Phofshoana e matla ea Lorcaserin HCL (846589-98-8)

October 30, 2018

Raw Lorcaserin hydrochloride powder ke serotonin 2C (5-HT2C) receptor agonist le meriana e fanoang ka molomo e khothalletsang….


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1380kg / khoeli

Molumo oa phofo ea Lorcaserin HCL (846589-98-8) video

 

Ho hlahisa phofo ea Lorcaserin HCL (846589-98-8) Lintlha

Name Product Raw Lorcaserin Hydrochloride powder
Lebitso la lik'hemik'hale Phofshoana e khōlō ea Lorcaserin HCL, Lorcaserin
Brand Name BELVIQ
Sehlopha sa Lithethefatsi 5-HT2C receptor inhibitor
Nomoro ea CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
limolek'hule Formula C11H15Cl2N
limolek'hule Wtse robeli 232.15
Masapo a monoisotopic 231.058154899
Ho qhibiliha Poli  Ha ho dintlha tse fumanehang
Fho tsosolosa Poli Ha ho dintlha tse fumanehang
Likokoana-hloko tsa Half-Life Bophelo ba halofo ea lorcaserin e ka ba lihora tse ka bang 11.Ka phofo ea mokokotlo e felisoa haholo-holo mokokotlong (92%) le lijong tse ling (2.2%)
Color Pula e tšoeu
Solubility  Metsoako a metsi: 0.0709 mg / mL
Storage Tmocheso  -20 ° C.
Aho latela Serotonin 2C (HT2C) e amohelang batho ba amohelang boima ba 'mele.

 

Raw Lorcaserin Hcl phofo (846589-98-8) Tlhaloso

Raw Lorcaserin hydrochloride powder ke hydrochloride e fumanoang ka karabelo ea phofo ea lorcaserin e nang le e lekanang le hydrochloric acid. E sebelisoa e le setlhare se loantšang botenya. Lorcaserin hydrochloride ke 5HT2c receptor agonist e bontšitsoeng hore e ka sebelisoa ho batho ba baholo ba nang le BMI -30, kapa ba nang le BMI -27 le bonyane boemo bo le bong bo amanang le boima ba 'mele joaloka khatello ea mali, mofuta oa 2 lefu la tsoekere kapa dyslipidemia. e etsa hore motho a ikutloe a khotsofetse, 'me ho nahanoa hore e ka thibela pula ea lefu la pelo ea valvular e amanang le ts'ebetso ea li-receptor tsa 5-HT2B, sebaka sa boko se tsejoang hore se bapala karolo e kholo ho laoleng tlala le lijo. Ka ho kenya tšebetsong li-receptor tsena, phofo ea Lorcaserin hydrochloride e ka fokotsa ts'ebeliso ea lijo ka ho fokotsa takatso ea lijo le ho etsa hore motho a ikutloe a khotsofetse leha a se a jele lijo tse fokolang ho feta tloaelo. e amohetsoe kajeno ke FDA ka qeto e ikhethang kamora lilemo tse 2 tsa tlhahlobo.

Lorcaserin hydrochloride powder e hlalosoa ka ho khetheha e le mokhoa o fokolang oa ho ja lijo tse nang le lik'hilojule le ho eketseha ka tsela ea 'mele bakeng sa ho laola boima ba' mele ho batho ba baholo haholo (BMI ea 30 kg / m2 kapa e kholo) le batho ba baholo ba fetang boima ba 'mele (BMI ea 27 kg / m2 kapa e kholo) bonyane boemo bo bong bo amanang le boima bo amanang le boima.

Lorcaserin hydrochloride powder e sebelisoa hammoho le ho ja le ho ikoetlisa ho phekola botenya. Ka linako tse ling ho sebelisoa ho phekola botenya bo ka 'nang ba amana le lefu la tsoekere, k'holeseterole e phahameng kapa khatello ea mali e phahameng.

Lorcaserin hydrochloride e ke ke ea sebetsana le boemo leha e le bofe ba bophelo bo botle (joalo ka lefu la pelo, lefu la tsoekere, khatello e phahameng ea mali). Tsoela pele ho noa meriana efe kapa efe eo ngaka eo ue laetseng hore e phekole maemo ana.

Lorcaserin Hcl phofo (846589-98-8) Mokhoa oa Ketso

Le hoja mokhoa o sa tsejoeng o sa tsejoe, ho lumeloa hore ho na le li-receptor tsa 5-HT2C tse khethollang li-anorexigic pro-opiomelanocortin neurons mokokotlong oa arpothalamus. Sena se fella ka ho fokotseha ho ja lijo le ho fokotsa lijo ka ho khothalletsa ho lokolloa ha alpha-melanocortin e susumetsang hormone, e sebetsang ka melanocortin-4 receptors.

Lorcaserin hydrochloride powder e sebetsa ka ho laola takatso ea lijo - haholo-holo ka ho kenya li-receptor tsa boko bakeng sa serotonin, neurotransmitter e bakang maikutlo a ho khora le khotsofalo. Ho jeoa ha lijo ho laoloa ke setsi sa satiety, se fumanehang kahare ho moea oa hypothalamus le setsi sa tlala se teng hamorao ho hypothalamus. Lits'ebetso tse fapaneng tse tsoang litsing tse phahameng le lipampitšana tsa mala li kopana le khubung ea arcuate, moo ho nang le mefuta e 'meli ea methapo ea kutlo e laolang ho ja. Taba ea mantlha, sehlopha se susumetsang lijo tse hlahisang protheine e amanang le agouti le neuropeptide Y; mme la bobeli, sehlopha se thibelang ho ja lijo se nang le k'hok'heine le amphetamine (CART) le li-neuron tsa pro-opiomelanocortin (POMC). POMC e na le li-receptor tsa 5-HT 2C, tseo ha li kengoa tšebetsong li hlahisang alpha-melanocyte-e susumetsang hormone (alfa-MSH). Paraventricular nucleus e na le melanocyte 4 receptors (MC4R) e thibelang takatso ea kalafo litekanyetsong tsa kalafo ea lorcaserin hydrochloride powder e sebetsa joalo ka khetho ea 5-HT 2C agonist ho li-neurone tsa POMC, e leng eona e bakang ho lokolloa ha alfa MSH. Alfa e tsoelang pele MSH e sebetsa ka MC4R ka khubung ea paraventricular ho hypothalamus, e lebisang ho fokotseheng ha takatso ea lijo. Ka litekanyetso tsa supratherapeutic, lorcaserin hydrochlorider e boetse e sebetsa ho li-receptor tsa 5-HT 2B le 5-HT 2A.

melemo e ea Lorcaserin Hcl powder (846589-98-8)

  • Phofo ea Lorcaserin HCL ke khetho ea 5-HT2C e amohelang batho ba nang le bokooa e nkoang e fokotsa lijo tse kenang ka har'a mokhoa oa POMC. Litlhoko tsa phofo tsa Lorcaserin HCL:
  • Lorcaserin HCL phofo e sebelisitsoe hammoho le ho ja le ho ikoetlisa ho phekola botenya.
  • Ka linako tse ling phofo ea Lorcaserin HCL e sebelisoa ho phekola botenya bo ka amanang le lefu la tsoekere, k'holeseterole e phahameng kapa khatello ea mali e phahameng.
  • Lorcaserin HCL phofo e ke ke ea tšoara boemo leha e le bofe ba bophelo bo botle (tse kang lefu la pelo, lefu la tsoekere, khatello e phahameng ea mali).

Khothalletso ea Lorcaserin Hcl (846589-98-8) Palo

Phofo ea Lorcaserin HCL e tla ka foromo ea letlapa mme e nkuoa hangata ka makhetlo a 1-2 ka letsatsi, e na le kapa e se na lijo. Lorcaserin e tlameha ho sebelisoa hammoho le lijo tse fokotsehileng tsa khalori le moralo oa boikoetliso.

Tekanyo e khothalletsoang ea lorcaserin hcl phofo ke 10 mg e tsamaisoang ka molomo habeli ka letsatsi. Lorcaserin e ka nkoa ntle le lijo. Lorcaserin hcl e lokela ho emisoa ho bakuli ba sa atleheng ho fumana bonyane tahlehelo ea boima ba 5% ka beke ea 12 ho tloha ha bakuli bana ba se na monyetla oa ho lahleheloa ke boima ba 'mele ka kalafo e tsoelang pele.

Litla-morao ea Lorcaserin Hcl powder (846589-98-8)

Phofo ea Lorcaserin Hcl e sebelisetsoa ho phekola taolo ea boima bo sa foleng ho batho ba baholo ba nang le index ea boima ba 'mele (BMI) ea 30 kapa ho feta (botenya) joalo ka tlatsetso ea phepo e fokotsoang ea khalori le boikoetliso. E boetse e amoheloa hore e sebelisoe ke batho ba baholo ba nang le BMI ea 27 kapa ho feta (boima bo fetang boima ba 'mele) mme ba nang le bonyane boemo bo amanang le boima bo joalo ka khatello e phahameng ea mali (hypertension), kapa cholesterol e phahameng (dyslipidemia). Leha ho le joalo, e kanna ea ba le litla-morao tse ling. Jwalo ka tlase:

 Tlitla-morao tse tloaelehileng haholo:

  • -Ke hlahlamang,
  • -Boiketsi,
  • -Fatigue,
  • -Ba baka,
  • -Khala molomo,
  • -Constipation, le
  • -Hygoglycemia (tsoekere e tlaase ea mali).

 Litla-morao tse ling tse tloaelehileng empa tse tebileng tse amanang le lorcaserin li kenyelletsa:

  • -Bala mathata a li-valve,
  • -Ka ho ela hloko kapa ho hopola,
  • Mathata a kelello,
  • -Khatello kapa maikutlo a ho ipolaea,
  • -Ke likhetho tse ntle,
  • -Ka otla pelo,
  • -A theohela palo ea lisele tsa mali, le
  • -Ka eketseha ha hormone, prolactin.