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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) ke agoist ea endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha). Ke …… ..


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Litlhaloso tsa Oleoylethanolamide (OEA) (111-58-0) Litlhaloso

Name Product Oleoylethanolamide (OEA)
Lebitso la lik'hemik'hale n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

Nomoro ea CAS 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
Smile CCCCCCCCC = CCCCCCCCC (= O) NCCO
Molecular Formula C20H39NO2
Boima ba 'mele 325.5 g / mol
Masapo a monoisotopic 325.537 g · molâ'1
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
Boiling Point 496.4 ± 38.0 ° C (E boletsoe esale pele)
segokanyipalo 0.915 ± 0.06 g / cm3 (E boletsoe esale pele)
Color White
Stempage temp -20 ° C
Solubility ho ethanol le DMSO Sesola
kopo Sebaka sa Phamaceutical; limenyemenye;

Oleoylethanolamide (OEA) ke eng?

Oleoylethanolamide (OEA) ke agoist ea endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha). Ke glycolamide lipid ka tlhaho e nang le thepa e fapaneng ea homeostasis e fapaneng le taolo ea takatso ea lijo, mesebetsi e khahlanong le ho ruruha, ho tsosa lipolysis le mafura a oxidation. Oleoylethanolamide e ka nkoa e le hormone ea mokokotlo oa mokokotlo oa mokokotlo. Oatmeal, linate le phofo ea cocoa ke mehloli e meholo ea lijo tsa Oleoylethanolamide lijong. Leha ho le joalo, palo ea Oleoylethanolamide e fumanoang lijong tsena e tlase (e tlase ho 2 µg / g).

Joalo ka ha e le bioloji e sebetsang ea lipid e mahareng, oleylethanolamide (OEA) e hlahisoa ka mpeng le liseleng tse ling, 'me e ameha taolong ea tekanyetso ea matla a mammalian, ho laola tšebeliso ea lijo le lipid metabolism, joalo ka ha e ka laola lijo tsa Vertebrate le boima ba' mele. Oleoylethanolamide ke mafura a acid ethanolamide (FAE), analog e nang le monounsaturated ea endocannabinoid arachidonic acid ethanolamide (anandamide), le mohanyetsi ea sebetsang oa anandamide. Hoa bohlokoa ho hlokomela hore Oleoylethanolamide e fapane le anandamide, e ikemetse ka cannabinoid receptor, mme e fana ka ts'ebetso ea eona ea tlhaho ka litsela tse ling, e laola ts'ebetso ea PPAR-α ho susumetsa lipolysis. Oleoylethanolamide ke lithethefatsi tse ka bang teng ntle le tse sireletsehileng tse khahlanong le botenya tse nkang mohanyetsi oa CB1.

Boithuto ba preclinical bo bonts'itse hore Oleoylethanolamide le eona ke sesebelisoa se sebetsang sa anti-inflammatory le antioxidant se fanang ka litlamorao tsa neuroprotective ho joala. Tsamaiso ea Exo native ea Oleoylethanolamide e ka thibela hantle li-cascades tse nooang ke TLR4, ka ho etsa joalo, ea fokotsa phallo ea khatello ea methapo ea methapo, "oxidative" le khatello ea methapo, 'me qetellong ea thibela ts'abo ea methapo ho methapo ea methapo.

Oleoylethanolamide (OEA) e sebetsa ka eng?

Ho batho ba batenya, OEA e ka laola homeostasis ea matla le takatso ea lijo haholo ka ts'ebetso ea li-receptor tse fapaneng ho kenyelletsa proximal proliferator-activated receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) le receptor e fumanehang ea nakoana cation chiteshi ka V (TRPV1). Ehlile, OEA e kenya tšebetsong li-receptor tsena le ho lieha ho qala lijo, e fokotsa boholo ba lijo, e fokotse linako lipakeng tsa lijo mme qetellong e fetole boima ba 'mele.

Ho feta moo, liphuputso tse ling tsa liteko li bonts'a hore OEA e hatella polelo ea IL-6, interleukin-8 (IL-8), methapo ea methapo ea methapo ea methapo-1 (ICAM-1) le vasellion cell adhesion molecule-1 (VCAM-1) ho TNF -Ie kenyellelitse ho ruruha liseleng tsa motho tsa maqhubu a methapo ea kutlo ka ts'ebetso ea li-receptor tsa ts'oaetso. OEA e boetse e thibetse tsela ea nyutlelie kappa-B (NF-kB) 'meleng. Patlisisong ea YT et al, OEA (50 µmol / L) e thibelitse polelo ea TNF-α e hlahisang polelo ea VCAM-1 e HUVEC.

Melemo ea Oleoylethanolamide (OEA)

Ha e le inhibitor ea ceramidase, agonist ea endo native ea GPR119 receptor, Oleoylethanolamide e sebetsa khahlano le mafu a neurodegenerative, anti-atherosclerosis, apoptosis, liphallelo tsa bohloko, metabolid ea lipid e ntlafalitsoeng, le lisele tse ka seleng ea islet β. Tšireletso le mafu a mang a metabolic a na le phello e ntle ea tšireletso. Ntle le moo, e ka fokotsa mafura a 'mele ka ho laola takatso ea lijo, ho laola boima ba' mele le ho fihlella boima ba 'mele. Oleoylethanolamide e boetse e na le bokhoni ba ho fokotsa ho ruruha le maemo a tlase a cholesterol.

Ts'ebeliso ea Oleoylethanolamide (OEA)

  • Phamaceutical tšimo lijo tsa manane a lijo
  • Gaetani S, Oveisi F, Piomelli D (2003). "Modular ea phetoho ea lijo ka har'a Rate ka moemeli oa lipid mediid oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Taolo ea karolelano ea lijo ke oleoylethanolamine". Sele. Mol. Bophelo ba Saense. 62 (6): 708–16. Doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Dani Piomelli (2005-12-22). "Keketseho ea postprandial ea oleoylethanolamine mobilization ka mpeng e nyane ea Burmese python (Python molurus)". Am J Physiol Regul integrated Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Lwetse 2008). "Karolo ea li-endocannabinoids le lipapatso tsa bona bothateng le mathata a ho ja". E-ja boima ba 'mele. 13 (3): e42-8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: litlamorao ho li-transmitter tsa hypothalamic le li-peptide tse laolang ho ja lijo. Neuropharmacology. (2011)

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