Dihydromyricetin (DHM) (27200-12-0)

March 9, 2020

Dihydromyricetin (kapa DHM) ke motsoako oa Sefate sa Mopresidente oa Japane se sebelisitsoeng makholo a lilemo joalo ka anti-joala ……….


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Dihydromyricetin (DHM) (27200-12-0) video

Dihydromyricetin Slitšobotsi

Name Product Dihydromyricetin (DHM)
Lebitso la lik'hemik'hale Ampelopsin
Ampeloptin
(+) - Dihydromyricetin
Name Brand N / A
Sehlopha sa Lithethefatsi phytochemical; litekanyetso tsa boits'ebetso tse tsoang ho litlama tsa litlama tsa China (TCM);; litlama tse emeng hantle; sehlahisoa sa tlhaho; Inhibitors; Flavanones;
Nomoro ea CAS 27200-12-0
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
limolek'hule Formula C15H12O8
limolek'hule Wtse robeli 320.25 g / mol
Masapo a monoisotopic 320.053217 g / mol
Sebaka se belang 780.7 ± 60.0 ° C (E boletsoe esale pele)
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life N / A
Color ho tšoeu ho beige
Sho khoneha DMSO: ≥5mg / mL (e futhumetse)
Storage Tmocheso <+ 8 ° C
Aho latela 1. E sebelisoa indastering ea phepelo, phofo ea dihydromyricetin e sebelisoang e le lisebelisoa tse tala;
2. E sebelisoa sehlahisoa sa bophelo bo botle, phofo ea dihydromyricetin e sebelisoang e le lisebelisoa tse tala ho matlafatsa boits'ireletso ba mmele;
3. E sebelisoa tšimong ea litlama, dihydromyricetin phofo e sebelisoang e le lipilisi kapa lipilisi ho phekola tšoaetso ea phepelo ea phefumoloho le ho sireletsa sebete.

Nalane ea Dihydromyricetin

Dihydromyricetin (kapa DHM) ke motsoako o tsoang Sefateng sa Japane sa Raisin se 'nileng sa sebelisoa ka lilemo tse ngata e le setlama se loantsang joala le hangover ho litlhare tsa setso tsa Korea le China. Boithuto ba morao-rao bo bonts'a hore DHM e ka fokotsa boemo ba joala ba mali le ho sireletsa sebete sa hau tšenong le ho mafu.

DHM ke flavonoid hangata e ntšitsoeng ho Veine ea Vine empa hape e ka nts'oa lekhapetleng la sefate sa Holvenia Dulcis. Habohlokoa le ho feta, Dihydromyricetin e na le pale e telele ea ho nkuoa ka kotloloho ka sepheo sa ho phekola hlooho le lihango.

Dihydromyricetin ke eng?

Dihydromyricetin, eo hape a bitsoang Ampelopsin, ke flavanonol, mofuta oa flavonoid. E fumanoa mefuta ea Ampelopsis japonica, megalophylla, le grossedentata; Cercidiphyllum japonicum; Hovenia dulcis; Rhododendron cinnabarinum; mefuta e meng ea Pinus; le mefuta e meng ea Cedrus, hammoho le Salix sachalinensis.

Dihydromyricetin powder e ntšoa, motsoako o ka sehloohong ke flavonoids. Ka mesebetsi ea ho tlosa li-radicals tsa mahala, li-antioxidants, li-antithrombotic, Tumor, anti-inflammatory le litlamorao tse ling tse ikhethang; Dihydromyricetin ke motsoako o khethehileng oa flavonoid. Ntle le litšobotsi tse akaretsang tsa flavonoids, e boetse e na le bokhoni ba ho kokobetsa chefo ea joala, ho thibela sebete sa joala, sebete sa mafura le lisele tsa sebete. Ho fokotseha le ho fokotsa liketsahalo tsa mofets'e oa sebete. Ke sehlahisoa se setle sa ho sireletsa sebete le hangover.

Dihydromyricetin melemo e

TLHOKOMELISO ANTI-HANGOVER

Molemo o ka sehloohong oa DHM ke thibelo le phokotso ea li-hangovers, ho sireletsa sebete le bokong ba hau. Sena se fihlelloa ke ntlafatso ea joala dehydrogenase (ADH) le acetaldehyde dehydrogenase (ALDH), tseo e leng li-enzyme tse ka sehloohong tse ikarabellang ho feliseng joala le acetaldehyde kahare ho 'mele.

Acetaldehyde ka ho khetheha ke lik'hemik'hale tse nang le chefo haholo 'me ke sesosa se ka sehloohong sa li-hangovers. Ha li-enzyme tsena li ntlafatsoa, ​​joala le acetaldehyde li ka robeha ka potlako ho feta ho tloaelehileng.

PUSELETSO CELLULAR

DHM e na le thepa e ngata ea bophelo bo botle ea cellular e iphumatsang e le ho khothaletsa bophelo bo botle ba kelello. Sena se etsahala hobane DHM e khothaletsa heme-oxygenase-1 (HO-1), enzyme e thusang ho senyeha ha heme le ho ferekanya thepa ea cellular ea bophelo bo botle. Dihydromyricetin e ka boela ea ntlafatsa bophelo ba sebete.

Melemo e meng ea dihydromyricetin

1) Dihydromyricetin e ka hlakola ho se lekane ha mmele 'meleng le antioxidation

2) Dihydromyricetin e ka thibela liketso tsa antibiotic

3) Dihydromyricetin e ka Sireletsa Sebete: Dihydromyricetin e na le ts'ebetso e matla ea inhibitory ea ho hlaha ha ALT le AST maling a Serum. E ka theola bilirubin e felletseng ka hara serum ea mali. Kahoo e na le ketso e matla ea ho theola aminotransferase le jaundice.

4) Dihydromyricetin e ka fokotsa maemo a tsoekere ea mali le mafura a mangata: Dihydromyricetin e ka fokotsa maemo a mafura a mali ka toeba. E ka fokotsa tšenyo ea lisele tsa sebete tse bakoang ke mafura a mangata a mali le ho ntlafatsa bokhoni ba antioxidation. Ka nako e ts'oanang, e ka theola maemo a tsoekere e phahameng ea mali.

5) Dihydromyricetin e ka khahlano le ho ruruha

6) Dihydromyricetin e ka thibela anti-tumor: Ho tlosa phofo ea Dihydromyricetin e na le matla a ho thibela cell ho eketseha ha lisele tse ling tsa tumor.

Litla-morao tsa Dihydromyricetin.

Ka kakaretso ho na le lithuto tse 'maloa feela ho fihlela joale tse shebileng profilse ea li-DHM tsa litlamorao mme ho fihlela joale ha ho na mathata a bohloko a tlalehiloeng.

Patlo e potlakileng ho Amazon e tla bonts'a maikutlo a likete. Ha u ntse u li sheba, ho na le litlaleho tsa ho se khotsofale ka mpeng, ho nyekeloa le pelo le lets'ollo. Leha ho le joalo, ha ho na bareki ba bangata ba tlalehang litla-morao tsena.

Dihydromyricetin e sebelisa le ho e sebelisa

Sebeliso:

  1. Dihydromyricetin phofo e sebelisetsoang ho sireletsa sebete;
  2. Dihydromyricetin phofo e sebelisetsoang ho laola mali a tsoekere a mali;
  3. Dihydromyricetin phofo e na le phello ea ho matlafatsa boits'ireletso ba mmele;
  4. Dihydromyricetin phofo ka ts'ebetso ea antioxidant le anti-cancer;
  5. Dihydromyricetin phofo e sebelisetsoang ho thibela lithibela-mafu, ho phekola ho khohlela, bohloko le ho felisa chefo ea mosi.
  6. Dihydromyricetin e na le tebello e ntlafatsang ea nts'etsopele ha ho lokisoa lihlahisoa kapa litlhare tsa tlhokomelo ea letlalo bakeng sa ho thibela le ho phekola likotsi tsa letlalo.

kopo

  1. E sebelisoa indastering ea phepelo, phofo ea dihydromyricetin e sebelisoang e le lisebelisoa tse tala;
  2. E sebelisoa sehlahisoa sa bophelo bo botle, phofo ea dihydromyricetin e sebelisoang e le lisebelisoa tse tala ho matlafatsa boits'ireletso ba mmele;
  3. E sebelisoa tšimong ea meriana, dihydromyricetin phofo e sebelisoang e le lipilisi kapa lipilisi ho phekola tšoaetso ea phepelo ea methapo le ho sireletsa sebete.

Dihydromyricetin ho etsa lipatlisiso in Khahlano le Kankere

Ebile, ho na le lipatlisiso tse ntle tse khothatsang tse bonts'ang hore dihydromyricetin e na le monyetla oa ho thusa ka boemo bo amanang le joala bo bitsoang Hepatocellular carcinoma (HCC). HCC ke boemo bo bonts'a e 'ngoe ea lisosa tse phahameng tsa ho fokola ha sekhahla le ho shoa ha batho lefatšeng ka bophara,' me e hlahisa sehlooho se ka sehloohong sa mofetše oa kankere ea sebete. Joalokaha DHM e bonts'a bokhoni ba ho itšireletsa sebete (ke phepo e amanang le lefu la sebete) diphetho li bontšitse hore e ne e thibela haholo ho ata ha sele le ho tsitsisa apoptosis ea cell meleng ea li-HCC, e bonts'a hore DHM ke moemeli ea ts'episang bakeng sa kalafo ea HCC.

Reference:

Dihydromyricetin e fokotsa dysorubicin-ikiwa ea lefu la pelo ka ho thibela inflmasmome ea NLRP3 ka ts'ebetso ea SIRT1. Letsatsi Z, Lu W, Lin N, Lin H, Zhang J, Ni T, Meng L, Zhang C, Guo H. Biochem Pharmacol. 2020 Feb 26: 113888. Doi: 10.1016 / j.bcp.2020.113888. [Epub pele ho khatiso]

Metabolomics of the Protential Athor of Ampelopsis grossedentata le Diorromyricetin ea eona e Hloekileng e sebetsang ka Sebakeng sa Lijo tse Phahameng tsa Lijo tse Phahameng. Fan L, Qu X, Yi T, Peng Y, Jiang M, Miao J, Xiao P. Evid based Complement Alternat Med. 2020 Jan 28; 2020: 3472578. Doi: 10.1155 / 2020/3472578. eCollection 2020.

Taolo ea litsela tse saenneng ke Ampelopsin (Dihydromyricetin) litsing tse fapaneng: ho hlahloba litsela le litsela tse nyane tseo a sa tsamaee ka tsona. Fayyaz S, Qureshi MZ, Alhewairini SS, Avnioglu S, Attar R, Sabitaliyevich UY, Buha A, Salahuddin H, Adylova A, Tahir F, Pawlak-Adamska E. Cell Mol Biol (Noisy-le-grand). 2019 Sep 30; 65 (7): 15-20.

Golgi reassembly le ho boloka protheine ea 65 ea tlase e ea hlokahala bakeng sa phello ea anti-kankere ea dihydromyricetin liseleng tsa kankere ea mahe a motho. Wang F, Chen X, Yuan D, Yi Y, Luo Y.

PloS One. 2019 Nov 26; 14 (11): e0225450. doi: 10.1371 / journal.pone.0225450. eCollection 2019.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.