Anandamide (AEA) (94421-68-8)

March 15, 2020

Anandamide, e tsejoang hape e le N-arachidonoylethanolamine (AEA), ke mafura a nang le asiti e tsoang ho …… ..

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum

 

Video ea Anandamide (AEA) (94421-68-8)

Anandamide (AEA) (94421-68-8) Slitšobotsi

Name Product Anandamide (AEA)
Lebitso la lik'hemik'hale Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

Nomoro ea CAS 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Smile CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Molecular Formula C22H37NO2
Boima ba 'mele 347.53
Masapo a monoisotopic 347.282429 g / mol
Melting Point N / A
Boiling Point 522.3 ± 50.0 ° C (E boletsoe esale pele)
segokanyipalo 0.92 g / mL ho 25 ° C (mat.)
Color mosehla o bobebe
Stempage temp -20 ° C
Solubility ethanol: qhibilihang
kopo E sebelisoa bakeng sa mohopolo, tšusumetso, ts'ebetso ea kelello, taolo ea ho sisinyeha, taolo ea bohloko, takatso ea takatso le boiqapelo.

 

Anandamide (AEA) ke eng?

Anandamide, e tsejoang hape e le N-arachidonoylethanolamine (AEA), ke mafura a nang le mafura a nang le mafura a tsoang ho metabolism e se nang oxidative ea eicosatetraenoic acid (arachidonic acid. e silafalitsoeng haholo-holo ke enzyme ea mafura a amide hydrolase (FAAH), e fetolang anandamide hore e be ethanolamine le arachidonic acid, Qetellong, Anandamide e entsoe ka neuron ka karabelo ea condensation e hlahang lipakeng tsa arachidonic acid le ethanolamine tlasa taolo ea calcium ion le cyclic monophosphate adenosidase. Ke selelekela sa sehlopha sa lintho tse sebetsang 'meleng (Prostamides) tse phethang karolo e kholo mesebetsing e mengata ea' mele, ho kenyelletsa takatso ea lijo, mohopolo, bohloko, khatello ea maikutlo le ho ba le thari.

Anandamide e teng linthong tse ngata, joalo ka sea urchin roe, boko ba likolobe le litoeba tsa litoeba, jj, empa palo ea eona e nyane. Hape, bafuputsi ba fumane Anandamide le lintho tse peli (N-oleoylethanolamine le N-Linoleylethanolamine) ka chokolete e lefifi. Anandamide e bile e teng le lithorong tse ling tse sebetsitsoeng, (bohobe bo bosoeu), joala (haholo-holo tšebeliso e sa foleng kapa ho itlopa joala), tsoekere e ntlafalitsoeng, mafura a Trans, Lijo tse halikiloeng ka oli ea meroho le lijo tse seng tsa manyolo tse nang le chefo e bolaeang likokoanyana jj

E le karolo ea tsamaiso ea endocannabinoid (ECS), Anandamide e khethiloe e le molaoli oa homeostasis hammoho le sehlopha se seng sa "cannabis" se tšoanang le lik'hemik'hale tsa "cannabis" tse tšoanang le mmele. Sisteme ena e teng ho li-vertebrates tsohle. Anandamide e bapala karolo ea ho laola boitšoaro ba ho fepa le takatso ea neurogenic le thabo, ho boloka 'mele le likelello tsa rona li le tekong. Boithuto bo fumane hore maikutlo a rona, thabo, tšabo, matšoenyeho le bokhoni ba ho mamella khatello ea maikutlo kaofela li laoloa ke tsamaiso ea endocannabinoid, le mafu a fapa-fapaneng ho tloha ho schizophrenia ho isa khatello ea maikutlo a tsamaeang le maemo a sa tloaelehang a anandamide.

Anandamide, e ts'oanang le THC, ke agonist ea karoloana ea CB1R. E kanna ea baka likhathatso tse ka bang teng ka ts'ebetso e "phethahetseng" ea sistimi ea boko. Ke habohlokoa ho hlokomela hore liphello tsena tsohle tsa Anandamide li bonahala li ntlafatsoa ka mokhoa oa phekolo ea meriana o thibelang ho senyeha ha 'mele. Ho sibolloa ha Anandamide ho ka lebisa ho nts'etsopele ea lelapa le lecha la meriana ea kalafo.

 

Melemo ea Anandamide (AEA)

Anandamide, eo hape e tsejoang e le "molek'hule ea thabo", e matlafatsa maikutlo, methapo ea kutlo le endocannabinoid, e nang le melemo e mengata ea bophelo bo botle le kelello:

Anandamide e fokotsa sebopeho sa lisele tsa mofetše kapele. Ka 1998, sehlopha sa bo-rasaense ba Italy se ile sa sibolla hore anandamide e ka khothaletsa neurogeneis le ho etsa lisele tse ncha tsa methapo, ka potlako ea theha / eketsa boleng ba lisele tsa mofetše oa matsoele.

Bokhoni ba Anandamide ba ho ntšetsa pele neurogeneis (sebopeho sa li-neuron tse ncha) e bapala karolo ea ho laola boitšoaro ba phepo le ho hlahisa tšusumetso le thabo ho litoeba. Sena se thusa ho fokotsa matšoao a khatello ea maikutlo le matšoenyeho. Phuputso ho 2015 ea batho le litoeba e fumane hore maemo a phahameng a anandamide a ka khothaletsa ntlafatso ea maikutlo le phokotso ea tšabo.

Ntle le moo, matla a anandamide a ho tlama li-receptor tsa CB1 le CB2 a tla ama haholo mekhoa e mengata ea mmele, a bonts'a melemo e metle mabapi le mohopolo, tšusumetso, lits'ebetso tsa kutlo, taolo ea motsamao, taolo ea bohloko, tšusumetso ea takatso ea lijo le kemolo.

 

Mokhoa oa ho eketsa anandamide(AEA) maemo 'meleng oa motho?

Hobane anandamide e na le karolo ea ho sebetsa joaloka neurotransmitter, moemeli oa li-vasodilator le serum metabolite ea motho, le melemo ea bophelo bo botle le kelello bo bontšitsoeng, o kanna oa batla ho eketsa boemo ba anandamide 'meleng oa hau. Mona ke mekhoa e meng ea ho eketsa nakoana ea li-ananamide 'meleng oa motho:

- BoikoetlisoIng

Phuputso e fumane hore kamora ho qeta metsotso e 30 feela, litaba tsa anandamide (AEA) tsa batho le lintja li eketsehile. Kahoo haeba u batla ho fumana molemo o moholo, ikoetlise hangata.

- Ho ja chokolete e lefifi

Chokolete e lefifi e na le karolo e phahameng ea theobromine ka chokolete e phetseng hantle, 'me theobromine e thusa ho eketsa tlhahiso ea anandamide bokong mme ka nakoana e liehise ho phatloha ha eona.

- Ho ja truffle e ntšo

Furu e ntšo (fungus e ntšo) ka tlhaho e na le anandamide. Le ha fungus e sa khone ho sebelisa anandamide ka tsela efe kapa efe, bafuputsi ba lumela hore e sebelisetsoa ho hohela liphoofolo hore li e je le ho ikatisa hape.

- Ho tsepamisa maikutlo

Patlisiso e bonts'a hore ha motho a le maemong (a bitsoang "a phallang" kapa "sebakeng",) sa mohopolo o phahameng, ts'ebetso, le ho tsepamisa mohopolo, ha o na ho atleha feela kapa ho hlahisa mesebetsi e betere bokong ba hau. palo e kholo ea lik'hemik'hale, joalo ka serotonin, dopamine, endorphin le anandamide.

Ho feta moo, tee, coriander le celery le tsona li ka thusa ho eketsa tlhahiso ea anandamide.

 

Tlhaloso:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Mots'eanong 2001). "Anandamide le lijo: Ho kenyelletsoa ha lijo tsa arachidonate le docosahexaenoate ho lebisa boemong bo eketsehileng ba boko ba N-acylethanolamines e lumellanang le likolobe". Ts'ebetso ea Sekolo sa Naha sa Saense. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMID 33480.
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  • Habib, Abdella M .; Okorokov, Andrei L .; Leralla, Matthew N .; Bras, Jose T .; Lee, Motho-Cheung; Li, Shengnan; Gossage, Samuel J .; van Drimmelen, Marie; Morena, Maria (Hlakubele 2019). "Microdeletion ka pseudogene e khetholloang ho mokuli ea nang le likhakanyo tse phahameng tsa anandamide le ho se utloisise bohloko". Koranta ea Brithani ea Anesthesia. 123: e249– doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Pulungoana 2007). "Endocannabinoid hedonic hotspot bakeng sa monyaka oa kutlo: anandamide ka khubung e bokella khetla e ntlafatsa 'ho rata' moputso o monate". Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
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