Ganglioside GT1b (59247-13-1)

March 15, 2020

Lebitso Ganglioside le sebelisitsoe ka lekhetlo la pele ke rasaense oa Mojeremane Ernst Klenk ka 1942 ho lipids tse sa tsoa itšehla thajana tse tsoang liseleng tsa "ganglion brain" ..

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum

 

Video ea Ganglioside GT1b (59247-13-1)

Ganglioside GT1b Slitšobotsi

Name Product Ganglioside GT1b
Lebitso la lik'hemik'hale GANGLIOSIDE GT1B TRISODIUM LETSOAI; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + LETSOAI); ganglioside, gt1; (ganglioside gt1B) ho tsoa bokong ba likhomo; trisialoganglioside-gt1b e tsoang bokong ba likhomo; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (letsoai la NH4 +)
Nomoro ea CAS 59247-13-1
InChIKey EA-XNUMX-SDF
Molecular Formula C95H162N5Na3O47
Boima ba 'mele 2158.4 g / mol
Masapo a monoisotopic 2157.119189 g / mol
Melting Point N / A
Stempage temp -20 ° C
Solubility DMSO: qhibilihang
kopo Bongaka; chromatography;

 

ke eng Ganglioside GT1b?

Lebitso Ganglioside le sebelisitsoe ka lekhetlo la pele ke rasaense oa Mojeremane Ernst Klenk ka 1942 ho lipids tse sa tsoa ikhetholla tse tsoang liseleng tsa bokokoane ba boko. Ke molek'hule e entsoeng ka glycosphingolipids (ceramide le oligosaccharides) le sialic acid e le 'ngoe kapa ho feta e hokahantsoeng le ketane ea tsoekere. Ke karolo ea lera la cytoplasmic le laolang liketsahalo tsa phetiso ea lisele tsa cellular. Ho tsejoa mefuta e fetang 60 ea li-gangliosides, mme phapang e kholo lipakeng tsa bona ke boemo le palo ea masala a NANA.

Ganglioside GT1b ke e 'ngoe ea li-ganglioside' me ke trisialic ganglioside e nang le masalla a sialic acid a kopantsoeng le yuniti ea galactose e ka hare. E na le tšusumetso e thibelang karabelo ea 'mele ea ho itšireletsa mafung. Ho 0.1-10 μM, e ka thibela tlhahiso e itlelang feela ea IgG, IgM le IgA ke lisele tsa mali tsa mononuclear tsa motho. Ganglioside GT1b le eona e hlahisitsoe e le moamoheli oa lisele tse amohelang vaerkel cell polyoma virus ebile e le mokhoa oa ho baka tšoaetso e bakang Merkel cell carcinoma.

Ganglioside GT1b e boetse e kenelletse liseleng tse 'maloa tsa methapo ea methapo' me e nkuoa e le sehlopha sa litlokotsebe se amanang le metastases ea boko. Boithuto bo fumane hore GM1, GD1a, le GT1b li na le litlamorao tse sitisang ho hlaha ha li-epidermal factor factor receptor signing and adhesion and migration of keratinocyte, 'me boteng ba tsona e kanna ea ba biomarker e sebetsang bakeng sa ho lekola bokhoni ba boko ba metastatic.

Ganglioside GT1b le eona e ama sesole sa 'mele. Ganglioside GT1b e na le litlamorao tse thibelang 'mele oa motho ho itšireletsa mafung ebile e thibela li-immunoglobulin tse hlahisoang ke lisele tsa mali tsa mononuclear. Ho na le bopaki ba hore GD1b, GT1b, le GQ1b li ka ntlafatsa tlhahiso ea li-cytokine tsa Th1 ka ho thibela ts'ebetso ea adenylate cyclase, ha e ntse e thibela tlhahiso ea Th2.

Joaloka receptor e amohelang chefo e fapaneng ea sebopeho sa eona sa oligosaccharide, ganglioside GT1b ke receptor eo ka eona Clostridium botulinum bacterium botulinum neurotoxin e kenang lisele tsa methapo. Boithuto bo bontšitse hore tahi ea tetanus e kena liseleng tsa methapo ka ho ikopanya le GT1b le li-gangliosides tse ling, e thibela ho ntšoa ha li-neurotransmitters tsamaisong ea methapo ea kutlo, 'me e baka ho holofala ha lehare. Mofuta oa botulinum C oa neurotoxin o kenang methapong o fuputse phello e ka 'nang ea apoptotic ea lisele tse hlahisoang ke ganglioside GT1b e tlamang neuroblastoma.

Ntle le moo, ganglioside GT1b e laola ho tsamaisoa ha lisele, ho kenella le ho khomarela fibronectin (FN) ka ho sebelisana ka ho toba le limolek'hule le α5 subunit ea α5β1 inclin, e ka fumanoang e ka sebelisoang ho nts'etsapele kalafo ea mofets'e. Ho kopana ha GT1b le MAG holim 'a li-neuron ka hona ho ka laola ho sebelisana ha GT1b ka membrane ea plasma ea neurons, e hlahisang thibelo ea kholo ea methapo.

 

Melemo ea Ganglioside GT1b

Ganglioside GT1b ke acid e bitsoang glycosphingolipid e etsang metsoako ea lipid liseleng tsa methapo ea methapo ea methapo ea kutlo mme e ameha ho atoloseng lisele, phapang, khokahano, phetiso ea matšoao, tšebelisano ea sele le cell, tumorigenesis le metastasis.

Likarabo tsa autoimmune ho li-gangliosides li ka lebisa ho lefu la Guillain-Barre. Ganglioside GT1b e baka ho senyeha ha dopaminergic neuron, e ka tlatsetsang ho qaleng kapa nts'etsopele ea lefu la Parkinson.

Ganglioside GT1b ke scavenger ea • li-radicals tsa mahala tsa OH, tse sirelletsang boko ho tsoa tšenyo ea mtDNA, ho ts'oaroa le lipid peroxidation e hlahisoang ke lijenereithara tse sebetsang tsa oksijene.

Li-tumor tsa Ehrlich li hlahisa ganglioside GT1b, mme anti-GT1b e na le monyetla o moholo oa kalafo bakeng sa mofetše ona. Sehlopha sena sa litlokotsebe se boetse se amana le lefu la Miller Fisher.

 

Litla-morao tsa Ganglioside GT1b

Li-Gangliosides li ka tlama lectins, li sebetsa joalo ka li-receptor tsa sesole sa mmele le khokahano ea lisele, li nka karolo ho saena hoa sele, carcinogeneis le phapano ea lisele, li ama popeho ea placenta le kholo ea methapo, li nka karolo ho tsitsipaneng ea myelin le ho nchafala hoa methapo, le ho sebetsa joalo ka likokoana-hloko le ho kenella ha chefo liseleng. .

Ho bokelloa ha ganglioside GT1b ho hokahane le mafu a 'maloa ho kenyeletsa lefu la Thai-Sachs le lefu la Sandhof.

Ganglioside GT1b e thibela karabelo ea ho ata ha sele ea antigen kapa mitogen mme e fumanoe e le mokelikeli oa chefo ea botulinum, chefo e sa tloaelehang e nang le litlamorao tse mpe tsa mmele.

Ganglioside GT1b e fumaneha feela ka har'a lisele tsa methapo mme e hlahisoa ho adventitia. GT1b e khothaletsa phapang ea methapo ea kutlo le sebopeho sa dendritic, e hlahisang boits'oaro bo kotsi mme e ntlafatsa hyperalgesia le allodynia.

Ganglioside GT1b e ka ama sesole sa 'mele. E na le tšusumetso e thibelang karabelo ea 'mele ea motho ea boits'oaro mme e thibela immunoglobulin e hlahisoang ke lisele tsa mali tsa mononuclear tsa mali.

Ho phaella moo, Ganglioside GT1b e amana le mafu a latelang: ntaramane, guillain – garré syndrome, k'holera, tetanus, botulism, lepera le botenya.

 

Tlhaloso:

  • Erickson, KD, Garcea, RL, le Tsai, B. Ganglioside GT1b ke sebaka se amohelang sebaka sa Merokel cell polyomavirus. Tlaleho ea Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., le Tamaki, K. Ganglioside GT1b e hatella tlhahiso ea immunoglobulin ke lisele tsa mali tsa nyutlelie ea mali. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, le Ringler, NJ Binding ea botulinum le tetanus neurotoxins ho ganglioside GT1b le derivatives tsa eona. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Li-gangliosides, sebopeho, ketsahalo, biology le tlhahlobo ”. Laebrari ea Lipid. Mokhatlo oa American Chemists 'Society. E bolokiloe ho tloha mantlha ka 2009-12-17.
  • Nicole Gaude, Koranta ea Biology Chemistry, Moq. 279: 33 maq. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, jj Biosynthesis ea li-gangliosides tse kholo tsa boko GD1a le GT1b. Glycobiology, Buka ea 22, Khatiso ea 10, Mphalane 2012, Maqephe 1289–