Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020
SKU: 16589-24-5
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Oleoylethanolamide (OEA) ke agoist ea endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha). Ke …… ..


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Oleoylethanolamide (OEA) (111-58-0) video

Litlhaloso tsa Oleoylethanolamide (OEA) (111-58-0) Litlhaloso

Name Product Oleoylethanolamide (OEA) phofo
Lebitso la lik'hemik'hale n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

Nomoro ea CAS 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
Smile CCCCCCCCC = CCCCCCCCC (= O) NCCO
Molecular Formula C20H39NO2
Boima ba 'mele 325.5 g / mol
Masapo a monoisotopic 325.537 g · molâ'1
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
Boiling Point 496.4 ± 38.0 ° C (E boletsoe esale pele)
segokanyipalo 0.915 ± 0.06 g / cm3 (E boletsoe esale pele)
Color Pula e tšoeu
Stempage temp -20 ° C
Solubility ho ethanol le DMSO Sesola
kopo Sebaka sa Phamaceutical; limenyemenye;

Overview

Oleoylethanolamide (OEA) kapa N-Oleoylethanolamide (OEA) ke molek'hule e hlahisoang 'meleng, hangata e fumanoang ka mala. Bopaki bo ntseng bo eketseha bo fana ka maikutlo a hore OEA e ka sebetsa e le sesosa sa ts'ebetso ea methapo le ho nka karolo taolong ea boits'oaro bo amanang le moputso. Hape, e hlalositsoe e le moemeli ea sebetsang ea sa feleng ea fokotsang takatso ea lijo le boima ba 'mele.

Oleoylethanolamide (OEA) ke eng?

Oleoylethanolamide (OEA) ke agoist ea endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha). Ke glycolamide lipid ka tlhaho e nang le thepa e fapaneng ea homeostasis e fapaneng le taolo ea takatso ea lijo, mesebetsi e khahlanong le ho ruruha, ho tsosa lipolysis le mafura a oxidation. Oleoylethanolamide e ka nkoa e le hormone ea mokokotlo oa mokokotlo oa mokokotlo. Oatmeal, linate le phofo ea cocoa ke mehloli e meholo ea lijo tsa Oleoylethanolamide lijong. Leha ho le joalo, palo ea Oleoylethanolamide e fumanoang lijong tsena e tlase (e tlase ho 2 µg / g).

Joalo ka ha e le bioloji e sebetsang ea lipid e mahareng, oleylethanolamide (OEA) e hlahisoa ka mpeng le liseleng tse ling, 'me e ameha taolong ea tekanyetso ea matla a mammalian, ho laola tšebeliso ea lijo le lipid metabolism, joalo ka ha e ka laola lijo tsa Vertebrate le boima ba' mele. Oleoylethanolamide ke mafura a acid ethanolamide (FAE), analog e nang le monounsaturated ea endocannabinoid arachidonic acid ethanolamide (anandamide), le mohanyetsi ea sebetsang oa anandamide. Hoa bohlokoa ho hlokomela hore Oleoylethanolamide e fapane le anandamide, e ikemetse ka cannabinoid receptor, mme e fana ka ts'ebetso ea eona ea tlhaho ka litsela tse ling, e laola ts'ebetso ea PPAR-α ho susumetsa lipolysis. Oleoylethanolamide ke lithethefatsi tse ka bang teng ntle le tse sireletsehileng tse khahlanong le botenya tse nkang mohanyetsi oa CB1.

Boithuto ba preclinical bo bonts'itse hore Oleoylethanolamide le eona ke sesebelisoa se sebetsang sa anti-inflammatory le antioxidant se fanang ka litlamorao tsa neuroprotective ho joala. Tsamaiso ea Exo native ea Oleoylethanolamide e ka thibela hantle li-cascades tse nooang ke TLR4, ka ho etsa joalo, ea fokotsa phallo ea khatello ea methapo ea methapo, "oxidative" le khatello ea methapo, 'me qetellong ea thibela ts'abo ea methapo ho methapo ea methapo.

Mehloli ea Oleoylethanolamide (OEA)

Ho na le mehloli e 'meli ea ho fumana Oleoylethanolamide (OEA), e' ngoe e tsoa ho limela tsa tlhaho, 'me e' ngoe e entsoe ka lebitso la Labobeli.

Achyranthes Aspera, ea hlahetseng India, China le linaha tse ling tse ngata tsa Asia, ho thoe o na le Oleoylethanolamide OEA. Bothata ba Oleoylethanolamide ea tlhaho-e nang le tlhaho ke hore ho na le karo-karolelano feela e fumanehang, 15: 1 ke mofuta o tsebahalang, 'me ha o na matla joalo ka ha bareki kapa baetsi ba tlatsetso ba lebelletse. Ke 'nete hore e ka ba holimo, empa litšenyehelo li tla ba holimo haholo, ka hona ha ho na thuso ho etsa Oleoylethanolamide OEA ea tlhaho ka bongata.

Mohloli o ka sehloohong oa Oleoylethanolamide o entsoe ho tloha oleic acid, e sebelisitsoeng e le moetapele oa N-oleoyl-phosphatidylethanolamine, eo ka nako eo e hlakotsoeng ke N-acyl-phosphatidylethanolamine-selection phospholipase D (PLD) ho lokolla Oleoylethanolamide OEA.

Oleoylethanolamide ke metabolite ea tlhaho ea oleic acid. Ka hona, lijo tse nang le oleic acid ke mohloli o tobileng oa OEA.

Oleoylethanolamide (OEA) e sebetsa joang?

Ho batho ba batenya, OEA e ka laola homeostasis ea matla le takatso ea lijo haholo ka ts'ebetso ea li-receptor tse fapaneng ho kenyelletsa proximal proliferator-activated receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) le receptor e fumanehang ea nakoana cation chiteshi ka V (TRPV1). Ehlile, OEA e kenya tšebetsong li-receptor tsena le ho lieha ho qala lijo, e fokotsa boholo ba lijo, e fokotse linako lipakeng tsa lijo mme qetellong e fetole boima ba 'mele.

Ho feta moo, liphuputso tse ling tsa liteko li bonts'a hore OEA e hatella polelo ea IL-6, interleukin-8 (IL-8), methapo ea methapo ea methapo ea methapo-1 (ICAM-1) le vasellion cell adhesion molecule-1 (VCAM-1) ho TNF -Ie kenyellelitse ho ruruha liseleng tsa motho tsa maqhubu a methapo ea kutlo ka ts'ebetso ea li-receptor tsa ts'oaetso. OEA e boetse e thibetse tsela ea nyutlelie kappa-B (NF-kB) 'meleng. Patlisisong ea YT et al, OEA (50 µmol / L) e thibelitse polelo ea TNF-α e hlahisang polelo ea VCAM-1 e HUVEC.

Melemo ea Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) phofo e ntle ho fokotsa boima ba 'mele joaloka takatso ea taolo ea lijo' me e ts'ehetsa maemo a cholesterol a phetseng hantle ho batho ba baholo.

Oleoylethanolamide (OEA) e le khatello ea khatello ea Appetite

Ho hatella takatso ea lijo mme ka hona ho fokotsa takatso ea lijo ke tsela e sebetsang ea ho laola matla le boima ba 'mele. Kaha khatello ea takatso ea lijo ke sebaka se ka sehloohong se laolang matla a lijo (lijo), ho laola takatso ea lijo ho bohlokoa ho laola boima ba 'mele bo nepahetseng, haholo-holo ha bo kopantsoe le likhetho tsa bophelo bo botle tse kenyelletsang ho ja lijo tse nepahetseng, tlatsetso ea lijo le boikoetliso.

Tlatsetso ea Oleoylethanolamide e thusa ho laola metabolism ea lipid, e thusa ho laola tlala ka ho romela melaetsa ea takatso ea takatso ho bokong mme e bonts'itsoe ho thusa ho fokotsa maemo a triglyceride le a cholesterol ea mali.

Oleoylethanolamide bakeng sa taolo ea mafura a 'mele

OEA ke mokhoa o sireletsehileng haholo oa ho laola takatso ea lijo le tšebeliso ea matla.

Litlamorao tsa OEA li ile tsa ithutoa pele hobane li arolelana ho ts'oana le lik'hemik'hale tse ling, cannabinoid e tsejoang e le anandamide. Li-cannabinoids li amana le semela Cannabis, mme li -amcode tse teng semeleng (le matekoane) li ka holisa takatso ea motho ea ho ts'oasa ka ho baka karabelo ea ho fepa. Ho latela Wikipedia, Oleoylethanolamide ke analogue ea monounsaturated ea endocannabinoid anandamide. Le ha OEA e na le sebopeho sa lik'hemik'hale se ts'oanang le anandamide, litlamorao tsa ho ja le taolo ea boima ba 'mele li fapane. Ho fapana le anandamide, OEA e sebetsa ka mokhoa o ikemetseng oa tsela ea cannabinoid, e laolang mosebetsi oa PPAR-α ho hlohlelletsa lipolysis.

Oleoylethanolamide bodybuilding

Motho e mong le e mong o batla bophelo bo botle ka ho haha ​​'mele boikoetlisong. OEA e ntse e ratoa haholo ke lihahi tsa 'mele. Masimong a tlatsanang le li-supplement tsa mmele, TTA (tetradecylthioacetic acid) hangata e sebelisoa ka mokhoa o kopaneng le oleoylethanolamide (OEA) tseo ka bobeli li thusang ho chesa mafura le ho fokotsa tlala. TTA e kanna ea ts'episa haholo har'a li-supplement tsa anti-mafura, hobane e bonahala e chesa mafura a ikemtseng ka boikoetliso; Liphetho tsa pele li fana ka maikutlo a hore mmele o bonahala o "tlosa" mafura ho e-na le ho o hloka hore o chese ka ho ikoetlisa.

Oleoylethanolamide (OEA) e fokotsa triglycerides le cholesterol, mme, e kopantsoe le mohanyetsi oa cannabinoid, e thibela boima ba 'mele mme e ntlafatsa dyslipidaemia mehlaleng ea liphoofolo tsa botena.

Ntle le moo, tsamaiso ea systemic ea oleoylethanolamide e fumanoe e le ho fetolela homeostasis ea glucose, hammoho le ho lokolloa ha insulin le ho tšoaetsoa ha insulin ho li-hepatocytes le adipocytes.

Rereearch e 'ngoe e bontša hore tlatsetso ea oleoylethanolamide e na le litlamorao tse ntle ho tšoenyeha,' me ho hlokahala litsela le bopaki bo eketsehileng ho tšehetsa.

Mokhoa oa ho sebelisa Oleoylethanolamide OEA

Oleoylethanolamide litlamorao

Oleoylethanolamide OEA e batla e le ncha 'marakeng oa tlatsetso,' me ha ho litlamorao tse mpe tse tlalehiloeng. Tsamaiso ea Lijo le Lithethefatsi ea US (FDA) e ne e sena lipelaelo mabapi le polokeho ea OEA. Bophelong ba letsatsi le letsatsi, oleoylethanolamide ke mokhoa o sireletsehileng oa ho theola boima ba 'mele, o sebelisetsoang ho lekola tekanyo ea catabolism ka mpeng ea gastro-intestinal, ho thusa ho fokotsa mafura ntle le litlamorao tse sa lebelloang.

Oleoylethanolamide tekanyo

Ha ho na moriana o khothalletsoang phatlalatsa bakeng sa oleoylethanolamide kaha litlatsetso tsa oleoylethanolamide li ntse li sa ratoa haholo ebile li le qalong. RiduZone e bile phofo ea pele ea OEA ho hlahisoa ka selemo sa 2015.

Mofuta o khothalletsoang oa oleoylethanolamide ke capsule e le 'ngoe ea 200mg ha e nkuoa ntle le motsoako

Patlisiso e fana ka maikutlo a hore u ka fokotsa kapa u eketsa litekanyetso tsa letsatsi le letsatsi ho latela boima ba 'mele oa hau.

100mg bakeng sa motho ea 150lb

145mg bakeng sa motho ea 200lb

180mg bakeng sa motho ea 250lb

Kopo ea Oleoylethanolamide (OEA)

Oleoylethanolamide phofo e sebelisitse ho tlatsetso ea Tlhokomelo ea bophelo bo botle, e entsoeng ka har'a komporo e thata kapa letlapa bakeng sa tahlehelo ea Weight.

Tlhaloso:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Modular ea phetoho ea lijo ka har'a Rate ka moemeli oa lipid mediid oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Taolo ea karolelano ea lijo ke oleoylethanolamine". Sele. Mol. Bophelo ba Saense. 62 (6): 708–16. Doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Dani Piomelli (2005-12-22). "Keketseho ea postprandial ea oleoylethanolamine mobilization ka mpeng e nyane ea Burmese python (Python molurus)". Am J Physiol Regul integrated Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Lwetse 2008). "Karolo ea li-endocannabinoids le lipapatso tsa bona bothateng le mathata a ho ja". E-ja boima ba 'mele. 13 (3): e42-8. PMID 19011363.

  • Serrano A, et al. Oleoylethanolamide: litlamorao ho li-transmitter tsa hypothalamic le li-peptide tse laolang ho ja lijo. Neuropharmacology. (2011)

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.