Rafi ea Caffeic acid e bitsoang phenethyl ester phofo (104594-70-9)

December 28, 2018

Raw Caffeic acid phenethyl ester phofo ke phenethyl alcohol ester ea caffeic acid le bioactive …… ..


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1180kg / khoeli

Nako e kholo ea caffeic acid e bitsoang phenethyl ester powder (104594-70-9) video

 

Rafi ea Caffeic acid e bitsoang phenethyl ester phofo (104594-70-9) Slitšobotsi

Name Product Raw e caffeic acid e bitsoang phenethyl ester phofo
Lebitso la lik'hemik'hale Rafi ea Cafeic acid e phofshoana ea phenethyl ester;

Caffeate ea Phenylethyl; Cafeate ea Phenethyl; Caffeic acid e le 2-phenylethyl ester; β-Phenylethyl caffeate;

2-Phenylethyl (2E) -3- (3,4-dihydroxyphenyl) acrylate

Brand Name Ha ho data e fumanehang
Sehlopha sa Lithethefatsi Tyrosine Kinase Inhibitors, Inhibitors
Nomoro ea CAS 104594-70-9
InChIKey SWUARLUWKZWEBQ-VQHVLOKHSA-N
limolek'hule Formula C17H16O4
limolek'hule Wtse robeli 284.311 g / mol
Masapo a monoisotopic 284.31 g · molâ'1
Ho qhibiliha Poli  125-126ºC (dec.)
Sebaka se belang 498.6 ± 45.0 ° C ho 760 mmHg
Likokoana-hloko tsa Half-Life Ha ho Ditshebeletso tse fumanehang
Color e isang bosoeung
Sho khoneha  Sesole ka ethyl acetate ka 50mg / ml. Ho qhibiliha ka DMSO le ethanol.
Storage Tmocheso  Boloka ho XNUM ° C
Rafi ea Caffeic acid e phofshoana ea phenethyl ester Aho latela Cytotoxic moemeli khahlanong le kankere ea lisele tsa kankere. Inhibitor of decorboxylase ea li-ornithine le protheine tyrosine kinase. E fumanoe e le inhibitor e khethehileng ea ntho e ngotsoeng ka nyutlelie, NF-kB. E boetse e bontšitsoe ho thibela haholo lipoxygenase tsela ea arachidonic acid e metabolism nakong ea ho ruruha.

 

Rafi ea Caffeic acid e bitsoang phenethyl ester phofo (104594-70-9) Tlhaloso

Peso ea Rafi ea Caffeic acid e phofshoana ea ester ke phenethyl alcohol ester ea acid e caffeic le karolo ea bioactive ea honeybee hive propolis, e nang le li-antineoplastic, mesebetsi ea cytoprotective le immunomodulating. Ka mor'a tsamaiso, Raw Caffeic acid e bitsoang phenethyl ester powder (CAPE) e thibela ho sebelisoa ha NF-kappa B e nkiloeng ka nyutlelie 'me e ka thibela p70S6K le litsela tsa ho tsebahatsa Akt. Ho phaella moo, CAPE e thibela ho ata ha li-cell-cell mesifa ka methapo ea p38-activated kinase (MAPK) le hypoxia-inducible factor (HIF) -1alpha le ho kenngoa ha heme oxygenase-1 (HO-1) .

Caffeic acid phenethyl ester e tlalehiloe e na le li-anti-carcinogenic, anti-inflammatory, le thepa ea immunomodulatory. CAPE e boetse e thibela HIV-1 integrase. Ho nahanoa hore litšobotsi tse khahlano le ho ruruha li bakoa ke ho hatella tsela ea lipoxygenase ea arachidonic acid metabolism ke CAPE. Boithuto bo boetse bo bonts'itse CAPE ho ba inhibitor e ikhethileng le e matla ea ts'ebetso ea transaction ea nyutlelie NF kappa B, e leng rarahanyo ea protheine e laolang phetolelo ea DNA. Caffeic Acid Phenethylester ke sesitisi sa ODC le Tyrosine Kinase

Caffeic acid phenethyl ester phofo (104594-70-9) Mokhoa oa Ketso

Caffeic acid e bitsoang phenethyl ester ke karolo ea propolis ea mahe a linotši, e thibela ho ts'oaroa ha NF-κB e bakoang ke phorbol ester, ceramide, okadaic acid, le hydrogen peroxide ka ho thibela phetoho ea karoloana ea p65 ea NF-κB ho ea lehaeng. Lethathamong la liphatsa tsa lefutso, li-caffeic acid e phenethyl ester e bontša mosebetsi o tšepisang oa ho thibela tšoaetso le EC50 ea 1.76, 3.16, 13.7 le 44.0 μM khahlanong le murine colon 26-L5, melineoma ea B16-BL6, HT-1080 fibrosarcoma le mapheo a batho A549 lisele tsa adenocarcinoma, ka ho latellana. Caffeic acid e bitsoang phenethyl ester, e le antioxidant e matla, e na le phello ea eona e khahlanong le apoptotic liseleng tsa grerele tsa cerebellar ka ho thibela sebopeho sa ROS le ho thibela mosebetsi oa caspase. Ho feta moo, e-caffeic acid e phenethyl ester e thibela phenotype ea pro-inflammatory ea HPS-e tsosolositsoeng ea HSC, le tlhahiso ea LPS e susumelitsoeng ke LPS ho li-cytokine tsa fibrogenic ka ho thibela NF-κB ho paka.

Ka vivo, Caffeic acid e phenethyl ester (10 mg / kg, ip) e thibela kholo le angiogenesis ea lihlahala tse ka sehloohong ho C57BL / 6 le BALB / c mice e kenngoeng ka Lewis lung carcinoma, colon carcinoma le lisele tsa melanoma. Caffeic acid e bitsoang phenethyl ester (5, 10, 20 mg / kg) e boetse e bontša liphello tsa immunomodulatory in vivo ka ho fokotsa thymus boima le / kapa cellularity ea thymus le spleen.

Tšebeliso ea phofo ea Caffeic acid phéethyl ester (104594-70-9)

▪ Moriana o thibelang mali

▪ Sesosa-mollo

▪ Moqhekelli

▪ Noka ea NFkB

Melemo ea ho Caffeic acid e phofsho ea esethyl ester (104594-70-9)

Phenethyl caffeate ke motsoako o fumanoang propolis, motsoako o hlahisoang ke linotši. Caffeic acid phenethyl ester (CAPE) e ka sebetsa hantle thibelong le kalafong ea maloetse a ruruhang ho kenyelletsa ramatiki ea ramatiki, systemic lupus erythematosus le psoriasis, mefuta e fapaneng ea mofetše le maloetse a nang le hlahala, lera la mahlo le mafu a mang a bakoang ke khatello ea mali. Ho feta moo, CAPE e ka sebelisoa ho alafa tšoaetso ea HIV ha e kopantsoe le metsoako ea meriana le ntho e thibelang ho ipheta ha HIV. E ka sebelisoa ho anti-atherosclerotic, antioxidative, cardioprotective, anti-obesity le antimitogenic.