Nicotinamide Mononucleotide (NMN) (1094-61-7)

October 30, 2018
SKU: 1094-61-7

Raw Nicotinamide Mononucleotide (NMN) phofo e hatella boima ba 'mele bo amanang le lilemo ……


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Video ea Nicotinamide Mononucleotide (NMN) (1094-61-7)

Nko e kholo ea Nicotinamide Mononucleotide (NMN) (1094-61-7) Tlhaloso

Phofo e khōlō ea Nicotinamide Mononucleotide ("NMN" le "β-NMN") ke nucleotide e nkiloeng ho ribose le nicotinamide. Joaloka nicotinamide riboside, NMN ke tsoa ho nicin, 'me batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide (NADH).

Hobane NADH ke motsoako oa lik'hemik'hale bakeng sa mekhoa e ka hare ho mitochondria, bakeng sa li-siretu, le bakeng sa PARP, NMN e 'nile ea ithutoa ka mehlape ea liphoofolo e le moemeli ea nang le tšoaetso ea mali le ea tsofetseng. Lik'hamphani tsa tlatsetso ea lijo li 'nile tsa rekisa lihlahisoa tsa NMN ka mokhoa o mabifi tse bolelang melemo eo, le hoja ho se na thuto ea meriana ea batho e hatisitsoeng.

 

Nko e makhaola-khang ea Nicotinamide Mononucleotide (NMN) (1094-61-7) Lintlha

Name Product Phororo e khōlō ea Nicotinamide Mononucleotide (NMN)
Lebitso la lik'hemik'hale Beta-nicotinamide ribose monophosphate; Phofo e khōlō ea Nicotinamide Mononucleotide; AC1Q6RVF; AC1L23AN; NMN (+); SCHEMBL6858129
Brand Name Mirailabo
Sehlopha sa Lithethefatsi Phepo ea lijo
Nomoro ea CAS 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
limolek'hule Formula C11H15N2O8P
limolek'hule Wtse robeli 334.22
Masapo a monoisotopic 335.229 g / mol
Ho qhibiliha Poli  > 96 ° C
Fho tsosolosa Poli Ha ho letsatsi le fumanehang
Likokoana-hloko tsa Half-Life Kahoo, joalokaha ho bontšitsoe setšoantšong sa 3, nicotinamide e ile ea nyamela mali le halofo ea lihora tsa 5.3, athe halofo ea bophelo ea nicotinic acid e ne e le hora ea 1.1.
Color Bosoeu bo bosoeu bo bosoeu
Sho khoneha  Methanol (hanyenyane), metsi (hanyenyane)
Storage Tmocheso  Hygroscopic, -20˚C Freezer, Tlas'a Sebaka sa Inert
Aho latela E le hore o phethe karolo ea ho eketsa bophelo le ho phekola lefu la tsoekere

 

Monotucleotide e khōlō ea Nicotinamide (NMN) phofo (1094-61-7) Tlhaloso

Phofo e khōlō ea Nicotinamide Mononucleotide ("NMN" le "β-NMN") ke nucleotide e nkiloeng ho ribose le nicotinamide. Joaloka nicotinamide riboside, NMN ke tsoa ho nicin, 'me batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide (NADH).

Phuputso e ncha e fana ka maikutlo a hore NMN e ka tsosolosa metabolism ea cellular, 'me ea ba le liphello tse tebileng tse khahlanong le botsofali. Ho etsahalang ka tlhaho 'meleng, NMN (β-Nicotinamide mononucleotide) ke ea bohlokoa bakeng sa ho fetoha ha limatlafatsi ka matla. Ho tlatsetsa NMN e le karolo ea puso ea hau ea letsatsi le letsatsi e ka fana ka matla a ho tsosolosa matla, ho sireletsa botsofaling, le ho fokotsa kotsi ea mathata a pelo. NMN ke motsoako oa li-redox, e leng ts'ebetso e bohlokong ea ts'ebetso ea ts'ebetso ea motlakase ho thehoa ha ATP molek'hule e fanang ka matla e phahameng. NMN e na le motsoako o kenyang letsoho o khothalletsang ho nepahala ha metsoli le bophelo bo bolelele.

Tšebeliso ea Nicotinamide Mononucleotide (NMN) phofo (1094-61-7)

  1. Nicotinamide mononucleotide ka lisele tsa motho e phetha karolo ea bohlokoa ho hlahisa matla a matla, e kenngoa ka NAD ea methapola (nicotinamide adenine dinucleotide, cell energy conversion e bohlokoa coenzyme) synthesis, e sebelisetsoang ho hlola botsofali, ho oa ha tsoekere ea mali le meriana e meng ea tlhokomelo ea bophelo.
  2. Nicotinamide Mononucleotide ke vithamine e qhibilihisang metsi, Sehlahisoa se na le phofo e tšoeu ea kristalline, e sa nkhang hamonate kapa e batlang e le monko o bohloko, e nang le tatso e bohloko, e tsitsitseng ka bolokolohi metsing kapa ethanol, e qhibilihisitsoeng ka glycerin.
  3. Nicotinamide Mononucleotidepowderis e bonolo ho noa molomo, 'me e ka fetisoa ka hohle' meleng, metabolite e feteletseng kapa sebopeho se potlakileng se leleka mokokotlong. Nicotinamide ke karolo ea coenzyme I le coenzyme II e phethang karolo ea ha hydrogen e tsamaisoang ka khase ea likokoana-hloko ea phefumoloho, e ka khothalletsa mekhoa ea ho ts'ebetso ea likokoana-hloko le mesifa ea metabolism, ho boloka lisele tse tloaelehileng (haholo-holo letlalo, tšitiso ea lijo le tsamaiso ea methapo) botšepehi bo na le karolo ea bohlokoa.

Ho phaella moo, nicotinamide e na le thibelo le phekolo ea pelo e thibelang pelo, sebono sa sinus le mananeo a khahlanong le potlako a ho leka-lekana, nicotinamide e ka ntlafatsa haholo sekhahla sa pelo le sebopeho sa atrioventricular se bakoang ke verapamil.

melemo e ea Nicotinamide Mononucleotide (NMN) phofo (1094-61-7)

  • NMN e Matlafatsa Metabolism ea Matla - NAD + e thusa ho senya lijo joalo ka tsoekere hore e be matla.
  • E khothaletsa Bokooa bo Botle le Mesebetsi ea Motlakase.
  • Ho lokisa DNA ea ho Tsofala - NAD + e sebelisetsoa ho lokisa likhoele tsa DNA tse robehileng.
  • SIRTUIN Activator - NAD + ea hlokahala bakeng sa liphatsa tsa rona tsa bophelo bo bolelele ho sebetsa.
  • NMN ke moqhaka o sebelisitsoeng ke Harvard Scientists ho fetola matšoao a mang a mahlahahlaha a tsofetseng litoeba tse qalileng ho potlakisa NAD.
  • Kalafo ea NMN e sireletsa khahlanong le kotsi e entsoeng ke boko bo entsoeng ke CICH
  • Tlhahlobo ea NMN e lopolla ho holofala ha maikutlo
  • Nicotinamide mononucleotide e thibela ts'ebetso ea JNK ho fetola lefu la Alzheimer
  • NMN e ka tsosolosa tlhokomelo ka likhoto tsa mohlala tsa AD

E khothalletsoa Nicotinamide Mononucleotide (NMN) phofo (1094-61-7) Tekanyo

Tekanyo e atisang ho kgothaletswa ya Nicotinamide Mononucleotide powder ke kae kapa kae pakeng tsa 250 - 1500 mg ka letsatsi.

NMN e kenngoa ka potlako haholo 'me e na le halofo ea bophelo bo khutšoanyane, kahoo ho boloka litekanyetso tsa NAD + li phahame ka nako e ngata kamoo ho ka khonehang ho buelloa ho nka capsule e le' ngoe ea 125 mg ka ho tsoha le e mong ka thapama ha u nka 250 mg ka letsatsi.

Litla-morao ea Nicotinamide Mononucleotide (NMN) phofo (1094-61-7)

Le ha phofo ea Nicotinamide mononucleotide (NMN) e le tlatsetso e ncha le lipatlisiso li ntse li tsoela pele, lithuto tse entsoeng ho fihlela joale li bontšitse hore e bolokehile haholo ebile ha e na chefo.

Litla-morao ha li fumanehe hangata, empa bolutu, ho ba le botenya, ho fufuleloa le ho nyefoloha ho 'nile ha tlalehoa maemong a mang.

 

References
  1. Nina Klimova, Tibor Kristian. Phello e lebisitsoeng ho bongata ba Nicotinamide Mononucleotide ho Brain Bioenergetic Metabolism. Setsi sa Neurochem Res. 2019 Mphalane; 44 (10): 2280-2287. doi: 10.1007 / s11064-019-02729-0. PMID: 30661231.
  2. Aaron N Long, Katrina Owens, Anna E Schlappal, Tibor Kristian, Paul S Fishman, Rosemary A Schuh. Phello ea nicotinamide mononucleotide ho likhaello tsa phefumoloho ea mitochondrial ho mofuta oa moroto oa Alzheimer's-murine. BMM Neurol. 2015 Mar 1; 15: 19. doi: 10.1186 / s12883-015-0272-x. PMID: 25884176.
  3. Ji H Park, Aaron Long, Katrina Owens, Tibor Kristian. Nicotinamide mononucleotide e thibela ho senyeha ha NAD (+) kamora 'ischemic mme e matlafatsa haholo tšenyo ea boko kamora' ischemia ea lefats'e ea lefats'e. Neurobiol Dis. 2016 Nov; 95: 102-10. doi: 10.1016 / j.nbd.2016.07.018. Epub 2016 Jul 15. PMID: 27425894, PMCID: PMC558024.
  4. Junichiro Irie, Hiroshi Itoh. Botsofali le homeostasis. Maloetse a amanang le lilemo le ts'ebeliso ea bongaka ea NMN (Nicotinamide Mononucleotide). Clin Calcium. 2017; 27 (7): 983-990. PMID: 28649105.
  5. Golam Mezbah Uddin, Neil A Youngson, Bronte M Doyle, David A Sinclair, Margaret J Morris. Tlatsetso ea Nicotinamide mononucleotide (NMN) e ntlafatsa phello ea botenya ba bakhachane ho litoeba: papiso le boikoetliso. Sci Rep. 2017 Nov 8; 7 (1): 15063. doi: 10.1038 / s41598-017-14866-z. PMID: 29118320, le PMCID: PMC5678092.
  6. Lithethefatsi tsa morao-rao tsa ho tsofala: Nicotinamide Mononucleotide (NMN)