Video ea NADP ea letsoai la disodium (24292-60-2)
salt-Nicotinamide adenine dinucleotide phosphate disodium letsoai (NADP letsoai la letsoai) Slitšobotsi
| Name Product | salt-Nicotinamide adenine dinucleotide phosphate disodium letsoai (letsoai la disodium la NADP) |
| Lebitso la lik'hemik'hale | Disodium ea NADP; Nadide phosphate disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium letsoai; |
| Nomoro ea CAS | 24292-60-2 |
| InChIKey | TLHOKOMELANG-LITLHOTSE-WUEGHLCSSA-L |
| Smile | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+] |
| Molecular Formula | C21H26N7Na2O17P3 |
| Boima ba 'mele | 787.37 |
| Masapo a monoisotopic | 787.039342 g / mol |
| Melting Point | 175-178 ° C |
| Color | Yellow |
| Stempage temp | -20 ° C |
| metsi Solubility | > 50 g / L. |
| kopo | Coenzyme ka li-oxidations tsa aerobic le anaerobic |
Β-Nicotinamide adenine dinucleotide phosphate disodium letsoai (letsoai la NADP disodium) ke eng?
Nicotinamide adenine dinucleotide phosphate (NADP +) ke cofactor e sebelisitsoeng liketsong tsa anabolic. salt-Nicotinamide adenine dinucleotide phosphate disodium letsoai ke letsoai le nang le disodium ea NADP +, ke coenzyme e hlokahalang bakeng sa ho belisa joala ha tsoekere le dehydrogenation ea oxidative ea lintho tse ling. 'Me e hlaha haholo lithong tse phelang, haholo sebeteng.
Nicotinamide adenine dinucleotide phosphate (NADP) le NADPH ba etsa mofuta oa redox. Tekanyo ea NADPH / NADP e laola bokhoni ba redox ea intracellular, haholo-holo karabelo ea anaerobic, ka hona e ama karabelo ea metabolic 'meleng. Mehlala ke lipid le syntic acid synthesis. NADP hape ke li-coenzyme tse peli ka har'a li-system tse fapaneng tsa cytochrome P450 le oxidase / reductase reaction system tse kang thioredoxin reductase / thioredoxin system.
NADPH e fana ka phokotseho e lekanang ea karabelo ea biosynthetic hape e fana ka litlamorao tsa redox ho thibela kotsi ea mefuta ea oksijene e sebetsang (ROS), ka hona e nchafatsa glutathione (GSH). E boetse e sebelisoa litseleng tsa anabolic tse kang cholesterol synthesis le ho eketsoa ha mafura a acid.
Ntle le moo, Sisteme ea NADPH e boetse e ikarabella bakeng sa ho hlahisa li-radicals tsa mahala liseleng tsa 'mele tsa ho itšireletsa mafung ka NADPH oxidase. Li-radicals tsena tsa mahala li sebelisetsoa ho senya likokoana-hloko ka mokhoa o bitsoang phefumoloho. Ke phapang e lekanang le mohloli oa li-aromatics tsa cytochrome P450 hydroxylated, li-steroid, li-alcohols le lithethefatsi.
kopo ea β-Nicotinamide adenine dinucleotide phosphate disodium letsoai
Nicotinamide adenine dinucleotide phosphate (NADP) le NADPH ba etsa mofuta oa redox. NADP / NADPH ke coenzyme e tšehetsang maikutlo a redox ka ho tsamaisa lielektrone ka bongata ba lits'ebetso, haholo-holo karabelo ea anaerobic e kang lipid le syntic acid synthesis. NADP / NADPH ke banyalani ba Coenzyme ka har'a li-system tse fapaneng tsa cytochrome P450 le oxidase / reductase reaction system, joalo ka thioredoxin reductase / thioredoxin system.
Li-enzyme tse ling tse sebelisang NADP joalo ka coenzyme ke: Alcohol dehydrogenase: NADP e itšetlehileng ka eona; Adomatic ADH: Ho latela NADP; Ffereoxin-NADP reductase; L-Fucose dehydrogenase; Sebaka sa polokelo ea litaba; Galactose-1-phosphate uridyl e fetisoang; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP e ikhethang; Isocitric dehydrogenase; Li-enzyme tsa Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase le Succinic semialdehyde dehydrogenase.
Tlhaloso:
- Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism e Tšehetsa Leseli le Nang le Boemo ba Li-NADP Limeleng. Mofuta oa Semela oa Front. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
- Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Mofuta oa lefuba ke chefo ea NAD + le NADP + glycohydrolase e nang le thepa e ikhethang ea enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
- Liang J, Huang H, Wang S. Distribution, Evolution, Catalytic Mechanism, le Mesebetsi ea 'mele ea Flavin-based Electron-Bifurcating NADH-Dependent Feduoxin: NADP + Oxidoreductase. Bokapele ba Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
- Kawai S, Murata K. "Sebopeho le ts'ebetso ea NAD kinase le NADP phosphatase: li-enzyme tsa bohlokoa tse laolang botsitso ba li-intracellular tsa NAD (H) le NADP (H)". Bioscience, Biotechnology, le Biochemistry. 72 (4): 919-30. doi: 10.1271 / bbb.70738. PMID 18391451.
- Hanukoglu I. "Tlhokomelo ea Li-Enzyme-Coenzyme Interfaces ho FAD le NADP Binding Adrenodoxin Reductase-A Enzyme e Tloaelehileng". Leqephe la Phetoho ea Limolek'hule. 85 (5-6): 205–218. Bibcode: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9. PMID 29177972.
