Palmitoylethanolamide (PEA) kakaretso

Ho na le tlaleho ea hore Tsamaiso ea Lijo le Lithethefatsi e lumelletse ho kenya kopo ea teko ea bongaka ea ho phekola COVID-19 ka ho sebelisa sethethefatsi se iketsisang se etsisang ketso ea molek'hule e fumanoang ka matekoane.

Moriana oa maiketsetso, o bitsoang ultiticicronized palmitoylethanolamide (micro PEA), ho lumeloa hore o sebetsa e le anti-inflammatory. Palmitoylethanolamide (PEA) ke "asiti ea mafura e hlahang ka tlhaho" e ts'oanang le endocannabinoid, e 'ngoe ea limolek'hule tse fumanoang ka kannabiseng e shebileng li-receptor tsa CB2. Ho nahanoa hore li-receptor tsa CB2 li ka ruruha le bohloko hohle 'meleng oa motho.

Kaha [micro PEA] e sebelisitsoe Europe ka lilemo tse 20, bafani ba bang ba tlhokomelo ea bophelo ba Italy ba ne ba khothaletsa ts'ebeliso ea Micro PEA ho phekola bakuli ba COVID-19 mme ba ne ba fumana katleho.

COVID-19 e matla e khetholloa ka karabelo e feteletseng ea ho ruruha e ka lebisang sefefong sa cytokine. "PEA e nyane ha e bolaee vaerase, empa ba lumela hore e ka fokotsa karabelo ea boits'ireletso ba mmele, e ka bolaeang.

 

Palmitoylethanolamide (PEA) ke eng?

Palmitoylethanolamide (PEA) ke lipid e etsahalang ka tlhaho 'meleng oa rona ka karolo ea mafura a acid. Ke ka lebaka leo e leng lipid ea tlhaho. PEA e boetse e hlahisoa ka tlhaho ho limela le liphoofolo.

Palmitoylethanolamide (PEA) e ka fumanoa lijong tse kang lebese, linaoa tsa soya, lierekisi tsa serapeng, lecithin ea soya, nama, mahe le linate.

Mohapi oa Khau ea Nobel Levi-Montalcini o supile Palmitoylethanolamide (PEA) joalo ka molek'hule e itlhahelang ka tlhaho, e hlalosang boleng ba eona ba ho phekola mafu a sa foleng le bohloko. Kamora ho sibolloa ha hae, lithuto tsa mahlale tse makholo li entsoe ho bonts'a hore e sebetsa hantle ebile e bolokehile ho e sebelisa. Palmitoylethanolamide (PEA) e hlalosoa lingoliloeng tsa mahlale e le setlhare sa bohloko ba tlhaho.

 

Palmitoylethanolamide (PEA)

Palmitoylethanolamide melemo - Palmitoylethanolamide e sebelisetsoa eng?

Palmitoylethanolamide (PEA) ke mafura a nang le asiti e ngata mme e hlophisitsoe mme e sebetsa kahare ho 'mele ea rona bakeng sa taolo ea mesebetsi e fapaneng. Ke acid e nang le mafura e sa feleng, eo e leng ea sehlopha sa li-agonists tsa nyutlelie. Palmitoylethanolamide (PEA) e hlile e fumanoe ka bongata mefuteng e mengata ea liphoofolo e ruruhileng, hammoho le litekong tse 'maloa tsa bongaka.

Ke setlhare se bohloko sa tlhaho mme e ka sebelisoa bakeng sa bohloko bo sa foleng le ho ruruha. E boetse e na le litlamorao tse ling tse ntle joalo ka bohloko ba methapo ea pelo, fibromyalgia, sclerosis e 'maloa, ho tsoa likotsi tse ngata khafetsa, tšoaetso ea pampiri ea phefumoloho le mathata a mang a mangata.

Tse ling tsa melemo e tlalehiloeng ea Palmitoylethanolamide e kenyelletsa;

 

i. E tšehetsa bophelo bo botle ba boko

Melemo ea Palmitoylethanolamide ho ntlafatsa bophelo bo botle ba boko e tsamaisana le bokhoni ba eona ba ho loants'oa maqhubu a neural le ho phahamisa lisele tsa neural li sa phela. Sena se bonoa haholo le batho ba nang le mathata a methapo ea kutlo le stroke.

Mohlala, phuputsong ea batho ba 250 ba nang le stroke, tlatsetso ea palmitoylethanolamide e tsamaisoang hammoho le luteolin e fumanoe e ntlafatsa bophelo. PEA e fumanoe e ntlafatsa mohopolo, bophelo bo botle ba boko le ts'ebeliso ea letsatsi le letsatsi. Litholoana tsa phofo ea palmitoylethanolamide li ile tsa hlokomeloa matsatsi a 30 kamora tlatsetso mme tsa eketseha ho feta khoeli e le 'ngoe.

 

ii. Fokotsa bohloko bo bongata le ho ruruha

Bo-rasaense ba fana ka bopaki bo bongata ba thepa ea ho fokotsa bohloko ba Palmitoylethanolamide. Ha e le hantle, Palmitoylethanolamide e fana ka liphallelo ho mefuta e fapaneng ea bohloko le ho ruruha. Lithuto tse ling tse bonts'ang thepa ea lithuso tsa bohloko ba Palmitoylethanolamide;

Phuputsong e amang liphoofolo, tlatsetso ea palmitoylethanolamide Hammoho le quercetin ho fumanoe ho fana ka phomolo ho bohloko ba manonyeletso hammoho le ho ntlafatsa tšebetso e kopaneng le ts'ireletso ea lefufuru tšenyo.

Liphuputso tse ling tsa pele li bonts'a hore PEA e ka thusa ho fokotsa bohloko ba methapo ho bakuli ba lefu la tsoekere (lefu la tsoekere).

Phuputsong e 'ngoe le batho ba 12, moriana oa Palmitoylethanolamide oa 300 le 1,200 mg / letsatsi le fanoeng bakeng sa libeke tse 3 ho isa ho tse robeli o fumanoe a theola leholo la bohloko bo sa foleng le ba neuropathic.

Phuputso ea bakuli ba 80 ba nang le lefu la Fibromyalgia e fumane hore PEA ntle le meriana e meng bakeng sa pherekano e ka fokotsa bohloko.

Ho ea pele, lithuto tse ling tse 'maloa li bonts'a liphallelo tsa bohloko ba Palmitoylethanolamide ho kenyelletsa bohloko ba pelvic, bohloko ba sciatic, bohloko ba morao, bohloko ba kankere har'a ba bang.

 

iii. E thusa ho fokotsa matšoao a khatello ea maikutlo

PEA e susumetsa ka mokhoa o sa tobang li-receptor tse ikarabellang bakeng sa maikutlo. Liphuputso tse ling li bonts'a phomolo ea matšoenyeho ea palmitoylethanolamide e le karolo ea bohlokoa ho loantseng khatello ea maikutlo.

Phuputsong ea bakuli ba 58 ba nang le khatello ea maikutlo, tlatsetso ea Palmitoylethanolamide ho 1200 mg / letsatsi hammoho le meriana ea antidepressant (citalopram) e tsamaisitsoeng bakeng sa libeke tse 6 e fumanoe e ntlafatsa haholo mohopolo le matšoao a kakaretso a khatello ea maikutlo.

 

iv. E kokobetsa sefuba se tloaelehileng

Palmitoylethanolamide e rua molemo ho loantšeng serame se tloaelehileng molemong oa eona oa ho senya vaerase e ikarabellang bakeng sa sefuba se tloaelehileng. Ho makatsang ke hore, sefuba se tloaelehileng se etsahala hohle mme se ama motho e mong le e mong haholo-holo batho ba nang le boits'ireletso ba mmele.

Phuputso e entsoeng le masole a manyane a 900 e bonts'itse hore litla-morao tsa Palmitoylethanolamide ka 1200 mg ka letsatsi li theole nako e nkuoeng ke karolo ea morupeluoa ho folisa ho tloha mochesong le matšoao a kang hlooho, feberu le 'metso.

Palmitoylethanolamide (PEA)

v. Ho theola matšoao a "insular" (multiple) sclerosis

Ka thepa e thibelitsoeng ea Palmitoylethanolamide e netefalitsoeng, ntle ho pelaelo PEA e loketse kalafo ea kalafo ea methapo.

Phuputsong ea bakuli ba 29 ba nang le multiple sclerosis e tsoetseng pele, PEA e ile ea eketsoa ka tekanyetso e tloaelehileng ea interferon IFN-β1a e fumanoe e theola bohloko le ho ntlafatsa boleng ba bophelo ba bakuli.

 

vi. Palmitoylethanolamide e ntlafatsa metabolism

Palmitoylethanolamide (PEA) e khona ho itlama ho PPAR- α, e amohelang mokhelo e ikarabellang ho metabolism, takatso ea lijo, ho theola boima ba 'mele le mafura a tukang. Ha mokelikeli oa PPAR- α a qholotsoa o ba le matla a phahameng a thusang 'mele ho chesa mafura a mangata mesebetsing ka hona o theola boima ba' mele.

 

vii. Palmitoylethanolamide e ka fokotsa takatso ea hau ea lijo

Palmitoylethanolamide lahleheloa ke boima ba 'mele e bontšoa bokhoni ba eona ba ho susumetsa takatso ea hau ea lijo. E ts'oanang le ho ntlafatsa metabolism, ha PPAR- α receptor e sebetsoa e lebisa ho boikutlo ba ho khora ha ho ja ka hona ho u thusa ho laola boholo ba lik'halori tse jang.

Ho feta moo, PEA e nkoa e le mafura a acid ethanolamides a phethang karolo ea bohlokoa ho fepheng boitšoaro. Phuputsong ea likhoto tse fetisitsoeng ka bongata bo nang le boima bo phahameng ba 'mele, li-supplement tsa PEA ka boima ba' mele ba 30 mg / kg bakeng sa libeke tse 5 li fumanoe li theola haholo tekanyo ea lijo, mafura a mangata mme ka lebaka leo boima ba 'mele.

 

viii. Liphello tse khahlanong le ho ruruha ha Palmitoylethanolamide nakong ea boikoetliso

Motho a ka 'na a utloa bohloko le ho ruruha nakong le ha a qeta ho ikoetlisa ka lebaka la boima bo feteletseng. Ha e le hantle, tlatsetso ea PEA e ka thusa ho thibela sena ka ho hlohlelletsa ts'ebetso e khahlano le ho ruruha ea PPAR- α receptor. Palmitoylethanolamide e ka boela ea thibela ho lokolloa ha li-enzyme tsa ho ruruha ka har'a lisele tsa motho tsa adipose.

 

Ke mang ea lokelang ho nka tlatsetso ea Palmitoylethanolamide (PEA)?

Tlatsetso ea Palmitoylethanolamide (PEA) e loketse bohle ba nang le bohloko bo bohloko kapa ho ruruha hape le mang kapa mang ea ratang ho fokotsa boima ba 'mele ebang ke moriana kapa che. PEA e se e bonoa e ntlafatsa ts'ebetso ea lithethefatsi tse ling. Ke khetho bakeng sa ba sa fumaneng topollo ka ho sebelisa litlolo tse boletsoeng esale pele.

Phomolo ea matšoenyeho a Palmitoylethanolamide ke tšobotsi e ntlehali ea hore mang kapa mang ea kotsing ea ho tepella maikutlong kapa ea nang le khatello ea maikutlo o lokela ho nka PEA bakeng sa.

Ntle le moo, e mong o ne a tla kotula tse ling tsa PEA ho tsoa litlhahisong kaha baetsi ba liforamo ba batla metsoako e eketsang Palmitoylethanolamide bioavailability 'meleng oa hau.

 

PEA e tsoa ho eng?

Pea ea tlhaho e etsoa ka 'mele ea rona le liphoofolo le limela. Leha ho le joalo, bakeng sa batho ba nang le bohloko bo sa foleng kapa ba ho ruruha, PEA e etsahala ka ho sa lekanang kahoo tlhoko ea lisebelisoa tsa tlatsetso ea PEA.

Palmitoylethanolamide e ka fumanoa mehloling ea lijo e nang le liprotheine tse ngata tse kang lebese, nama, linaoa tsa soya, lecithin ea soya, makotomane le lierekisi tsa serapeng har'a tse ling. Leha ho le joalo, PEA e fumanoang mehloling ea lijo e nyane haholo. Sena se etsa hore tlhahiso ea bongata ba palmitoylethanolamide e hlokahale ho fihlela litlhoko tsena tsa lijo.

 

Na PEA e u phahamisa?

Phenethylamine le Palmitoylethanolamide ka bobeli li ka bitsa PEA, empa ke lihlahisoa tse fapaneng ka botlalo.

Phenethylamine (PEA) ke motsoako oa manyolo, monoamine alkaloid ea tlhaho, le trace amine, e sebetsang joalo ka sistimi ea methapo e susumetsang batho. Phenethylamine e hlohlelletsa 'mele ho etsa lik'hemik'hale tse itseng tse phethang karolo ea khatello ea maikutlo le maemo a mang a kelello.

E nkiloe ka tekanyo ea 500mg-1.5g ka litekanyetso, lihora tse ling le tse ling tse seng kae, PEA e fa mosebelisi maikutlo a nyakallo, matla, ho hlasimoloha le ho phela hantle ka kakaretso.

Leha ho le joalo, ka kopo ka mosa hlokomela hore Phenethylamine (PEA) ha se Palmitoylethanolamide (PEA). Phenethylamine supplements ha e so amoheloe ke FDA bakeng sa ts'ebeliso ea bongaka. Palmitoylethanolamide (PEA) ke ntho ea tlhaho e hlahisoang ke 'mele; e sebetsa haholo ebile e bolokehile ho e sebelisa e le tlatsetso bakeng sa bohloko le ho ruruha.

 

Ke PEA tlatsetsa sireletsehileng?

Palmitoylethanolamide (PEA) ke ntho ea tlhaho e hlahisoang ke 'mele; e sebetsa haholo ebile e bolokehile ho e sebelisa e le tlatsetso bakeng sa bohloko le ho ruruha. Ha ho litla-morao tse bohloko tsa palmitoylethanolamide tse tlalehiloeng hape ha ho litšebelisano tse mpe le lithethefatsi tse ling.

 

Litla-morao tsa PEA ke life?

Ha ho na litla-morao tse mpe kapa litšebelisano tsa lithethefatsi le lithethefatsi li tlalehiloe ho fihlela joale. Palmitoylethanolamide e ka nkoa hammoho le ntho efe kapa efe. E ntlafatsa phello ea ho kokobetsa bohloko ea li-analgesics tsa khale le li-anti-inflammatories.

 

Na Palmitoylethanolamide e sireletsehile nakong ea bokhachane?

Ha ea lokela ho sebelisoa ke bakhachane.

Palmitoylethanolamide e ka thusa ho rarolla phepelo le bohloko bo sa foleng.

E lokela ho nkoa feela tlasa tlhokomelo ea bongaka.

 

Palmitoylethanolamide halofo ea bophelo - Ho nka nako e kae hore pea e sebetse?

Palmitoylethanolamide (PEA) e ka nkoa hammoho le meriana e meng ea bohloko kapa u le mong, joalo ka ha u eletsoa ke setsebi sa tlhokomelo ea bophelo, ho ts'ehetsa phomolo ea bohloko.

Katleho ea phomolo ea bohloko ke 8 hr

Liphetho lia fetoha; sephetho nakong ea lihora tse 48 ho batho ba bang, empa se sebelisetsoe libeke tse 8 bakeng sa sephetho se phahameng, se ka sebelisoa nako e telele bakeng sa bohloko bo sa foleng ba methapo.

 

PEA e sebetsa joang bakeng sa bohloko?

Lipatlisiso li bontšitse hore PEA e na le thepa e khahlanong le ho ruruha le anti-nociceptive mme ho e nka khafetsa ho ka matlafatsa karabelo ea 'mele ea hau ho bohloko ka ho nyenyefatsa karabelo ea lisele tsa methapo tse bakang bohloko.

Palmitoylethanolamide e boetse e sebetsa ka mokhoa o sa tobang ho susumetsa mesebetsi ea li-receptor tse ling tse kang li-receptor tsa kannete. PEA ka mokhoa o sa tobang e susumetsa li-cannabinoid receptors (CB1 le CB2) ka ho sebetsa joalo ka enzyme (FAAH -fatty acid amide hydrolase) e amehang ho senyeheng ha li-cannabinoid anandamide. Thuso ena ho phahamiseng maemo a anandamide 'meleng ea rona, e ikarabellang bakeng sa ho phomola le ho loantša bohloko.

 

PEA ke eng bakeng sa phomolo ea bohloko?

Palmitoylethanolamide (PEA) ke ntho ea tlhaho e hlahisoang ke 'mele; ke amide e nang le mafura a sa feleng, eo e leng ea sehlopha sa li-agonists tsa nyutlelie, 'me e ka sebelisoa e le tlatsetso bakeng sa kalafo ea bohloko le ho ruruha. PEA ke molek'hule ea tlhaho, e sireletsang, e mafura e hlahisoang 'meleng oa rona, e thusang ho ts'ehetsa methapo ea methapo ea myelin bakeng sa ts'ebetso e ntle ea methapo.

PEA ke asiti e mafura e amehang mesebetsing e fapaneng ea lisele ka ho ruruha le bohloko bo sa foleng, mme ho bonts'itsoe hore e na le neuroprotective, anti-inflammatory, anti-nociceptive (anti-pain) le anti-convulsant. E boetse e fokotsa ho ata ha masapo le keketseho ea lisele tsa mofetše, hape le ho sireletsa methapo ea methapo e ka pelong ea ischemic. Hangata ho batho ba nang le mathata a sa foleng, 'mele ha o hlahise PEA e lekaneng, ka hona ka ho nka PEA ho tlatselletsa khaello ea' mele ho ka ba molemo ho thusa ho sebetsana le maemo ana.

 

Na Pea e khahlanong le ho ruruha?

Palmitoylethanolamide (PEA) ke ntho e khahlisang e khahlanong le ho ruruha ebile e ka ba le ts'episo e kholo bakeng sa kalafo ea (auto) mafu a 'mele a ho itšireletsa mafung, ho kenyeletsoa le mafu a ho ruruha a mala le mafu a ho ruruha a CNS.

 

Na pea e loketse ramatiki?

Palmitoylethanolamide (PEA) e fana ka molemo oa ramatiki mabapi le ho fokotsa nts'etsopele le tlhokomelo ea bohloko bo sa foleng empa hape le ho thusa ho fokotsa tsoelo-pele ea timetso e kopaneng e amanang le ramatiki.

 

Ke lipilisi life tse bohloko ka ho fetisisa tsa bohloko ba methapo?

PEA (palmitoylethanolamide) esale e le teng ho tloha ka li-1970 empa e ntse e tsebahala e le moemeli e mocha oa ho phekola ho ruruha le bohloko. Ha ho litšebelisano tsa lithethefatsi kapa litlamorao tse mpe tse fumanoeng.

PEA e bonts'itse katleho ea bohloko bo sa foleng ba mefuta e mengata e amanang le maemo a mangata a bohloko, haholoholo bohloko ba methapo ea kutlo, bohloko ba ho ruruha le bohloko ba visceral bo kang endometriosis le interstitial cystitis.

 

Nka phekola bohloko ba methapo lapeng joang?

PEA ke molek'hule e mafura e thusang ho ts'ehetsa methapo ea methapo ea myelin bakeng sa ts'ebetso e ntle ea methapo.

Ho haella ha livithamini sehlopheng sa B ho ke ke ha baka bohloko ba methapo feela, empa hape hoa e eketsa.

Matšoao a mang a sa thabiseng a ka boela a hlaha, joalo ka ho thekesela, ho sisinyeha le ho longoa ke matsoho le maoto, maikutlo a hore motho o tsamaea terateng e hlabang kapa boea ba k`hothone kapa ho ba bohale

matsoho le maoto.

Vithamine B1 e nyane haholo e lebisa pherekanong ts'ebetsong ea methapo mme ka lebaka leo ho isa ho neuropathy le bohloko ba methapo. Ha o eketsa vithamine B1, bohloko boa fokotseha mme ts'ebetso ea methapo e ea ntlafala. Vithamine B1 e ka nkoa hammoho le PEA, sena se fana ka ts'ehetso e nepahetseng ts'ebetsong ea methapo, e thibela bohloko ba methapo kapa bohloko bo mpefalang. Liphuputso tsa morao-rao li bontšitse hore batho ba bangata ba nang le bohloko bo sa foleng, batho ba tsofetseng le ba nang le lefu la tsoekere ba na le livithamine tsena tse lekaneng maling a bona. Lena ke le leng la mabaka a etsang hore batho bana ba se ke ba phekoloa feela ka lipilisi tsa bohloko; ba hloka

ho feta moo. Li-vithamine tsa PEA hammoho le B li tšehetsa tsamaiso ea methapo le boits'ireletso ba mmele maemong a bohloko ba methapo.

 

Palmitoylethanolamide (PEA)

Na Palmitoylethanolamide ke cannabinoid?

CBD (Cannabidiol) ke metsoako e ntšitsoeng hemp le matekoane. Ha 'mele o hlahisa li-cannabinoids ka tlhaho, CBD e kentsoe tšebetsong ho fihlela tlhoko.

Li-cannabinoids ke lik'hemik'hale tse sebetsang tse hlahisang 'mele tse ikarabellang bakeng sa ho hopola, bohloko, takatso ea lijo le ho sisinyeha. Bo-rasaense ba hakanya hore li-cannabinoids li ka ba molemo ho fokotsa ho ruruha le ho tšoenyeha, ho senya lisele tsa mofetše, ho fana ka phomolo mesifa le ho matlafatsa takatso ea lijo.

PEA ke mafura a acid hape a hlahisoang 'meleng' me a ka bitsoa cannabimimetic. Hona ho bolela hore e etsisa mesebetsi ea CBD 'meleng oa hau.

Ka bobeli CBD le PEA li sebetsa ka kotloloho ka ho thibela mafura a acid amide hydrolase (FAAH), eo hangata e senyehang anandamide le ho e fokolisa. Sena se fella ka maemo a phahameng a anandamide. Anandamide e bapala karolo ea bohlokoa maikutlong le tšusumetso. Maemo a eketsehileng a anandamide a susumetsa ts'ebeliso ea endocannabinoid hantle.

PEA e fumane botumo mme e tsekisana le CBD. PEA e nkuoa e le mokhoa o bolokehileng oa CBD ka lebaka la mathata a molao a tobaneng le ona hape le taba ea hore batho ba bangata ha ba khone ho mamella maemo a phahameng a 'lejoe' a tlang le CBD.

Ho feta moo, PEA e theko e tlase haholo ho feta CBD. Leha ho le joalo, PEA e ka sebelisoa ho kenyelletsa CBD ho fihlela litlamorao tsa synergetic.

 

Na Pea ke endocannabinoid?

Che, Palmitoylethanolamide (PEA) ke mokena-lipid oa lipid ea endocannabinoid ea nang le li-analgesic le anti-inflammatory properties. PEA e ts'ehetsa ECS ka ho hlophisa matšoao a endocannabinoid le ho kenya tšebetsong ka mokhoa o sa tobang li-receptor tsa li-cannabinoid.

Sistimi ea endocannabinoid (ECS) ke sistimi ea bohlokoa ea bioloji e laolang le ho leka-lekanya mesebetsi e fapaneng ea mmele 'meleng. Patlisiso ka ECS e lebisitse ho khetholloeng ha li-endocannabinoids feela joalo ka anandamide (AEA) le 2-arachidonoylglycerol (2-AG), empa le li-endocannabinoid-like lipid mediators tse kang palmitoylethanolamide (PEA). Lik'hemik'hale tsena tse kang endocannabinoid hangata li arolelana mekhoa e ts'oanang ea metabolic ea li-endocannabinoids empa ha li na kamano e tlamang ea mofuta oa khale oa li-cannabinoid receptor 1 le mofuta oa 2 (CB1 le CB2).

 

Palmitoylethanolamide (PEA) le Anandamide

Palmitoylethanolamide le anandamide li amana haufi-ufi kaha ka bobeli ke li-acid amide tse hlahisoang 'meleng.

Ho thoe PEA le anandamide li na le litlamorao tsa kalafo ea bohloko hape li matlafatsa babolai ba bohloko ba sebelisitsoeng.

Li boetse li robehile ke enzyme e nang le mafura a 'mele' meleng, ka hona litlamorao tse fumanoang ha li sebelisoa hammoho li feta ha li sebelisoa tlatsong ea boemo bo tlase.

 

Palmitoylethanolamide VS Phenylethylamine

Phenethylamine ntho e nang le lik'hemik'hale eo ka tlhaho e hlahisoang ke 'mele. E sebelisoa haholo bakeng sa ho ntlafatsa ts'ebetso ea baatlelete hape e ka thusa ho imolla khatello ea maikutlo, thuso ea ho fokotsa boima ba 'mele le ho matlafatsa mohopolo.

Palmitoylethanolamide ka lehlakoreng le leng ke mafura a acid e tsejoang haholo ka phallo ea bohloko le ho ruruha.

Likaroloana tsena tse peli ha li amanang. Ntho feela e ba kopanyang ke hore ka bobeli ba khutsufalitsoe e le PEA.

 

Ke nka tlatsetso ea Palmitoylethanolamide (PEA) joang?

Ha re ntse re totobatsa molemo oa ho loants'oa mafu a Palmitoylethanolamide hara melemo tse ling, ho bohlokoa ho tlisa tlhokomelong ea hau lintlha tse ling ka PEA. PEA e hlaha ka likaroloana tse kholo ebile ha e na metsi ka bongata, hona ho etsa hore Palmitoylethanolamide bioavailability le ho inoa e be teng.

Litaba tse monate, leha ho le joalo, ke hore baetsi ba tsepamisitse mohopolo molemong oa ts'ebeliso ea li-Palmitoylethanolamide bioavailability bakeng sa tšebeliso e phahameng 'meleng oa hau. Bakeng sa tsena, PEA phofo li fumaneha ka foromo e tloaelehileng ea phofo le foromo ea phofo ea micromized.

 

O ka reka phofo ea Palmitoylethanolamide (PEA) hokae?

Re nakong e khahlisang moo mabenkele a marang-rang a fetohileng lebenkele le le leng la ho emisa ntho e ngoe le e ngoe ho kenyelletsa le lisebelisoa tsa bongata tsa palmitoylethanolamide. Haeba u nahana ho nka PEA, etsa lipatlisiso tse pharaletseng bakeng sa baetsi ba tlatsetso ba bongata ba palmitoylethanolamide. Boholo ba basebelisi ba palmitoylethanolamide ba e reka mabenkeleng a marang-rang mme ba lokela ho nahana ka litlhahlobo tsa bona bakeng sa phofo e ntle ea PEA 'marakeng.

 

khutsufalitsoeng

AEA: Anandamide

CB1: Mofuta oa kamohelo ea li-cannabinoid I

CB2: Mofuta oa bobeli oa li-cannabinoid receptor

Bohareng: Cochrane Central Register ea Liteko tse Laoloang

FAAH: Mafura-asiti amide hydrolase

NAAA: N-acylethanolamine hydrolyzing acid amidase

NAE: N-acylethanolamines

PEA: Palmitoylethanolamid

PPARα: Peroxisome proliferator-activated receptor alpha

PRISMA-P: Lintho tse khethiloeng tsa ho tlaleha litlhahlobo tse hlophisitsoeng le li-Protocol tsa Meta-Analysis

VAS Pain: Palo ea Analog Scale ea Bohloko

ECS: sistimi ea endocannabinoid

 

Tlhaloso:

[1] Artukoglu BB, Beyer C, Zuloff-Shani A, le al. Ts'ebetso ea palmitoylethanolamide bakeng sa bohloko: tlhatlhobo ea meta. Ngaka ea bohloko ea 2017; 20 (5): 353-362.

[2] Schifilliti C, Cucinotta L, Fedele V, et al. Micronized palmitoylethanolamide e fokotsa matšoao a bohloko ba methapo ho bakuli ba nang le lefu la tsoekere. Phekolo ea Phekolo ea bohloko 2014; 2014: 849623.

[3] Keppel Hasselink JM, Hekker TA. Phekolo ea thuso ea palmitoylethanolamide ha ho phekoloa bohloko ba methapo bo amanang le maemo a fapaneng a mafu: letoto la linyeoe. J Pain Res 2012; 5: 437-442.

[4] Keppel Hasselink JM, Kopsky DJ. Karolo ea palmitoylethanolamide, autacoid, kalafong ea matšoao a mesifa ea mesifa: litlaleho tse tharo tsa linyeoe le tlhahlobo ea lingoliloeng. J Clin Case Rep 2016; 6 (3).

[5] Costa B, Colombo A, Bettoni I, Bresciani E, Torsello A, Comelli F. The endogenous ligand palmitoylethanolamide e kokobetsa bohloko ba methapo ea pelo ka mast cell le microglia modulation. Seboka sa bo21 sa Selemo le Selemo sa Mokhatlo oa Machaba oa Lipatlisiso oa Cannabinoid. Mohalaleli Charles, Il. Usa: Pheasant e matha; 2011.

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