Pyrroloquinoline quinone (PQQ) (72909-34-3)

March 11, 2019

Pyrroloquinoline quinone (PQQ), eo hape e bitsoang methoxatin, ke redox cofactor. E fumanoa mobung le lijong tse kang kiwifruit, joalo ka …… ..

 


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Pyrroloquinoline quinone (PQQ) (72909-34-3) video

Litlhaloso tsa Pyrroloquinoline quinone (PQQ) (72909-34-3) Litlhaloso

Name Product Pinroloquinoline quinone (PQQ)
Lebitso la lik'hemik'hale Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Nomoro ea CAS 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
Smile C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Molecular Formula C14H6N2O8
Boima ba 'mele 330.21
Masapo a monoisotopic 330.012415 g / mol
Ntlha ea Boliing 1018.6 ± 65.0 ° C (E boletsoe esale pele)
Ntlha ea Flashing 569.8 ° C (1,057.6 ° F; 842.9 K)
segokanyipalo 1.963 ± 0.06 g / cm3 (E boletsoe esale pele)
Color Orange-Red Tiileng
Setsi sa polokelo 2-8 ° C
Solubility Ho qhibiliha ka metsing
kopo PQQ ho tlalehiloe hore e sebetsa e le vithamine / cofactor e qhibilihang ka metsing le joalo ka antioxidant. E boetse e etselitsoe tšebeliso ea tlatsetso ea phepelo ea lijo, joalo ka matla, phetisetso ea lijo, le mekoallo e sirelelitsoeng jj.

 

ke eng Pinroloquinoline quinone(PQQ)?

Pyrroloquinoline quinone (PQQ), eo hape e bitsoang methoxatin, ke redox cofactor. E fumanoa mobung le lijong tse kang kiwifruit, hammoho le lebese la matsoele la motho. Pyrroloquinoline quinone ke sehlopha sa pyrroloquinoline se nang le lihlopha tsa oxo maemong a 4 le a 5 le li-carboxy libakeng tsa 2-, 7- le 9. E na le karolo e le vithamini e qhibilihang ka metsing le cofactor. Hape, ke sesupo sa liprotheine tsa kinase e kenyang karohano ea lisele tsa mammalian. Bokhoni ba boleng bo phahameng ba ho sebelisa hape ba "PQQ" bo ka ba ba e fa karolo ea bohlokoa ea meriana ho itšireletsa khahlanong le neurodegeneration le mofets'e. (Joaloka moemeli oa redox, Pyrroloquinoline quinone e tsitsitse haholo 'me e ka nka karolo liketsong tse makholo ho feta li-antioxidants tse ling, tse kang ascorbic acid, quercetin le epratechin.

Pyrroloquinoline quinone ke biofactor ea palema, 'me e ile ea amoheloa e le cofactor ea enzyme ho libaktheria. Liphuputso li bonts'a hore mohlomong "Pyrroloquinoline quinone" e bile teng ho pholletsa le mohopolo oa tlhaho ea tlhaho le khopolo ea ho iphetola ha lintho. Ha e le semela se matla sa kholo ea semela, e teng ka kholo ea liphoofolo le batho. Pyrroloquinoline quinone e tlaleha ho nka karolo mesebetsing e fapaneng ea biolo ka melemo ea ho pholoha e teng (mohlala, kholo e ntlafalitsoeng ea neonatal le ts'ebetso ea ho ikatisa) ho liphoofolo.

Ho feta moo, Pyrroloquinoline quinone e na le ts'ebetso ea antioxidant le B-vithamine, e nang le melemo e mengata bakeng sa boko le 'mele. E phahamisa bophelo bo botle ba kelello le memori ka ho loants'a ho se sebetse hantle ha methapo ea mali le ho sireletsa li-neuron ho tsoa tšenyo ea oxidative. Boithuto ba tsa bongaka ho batho bo bonts'itse hore Pyrroloquinoline quinone e ntlafatsa mohopolo oa nako e khuts'oane le tlhokomelo, e ntlafatsa metabolism ea matla le botsofali bo phetseng hantle, hape e fokotsa mats'oao a tšoaetso, hammoho le ho ntlafatsa maikutlo a akaretsang a ho phela hantle.

 

Pyrroloquinoline e sebetsa joang? quinone(PQQ) sebetsa?

Liphuputso tsa likhoto li bonts'a katleho e ntle bakeng sa Pyrroloquinoline quinone ho matlafatseng biogenesis ea mitochondrial. Li-hepatocyte tsa likhoto tse kentsoeng ke PQQ ho 10-30 μM bakeng sa 24-48 h e bonts'itse "ts'ebetso ea citrate synthase le cytochrome c oxidase, ho silafatsa Mitotracker, litaba tsa DNA tsa mitochondrial le phefumoloho ea oksijene ea lisele. Ts'ebetso ea ts'ebetso ena e etsahetse ka ts'ebetsong ea cAMP response element-binding protein (CREB) le peroxisome proliferator-activated receptor-γ coactivator-1cy (PGC-1α), tsela e tsejoang ho laola mitochondrial biogenesis. " Liphuputsong tsa vivo ka likhoto le tsona li bonts'a litlamorao tse tsoang ho tlatsetso ea lijo le PQQ (2mg PQQ / kg ea lijo). Tsena li kenyelletsa ho fokotseha ha triglycerides ea plasma, tšebeliso e eketsehileng ea matla (e amanang le hepatic mitochondrial content), le ntlafatso ea mamello ho ischemia / reperfusion ea pelo. Mehlala ea liteko ea stroke le mokokotlo oa mokokotlo li bontša hore Pyrroloquinoline quinone e thibela lefu la sele ea neuronal, karolo e 'ngoe ka Pyrroloquinoline quinone e sirelletsang li-receptor tsa N-methyl-d-aspartic acid (NMDA). Mefuta ea likhoto ea lefu la Parkinson e bonts'a hore Pyrroloquinoline quinone supplementation e fokotsa tahlehelo ea methapo ea kutlo, e eketsa mefuta ea oksijene e sebetsang, 'me e fana ka ts'ireletso ka mekhoa e meng.

 

Melemo ea Pinroloquinoline quinone(PQQ) melemo

Bokong le 'meleng, PQQ e na le melemo e mengata.

- PQQ e ts'ehetsa ts'ebetso e nepahetseng ea mitochondrial

Mitochondria ke bahlahisi ba matla liseleng tsa rona mme ba bapala karolo ea bohlokoa bophelong ba rona ka kakaretso. PQQ ka ho sireletsa li-mitochondria tse seng li ntse li le teng mme e khothaletsa moloko oa mitochondrial, ka hona hlahisa ATP (Energy). Ho sebetsa haholoanyane mitochondria, matla a eketsehileng.

- PQQ e tšehetsa lintlha tsa kholo ea methapo

PQQ e matlafatsa tlhahiso ea Nerve Growth Factor (NGF.), E sirelletsa le ho khutlisetsa lisele tse senyehileng tsa kelello le methapo, ka hona e thibela ho theoha hoa kelello (tahlehelo ea mohopolo, mathata a ho ithuta, jj.) Ka lebaka la botsofe, stroke kapa mathata a methapo, hape a khothaletsa mmele le antioxidant mesebetsi, le ts'ireletso ho tsoa liketsahalong tsa pelo le methapo.

- PQQ e thibela khatello ea mali

PQQ e fana ka ts'ireletso e matla ea li-antioxidant, e sirelletsa lisele tse 'meleng ho senyehang ha li-oxidative le li-radicals tsa mahala. E ts'ehetsa metabolism ea matla le botsofali bo phetseng hantle, 'me e nkile cofactor e ncha e nang le ts'ebetso ea antioxidant le B ea mofuta oa v.

Ntle le moo, PQQ e kanna ea thibela le ho phekola tšenyo ea sebete le ts'ebetso e matla ea anticancer.

Ts'ebeliso / ts'ebeliso ea Pinroloquinoline quinone(PQQ)

Phuputsong ea 2009 e phatlalalitsoeng koranteng ea bongaka ea Lijo ka mokhoa oa Lijo, Pyrroloquinoline Quinone o bontšitsoe a na le bokhoni ba ho thusa ho sireletsa. E sebelisoa ho phekola ho fokotseha hoa kelello (ho lahleheloa ke mohopolo, ho thatafalloa ho ithuta, joalo-joalo) ka lebaka la botsofali, stroke kapa mathata a methapo, le ts'ireletso liketsahalong tsa pelo le methapo ea mokokotlo. Liphetho tse tšoanang li tlalehiloe phuputsong e latelang ea 2011 moo Pyrroloquinoline Quinone le eona e fanoeng ka kotloloho e le tlatsetso ea lijo, joalo ka lino tse tahang tse entsoeng ka lebese.

 

Ho lekana joang Pinroloquinoline quinone(PQQ)?

Bophelong, o ka fumana PQQ ho tsoa lijong tse ling tse tsoekere, ka tlhaho e teng lijong le lino tse fapaneng, ho kenyeletsoa pelepele e tala, parsley, tee kapa kiwifruit jj. Ha re na ho fumana PQQ e lekaneng lijong tsa rona tsa letsatsi le letsatsi. Ka hona, haeba u batla melemo e mengata ho feta, u ka fumana PQQ e ngata ka litsela tse ling, joalo ka tlatsetso ea PQQ ea lijo.

 

Tlhaloso:

  • Phala, Kelsey (12 Hlakola 2017). "Antioxidant ea Tlhaho e ka Thibela Mafu a Sebete". lehlohonolo. E khutlisitsoe ka la 14 Hlakola 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: excretion ka methylotrophs le tlhoko ea kholo bakeng sa likokoana-hloko". Li-BioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Biochemistry: karolo ea PQQ joalo ka cammactor ea enzyme ea mammalian?". Tlhaho. 433 (7025): E10, puisano E11–2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "Sehlopha sa maiketsetso sa methanol dehydrogenase e tsoang ho Hyphomicrobium X: bopaki ba molumo oa elektronike bakeng sa sebopeho sa quinone". Phekolo ea Biochem Biophys Res. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline dehydrogenase e itšetlehileng ka "li-bacteria" tsa acetic acid.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. Doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.