J-147 phofo (1146963-51-0) video
J-147 phofo (1146963-51-0) Litlhaloso
| Name Product | J-147 phofo |
| Li-synonyms | J147; j 147; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide |
| Nomoro ea CAS | 1146963-51-0 |
| Sehlopha sa Lithethefatsi | Ha ho dintlha tse fumanehang |
| InChI Key | HYMZAYGFKNNHDN-SSDVNMTOSA-N |
| Smile | CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C |
| Molecular Formula | C18H17F3N2O2 |
| Boima ba 'mele | 350.341 g / mol |
| Masapo a monoisotopic | 350.124 g / mol |
| Melting Point | Ha ho dintlha tse fumanehang |
| Boiling Point | Ha ho dintlha tse fumanehang |
| Efokotsa halofo ea bophelo | Ha ho dintlha tse fumanehang |
| Color | Tšoeu ho ea phofo e tšoeu |
| Solubility | DMSO (>30 mg/ml) kapa EtOH (>30 mg/ml) |
| Stempage temp | refrigerate |
| kopo | sethethefatsi sa liteko se nang le litlamorao tse tlalehiloeng khahlano le lefu la Alzheimer le botsofali mefuteng ea litoeba tsa botsofali bo potlakileng |
Kakaretso ea J-147
J-147 phofo e bile teng ka 2011 ho Cellular Neurobiology Laboratory ea Salk Institute. Ho tloha qalong, ho bile le liphuputso tse ngata tse tiisitseng katleho ea eona ho phekoleng lefu la Alzheimer le ho khutlisa botsofali.
Dr. Dave Schubert le bafuputsi-'moho le eena Salk Institute ba phethile karolo ea bohlokoa thutong ea J-147 curcumin. Ho 2018, lingaka tsa methapo ea kutlo li senole ts'ebetso ea J-147 ea ts'ebetso ea nootropic le karolo ea eona ho laoleng mafu a methapo ea mafu.
Boithuto le lipatlisiso tsa sethethefatsi sena se tsepamisitsoe holim'a bohlokoa ba sona taolong ea boemo ba Alzheimer's. Leha ho le joalo, basebelisi ba phetseng hantle ba 'nile ba thahasella melemo ea J-147 e kang ho ntlafatsa mohopolo, ho matlafatsa bokhoni ba ho ithuta, le ho nchafatsa methapo ea kutlo.
Ho 2019, bo-rakhemisi ba ile ba qala ho leka litlhare tsa J-147 Alzheimer's bathong.
Phofo ea Nootropic J-147 ke eng?
J-147 phofo e tsoa ho curcumin le Cyclohexyl-Bisphenol A. Setlhare se bohlale se na le litšobotsi tse peli tsa neuroprotective le neuroogenic. Ho fapana le li-nootropic tse ngata, tlatsetso ea J-147 e khahlanong le botsofali e ntlafatsa tsebo ntle le ho ama li-enzyme tsa acetylcholine kapa phosphodiesterase.
Curcumin ke karolo e mafolofolo ea turmeric mme ho molemo ho laola mafu a methapo ea kutlo. Leha ho le joalo, polyphenol ena ha e tšele tšitiso ea mali le bokong ka nepo. Ka lebaka leo, J-147 nootropic e ile ea fetoha karolo ea mantlha ha e ntse e tšela mokoallo oa mali le boko habonolo.
J-147 e Sebetsa Joang?
Ho fihlela 2018, phello ea J-147 seleng e ile ea lula e makatsa ho fihlela Salk Institute Neurobiologists e hlakola selotho. Lithethefatsi li sebetsa ka ho tlama ATP synthase. Protheine ena ea mitochondrial e hlophisa tlhahiso ea matla a cellular, ka hona, e laola ts'ebetso ea botsofali.
Boteng ba tlatsetso ea J-147 tsamaisong ea motho bo thibela chefo e amanang le lilemo e bakoang ke mitochondria e sa sebetseng le tlhahiso e fetelletseng ea ATP.
Mokhoa oa ts'ebetso oa J-147 o tla eketsa maemo a li-neurotransmitters tse fapaneng ho kenyelletsa NGF le BDNF. Ntle le moo, e sebetsa maemong a beta-amyloid, a lulang a le holimo har'a bakuli ba nang le lefu la Alzheimer's le 'dementia'.
Litholoana tsa J-147 li kenyelletsa ho fokotsa tsoelo-pele ea Alzheimer's, ho thibela khaello ea mohopolo, le ho eketsa tlhahiso ea lisele tsa neuronal.
Melemo e ka bang teng ea J-147
Ho Matlafatsa Ho Utloisisa
Tlatsetso ea J-147 e ntlafatsa mohopolo oa sebaka le oa nako e telele. Lithethefatsi li khutlisa bofokoli ba kutloisiso har'a batho ba baholo ba nang le bothata ba ho holofala. J-147 ea rekisoa e fumaneha e le tekanyetso ea thekiso 'me moloko o monyane oa e nka ho matlafatsa bokhoni ba ho ithuta.
Ho noa lithethefatsi tse thibelang botsofali tsa J-147 hape ho tla ntlafatsa mohopolo, pono le ho hlaka kelellong.
Tsamaiso ea Lefu la Alzheimer's
J-147 e thusa bakuli ba nang le Alzheimer's ka ho liehisa kholo ea boemo. Mohlala, ho nka tlatsetso ho theola maemo a "beta-amyloid" e qhibilihang, e lebisang ho ho se sebetse hoa kelello. Ntle le moo, J-147 curcumin e hlophisa lets'oao la neurotrophin ho netefatsa pholoho ea methapo ea kutlo, ka hona, ho theoa hoa memori le kutloisiso.
Bakuli ba nang le AD ba na le mabaka a fokolang a neurotrophic. Leha ho le joalo, ho nka tlatsetso ea J-147 Alzheimer's ho matlafatsa NGF le BDNF ka bobeli. Li-neurotransmitters tsena li thusa ho theha mohopolo, ho ithuta le ts'ebetso ea kelello.
neuroprotection
J-147 nootropic e thibela lefu la neuronal le bakoang ke khatello ea oxidative.
Tlatsetso ena e boetse e thibela ts'ebetso e fetelletseng ea li-receptor tsa NMDA (N-Methyl-D-aspartate), e ikarabellang bakeng sa methapo ea kutlo.
Ho nka setlhare sa J-147 ho tla eketsa mabaka a amanang le neurotrophic (BDNF) le lisosa tsa kholo ea methapo (NGF). Li-neurotransmitters tsena tse peli li theola mafu a methapo e kang Alzheimer's le 'dementia'. Ho feta moo, BDNF e bohlokoa ho neurogeneis.
E ntlafatsa Mosebetsi oa Mitochondrial
Ho nka sethethefatsi sa J-147 ho tla ntlafatsa maemo a ATP ka tsela e sa tobang ka ho matlafatsa mesebetsi ea mitochondrial.
Botsofali bo ikarabella bakeng sa ho fokotseha ha mitochondria ka lebaka la ho se sebetse hantle le ho eketseha ha mefuta ea oksijene e sebetsang. Leha ho le joalo, tlatsetso ea J-147 e loantša mokhoa ona ka ho thibela ATP5A synthase. Lithuto tse se nang palo li itšetleha ka moriana bakeng sa ho lelefatsa bophelo ba motho.
J-147 le Anti-botsofali
Ho ea ka Bafuputsi ba Salk, tlatsetso ea J-147 e khahlanong le botsofali e etsa hore lisele tsa botsofali li bonahale li le bacha.
Mitochondria e sa sebetseng e potlakisa ho tsofala. Lisele tsa homeostasis li tla fokotsa, ka hona, ho fokotseha ha ts'ebetso ea mmele. Ntle le moo, tšenyo ea sele le ho senyeha ha mitochondrial ho tla latela ka lebaka la tlhahiso ea ROS (mefuta e sebetsang ea oksijene). Ho nka phofo ea J-147 ho tla loants'a sena, ka hona, ho liehisa senescence.
Botsofali bo boetse bo amahanngoa le ho fokotseha ha kelello le mathata a neurodegenerative. Leha ho le joalo, liphihlelo tse 'maloa tsa J-147 li tiisa katleho ea sethethefatsi ho khutlisa tahlehelo ea mohopolo, ho ntlafatsa bokhoni ba kelello, le ho phekola dementia, Alzheimer's, le mafu a mang a amanang le lilemo.
Tekanyo e tloaelehileng ea J-147
(1) Tekanyo e tloaelehileng
Tekanyetso e tloaelehileng ea letsatsi le letsatsi ea J-147 e pakeng tsa 5mg le 30mg. O ka arola litekanyetso tsa J-147 likoto tse peli. Ka ho khetheha, tekanyetso ea hau e lokela ho ba maemong a tlase 'me e e phahamise ho ipapisitsoe le mamello ea' mele oa hau.
Tlatsetso ena e sebetsa ka molomo. Ha ua lokela ho e nka hamorao mantsiboea kapa bosiu hobane litlhahlobo tse ling tsa J-147 li re e kanna ea senya mokhoa oa hau oa ho robala.
(2) Tekanyo ea mokuli
Bafuputsi ba sebelisitse 10mg / kg ea litekanyetso tsa J-147 ho phekola lefu la Alzheimer ka mefuta ea litoeba.
Leha ho le joalo, tekanyo ea hau e lokela ho itšetleha ka boemo ba hau. Nka, mohlala, haeba u se u ntlafalitse tsebo ea hau, u lokela ho netefatsa ho nka 5mg ho 15mg. Ka lehlakoreng le leng, bakeng sa ts'ireletso ea methapo le taolo ea mathata a neurodegenerative, o ka nyolla lethal dose ho isa ho 20mg le 30mg.
Litekong tsa bongaka tsa J-147, bafo ba ne ba tla nka lethal dose hang ka mor'a ho itima lijo ka lihora tse 8.
Phapang lipakeng tsa J-147 le T-006
T-006 ke se tsoang ho J-147 nootropic. Motsoako ona o entsoe ka ho tlosa sehlopha sa methoxyphenyl sa phofo ea curcumin ea J-147 ka tetramethylpyrazine.
Ho tlatselletsa ka T-006 nako e ka etsang likhoeli tse tharo ho tla fokotsa moholi oa boko le ho phahamisa matla ka kakaretso. Ho feta moo, phofo e eketsa kutloisiso ea mantsoe 'me e etsa hore mosebelisi a khobe matšoafo. Ho fapana le hoo, liphihlelo tsa J-147 li kenyelletsa mohopolo o ntlafalitsoeng, pono le monko.
Leha ho na le liphapang tse sa reng letho, litlatsetso tse peli li na le litlamorao tse tšoanang.
Na J-147 e bolokehile ha e sebelisoa?
Lithethefatsi tsa J-147 li bolokehile. E atlehile ho feta tlhahlobo ea chefo litekong tsa liphoofolo joalo ka ha ho hlokoa ke Tsamaiso ea Lijo le Lithethefatsi (FDA). Ntle le moo, liteko tsa bongaka tsa J-147 li ntse li tsoela pele ka nako e telele.
Ha ho na litlaleho tsa litlamorao tse mpe tsa J-147 litekong tsa pele le tsa batho.
Teko ea bongaka ea J-147
Karolo ea pele ea teko ea bongaka ea J-147 e qalile mathoasong a 2019 joalo ka ha e tšehelitsoe ke Abrexa Pharmaceuticals, Inc. Morero oa phuputso e ne e le ho lekanya polokeho le mamello ea ho nka nootropic, le thepa ea eona ea pharmacokinetic lithutong tse phetseng hantle.
Phuputso ea bongaka e ne e kenyelletsa bacha le batho ba baholo. Sehlopha sa lipatlisiso se ne se laoloa ka mokhoa o ikhethileng, o foufetse habeli, hape o laoloa ka "placebo" ka litekanyetso tse le 'ngoe tse nyolohang.
Qetellong ea teko ea motho, bo-rasaense ba lokela ho theha sephetho ho latela liphello tse mpe, lebelo la pelo le morethetho, liphetoho tsa 'mele, le melemo ea J-147 tsamaisong ea methapo.
Tlhahlobo / boiphihlelo ba mosebelisi kamora ho sebelisa J-147
Tse ling tsa litlhahlobo tsa J-147 ke tsena;
Capybara e re;
“… Ho ka ba le maikutlo a matla a mangata haholo qalong. Ha se mofuta oa matla a caffeine kapa amphetamine, empa ke matla a tlhaho. Ke thabetse karolo ena kaha ke ne ke khona ho nahana ka ho etsa ho hong ho kang ho palama baesekele, ebe ke e etsa ntle le ho tsilatsila kapa ho tlameha ho ikholisa hore ke tla qala. Ke ne ke ikitlaetsa ka matla ho ikhathatsa. Sena se qhalane haholo kamora libeke tse 'maloa,' me ha ke ntse ke natefeloa ke maikutlo ana, a mang a kanna a se ke a ba joalo, ka hona ke thathamisa sena e le litlamorao tse ka bang teng. "
F5fireworks e re;
“E shebahala joaloka nootropic e khahlisang le e ts'episang. Ho bonahala ho bile le thuto ea bongaka United States selemong se fetileng. ”
Mosebelisi e mong o re;
“Ho lokile, ke e fumane maobane mme ke se ke nkile 10mg bakeng sa litekanyetso tse 3. Ke e nkile ka mokhoa o hlakileng 'me ea qhibiliha hantle haholo. Ha e latsoehe hampe. Phello ea hanghang e qalile ka potlako ho nna. Pono ea ka le kelello li ne li bonahala li leotsa ka tsela e itseng, empa ekaba feela placebo. Ha ho bonahale eka ho na le phello e mpe ho hang, empa e sa le kapele haholo ho bolela… Ke utloile ntho e ngoe le e ngoe e lokile mme ke matlafalitsoe letsatsi lohle ka 10 mg e 'ngoe hoseng hoo e ka bang ka 6 hoseng. ”
Fafner55 o re;
"Ke ntse ke tsoela pele ho sebelisa J147 ntle le molemo o mong ntle le ho fokotsa ho ruruha le ho ruruha ho boletsoeng pejana."
Moetsi oa phofo ea J-147 - Re ka reka phofo ea J-147 hokae?
Molao oa nootropic ena e ntse e le lesapo la likhang empa e ke ke ea u thibela ho fumana lihlahisoa tse nepahetseng. Ntle le moo, liteko tsa bongaka tsa J-147 Alzheimer's li ntse li tsoela pele. U ka reka phofo mabenkeleng a marang-rang ha u ntse u fumana tokelo ea ho bapisa litheko tsa J-147 ho barekisi ba fapaneng. Leha ho le joalo, o lokela ho etsa bonnete ba hore o reka ho tsoa ho barekisi ba sebetsang ba nang le liteko tsa laboratori tse ikemetseng.
Haeba u batla ho rekisoa J-147, ikopanye le k'hamphani ea rona. Re fana ka li-nootropic tse ngata tlas'a taolo ea boleng. O ka reka ka bongata kapa oa reka o le mong ho latela sepheo sa hau sa psychonautic. Ka kopo hopola hore theko ea J-147 e bonolo ha feela u reka ka kakaretso.
References
- Lapchak, AP, Bombien, R., and Rajput, SP (2013). J-147 e leng Novel Hydrazide Lead Compound ho Phekola Neurodegeneration: Ceetox TM Tlhahlobo ea Tšireletso le Genotoxicity. Leqephe la Neurology le Neurophysiology.
- Pele, M., et al. (2013). K'homphieutha ea Neurotrophic J147 e Khutlisa Bofokoli ba Temoho Litoeba tsa Boloetse ba Alzheimer's. Patlisiso le Phekolo ea Alzheimer's.
- Lithethefatsi tsa Alzheimer li Thibela Motsoako oa Powerhouse of Cell. Salk Setsi.January 8, 2018.
- Qi, Chen., Le al. (2011). Setlhare sa Novel Neurotrophic bakeng sa Ntlafatso ea Kelello le Lefu la Alzheimer's. Laeborari ea Sechaba ea Saense.
- Daugherty, DJ, le al. (2017). Sesebelisoa sa Novel Curcumin bakeng sa Phekolo ea lefu la tsoekere la lefu la tsoekere.
- Lejing, Lian., et al. (2018). Litlamorao tse kang tsa anti-depressant tsa Novel Curcumin Derivative J147: Kenyeletso ea 5-HT1A Neuropharmacology.
