Lintlha tsa lik'hemik'hale tsa 5a-hydroxy laxogenin phofo
| Name Product | 5a-hydroxy laxogenin phofo |
| Li-synonyms | 5alpha-Hydroxy laxogenin; 5-alpha-Hydroxy-laxogenin; 5 alpha hydroxy laxogenin; 5-alpha hydroxy laxogenin; 5-alpha-hydroxy laxogenin; 5a hydroxy laxogenin; 5a-hydroxy Laxogenin |
| Motsoako Bohloeki | > = 99% |
| Nomoro ea CAS | 56786-63-1 |
| Sehlopha sa Lithethefatsi | spirostani analogue ea brassinosteroid |
| InChI Key | HCRGPOQBVFMZFY-PPCFKNSFSA-N |
| Smile | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC(=O)C6(C5(CCC(C6)O)C)O)C)C)OC1 |
| Molecular Formula | C27H42O5 |
| Boima ba 'mele | 446.6 |
| Masapo a monoisotopic | 446.30322444 |
| Melting Point | 247-250 ° C |
| Boiling Point | 578.4 ± 50.0 ° C (E boletsoe esale pele) |
| Efokotsa halofo ea bophelo | dihora tse 6-8 |
| Color | Pula e tšoeu |
| Solubility | DMF: 15mg/mL; DMSO: 10mg/mL |
| Stempage temp | E tiisitsoe ka ho omme, Mocheso oa Kamore |
| kopo | Tlatsetso; kaho ea 'mele; fumana mesifa |
Lihahi tsa 'mele le baatlelete ba atisa ho batla mekhoa ea ho eketsa mesifa e boima ntle le ho eketsa mafura a' mele 'meleng. E 'ngoe ea litsela tse bonolo ka ho fetisisa tsa ho finyella sena ke ho sebelisa li-anabolic steroids, empa tšebeliso ea nako e telele ea li-steroid tsena e na le litla-morao tse itseng tse ka' nang tsa se ke tsa e-ba teng ho ba bangata.
Liphuputso tsa morao-rao li fumane sehlahisoa sa semela seo bo-rasaense ba lumelang hore se na le liphello tse tšoanang le tsa anabolic steroids, leha ho le joalo, ntle le litla-morao tse mpe tsa steroids.
Motsoako ona o tsejoa e le 5a hydroxy laxogenin hangata kapa ka lebitso la eona la saense, 5-alpha-hydroxy laxogenin. 5a hydroxy laxogenin phofo e rekisoa ke boholo ba bafani ba phofo ea 5a hydroxy laxogenin e le tlatsetso ea ho haha 'mele ka lebaka la melemo e mengata ea sehlahisoa.
5a-hydroxy laxogenin ke eng?
5a-hydroxy laxogenin, e tsoa ho laxogenin, k'hemik'hale e fumanoang tlhahong, limeleng. Laxogenin kapa 3beta-hydroxy-25D,5alpha-spirostan-6-one, ke anabolic steroid e thehiloeng ho semela e seng e tumme har'a baatlelete le baetsi ba 'mele bakeng sa thepa ea eona ea ho matlafatsa mesifa.
Lebaka la botumo bo ntseng bo eketseha ba Laxogenins ke karolo ea bona limela. Ke lihomone tsa semela, tse tsejoang hape e le brassinosteroids tse nang le sebopeho le ts'ebetso, tse ts'oanang hantle le lihomone tsa steroid tsa motho. Ka lebaka la sena, ba nkela li-anabolic steroids sebaka.
Laxogenins e ka fumanoa ho tsoa ho eiee ea Machaena kapa kutu e ka tlas'a lefatše ea semela sa Asia, Smilax sieboldii. Laxogenins, ka bongata ba li-supplement tse hlahisoang le ho rekisoa ke moetsi oa phofo ea 5a-hydroxy laxogenin, e hlile e tsoa ho semela se seng sa steroid diosgenin. Semela sena sa steorid se boetse se sebelisoa ha ho etsoa lihomone tse ling tse ngata tsa maiketsetso tse kang progesterone, e sebelisoang haholo lipilising tsa thibelo ea bokhachane.
Mefuta e mengata e nang le phofo ea 5a hydroxy laxogenin e rekisoang, e le tlatsetso, e na le motsoako ona oa laxogenin, o tsoang ho diosgenin, ho e-na le ho ba le laxogenin ea tlhaho. Leha ho le joalo, sena ha se taba e kholo hobane melemo ea 5-alpha-hydroxy-laxogenin e tšoana le ea laxogenin.
Na 5-alpha-hydroxy laxogenin ke prohormone?
Baetsi ba bangata ba 5a hydroxy laxogenin le 5a hydroxy laxogenin powder bafani ba reha motsoako e le prohormone. Prohormone ke motsoako oo hang ha 'mele o tla ba le liphetoho ho ba hormone e itseng.
Mohlala o loketseng e ka ba li-androgens, tse sebetsang e le li-prohormones 'me hang ha li kenngoa le ho kenngoa ka metabolized, li fetolela ho hormone, testosterone. 5a hydroxy laxogenin phofo hase hormone ea pele kaha ha e fetohe hormone, empa ho e-na le hoo e na le melemo e tšoanang le ea hormone ea steroid.
Na 5-alpha-hydroxy laxogenin ke steroid?
5a hydroxy laxogenin ke semela sa steroid se arolelanang lintho tse ngata tse tšoanang le lihomone tsa steroid tsa liphoofolo. Ke eona e ts'oanang ka ho fetesisa le lihormone tsa thobalano 'meleng oa motho tse tsoang ho cholesterol. Ke habohlokoa ho bontša hore phofo ea 5a hydroxy laxogenin e na le ts'ebetso ea ho hōla ha limela empa liphello tsa eona 'meleng oa motho li rarahane haholo ho feta moo.
Ho e-na le ho feta ka har'a lera le ho etsa hore ho be le phetoho ka boeona, motsoako ona o tlama ho receptor ebe o kenya ketane ea pontšo, e qetellang ka keketseho e kholo ea bokhoni ba ho haha mesifa ea 'mele.
Protheine e khethehileng e sebelisoang ke 5a hydroxy laxogenin phofo ke protheine kinase B kapa AKT 1. Protheine ena e tsejoa haholo ka bokhoni ba eona ba ho eketsa tlhahiso ea mesifa 'meleng oa motho empa hape le ho thibela ho senyeha ha mesifa.
Liprotheine tsa mesifa li senyeha nakong ea boikoetliso bo bongata empa ho nahanoa hore melemo e fapa-fapaneng ea 5-alpha-hydroxy laxogenin e kenyelletsa ho thibela ho senyeha ha protheine le ho senyeha nakong ea boikoetliso.
Mokhoa o mong oo ka oona 5a hydroxy laxogenin phofo e hlahisang melemo e ipiletsang ho baetsi ba 'mele le baatlelete ke ho thibela ho senyeha ha enzyme ea bohlokoa, e leng, cAMP.
Ho eketsa bongata ba enzyme ena 'meleng ka ho thibela ho senyeha ha eona ho fella ka ho senyeha ho eketsehileng ha mafura' meleng. Ka nako e ts'oanang, ho eketsa enzyme ena ho boetse ho fella ka karabelo e matlafalitsoeng ea ho loana kapa ho fofa.
Ka kakaretso, bafani ba phofo ba 5a hydroxy laxogenin ba rekisa sehlahisoa se eketsang boima ba mesifa, se fokotsa ho senyeha ha protheine, le ho eketsa ho senyeha ha mafura, ka nako e le 'ngoe. Ho lumeloa hore liphello tsena li etsahala kaha tsena ke liphello tse atisang ho bonoa mefuteng e fapaneng ea lithuto tsa 5a hydroxy powder tse etsoang ka mehlala ea liphoofolo kapa in vitro, ka laboratoring. Leha ho le joalo, liphello tsena li ka 'na tsa se ke tsa bonoa' meleng oa motho ha li-supplement tse rekisoang ke baetsi ba phofo ba 5a hydroxy laxogenin ba fapaneng ba nkoa.
Na 5a-hydroxy laxogenin e tšoana le Laxogenin: 5a hydroxy laxogenin vs laxogenin
5a-hydroxy laxogenin e tsoa ho hormone ea semela, laxogenin. Li na le melemo e tšoanang, ho latela likarolo tse fapaneng tsa lipatlisiso tse entsoeng ka mehlala ea liphoofolo. Leha ho le joalo, ha li tšoane.
5-alpha-hydroxy laxogenin e etsa eng?
5-alpha hydroxy laxogenin ke eona e ts'oanang ka ho fetesisa le lihormone tsa thobalano tse entsoeng ho tsoa ho k'holeseterole 'meleng oa motho. Li-hormone tsena tsa thobalano tse fumanoang ka tlhaho 'meleng oa motho li sebetsa ho li-receptor tsa nyutlelie, athe 5a hydroxy laxogenin e khomarela ho amohela lisele, holim'a sele.
Lik'hamphani tse ngata tse nang le phofo ea 5a hydroxy laxogenin e rekisoang hangata li rekisa tlatsetso ena ka papatso ea hore e na le potency ea 200 lekholong 'me e ka ntlafatsa molumo oa mesifa har'a baatlelete haholo. Litlaleho tsena tse entsoeng ke bahlahisi ba fapaneng ke litholoana tsa lithuto tse 'maloa tse entsoeng ka sepheo sa ho hlahloba thepa ea ho ntlafatsa mesifa ea laxogenins.
Patlisiso ea morao-rao ea Serussia mabapi le mefuta ea liphoofolo e fumane hore metsoako ea thermogenic e tsoa sehlopheng se le seng sa lihomone tsa semela joalo ka laxogenin, e nang le litlamorao tse tšoanang le tsa laxogenin. Ho ea ka phuputso ena, lihlahisoa tsena tsa brassinosteroid li ile tsa khona ho eketsa protheine ea sebete, pelo, liphio le mesifa ea maoto. Ho feta moo, bafuputsi ba fumane hore lihlahisoa tsena ha lia hlahisa melemo ena ka ho pheta-pheta kapa ho etsisa phello ea li-hormone tsa thobalano 'meleng oa motho.
Phuputso e 'ngoe ea lipatlisiso e ileng ea boela ea etsoa ho mehlala ea liphoofolo le ho sebelisa li-hormone tsa sehlopha se le seng sa li-hormone tsa limela joalokaha laxogenin e khonne ho hlahisa liphello tse tšoanang le tsa thuto ea Russia. Liphuputso tse ling tse ngata li ile tsa etsoa ho netefatsa bonnete ba liphetho tsena 'me liphetho li fumanoe li kopitsoa habonolo, ka hona, li tiisa matla a tsona le katleho ea tsona.
Ke habohlokoa ho bontša hore le hoja basebelisi ba bangata ba 5a hydroxy laxogenin phofo ba bolela hore ba bona liphello tseo barekisi ba li phatlalalitseng, ho fumana bopaki bo tiileng ba saense ho tšehetsa tšebeliso ea bona ho bile thata. Bongata ba liphuputso li etsoa mefuteng ea liphoofolo le ho sebelisa metsoako eo e ka bang ea sehlopha sa lihomone tsa brassinosteroid kapa hormone e tšoanang ea semela, phytoecdysteroids. Li-laxogenin li tšoana le lihomone tsena 'me 5a hydroxy laxogenin e tsoa ho laxogenin, empa seo ha se tiise melemo e tšoanang le e bonoang le lihomone tse ling.
Phuputso e 'ngoe e ileng ea etsoa ho sebelisoa laxogenin ea tlhaho le ea maiketsetso sebakeng sa laboratori e fumane hore phofo ena e ka fokotsa khatello ea oxidative' meleng haholo. Phokotso ea khatello ea oxidative ka laxogenins e entsoe ka ho fokotsa li-radicals tsa mahala, mofuta oa ntho e kotsi 'meleng e ka kenyang letsoho liketsong tse fapaneng tsa lik'hemik'hale le ho lematsa' mele haholo. Phokotso ena ea li-radicals tsa mahala le khatello ea oxidative e ka hlalosa kamoo 5a hydroxy laxogenin phofo e khonang ho ntlafatsa ho hlaphoheloa ha mesifa, ka mor'a ho ikoetlisa. Leha ho le joalo, thuto ena e tlameha ho etsoa ho mehlala ea liphoofolo le lihlooho tsa batho pele liphetho tsa phuputso li lumeloa hohle.
Liphuputso tsohle tse boletsoeng ka holimo li entsoe ka morero oa ho fumana hore na laxogenin e ka khona ho eketsa boima ba mesifa le molumo. Leha ho le joalo, ts'ebeliso e le 'ngoe feela ea 5 alpha-hydroxy laxogenin ha se ho haha 'mele' me ke seo likarolo tse ling tsa lipatlisiso li neng li tšepile ho se paka.
Lithutong tse peli tse fapaneng, tšebeliso ea phofo ea 5-alpha-hydroxy laxogenin ho bakuli ba kankere ea colon e fokolitse boholo ba kankere haholo. Ka mokhoa o ts'oanang, nts'etsopele ea kankere ea matšoafo e ile ea fumanoa e fokotsehile ka tšebeliso ea phofo ea 5a hydroxy laxogenin mefuteng ea liphoofolo. Le hoja liphuputso tsena li sa khone ho fana ka bopaki bo tiileng bo hlokahalang bakeng sa tlatsetso leha e le efe kapa meriana e kenyelelitsoeng ho protocol ea phekolo, ke mohato o nepahetseng.
Ho nka 5-alpha-hydroxy laxogenin neng?
5-alpha-hydroxy laxogenin phofo tekanyo e qala ho tloha 25 mg, 'me ke hore na motho o lokela ho nka bokae ka nako leha e le efe e khethehileng. Leha ho le joalo, ho fihlela ho 6, le bonyane ba 3, litekanyetso li ka nkoa letsatsi lohle, ho etsa hore tekanyo ea tlatsetso, 150 mg ka letsatsi. E boetse e kgothaletswa ho nka phofo e tlatsetsang ka lijo ho eketsa ho monya ka mpeng.
5a hydroxy laxogenin phofo e ka nkoa ho fihlela likhoeli tsa 3 ho ea ho likhoeli tsa 4 ka nako hobane ke ha liphello li tla bonahala. E ka nkoa ka nako e telele ho feta moo haeba ho hlokahala kapa ho lakatsoa. Kaha motsoako oa tlhaho ha o na phello maemong a li-hormone 'meleng, ha ho hlokahale hore o behelloe ka nako e khutšoanyane.
Litla-morao tsa 5-alpha-hydroxy laxogenin ha li tsejoe hantle hobane boholo ba lithuto tse etsoang ho hlahloba katleho ea tlatsetso ha li etsoe litabeng tsa batho. Li etsoa ka mehlala ea liphoofolo 'me ha ho khonehe ho fumana melemo le litla-morao tse tsoang lithutong tsena. Leha ho le joalo, basebelisi ba li-supplement ha ba e-s'o tlalehe chefo leha e le efe kapa liphello tse mpe, tse lebisitseng tumelong ea hore tlatsetso ha e na litla-morao.
Ke mang ea lokelang ho nahana ka ho e sebelisa?
Baetsi ba 'mele, baatlelete, le mang kapa mang ea ka ratang ho eketsa mesifa le boima ba' mele ha a ntse a fokotsa mafura a 'mele o lokela ho nahana ka ho sebelisa 5a hydroxy laxogenin phofo.
Na 5-alpha-hydroxy laxogenin e molaong?
5a hydroxy laxogenin e nkoa e le motsoako o seng molaong oo Mokhatlo oa Lijo le Lithethefatsi kapa FDA oa United States o faneng ka litemoso tse ngata ka oona. Motsoako o 'nile oa behoa leihlo ke USADA nako e telele kaha ba fumane hore o lihlahisoa kapa li-supplement tse nang le lintho tse ling tse ntlafatsang ts'ebetso. Lebaka le leng la ho ameha ka 5a hydroxy laxogenin phofo ke hore e phatlalatsoa e le tlhaho, e thehiloeng ho limela tsa anabolic steroid. Ka bobeli FDA le USADA li hlahisitse lipotso mabapi le mohloli oa sebele oa 5a hydroxy laxogenin kaha mohloli oa semela sa tlhaho o fana ka hormone ea laxogenin feela. Ha ho so hlalosoe hore na hydroxy laxogenin e tsoa ho laxogenin joang.
USADA e entse tlhahlobo e qaqileng ea mefuta e fapaneng ea phofo ea 5a hydroxy laxogenin e rekisoang 'me e fumane halofo ea li-supplement tseo li tlatsitsoe ka lintho tsa doping. Boitekong ba ho pholosa baatlelete le sehahi sa 'mele ho tloha ho doping ka phoso ka ho sebelisa 'natural plant steroid', USADA e ba kopile hore ba ele hloko lisebelisoa life kapa life tse nang le laxogenin tse ka boleloang lethathamong la metsoako e le:
- UNII-HT7W184YG4
- HT7W184YG4
- SCHEMBL4027062
- Hisquequequequequequequeque hisquequequequequeque hisquequequequequeque hisqueque his hisquequequequequequequeque
- (25r) -3beta-hydroxy-5alpha-spirostan-6-one
- Q272800835
- alpha-hydroxy-laxogenin
- 5a-hydroxy-laxogenin
- 5-laxogenin
- (25R) -3beta,5alpha-dihydroxyspirostan-6-one
- 25-R-spirostan-5a-diol-6-one-3-one
- 25R spirostan-5a-diol-6-one-3-one decanoate
- 25R spirostan-5a-diol-6-one-3-one undecanoate
USADA e boetse e belaela hore lentsoe laxogenin lethathamong la metsoako e ka ba leseli le patiloeng bakeng sa ba batlang li-supplement tsa doping, ho bolelang hore ha ho na laxogenin ea sebele kapa 5a hydroxy laxogenin tlatsetsong.
FDA, joalo ka USADA, e na le mefuta e fapaneng ea li-laxogenin tse tlatselletsang lijong kaha ha ho na leseli le lekaneng mabapi le ts'ebeliso ea eona, polokeho le matla. Ka lipatlisiso tse eketsehileng, ho na le monyetla oa hore motsoako o amoheloe e le tlatsetso e matla ea ho matlafatsa mesifa.
Monyetla ona o teng hobane, leha USADA e phatlalatsa li-laxogenin le lintho tse tsoang ho tsona e le ntho e seng molaong, Baetapele ba Lefatše ba Khahlanong le Doping ha baa thibela tšebeliso ea bona har'a baatlelete. 5a hydroxy laxogenin ha e fihlelle litekanyetso tsa hore e khethoe e le ntho ea doping.
Ho feta moo, tlhahlobo ea lithethefatsi ea 5a hydroxy laxogenin e ne e ke ke ea e-ba ntle ha ho hlahlojoa lintho tsa doping ha feela phofo e sa senyeha kapa e tšeloa ka lintho tse ling tse thibetsoeng.
Litlhahlobo tsa 5-alpha-hydroxy laxogenin
Boholo ba basebelisi ba phofo ea 5-alpha-hydroxy laxogenin ba hlapanya ka eona mme ba bolela hore ba bona liphetho tsohle tse bapalitsoeng ho bona. Hoo e ka bang basebelisi bohle ba rorisa tšebetso ea tlatsetso ka potlako ho eketsa boima ba mesifa le molumo.
Ho na le litlhahlobo tse ngata tsa marang-rang tse bolelang hore li bone mesifa e ntlafetseng le ho eketseha ha mesifa, ka ho fokotseha ho hoholo ha mafura ka likhoeli tse tharo ho isa ho tse 'nè feela tsa ho sebelisa 5a hydroxy laxogenin phofo.
Molemo ka ho fetisisa oa phofo ea 5a-hydroxy laxogenin?
Phofo ea tlatsetso e ka rekoa ka 5a hydroxy laxogenin wholesale suppliers haeba ho hlokahala kapa e ka rekoa ka chelete e nyane. Phofo e ntle ka ho fetisisa eo u ka e rekang ke e entsoeng, ea alafshoa, 'me ea pakoa ka litataiso tse tiileng tsa polokeho kaha sena se tiisa hore ha ho na tšilafalo le lintho tse thibetsoeng 5a hydroxy laxogenin phofo.
References:
- Motsoako o seng molaong, 5-Alpha-Hydroxy-Laxogenin, e Hlaha ka Tlatsetso e Eketsehileng. Thuto, Moea oa Lipapali / Tšitoe 4, 2019
- Bioorg Med Chem. 2012 Apr 15;20(8):2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15. Litlhaloso tse ncha mabapi le kamano ea sebopeho-cytotoxicity ea spirostan saponins le glycosides e amanang le eona. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. PMID: 22405922
- YW Zhang, I Morita, L Zhang, G Shao, XS Yao, S Murota. Ho hlahlojoa ha li-anti-hypoxia/reoxygenation agents ka mokhoa oa in vitro. Karolo ea 2: Ho thibela ts'ebetso ea tyrosine kinase ho thibela kotsi e bakoang ke hypoxia / reoxygenation ho endothelial gap junctional intercellular communication. Planta Med. 2000 Mar;66(2):119-23. doi: 10.1055/s-2000-11126. PMID: 10763583
- Diana M. Cheng, Louis W. Kutzler, Dustin D. Boler, Jenny Drnevich, John Killefer, le Mary Ann Lilaa. Infusion e tsoelang pele ea 20-Hydroxyecdysone E Eketsehile 'Misa oa Triceps Brachii ka C57BL / 6 Litoeba. E hatisitsoe inthaneteng 2012 Apr 12. doi: 10.1002/ptr.4679. PMC3410052
- Debora Esposito, Slavko Komarnytsky, Sue Shapses, le Ilya Raskin.Anabolic effect of plant brassinosteroid. FASEB J. 2011 Oct; 25(10): 3708– doi: 10.1096/fj.11-181271. PMC3177571
