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Ganglioside GT1b (59247-13-1)

Lebitso Ganglioside le qalile la sebelisoa ke rasaense oa Mojeremane Ernst Klenk ka 1942 ho fihlela lipids tse ncha tse tsoang liseleng tsa maqhubu a boko ...


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Ganglioside GT1b Slitšobotsi

Name Product Ganglioside GT1b
Lebitso la lik'hemik'hale GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) ho tsoa bokong ba bovine; trisialoganglioside-gt1b ho tsoa bokong ba bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + letsoai)
Nomoro ea CAS 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
Molecular Formula C95H162N5Na3O47
Boima ba 'mele 2158.4 g / mol
Masapo a monoisotopic 2157.119189 g / mol
Melting Point N / A
Stempage temp -20 ° C
Solubility DMSO: qhibilihang
kopo Bongaka; chromatography;

ke eng Ganglioside GT1b?

Lebitso Ganglioside le qalile la sebelisoa ke rasaense oa Mojeremane Ernst Klenk ka 1942 ho fihlela lipids tse ncha tse tsoang liseleng tsa boko tsa maqhubu. Ke molek'hule e nang le li-glycosphingolipids (ceramides le oligosaccharides) le asiti e le 'ngoe kapa tse ngata tse hokahaneng le ketane ea tsoekere. Ke karolo ea cytoplasmic membrane e laolang liketsahalo tsa phapanyetsano ea li-cellular. Ho feta mefuta ea 60 ea li-gangliosides, 'me phapang e kholo lipakeng tsa tsona ke maemo le palo ea masala a NANA.

Ganglioside GT1b ke e 'ngoe ea li-ganglioside tse ngata mme ke sehlopha sa likhukhuni sa trisialic se nang le masala a mabeli a sialic acid a hokahaneng le yuniti e kahare ea galactose. E na le phello e thibelang karabelo ea 'mele ea motho ea ho itšireletsa mafung. Ho 0.1-10 μM, e ka thibela tlhahiso e ikemetseng ea IgG, IgM le IgA ke lisele tsa mali tsa nyutlelie ea motho. Ganglioside GT1b e boetse e hlahisitsoe e le receptor ea cell cell bakeng sa vaerase ea Merkel cell polyoma mme e le mokhoa o ka etsang ho tsosa mafu a bakang Merkel cell carcinoma.

Ganglioside GT1b e boetse e kenelletse liseleng tse 'maloa tsa methapo ea methapo' me e nkuoa e le sehlopha sa litlokotsebe se amanang le metastases ea boko. Boithuto bo fumane hore GM1, GD1a, le GT1b li na le litlamorao tse sitisang ho hlaha ha li-epidermal factor factor receptor signing and adhesion and migration of keratinocyte, 'me boteng ba tsona e kanna ea ba biomarker e sebetsang bakeng sa ho lekola bokhoni ba boko ba metastatic.

Ganglioside GT1b e boetse e ama sesole sa 'mele. Ganglioside GT1b e na le litlamorao tse sitisang karabelo ea 'mele ea motho ea ho itšireletsa mafung' me e thibela li-immunoglobulin tse hlahisoang ke lisele tsa mali tsa nyutlelie tsa mali tsa motho. Ho na le bopaki ba hore GD1b, GT1b, le GQ1b li ka ntlafatsa tlhahiso ea li-cytokine tsa Th1 ka ho thibela ts'ebetso ea adenylate cyclase, ha e ntse e thibela tlhahiso ea Th2.

Joaloka receptor e amohelang chefo e fapaneng ea sebopeho sa eona sa oligosaccharide, ganglioside GT1b ke receptor eo ka eona Clostridium botulinum bacterium botulinum neurotoxin e kenang lisele tsa methapo. Boithuto bo bontšitse hore tahi ea tetanus e kena liseleng tsa methapo ka ho ikopanya le GT1b le li-gangliosides tse ling, e thibela ho ntšoa ha li-neurotransmitters tsamaisong ea methapo ea kutlo, 'me e baka ho holofala ha lehare. Mofuta oa botulinum C oa neurotoxin o kenang methapong o fuputse phello e ka 'nang ea apoptotic ea lisele tse hlahisoang ke ganglioside GT1b e tlamang neuroblastoma.

Ntle le moo, ganglioside GT1b e laola ho tsamaisoa ha lisele, ho kenella le ho khomarela fibronectin (FN) ka ho sebelisana ka ho toba le limolek'hule le α5 subunit ea α5β1 inclin, e ka fumanoang e ka sebelisoang ho nts'etsapele kalafo ea mofets'e. Ho kopana ha GT1b le MAG holim 'a li-neuron ka hona ho ka laola ho sebelisana ha GT1b ka membrane ea plasma ea neurons, e hlahisang thibelo ea kholo ea methapo.

Melemo ea Ganglioside GT1b

Ganglioside GT1b ke acid e bitsoang glycosphingolipid e etsang metsoako ea lipid liseleng tsa methapo ea methapo ea methapo ea kutlo mme e ameha ho atoloseng lisele, phapang, khokahano, phetiso ea matšoao, tšebelisano ea sele le cell, tumorigenesis le metastasis.

Likarabo tsa Autoimmune ho li-gangliosides li ka lebisa ho Guillain-Barre syndrome. Ganglioside GT1b e baka dopaminergic neuron degeneration, e ka tlatsetsang ho qaleng kapa nts'etsopele ea lefu la Parkinson.

Ganglioside GT1b ke scavenger ea • li-radicals tsa mahala tsa OH, tse sirelletsang boko ho tsoa tšenyo ea mtDNA, ho ts'oaroa le lipid peroxidation e hlahisoang ke lijenereithara tse sebetsang tsa oksijene.

Li-tumor tsa Ehrlich li hlahisa ganglioside GT1b, mme anti-GT1b e na le monyetla o moholo oa kalafo bakeng sa mofetše ona. Sehlopha sena sa litlokotsebe se boetse se amana le lefu la Miller Fisher.

Litla-morao tsa Ganglioside GT1b

Li-Gangliosides li ka tlama lectins, li sebetsa joalo ka li-receptor tsa sesole sa mmele le khokahano ea lisele, li nka karolo ho saena hoa sele, carcinogeneis le phapano ea lisele, li ama popeho ea placenta le kholo ea methapo, li nka karolo ho tsitsipaneng ea myelin le ho nchafala hoa methapo, le ho sebetsa joalo ka likokoana-hloko le ho kenella ha chefo liseleng. .

Ho bokelloa ha ganglioside GT1b ho hokahane le mafu a 'maloa ho kenyeletsa lefu la Thai-Sachs le lefu la Sandhof.

Ganglioside GT1b e thibela karabo ea antigen kapa mitogen-induced T cell proliferation mme e fumanoe e le receptor ea botulinum, chefo e sa tloaelehang e nang le litlamorao tse matla tsa mmele.

Ganglioside GT1b e fumaneha feela ka har'a lisele tsa methapo ea kutlo 'me e bontšoa ho bahlahisi. GT1b e khothalletsa phapang pakeng tsa neuronal le sebopeho sa dendritic, se hlahisang boitšoaro bo sa tsotelleng le ho ntlafatsa hyperalgesia le allodynia.

Ganglioside GT1b e ka ama sesole sa 'mele. E na le phello e thibelang karabelo ea 'mele ea motho ea ho itšireletsa mafung' me e thibela immunoglobulin e hlahisoang ke lisele tsa mali tse nyarosang tsa mali.

Ho kenyelletsa moo, Ganglioside GT1b e amana le maloetse a latelang: ntaramane, guillain-garré syndrome, k'holera, tetanus, botulism, lepera le botenya.

Tlhaloso:

  • Erickson, KD, Garcea, RL, le Tsai, B. Ganglioside GT1b ke sebaka se amohelang sebaka sa Merokel cell polyomavirus. Tlaleho ea Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., le Tamaki, K. Ganglioside GT1b e hatella tlhahiso ea immunoglobulin ke lisele tsa mali tsa nyutlelie ea mali. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, le Ringler, NJ Binding ea botulinum le tetanus neurotoxins ho ganglioside GT1b le derivatives tsa eona. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, sebopeho, ketsahalo, tlhaologanyo le tlhahlobo ”. Laebrari ea Lipid. Mokhatlo oa Amerika oa Lik'hemik'hale tsa Lioli. E bolokiloe ho tloha ea mantlha ka 2009-12-17.
  • Nicole Gaude, Koranta ea Biology Chemistry, Moq. 279: 33 maq. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, joalo-joalo Biosynthesis ea li-gangliosides tsa kholo tsa boko GD1a le GT1b. Glycobiology, Buka ea 22, Tsoha 10, Mphalane 2012, maqephe a 1289-

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