Palmitoylethanolamide (PEA) ke eng?

Palmitoylethanolamide (PEA) ke lipid e etsahalang ka tlhaho 'meleng oa rona ka karolo ea mafura a acid. Ke ka lebaka leo e leng lipid ea tlhaho. PEA e boetse e hlahisoa ka tlhaho ho limela le liphoofolo.

Mehloli e meholo ea li-Palmitoylethanolamide (PEA) ke lebese, linaoa tsa soya, lierekisi tsa jareteng, soy lecithin, nama, mahe le makhapetla.

Palmitoylethanolamide e boetse e bitsoa palmitoylethanolamine kapa N-2 hydroxyethyl palmitamide e tsebahala ebile e sebelisetsoa karolo ea eona ho loantšeng bohloko le ho ruruha.

 

Palmitoylethanolamide (PEA) e sebetsa joang?

Palmitoylethanolamide (PEA) e bonts'a mekhoa e mengata ea ts'ebetso karolong ea eona e kang;

  • Hangata PEA e lebisa tlhokomelo ho PPAR-α receptor (peroxisome proliferator-activated receptor alpha). PPAR- α ke mokelikeli o sebetsang e le sesebelisoa se khahlanong le ho ruruha hape e thusa ho chesa mafura le ho matlafatsa metabolism. Ha PEA e tlama mokelikeli ona e thusa ho thibela ho tsoa ha lintho tse ngata tse ka lebisang ho ruruheng hammoho le liphatsa tsa lefutso tse amanang le ho ruruha (Pro-inflammatory genes). Ka hona e thusa ho thibela kapa ho fokotsa ho ruruha.
  • Palmitoylethanolamide e boetse e sebetsa ka tsela e sa tobang ho susumetsa mesebetsi ea li-receptor tse ling tse kang li-receptor tsa cannabinoid. PEA ka mokhoa o sa tobang e tsosa li-receptor tsa li-cannabinoid(CB1 le CB2) ka ho sebetsa joalo ka enzyme (FAAH -fatty acid amide hydrolase) e amehang ho senyeheng ha cannabinoid anandamide. Thuso ena ho phahamiseng maemo a anandamide 'meleng ea rona, e ikarabellang bakeng sa ho phomola le ho loantša bohloko.

 

Melemo ea Palmitoylethanolamide (PEA) ke efe?

Ho na le mefuta e mengata e fapaneng ea melemo ea palmitoylethanolamide e tsejoang ka lebaka la litšobotsi tsa eona tsa kalafo ho kenyeletsoa ho fokotsa kutloisiso ea bohloko, ho loantša ho ruruha, antiepileptic le neuroprotection.

Tse ling tsa melemo e tlalehiloeng ea Palmitoylethanolamide e kenyelletsa;

 

i. E tšehetsa bophelo ba boko

Melemo ea Palmitoylethanolamide ka ho ntlafatsa bophelo bo botle ba boko li amahanngoa le bokhoni ba eona ba ho loants'a ho ruruha ha methapo ea kutlo le ho phahamisa lisele tsa methapo ea kutlo. Sena se hlokomeloa haholoanyane ka batho ba nang le mathata a methapo ea pelo le stroke.

Mohlala, phuputsong ea batho ba 250 ba nang le lefu la stroke, supplement ea Palmitoylethanolamide e tsamaisitsoeng hammoho le luteolin e fumanoe e le ho thusa ho fola. PeA e fumanoe e le ho ntlafatsa mohopolo, bophelo bo botle ba kelello ka kakaretso hammoho le ts'ebetso ea letsatsi le letsatsi. Litlamorao tsa Palmitoylethanolamide phofo li ile tsa bonoa matsatsi a 30 kamora tšehetso le ho eketseha ho feta khoeli e le 'ngoe.

 

Ii. Phokotso ea bohloko bo bongata le ho Ruruha

Bo-rasaense ba fana ka bopaki bo bongata ba thepa ea ho fokotsa bohloko ba Palmitoylethanolamide. Ha e le hantle, Palmitoylethanolamide e fana ka liphallelo ho mefuta e fapaneng ea bohloko le ho ruruha. Lithuto tse ling tse bonts'ang thepa ea lithuso tsa bohloko ba Palmitoylethanolamide;

Phuputsong e amanang le liphoofolo, tlatsetso ea palmitoylethanolamide hammoho le quercetin e fumanoe e fana ka phomolo ho bohloko ba manonyeletso hammoho le ho ntlafatsa tšebetso e kopaneng le ts'ireletso ea lefufuru tšenyo.

Liphuputso tse ling tsa pele li bonts'a hore PEA e ka thusa ho fokotsa bohloko ba methapo ho bakuli ba lefu la tsoekere (lefu la tsoekere).

Phuputsong e 'ngoe le batho ba 12, moriana oa Palmitoylethanolamide oa 300 le 1,200 mg / letsatsi le fanoeng bakeng sa libeke tse 3 ho isa ho tse robeli o fumanoe a theola leholo la bohloko bo sa foleng le ba neuropathic.

Phuputso ea bakuli ba 80 ba nang le lefu la Fibromyalgia e fumane hore PEA ntle le meriana e meng ea lefu lena e ka fokotsa bohloko.

Ho ea pele, lithuto tse ling tse 'maloa li bonts'a liphallelo tsa bohloko ba Palmitoylethanolamide ho kenyelletsa bohloko ba pelvic, bohloko ba sciatic, bohloko ba morao, bohloko ba kankere har'a ba bang.

Palmitoylethanolamide

Iii. E thusa ho fokotsa matšoao a khatello ea maikutlo

PEA ka tsela e sa tobang e susumetsa li-receptor tse ikarabellang bakeng sa ho feto-fetoha ha maikutlo. Boithuto bo bong bo bontša Palmitoylethanolamide ho imoloha kelellong karolo ea bohlokoa ho loants'a khatello ea maikutlo.

Phuputsong ea bakuli ba 58 ba nang le khatello ea maikutlo, tlatsetso ea palmitoylethanolamide ho 1200 mg / ka letsatsi hammoho le meriana e loantšang khatello ea maikutlo (citalopram) e fuoang libeke tse 6 e fumanoe e ntlafatsa haholo maikutlo le matšoao a khatello ea maikutlo ka kakaretso.

 

Iv. E imolla sefuba se tloaelehileng

Palmitoylethanolamide e rua molemo ho loantšeng serame se tloaelehileng molemong oa eona oa ho senya vaerase e ikarabellang bakeng sa sefuba se tloaelehileng. Ho makatsang ke hore, sefuba se tloaelehileng se etsahala hohle mme se ama motho e mong le e mong haholo-holo batho ba nang le boits'ireletso ba mmele.

Phuputso e entsoeng le masole a manyane a 900 e bonts'itse hore litla-morao tsa Palmitoylethanolamide ka 1200 mg ka letsatsi li theole nako e nkuoeng ke karolo ea morupeluoa ho folisa ho tloha mochesong le matšoao a kang hlooho, feberu le 'metso.

 

v. E theola mats'oao a ho hlaseloa ke lefu la mokokotlo (multiple) sclerosis

Ka thepa e thibelitsoeng ea Palmitoylethanolamide e netefalitsoeng, ntle ho pelaelo PEA e loketse kalafo ea kalafo ea methapo.

Phuputsong ea bakuli ba 29 ba nang le multiple sclerosis e tsoetseng pele, PEA e ile ea eketsoa ka tekanyetso e tloaelehileng ea interferon IFN-β1a e fumanoe e theola bohloko le ho ntlafatsa boleng ba bophelo ba bakuli.

 

re. Palmitoylethanolamide ntlafatsa metabolism

Palmitoylethanolamide (PEA) e khona ho itlama ho PPAR- α, e amohelang motho ea ikarabellang bakeng sa metabolism, takatso ea lijo, ho theola boima ba 'mele le mafura a tukang. Ha mokelikeli oa PPAR- α a qholotsoa o ba le matla a phahameng a thusang 'mele ho chesa mafura a mangata mesebetsing ka hona o theola boima ba' mele.

 

VII. Palmitoylethanolamide e ka fokotsa takatso ea hau ea lijo

Palmitoylethanolamide lahleheloa ke boima ba 'mele e bontšoa bokhoni ba eona ba ho susumetsa takatso ea hau ea lijo. E ts'oanang le ho ntlafatsa metabolism, ha PPAR- α receptor e sebetsoa e lebisa ho boikutlo ba ho khora ha ho ja ka hona ho u thusa ho laola boholo ba lik'halori tse jang.

Ho feta moo, PEA e nkoa e le mafura a acid ethanolamides a phethang karolo ea bohlokoa ho fepheng boitšoaro. Phuputsong ea likhoto tse fetisitsoeng ka bongata bo nang le boima bo phahameng ba 'mele, li-supplement tsa PEA ka boima ba' mele ba 30 mg / kg bakeng sa libeke tse 5 li fumanoe li theola haholo tekanyo ea lijo, mafura a mangata mme ka lebaka leo boima ba 'mele.

 

Viii. Liphello tse khahlanong le ho ruruha ha Palmitoylethanolamide nakong ea boikoetliso

Motho a ka utloa bohloko le ho ruruha nakong le ha a ntse a ikoetlisa ka lebaka la boima bo feteletseng. Haele hantle, tlatsetso ea PEA e ka thusa ho thibela sena ka ho susumetsa Anti-inflammatory ketsahalo ea PPAR- α receptor. Palmitoylethanolamide le eona e ka thibela ho ntšoa ha li-enzyme tse tsoang kahare ke litho tsa thipa ea adipose.

 

Ke mang ea lokelang ho nka tlatsetso ea Palmitoylethanolamide (PEA)?

Tlatsetso ea Palmitoylethanolamide (PEA) e loketse bohle ba nang le bohloko bo bohloko kapa ho ruruha hape le mang kapa mang ea ratang ho fokotsa boima ba 'mele ebang ke moriana kapa che. PEA e se e bonoa e ntlafatsa ts'ebetso ea lithethefatsi tse ling. Ke khetho bakeng sa ba sa fumaneng topollo ka ho sebelisa litlolo tse boletsoeng esale pele.

Phallo ea matšoenyeho a Palmitoylethanolamide ke tšobotsi e ntle eo mang kapa mang ea kotsing ea khatello ea maikutlo kapa ea nang le khatello ea maikutlo a lokelang ho nka PEA bakeng sa.

Ntle le moo, e mong o ne a tla kotula tse ling tsa PEA ho tsoa litlhahisong kaha baetsi ba liforamo ba batla metsoako e eketsang Palmitoylethanolamide bioavailability 'meleng oa hau.

Palmitoylethanolamide

Na ho na le litlamorao?

Palmitoylethanolamide ha e chefo kaha e boetse e hlahisoa ka tlhaho 'meleng oa hau. Ha ho litla-morao tse bohloko tsa Palmitoylethanolamide tse tlalehiloeng hammoho le ho se sebelisane hampe le lithethefatsi tse ling.

Leha ho le joalo, basebelisi ba bang ba ne ba sa tlaleha litlamorao tse bobebe tsa Palmitoylethanolamide joalo ka ho opeloa ke mpa, lets'ollo le bonolo le ho hlonama ka mpeng kamora ho nka tlatsetso ea PEA.

 

Ke nka tlatsetso ea Palmitoylethanolamide (PEA) joang?

Ha re ntse re totobatsa molemo oa ho loants'oa mafu a Palmitoylethanolamide hara melemo tse ling, ho bohlokoa ho tlisa tlhokomelong ea hau lintlha tse ling ka PEA. PEA e hlaha ka likaroloana tse kholo ebile ha e na metsi ka bongata, hona ho etsa hore Palmitoylethanolamide bioavailability le ho inoa e be teng.

Litaba tse monate, leha ho le joalo, ke hore baetsi ba tsepamisitse mohopolo molemong oa ts'ebeliso ea li-Palmitoylethanolamide bioavailability bakeng sa tšebeliso e phahameng 'meleng oa hau. Bakeng sa tsena, Lintho tsa tlatsetso tsa PEA li fumaneha ka sebopeho sa capsule, foromo ea tafole, foromo ea phofo, esita le joalo ka li-creams tsa lihlooho.

Tlatsetso ea molomo hammoho le tranelate ea boleng bo holimo ea PEA e ka khothaletsoa liphetho tse ntle. Tekanyetso ea Palmitoylethanolamide ea 1200 mg / ka letsatsi e nkuoeng e le 1 capsule (4oomg) makhetlo a mararo ka letsatsi bakeng sa likhoeli tse 2-3 hammoho le tranelate e holimo e khothalletsoang.

 

Palmitoylethanolamide (PEA) le Anandamide

Palmitoylethanolamide le anandamide li amana haufi-ufi kaha ka bobeli ke li-acid amide tse hlahisoang 'meleng.

PEA le Anandamide ho thoe li na le litla-morao tsa ho phekola bohloko le ho matlafatsa ba bolaeang bohloko boo ba bo sebelisang.

Li boetse li robehile ke enzyme e nang le mafura a 'mele' meleng, ka hona litlamorao tse fumanoang ha li sebelisoa hammoho li feta ha li sebelisoa tlatsong ea boemo bo tlase.

 

Palmitoylethanolamide VS Phenylethylamine

Phenethylamine ntho e nang le lik'hemik'hale eo ka tlhaho e hlahisoang ke 'mele. E sebelisoa haholo bakeng sa ho ntlafatsa ts'ebetso ea baatlelete hape e ka thusa ho imolla khatello ea maikutlo, thuso ea ho fokotsa boima ba 'mele le ho matlafatsa mohopolo.

Palmitoylethanolamide ka lehlakoreng le leng ke mafura a acid e tsejoang haholo ka phallo ea bohloko le ho ruruha.

Likaroloana tsena tse peli ha li amanang. Ntho feela e ba kopanyang ke hore ka bobeli ba khutsufalitsoe e le PEA.

Palmitoylethanolamide

CBD khahlanong le PEA

CBD (Cannabidiol) ke metsoako e ntšitsoeng hemp le matekoane. Ha 'mele o hlahisa li-cannabinoids ka tlhaho, CBD e kentsoe tšebetsong ho fihlela tlhoko.

Li-cannabinoids ke lik'hemik'hale tse sebetsang tse hlahisang 'mele tse ikarabellang bakeng sa ho hopola, bohloko, takatso ea lijo le ho sisinyeha. Bo-rasaense ba hakanya hore li-cannabinoids li ka ba molemo ho fokotsa ho ruruha le ho tšoenyeha, ho senya lisele tsa mofetše, ho fana ka phomolo mesifa le ho matlafatsa takatso ea lijo.

PEA ke mafura a acid hape a hlahisoang 'meleng' me a ka bitsoa cannabimimetic. Hona ho bolela hore e etsisa mesebetsi ea CBD 'meleng oa hau.

Ka bobeli CBD le PEA e sebetsa ka tsela e sa tobang ka ho thibela mafura acid amide hydrolase (FAAH), eo hangata e arolang anandamide le ho e fokolisa. Sena se hlahisa maemo a phahameng a anandamide. Anandamide e bapala karolo ea bohlokoa mohopolong hape le tšusumetso. Maemo a eketsehang a anandamide a susumetsa hantle tsamaiso ea endocannabinoid.

PEA e fumane botumo mme e tsekisana le CBD. PEA e nkuoa e le mokhoa o bolokehileng oa CBD ka lebaka la mathata a molao a tobaneng le ona hape le taba ea hore batho ba bangata ha ba khone ho mamella maemo a phahameng a 'lejoe' a tlang le CBD.

Ho feta moo, PEA e theko e tlaase haholo ho feta CBD. Le ha ho le joalo, PEA e ka sebelisoa ho ekelletsa ho CBD ho fihlela litlamorao tsa synergetic.

 

FAQS

i. Ho nka nako e kae hore pea e sebetse?

Le ha ho le joalo, PEA ha se 'tlatsetso ea boselamose' joalo ka litlatsetso tse ngata tsa ho sebetsa hang-hang. Motho o lokela ho lebella phomolo ea bohlokoa ho bohloko ho libeke tse 2 ho isa ho tse 6 mme phaello e phahameng e ka kotuloa halelele joalo ka likhoeli tse 3 tsa ts'ebeliso.

 

Ii.Na Palmitoylethanolamide ke cannabinoid?

PEA ha e hlophisoe joalo ka cannabinoid. E sebetsa ka tsela e sa tobang ho kenya letsoho li-cannabinoid receptors (CB1 le CB2). Ho khahlisang, PEA e bonts'a litlamorao tsa synergistic le li-cannabinoids.

 

Iii. Na tlatsetso ea pea e bolokehile?

Tlatsetso ea PEA e nkuoa e bolokehile. Ha ho litla-morao tse bohloko tsa Palmitoylethanolamide tse tlalehiloeng. Leha ho le joalo, ho na le maemo a sa tloaelehang moo basebelisi ba PEA ba tlalehang litla-morao tse bobebe ho kenyeletsa le lets'ollo le bobebe, ho imeloa ke mpa le mathata a ka mpeng.

Kamehla ho bohlale ho buisana le ngaka ea hau ea bongaka hape le lipatlisiso tse ngata ho tlatsetso e itseng pele u e nka e le karolo ea lijo tsa hau.

 

Iv.  PEA e tsoa ho eng?

Pea ea tlhaho e etsoa ka 'mele ea rona le liphoofolo le limela. Leha ho le joalo, bakeng sa batho ba nang le bohloko bo sa foleng kapa ba ho ruruha, PEA e etsahala ka ho sa lekanang kahoo tlhoko ea lisebelisoa tsa tlatsetso ea PEA.

Palmitoylethanolamide e ka fumanoa mehloling ea lijo e nang le liprotheine tse ngata tse kang lebese, nama, linaoa tsa soya, lecithin ea soya, makotomane le lierekisi tsa serapeng har'a tse ling. Leha ho le joalo, PEA e fumanoang mehloling ea lijo e nyane haholo. Sena se etsa hore paletoylethanolamide bongata tlhahiso e hlokahalang ho fihlela litlhoko tsena tsa phepo.

 

V. Ho ea hokae reka Palmitoylethanolamide (PEA) phofo?

Re nakong e khahlisang moo mabenkele a marang-rang a fetohileng lebenkele le le leng la ho emisa ntho e ngoe le e ngoe ho kenyelletsa le lisebelisoa tsa bongata tsa palmitoylethanolamide. Haeba u nahana ho nka PEA, batlisisa ka botlalo bakeng sa tlatsetso ea bongata ba palmitoylethanolamide bahlahisi. Basebelisi ba bangata ba Palmitoylethanolamide ba e reka mabenkeleng a marang-rang mme ba lokela ho nahana ka litlhahlobo tsa bona bakeng sa phofo e ntle ka ho fetisisa ea PEA 'marakeng.

 

References
  1. Mattace Raso, G., Santoro, A., Russo, R., Simeoli, R., Paciello, O., Di Carlo, C., Diano, S., Calignano, A., & Meli, R. (2014) . Palmitoylethanolamide e thibela liphetoho tse amanang le ts'oaetso le ho khutlisetsa kutlo ea leptin ho likhoto tse ntšitsoeng ka mahe. Endocrinology, 155 (4), 1291-1301. doi.org/10.1210/en.2013-1823.
  2. Beggiato Sarah, TM (2019). Palmitoylethanolamide (PEA) jwaloka Moemeli ea ka Sebelisang Phekolo ho Lefu la Alzheimer's. Frontiers ho Pharmacology, 821. Doi: 10.3389 / fphar.2019.00821.
  3. Coppola, M. & Mondola, R… (2014). Na ho na le karolo ea palmitoylethanolamide kalafo ea khatello ea maikutlo? Menahano ea bongaka. EA-82. 10.1016 / j.mehy.2013.12.016.
  4. De Gregorio, D., Manchia, M., Carpiniello, B., Valtorta, F., Nobile, M., Gobbi, G., & Comai, S. (2018). Karolo ea Palmitoylethanolamide (PEA) maemong a sithabetsang: Bopaki ba ho fetolela. Tlaleho ea Mathata a Amehileng.Doi: 10.1016 / j.jad.2018.10.117.
  5. PULA EA PALMITOYLETHANOLAMIDE (544-31-0)

 

Tse ka Hare