-9) ke urolithin, mofuta oa metsoako ea phenolic e hlahisoang ka maleng a motho kamora ho monya lijo tse nang le li-ellagitannins tse kang kharenate, fragole, tse tala tse khubelu, walnuts kapa veine e khubelu ea khale ea oak . Urolithin B e fumanoa ka morong ka mokhoa oa urolithin B glucuronide.

Urolithin B e fokotsa ho senyeha ha protheine mme e baka mesifa ea hypertrophy. Urolithin B e thibela tšebetso ea aromatase, enzyme e fetolang estrogen le testosterone.

Urolithin B ke sehlahisoa sa tlhaho se nang le li-antiproliferative le antioxidant. Urolithin B e bonts'itsoe hore e tšele tšitiso ea boko ba mali, mme e kanna ea ba le litlamorao tsa ts'ireletso khahlanong le Lefu la Alzheimer's.

Urolithin B ke sebopeho sa "mala" sa "bactericial metabolite" sa "ellagitannis" mme se bonts'a ts'ebetso ea ts'ebetso ea anti-oxidant le pro-oxidant ho latela tsamaiso le maemo. Urolithin B e ka boela ea bonts'a mesebetsi ea estrogenic le / kapa anti-estrogenic.

Urolithin B e sebelisetsoa eng? Melemo ea Urolithin B (UB)

Melemo ea Urolithin B:

E tsosa liprotheine tsa mesifa

E fokotsa ho senyeha ha liprotheine tsa mesifa

E kanna ea ba le litlamorao tsa ts'ireletso ea mesifa

E kanna ea ba le Thepa ea Anti-Aromatase

Urolithin B bakeng sa boima ba mesifa

Urolithin B e ka fokotsa tšenyo ea mesifa e bang teng nakong ea boikoetliso bo matla le ho sireletsa mesifa khahlanong le khatello ea maikutlo e hlahisoang ke lijo tse nang le mafura a mangata. Patlisiso ea bongaka mabapi le Urolithin B ho litoeba e fumane hore e ntlafatsa kholo ea myotubes le phapang ka ho eketseha ha protheine. E bontšitse bokhoni ba ho thibela tsela ea ubiquitin-proteinasome (UPP), e leng mochini o ka sehloohong oa protabolism ea protheine. E boetse e kenyelletsa hypertrophy ea mesifa le ho fokotsa mesifa ea mesifa.

Ha e bapisoa le testosterone, Urolithin B ha e nkuoa ho 15 M e eketsehile ts'ebetso ea androgen receptor ka 90% ha testosterone e ne e khona ho etsa mosebetsi o eketsehileng oa li-receptor oa 50% ho 100uM. Sena se bolela hore ho nka Urolithin B e nyane haholo ho eketsa ts'ebetso ea androgen ka tsela e phahameng ka moo palo e phahameng ea testosteronewhich e eketsang ts'ebetso ea androgen ka tsela e sa sebetseng.

Ho feta moo, 15uM e sebetsang hantle haholo ea "protein" e kholo ea Urolithin B ka 96% ha e bapisoa le 100uM ea "insulin" e hlahisang protheine ea mesifa e kholo ka ho fetisisa ka 61%. Tumelo ke hore ho nka nako e telele ho feta Urolithin B ho holisa motsoako oa protheine ea mesifa ka katleho e kholo.

Boithuto bona bo bontša hore Urolithin B e ka thibela protheine ea protheine ha ka nako e ts'oanang e eketsa tlhahiso ea protheine, ke motsoako oa tlhaho o thusang ho aha mesifa ha o ntse o thibela ho senyeha ha mesifa.

Urolithin B ke e 'ngoe ea methapo ea methapo ea methapo ea ellagitannins, hape e na le litlamorao tse khahlano le ho ruruha le antioxidant. Urolithin B e thibela tšebetso ea NF-κB ka ho fokotsa phosphorylation le ho senyeha ha I VerBcy, hape e hatella phosphorylation ea JNK, ERK, le Akt, hape e ntlafatsa phosphorylation ea AMPK. Urolithin B hape ke molaoli oa masapo a mesifa.

Urolithin A 8-Methyl Ether ke eng?

Urolithins ke metabolites ea bobeli ea ellagic acid e tsoang ho ellagitannins. Ka hara batho ellagitannins e fetoloa ke gut microflora hore e be ligalelogic acid e fetotsoang hape e le urolithin A, urolithin B, urolithin C le urolithin D ka har'a mala.

Urolithin A 8-Methyl Ether ke sehlahisoa se mahareng nakong ea motsoako oa Urolithin A. Ke metabolite ea bohlokoa ea bobeli le ellagitannin mme e na le thepa ea antioxidant le anti-inflammatory.

Urolithin A 8-Methyl Ether e sebetsa joang?

(1) Lihlahisoa tsa antioxidant

Urolithin A 8-Methyl Ether e na le phello ea antioxidant ka ho fokotsa li-radicals tse sa lefelloeng, haholoholo ho fokotsa maemo a mefuta ea oksijene e sebetsang (ROS) liseleng, le ho thibela lipid peroxidation mefuteng e meng ea lisele.

(2) Lisebelisoa tse khahlanong le ho ruruha

Urolithin A 8-Methyl Ether e na le thepa e khahlanong le ho ruruha ka ho thibela tlhahiso ea nitric oxide. Li thibela ka ho khetheha polelo ea protheine e sa sebetseng ea nitric oxide synthase (iNOS) le mRNA e bakang ho ruruha.

Urolithin A 8-Methyl Ether melemo

Urolithin A 8-Methyl Ether ke sehlahisoa se bohareng nakong ea ts'ebetso ea Urolithin A, le metabolite ea bobeli ea bohlokoa ea ellagitannin, e nang le thepa ea antioxidant le e khahlanong le ho ruruha. Joaloka metabolite ea Urolithin A, e kanna ea ba le melemo ea Urolithin A:

(1) E ka lelefatsa nako ea bophelo;
(2) Thusa ho thibela mofetše oa tšoelesa ea senya;
(3) Ntlafatso ea kelello;
(4) Monyetla oa ho theola boima ba 'mele

Ts'ebeliso ea Urolithin A 8-Methyl Ether e tlatsetsang?

Li-supplements tsa Urolithin A li fumaneha habonolo 'marakeng joalo ka ha mohloli oa lijo o nang le ellagitannin. Joaloka sehlahisoa sa 'mele sa Urolithin A, Urolithin A 8-Methyl Ether le eona e ka sebelisoa ho tlatseng.

Leha ho le joalo, ha ho na lintlha tse ngata mabapi le tlhaiso-leseling e tlatselletsang, mme lipatlisiso tse ling lia hlokahala.

Tlhaloso:

1. Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Phello ea Metabolic ea Ellagitannins: Litlamorao ho Bophelo bo Botle, le Lits'ebetso tsa Patlisiso bakeng sa Lijo Tse Sebetsang Tse Sebetsang". Litlhahlobo tse Bohlokoa ho Saense ea Lijo le Phepo e Ntle. 54 (12): 1584–1598. doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.
2. Ryu, D. le al. Urolithin A e fokotsa mitophagy mme e lelefatsa bophelo ba motho ho C. elegans mme e eketsa ts'ebetso ea mesifa litoeba. Nat. Med. 22, 879-888 (2016).
3. "Tsebiso ea FDA GRAS ea GRN ea 791: urolithin A". Tsamaiso ea Tsamaiso ea Lijo le Lithethefatsi ea US. La 20 Tšitoe 2018. E khutlisitsoe ka la 25 Phato 2020.
4. Singh, A .; Andreux, P.; Blanco-Bose, W.; Ryu, D .; Aebischer, P.; Auwerx, J .; Rinsch, C. (2017-07-01). "Urolithin A e fanoang ka molomo e bolokehile ebile e ntlafatsa li-biomarker tsa mesifa le mitochondrial ho batho ba tsofetseng". Ntlafatso ea botsofaling. 1 (suppl_1): 1223-1224.
5. Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Tekolo ea polokeho ea urolithin A, metabolite e hlahisoang ke microbiota ea motho ka mpeng ha ho jeoa limela tse nkiloeng ke ellagitannins le ellagic acid". Lijo le Lik'hemik'hale Toxicology. EA-108-PT A: 289–297. doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.