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N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

NACET (N-Acetylcysteine ​​ethyl ester) ke "lipophilic cell-permeable cysteine" tse fumanehang ka mokhoa o sa tloaelehang oa pharmacokinetic le ntho e makatsang… ..


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Tlhaloso

Litlhaloso tsa NACET (59587-09-6)

Name Product NACET (59587-09-6)
Lebitso la lik'hemik'hale R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, ethyl;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl;
N-Acetylcysteine ​​ethylester;
Nomoro ea CAS 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
Smile CCOC (= O) C (CS) NC (= O) C
Molecular Formula C7H13NO3S
Boima ba 'mele 191.25
Masapo a monoisotopic 191.061614 g / mol
Melting Point 44.1-44.5 ° C
Boiling Point 337.6 ± 32.0 ° C (E boletsoe esale pele)
segokanyipalo 1.138 ± 0.06 g / cm3 (E boletsoe esale pele)
Color E isang bosoeung
kopo Nootropics le lithethefatsi tse bohlale, li ka sebelisoa bakeng sa ho matlafatsa mohopolo, ho tsepamisa maikutlo, bonohe, bohlale le tšusumetso. E ka sebelisoa hape e le tlatsetso ea lijo.

ke eng NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) ke "lipophilic cell-permeable cysteine" tse fumanehang ka mokhoa o sa tloaelehang oa pharmacokinetic le monyetla o hlollang oa antioxidant. NACET e na le bioavailability e phahameng ea molomo. Ke mofuta o matla oa antioxidant hape o ruileng oa GSH, o amanang le acid ea hae ea mahala N-acetyl -L e fapana le -cysteine ​​(NAC). NACET ke phofo e tšoeu ea mocheso oa kamore mme e qhibiliha ka bolokolohi metsing le linthong tse phelang.

NAC e tsoa ho cysteine. Ho tloha ka bo-1970, esale e sebelisoa ho phekola bakuli ba nang le mathata a mangata a acetaminophen le methapo ea kutlo, 'me e rekisoa e le tlatsetso ea meriana le phepo e nepahetseng. Ha e bapisoa le NAC, NACET e na le lipophilicity e phahameng le thepa ea pharmacological e ntlafalitsoeng haholo. E na le monyetla oa ho nkela pharmacological NAC, e le moemeli oa mucolytic, antioxidant, mofani oa GSH, paracetamol antidote, le bonyane Donor ea transmitter H 2 S le moemeli oa tšireletso ea UV.

Ntle le moo, matla a ho nyopa a matla le ho fokotsa matla a NACET le tsona li pakiloe liseleng tse khubelu tsa mali tsa motho. Ho fumanoe hore e bokellana liseleng tse khubelu tsa mali tsa motho, ho hanela tšilafalo ea oxidative e bakoang ke hydroperoxides. Ka hona, menyetla ea NACET e le anti-nitrite-induction antioxidant e kholo haholo ho feta ea NAC methemoglobinemia le li-oxidant tse ling tse matla. Lipatlisiso ho likhoto li fumane hore NACET e kenella ka potlako ho feta NACET ha NACET e tsamaisoa ka molomo. E khona ho kena liseleng le ho hlahisa NAC le cysteine, e eketsang hydrogen sulfide (H (2) S) potolohong. Ke khetho e ntle bakeng sa tšebeliso ea molomo joalo ka mohlahlami oa H (2) S,

Melemo ea NACET (N-Acetylcysteine ​​ethyl ester)

E le antioxidant e nang le matla, NACET e na le melemo e meholo ho bophelo ba motho.

- Ntlafatsa maemo a mangata a bophelo bo botle le ho imolla matšoao a bokuli ba kelello;

- Phekolo ea li-overdoses tsa acetaminophen, ts'ireletso ea liphio le sebete;

- E ntlafatsa ts'ebetso ea matšoafo ka ho fokotsa ho ruruha le ho heletsa mucus, ka hona ho fokotsa maloetse a sa foleng a phefumoloho.

- Khothaletsa bophelo bo botle ba kelello ka ho laola glutamate le ho tlatselletsa glutathione, e ka sebelisoa ho phekola mafu a kang lefu la Alzheimer le lefu la Parkinson;

- Ntlafatsa tsoalo ho banna le basali

- E ka ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung a mangata, thibela tšenyo ea oxidative ea pelo, le ho fokotsa kotsi ea lefu la pelo.

- E ka tsitsisa tsoekere ea Mali ka ho fokotsa ho ruruha ho lisele tse mafura

Sesebelisoa sa NAECT (N-Acetylcysteine ​​ethyl ester)

Hobane NACET e bonts'itse litlamorao tse kholo ho bokuli ba kelello, bokuli bo sa foleng ba bokuli le bokuli ba kelello, hangata e sebelisoa e le tlatsetso ea meriana le phepo e le ho sireletsa boko, ho ntlafatsa ts'ebetso ea kelello le 'mele, e le ho ntlafatsa ts'ebetso ea mohopolo, kelello le ts'ebetso ea moatlelete.

Tlhaloso:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): buka ea lipophilic cell-permeable cysteine ​​e fumanehang ka mokhoa o sa tloaelehang oa pharmacokinetic le bokhoni bo hlollang ba antioxidant. Biochem Pharmacol. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) le N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​litlhare tse thehiloeng ho lithethefatsi tse nang le lintlha tse ikhethang tsa pharmacological bakeng sa ts'ebeliso ea molomo joalo ka NO, H2S le bafani ba GSH le joalo ka li-antioxidants: Liphetho le kakaretso. 2018 Feb; 8 (1): 1-9. Doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Tlhahlobo. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester e le GSH e ntlafatsang liseleng tsa mantlha tsa endothelial ea motho: Phuputso e bapisoang le lithethefatsi tse ling. 2018 Oct; 126: 202-209. Doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) le N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​litlhare tse thehiloeng ho litlhare tse nang le lintlha tse ikhethang tsa pharmacological bakeng sa ts'ebeliso ea molomo joalo ka NO, H2S le bafani ba GSH le joalo ka li-antioxidants: Liphetho le kakaretso. Tlaleho ea Tlhahlobo ea meriana. Moqolo oa 8, Taba ea 1, Pherekhong 2018, leqepheng la 1-9.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


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