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Rafi ea Caffeic acid e bitsoang phenethyl ester phofo (104594-70-9)

Mafura a Caffeic acid e leng phantethyl ester phofo ke phenethyl alcohol ester ea caffeic acid le bioactive ......


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Nako e kholo ea caffeic acid e bitsoang phenethyl ester powder (104594-70-9) video

Rafi ea Caffeic acid e bitsoang phenethyl ester phofo (104594-70-9) Slitšobotsi

Name Product Raw e caffeic acid e bitsoang phenethyl ester phofo
Lebitso la lik'hemik'hale Rafi ea Cafeic acid e phofshoana ea phenethyl ester;

Caffeate ea Phenylethyl; Cafeate ea Phenethyl; Caffeic acid e le 2-phenylethyl ester; β-Phenylethyl caffeate;

2-Phenylethyl (2E) -3- (3,4-dihydroxyphenyl) acrylate

Brand Name Ha ho data e fumanehang
Sehlopha sa Lithethefatsi Tyrosine Kinase Inhibitors, Inhibitors
Nomoro ea CAS 104594-70-9
InChIKey SWUARLUWKZWEBQ-VQHVLOKHSA-N
limolek'hule Formula C17H16O4
limolek'hule Wtse robeli 284.311 g / mol
Masapo a monoisotopic 284.31 g · molâ'1
Ho qhibiliha Poli 125-126ºC (dec.)
Sebaka se belang 498.6 ± 45.0 ° C ho 760 mmHg
Likokoana-hloko tsa Half-Life Ha ho Ditshebeletso tse fumanehang
Color e isang bosoeung
Sho khoneha Sesole ka ethyl acetate ka 50mg / ml. Ho qhibiliha ka DMSO le ethanol.
Storage Tmocheso Boloka ho XNUM ° C
Rafi ea Caffeic acid e phofshoana ea phenethyl ester Aho latela Cytotoxic moemeli khahlanong le kankere ea lisele tsa kankere. Inhibitor of decorboxylase ea li-ornithine le protheine tyrosine kinase. E fumanoe e le inhibitor e khethehileng ea ntho e ngotsoeng ka nyutlelie, NF-kB. E boetse e bontšitsoe ho thibela haholo lipoxygenase tsela ea arachidonic acid e metabolism nakong ea ho ruruha.

Rafi ea Caffeic acid e bitsoang phenethyl ester phofo (104594-70-9) Tlhaloso

Peso ea Rafi ea Caffeic acid e phofshoana ea ester ke phenethyl alcohol ester ea acid e caffeic le karolo ea bioactive ea honeybee hive propolis, e nang le li-antineoplastic, mesebetsi ea cytoprotective le immunomodulating. Ka mor'a tsamaiso, Raw Caffeic acid e bitsoang phenethyl ester powder (CAPE) e thibela ho sebelisoa ha NF-kappa B e nkiloeng ka nyutlelie 'me e ka thibela p70S6K le litsela tsa ho tsebahatsa Akt. Ho phaella moo, CAPE e thibela ho ata ha li-cell-cell mesifa ka methapo ea p38-activated kinase (MAPK) le hypoxia-inducible factor (HIF) -1alpha le ho kenngoa ha heme oxygenase-1 (HO-1) .

Caffeic acid e bitsoang phenethyl ester e tlalehiloe hore e na le lik'hemik'hale tse khahlanong le kankere, li-inflammatory le immunomodulatory. CAPE e boetse e thibela HIV-1 integrase. Litšobotsi tse khahlanong le ho ruruha li 'nile tsa nahana hore li bakoa ke ho tlosoa ha lipoxygenase tsela ea arachidonic acid metabolism ke CAPE. Liphuputso li boetse li bontšitse hore CAPE e ka ba tšireletso e khethehileng le e matla ea ho kenyelletsa NF kappa B, e leng sebopeho sa protheine se laolang phetolelo ea DNA. Caffeic Acid Phenethylester ke thibelo ea ODC le Tyrosine Kinase

Cafeic acid e phofsho ea esethyl ester (104594-70-9) Mokhoa oa Ketso

Caffeic acid e bitsoang phenethyl ester ke karolo ea propolis ea mahe a linotši, e thibela ho ts'oaroa ha NF-κB e bakoang ke phorbol ester, ceramide, okadaic acid, le hydrogen peroxide ka ho thibela phetoho ea karoloana ea p65 ea NF-κB ho ea lehaeng. Lethathamong la liphatsa tsa lefutso, li-caffeic acid e phenethyl ester e bontša mosebetsi o tšepisang oa ho thibela tšoaetso le EC50 ea 1.76, 3.16, 13.7 le 44.0 μM khahlanong le murine colon 26-L5, melineoma ea B16-BL6, HT-1080 fibrosarcoma le mapheo a batho A549 lisele tsa adenocarcinoma, ka ho latellana. Caffeic acid e bitsoang phenethyl ester, e le antioxidant e matla, e na le phello ea eona e khahlanong le apoptotic liseleng tsa grerele tsa cerebellar ka ho thibela sebopeho sa ROS le ho thibela mosebetsi oa caspase. Ho feta moo, e-caffeic acid e phenethyl ester e thibela phenotype ea pro-inflammatory ea HPS-e tsosolositsoeng ea HSC, le tlhahiso ea LPS e susumelitsoeng ke LPS ho li-cytokine tsa fibrogenic ka ho thibela NF-κB ho paka.

Ka vivo, Caffeic acid e phenethyl ester (10 mg / kg, ip) e thibela kholo le angiogenesis ea lihlahala tse ka sehloohong ho C57BL / 6 le BALB / c mice e kenngoeng ka Lewis lung carcinoma, colon carcinoma le lisele tsa melanoma. Caffeic acid e bitsoang phenethyl ester (5, 10, 20 mg / kg) e boetse e bontša liphello tsa immunomodulatory in vivo ka ho fokotsa thymus boima le / kapa cellularity ea thymus le spleen.

Tšebeliso ea phofo ea Caffeic acid phéethyl ester (104594-70-9)

▪ Antineoplastic

▪ Ho sa tsotellehe seo

▪ Iimmunomodulator

▪ Thibelo ea NFkB

Melemo ea ho Caffeic acid e phofsho ea esethyl ester (104594-70-9)

Phenethyl caffeate ke motsoako o fumanoang propolis, motsoako o hlahisoang ke linotsi. Caffeic acid e bitsoang phenethyl ester (CAPE) e ka atleha ho thibela le ho phekola maloetse a chesang ho akarelletsa le ramatiki ea ramatiki, tsamaiso ea lupus erythematosus le psoriasis, mafu a mangata a kankere le maloetse a nang le likokoana-hloko tse entsoeng ka maqeba, li-cataracts le mafu a mang a bakoang ke khatello ea mali. Ho feta moo, CAPE e ka sebelisoa ho phekola tšoaetso ea HIV ha e kopantsoe moqeng oa meriana o nang le ntho e thibelang phetoho ea HIV. E ka boela ea sebelisoa ho khahlanong le atherosclerotic, antioxidative, cardioprotective, khahlanong le botenya le ho antimitogenic.

TLHOKOMELISO LE TLHALOSO:

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