L - (+) - Ergothioneine (EGT) (497-30-3)

March 15, 2020

Ergothioneine ke amino acid e itlhahelang feela ka tlhaho 'me ke thiourea e tsoang ho histidine, e nang le athomo ea sebabole ho …… ..


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum

 

L - (+) - video ea Ergothioneine (EGT) (497-30-3)

L - (+) - Ergothioneine (EGT) phofo Slitšobotsi

Name Product L - (+) - Ergothioneine (EGT)
Lebitso la lik'hemik'hale ERGOTHIONEINE;

L-Ergothioneine;

Kutloelo-bohloko;

k ergothioneine

Brand Name N / A
Sehlopha sa Lithethefatsi N / A
Nomoro ea CAS 497-30-3
InChIKey SSISHJJTAXXQAX-ZETCQYMHSA-N
limolek'hule Formula C9H15N3O2S
limolek'hule Wtse robeli 229.3 g / mol
Masapo a monoisotopic 229.088498 g / mol
Sebaka se belang  N / A
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life N / A
Color Ho soeufetse kapa ho se soeu
Sho khoneha  Soluble ka Metsing (ho fihlela 10 mg / ml)
Storage Tmocheso  -20 ° C
Aho latela l ergothioneine phofo e sebelisitse li-supplement tse phetseng hantle

 

L - (+) - Ergothioneine (EGT) (497-30-3) Kakaretso

Ergothioneine ke amino acid e hlahang ka tlhaho 'me ke sehlahisoa sa thiourea sa histidine, se nang le athomo ea sebabole lesaleng la imidazole. Motsoako ona o entsoe ka lintho tse fokolang haholo, haholo-holo Actinobacteria, Cyanobacteria le fungus e itseng. Ergothioneine e hloka morekisi ea khethehileng, EGT, eo hape a tsejoang e le OCTN1 (letshwao la lefutso la SLC22A4), ho kenya lisele. Polelo ea EGT e netefalitsoe meleng ea lisele tsa batho le tsa liphoofolo mme bokhoni ba eona ba ho tsamaisa ergothioneine bo netefalitsoe ho vivo.

L-ergothioneine ke tlhaho ea amino acid ka tlhaho 'me ke mofuta oa thiol / thione oa histidine. L-ergothioneine e fumanoa liphoofolong tse phahameng ka ho fetisisa li-mushroom le libaktheria le linthong tse tlase lijong tse ling ho kenyelletsa le crab, nama ea khomo, nama ea kolobe, konyana le khoho.

Leha ho na le boteng ba L-ergothioneine lijong tsa batho, biosynthesis ea bona e se e bonoe ho libaktheria le li-fungus tse itseng.

 

ke eng L - (+) - Ergothioneine (EGT) ?

L-Ergothioneine ke amino acid e fumanehang haholo ka har'a li-mushroom, empa hape le ka har'a crab, nama e tsoang liphoofolong tse jang joang bo nang le ergothioneine le lijo tse ling. Li-amino acid ke lik'hemik'hale tseo e leng lithunya tsa liprotheine. Ergothioneine e sebelisoa e le moriana.

Batho ba nka ergothioneine bakeng sa tšenyo ea sebete, lera la mahlo, lefu la Alzheimer, lefu la tsoekere le lefu la pelo.

L - (+) - ERGOTHIO ke mofuta oa tlhaho oa chiral amino-acid antioxidant biosynthesized ho libaktheria tse itseng le fungi. Ke motsoako oa bohlokoa oa "biioactive" o sebelisitsoeng e le "scavenger" e matla haholo, sefahleho sa ray ea ultraviolet, molaoli oa litheolelo tsa phokotso ea oxidation le li-cellular bioenergetics, le cytoprotector ea 'mele.

L-Ergothioneine ka linako tse ling e kenngoa ka ho toba letlalong ho thibela makhopho, ho fokotsa matšoao a letlalo le tsofetseng le ho fokotsa tšenyo ea letsatsi.

 

L - (+) - Melemo ea Ergothioneine (EGT)

L-ergothioneine e ikhethile ka hore e ka fihla botebong ba lisele tse itseng tse kang li-erythrocyte, ho fapana le li-antioxidants tse ling tsa khale tse kang livithamini C le E. Ha e le hantle e na le mofuta oa liprotheine tsa protheine e tsamaisang, o nolofalletsang hore o nkeloe tokelo ea ho pelo ea lisele. Ka hona, ke antioxidant e ka bang matla a litheko tse ngata haholo, a bohlokoa joaloka L-glutathione. Ntle le moo, e boetse e bontšitsoe e le chelator e matla, e e nolofalletsang hore e tlamelehe litsong tse boima tse nang le chefo, ha e ntse e sireletsa lisele tsa mali mefuteng eohle ea tšenyo.

Ba khothalelitsoe ke thepa ea eona ea li-antioxidant, bafuputsi ba ile ba hlahlobisisa litlamorao tsa eona tse khahlanong le ho ruruha, hobane ergothioneine e sebetsa, hara tse ling, pro-inflammatory cytokine, interleukin. L - (+) - Ergothioneine (EGT) ka hona e na le thepa e ngata e sebetsang ka hare ho 'mele oa motho:

  • e thusa hore ho se sebetsane le khatello ea maikutlo ea oxidative le ho fokotsa tšenyo ho DNA ea mitochondrial, oxidation ea liprotheine le lipid peroxidation;
  • Chelates - kapa maraba - mekhoa e metle ea tšepe e fapaneng;
  • E ka kenya tšebetsong li-enzyme tsa antioxidant joalo ka glutathione peroxidase kapa SOD, ha e ntse e thibela li-enzyme tse hlahisang superoxide radical;
  • Fokotsa oxidation ea li-haemoprotein tse fapaneng tse kang hemoglobin le myoglobin;
  • E sireletsa mitochondria;
  • L-ergothioneinereducer litlamorao tse mpe tsa mahlaseli a UV, joalo ka ts'ireletso bakeng sa Tlhokomelo ea Letlalo.
  • E boloka le ho boloka maemo a li-antioxidants tse ling tse kang livithamini C le E, glutathione le SOD;
  • E sireletsa boko ho li-neurotoxins mme ka hona e bapala karolo ea thibelo khahlanong le ho theoha ha kelello;
  • E khothaletsa ho phefumoloha ka seleng le ho phahamisa lipolysis, kahoo ho eketsa matla le boikoetliso bakeng sa boikoetliso ba 'mele;
  • Ha e kopantsoe le hyaluronic acid, glucosamine, collagen, e bonts'itsoe e fokotsa haholo bohloko ba manonyeletso le ho eketsa motsamao o kopaneng, o amanang haholo le litloaelo tse mpe tsa mosebetsi oa kamora nako, kamora tšebeliso ea libeke tse tšeletseng feela.

 

L - (+) - Ergothioneine (EGT) sebakeng se sireletsehileng

Le ha l-ergothioneine e arolelana lebitso mme e ka tsoa ho li-fungus tsa ergot, ha e na chefo ka tsela efe kapa efe.

European Union e na le litekanyetso tse tlatselletsang ho feta United States mme e ikemiselitse hore li-supplement tsa l-ergothioneine li bolokehile 'me ha li na litlamorao ho batho ba baholo le bana ba fetang.

Panel on Dietetic Products bakeng sa Lekhotla la Ts'ireletso ea Lijo ea Europe e fumana hore meeli e bolokehileng ea letsatsi le letsatsi ea 2.82 mg / kg ea boima ba 'mele bakeng sa masea, 3.39 mg / kg bakeng sa bana ba banyenyane, le 1.31 mg / kg ho batho ba baholo, ho kenyelletsa basali baimana le ba anyesa.

 

L - (+) - Ergothioneine (EGT) phofo sebelisa khanya le kopo

Tlatsetso e nepahetseng le / kapa lijo tse ntlafalitsoeng ho kenyelletsa livithamini tse telele tse kang L-ergothioneine tlatsetsa li ka fokotsa kotsi e kholo ea lefu le sa foleng le ho tsofala pele ho nako.

L-ergothioneine phofo ke motsoako o motle oa foromo e ntle ea phepo e nepahetseng.

Patlisiso e fana ka maikutlo a hore menyetla ea EGT antioxidant e sebetsa e le anti-inflammatory ho tsoela pele ho sireletsa lisele khahlano le mafu a mmele le a neurodegenerative.

  1. Ho ruruha

Phuputso e bonts'a hore joalo ka antioxidant, EGT e kanna ea itšireletsa khahlanong le ho ruruha.

Rheumatoid ramatiki ke lefu la autoimmune le tšoailoeng ke ho ruruha ho matla (mme hangata ho sa hlalosoang).

Ho ka etsahala hore EGT e ka fokotsa ho ruruha ho bakuli ba nang le ramatiki ea ramatiki.

  1. Maloetse a Neurodegenerative

Joaloka cytoprotectant, EGT ke tlatsetso e tsebahalang har'a bakuli ba Alzheimer's le Parkinson.

EGT e ts'ehetsa sistimi ea 'mele ea hau ea ts'ireletso ea antioxidant mme e ka sireletsa lisele tsa boko tšenyo ea oxidative le khatello ea maikutlo ho tsoa ho li-radicals tsa mahala.

Ka ho sireletsa lisele tsa boko, ho hlakile hore ho ka thibela lefu la lisele tsa bokong le ho sireletsa khahlanong le mafu a neurodegenerative.

  1. Maloetse a Seoa

Ka lebaka la bokhoni ba eona ba cytoprotectant le antioxidant, EGT ke amino acid eo e e ratang ho bakuli ba nang le lefu la sebete.

  1. Ho tsofala ho ka hlahisa bokhoni

Hangata o tla fumana EGT lihlahisoa tse ngata tsa tlhokomelo ea letlalo ka lebaka la thepa ea eona ea cytoprotectant le antioxidant- e ka sireletsang lisele tsa letlalo ho senyeha ha oxidative.

Tšenyo ea mahala ea khatello ea kelello le khatello ea maikutlo e tlatsetsa haholo ho tsofeng pele ho nako, letlalo le sa tsitsang le makhopho.

  1. Maloetse a Bofokoli

Lefapha la Ts'ireletso la Amerika le fane ka thuso ea $ 1.34 milione ho bafuputsi ba Univesithing ea Colorado ho ithuta ketso ea antioxidant ea EGT bakeng sa ho loants'a mafu a matšoafo ho loantseng li-veteran.

 

Reference:

  • Oumari M, et al. Nchafatso ea ergothioneine kamora karabelo ka oksijene ea singlet. Radic Biol Med ea mahala. 2019 Apr; 134: 498-504.
  • Cheah, LK, Halliwell, B. Ergothioneine; matla a antioxidant, ts'ebetso ea 'mele le karolo ea mafu, Biochim. Li-biophys. Acta 2012; (5): 784-793.
  • Genghof, DS Biosynthesis ea Ergothioneine le Hercynine ka. Fungi le Actinomycetales, J. Bacteriol., 1970; 103 (2): 475-478.
  • Pheta, JE, Elkins, ND Phello ea ergothioneine ka leqeba le bohloko la matšoafong le ho ruruha ho likhoto tsa "cytokine" tse se keng tsa fetoloa, Prev. Moedi 2012; (54): S79-S82.
  • Karolo ea EFSA mabapi le Lihlahisoa tsa Dietetic, Phepo e nepahetseng le Allergies (2017). "Polelo ka polokeho ea synthetic l-ergothioneine joalo ka lijo tsa lipale - tlatsetso ea phepelo ea lijo le tlhahlobo ea polokeho bakeng sa masea le bana ba banyenyane, basali ba baimana le ba anyesang". Tlaleho ea EFSA. 15 (11): 5060. doi: 10.2903 / j.efsa.2017.5060.