Nicotinamide riboside chloride (NR-CL) (23111-00-4)

March 11, 2020

Nicotinamide riboside (NR) ke nicotinamide adenine dinucleotide (NAD +) e sa tsoa sibolloa ea vithamine. …….

 


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Nikotinamide riboside chloride (NR-CL) (23111-00-4) video

Nicotinamide riboside chloride (NR-CL) (23111-00-4) S.litšobotsi

Name Product Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Lebitso la lik'hemik'hale NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
Nomoro ea CAS 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
Smile C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Molecular Formula C11H15ClN2O5
Boima ba 'mele 290.7002
Masapo a monoisotopic 290.066949 g / mol
Melting Point N / A
Color o mosoeu
Stempage temp -20 ° C Freezer
kopo lisebelisoa tsa tlatsetso ea lijo, tšimo ea litlama

 

ke eng Nicotinamide riboside chloride(NR-CL)?

Nicotinamide riboside (NR) ke vithamine e sa tsoa sibolloa ea nicotinamide adenine dinucleotide (NAD +). Mofuta oa kristale oa NR chloride o bitsoa NIAGEN, e leng mofuta oa maiketsetso oa nicotinamide riboside le mohloli oo nicotinamide ka sebopeho sa nicotinic acid e ka bang bioavava mme ka kakaretso e nkuoa e sireletsehile (GRAS). NR chloride ke taba ea tsebiso e ncha ea motsoako oa lijo, e sebelisoang haholo ho tlatsetso ea lijo.

Nicotinamide Riboside Chloride ke motsoako oa tlhaho o fumanoang lebeseng. E hlile e amana le niacin le mefuta e meng ea vithamine B3. Bafuputsi ba bang ba fumane hore Nicotinamide Riboside Chloride e na le litšobotsi tse ikhethang tse ka matlafatsang metabolism ea motho ho thusa ho chesa likhalori tse ngata le ho thibela boima ba 'mele. Ntle le ho theola boima ba 'mele, e boetse e thusa ho matlafatsa ts'ebetso ea mesifa, ho eketsa tšebeliso ea matla le ho fokotsa lisosa tsa kotsi tsa lefu la tsoekere.

Hape, patlisiso ho batho e bontšitse hore bobeli ba Nicotinamide Riboside Chloride e phahamisa maemo a NAD +, e thusang ho tsitsisa maemo a amanang le lilemo, leha e le haufinyane haholo ho tseba hore na e tla sebetsa hantle hakae.

 

Melemo ea ho Nicotinamide riboside chloride(NR-CL)

Nicotinamide riboside chloride ke mofuta oa maiketsetso oa nicotinamide riboside, melemo ea ona / ts'ebetso e ts'oana le nicotinamide riboside. E nka karolo ho metabolism 'meleng, e ka sebelisoa ho thibela pellagra kapa lefu le leng la niacin defence le ho theola k'holeseterole le triglycerides maling. E boetse e sebelisetsoa ho theola menyetla ea ho hlaseloa ke pelo ho batho ba nang le k'holeseterole e phahameng ba seng ba bile le lefu la pelo. Ka linako tse ling e sebelisetsoa ho phekola lefu la methapo ea pelo (atherosclerosis), ho sireletsa boko le sebete (pelo, methapo, lefu la tsoekere, lefu la Alzheimer's).

Ntle le moo, chloride ea Nicotinamide riboside le eona e na le melemo e meng ho motho:

  • Ho cheka ka nepo le ho monya protheine le mafura;
  • Thusa ho fetolela troptophan ea bohlokoa ea amino acid ho niacin;
  • Fokotsa ho hlatsa, le ho fokotsa sephetho sa ho nka li-antidepressant ka lebaka la molomo o omileng le ho hloekisoa ke metsi ka thata;
  • Khothaletsa synthetic acid synthesis le ho thibela ho tsofala ha lisele le litho, ka ho etsa joalo ho fihlela sepheo sa ho liehisa botsofali;
  • Ho thothomela ha mesifa ea mesifa, ho holofala ha lehare le ho ruruha hoa letsoho le maoto;
  • Phekolo ea tlhaho ea hypometabolism le ntlafatso ea metabolism;
  • Thibelo le kalafo ea khaello ea vithamine B6;
  • Phekolo ea carpal tunnel syndrome;
  • E thusa ho theola boima ba 'mele le ho matlafatsa ts'ebetso ea mesifa.
  • Ntlafatsa 'mele ho hanela lisele tsa mofetše
  • Thibela ho se utloe ha kutlo
  • Ke diuretic ea tlhaho.
  • Ho nka tekanyetso e kholo ho ka imolla ho lemalla lithethefatsi le ho ba le phello e ntle ea detoxation.
  • Ho ntlafatsa ts'ebetso ea lisele tsa "epidermal", le tšebetso ea lisele tse ling 'meleng oa motho, ho boloka letlalo le khanya.

 

Nicotinamide riboside chloride(NR-CL) ts'ebeliso

Hobane Nicotinamide riboside chloride e na le melemo ea meriana, e sebelisoa khafetsa lijong tsa tlatsetso, meriana le tšimo ea lijo.

 

 

Tlhaloso:

  • Conze D, Brenner C, Kruger CL. Ts'ireletso le Metabolism ea Ts'ebetso ea Nako e telele ea NIAGEN (Nicotinamide Riboside Chloride) ka Teko ea Clinical ea batho ba baholo ba nang le bophelo bo botle ba sa sebetseng. Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
  • Bogan, KL, Brenner, C. (2008). "Nicotinic acid, nicotinamide, le nicotinamide riboside: tlhahlobo ea limolek'hule ea li-vithamine tsa pele ho NAD + phepo ea motho". Annu. Moruti Nutr. 28: 115-130. doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
  • Chi Y, Sauve AA (Pulungoana 2013). "Nicotinamide riboside, e nang le limatlafatsi lijong, ke vithamine B3 e nang le litlamorao ho metabolism ea matla le neuroprotection". Tlhokomelo ea Curr Opin Clinic Nutrab Metab. 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. PMID 24071780.