Palesa e tala ea Orlistat (96829-58-2) video
Palesa e meholo ea Orlistat (96829-58-2)
Mofuta o moholo oa Orlistat o sehlopheng sa meriana e bitsoang lipase inhibitors e sebetsang ka ho thibela ho monya mafura a 25% lijong 'me e sebelisetsoa ho theola boima ba' mele ho batho ba baholo ba fetang boima ba 'mele, ba lilemo li 18 le ho feta, ha e sebelisoa hammoho le khalori e fokotsehileng le lijo tse se nang mafura a mangata. Raw Orlistat phofo ke setlhare se etselitsoeng ho phekola botenya. Mosebetsi oa ona oa mantlha ke ho thibela ho monya mafura ho tsoa lijong tsa batho, ka tsela eo ho fokotsa ho kenella ha khalori. Raw Orlistat phofo e sebetsa ka ho thibela pancreatic lipase, enzyme e pshatlang triglycerides ka maleng. Ntle le enzyme ena, triglycerides e tsoang lijong e thibeloa ho fuoa hydrolyzed hore e be mafura a mafura a sa keneng 'me a ntšoa ka ntle ho lijo. Pherese ea Orlistat ea phofo e sebelisoa ho batho ba nonneng haholo ba ka bang le khatello e phahameng ea mali, lefu la tsoekere, k'holeseterole e phahameng kapa lefu la pelo. Katleho ea phofo ea Raw Orlistat ho khothaletsa tahlehelo ea boima e hlakile empa e inyenyefatsa. Lintlha tse kopantsoeng tse tsoang litekong tsa bongaka li fana ka maikutlo a hore batho ba fuoe phofo ea Raw Orlistat ntle le liphetoho tsa bophelo, joalo ka lijo le boikoetliso, ba lahleheloa ke li-kilograma tse 2-3 (4.4-6.6 lb) ho feta ba sa sebeliseng sethethefatsi nakong ea selemo. Raw Orlistat phofo e boetse e fokotsa khatello ea mali ka boikokobetso mme e bonahala e thibela ho qala ha mofuta oa 2 lefu la tsoekere, ekaba ho tloha boima ba 'mele ka bohona kapa litlamorao tse ling. E fokotsa ts'oaetso ea lefu la tsoekere la mofuta oa II ho batho ba nang le botenya ho lekana le liphetoho tse etsoang ke bophelo.
Palesa e meholo ea Orlistat (96829-58-2) Lintlha
| Name Product | Palesa e meholo ea Orlistat |
| Lebitso la lik'hemik'hale | Tetrahydrolipstatin, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate |
| Brand Name | Alli, Xenical |
| Sehlopha sa Lithethefatsi | lipase inhibitors |
| Nomoro ea CAS | 96829-58-2 |
| InChIKey | AHLBNYSZXLDEJQ-FWEHEUNISA-N |
| limolek'hule Formula | C29H53NO5 |
| limolek'hule Wtse robeli | 495.745 g / mol |
| Masapo a monoisotopic | 495.392 g / mol |
| Ho qhibiliha Poli | <50 ° C |
| Fho tsosolosa Poli | Ha ho letsatsi le fumanehang |
| Likokoana-hloko tsa Half-Life | E itšetlehile ka boitsebiso bo lekanyelitsoeng, halofo ea bophelo ea phofo ea Raw Orlistat e nkiloeng e le ka har'a 1 ho ea ho lihora tsa 2. |
| Color | Pula e tšoeu |
| Solubility | DMSO: 19 mg / mL |
| Storage Tmocheso | nako ea ho boloka. 2-8 ° C |
| Aho latela | Sebelisa ho tšoara botenya. |
Raw Orlistat phofo (96829-58-2) Tlhaloso
Pula e mafura ea Orlistat e ka sehlopheng sa meriana e bitsoang lipase inhibitors e sebetsang ka ho thibela ho kenngoa ha 25% ea mafura a lijo le ho sebelisoa ho fokotsa boima ba batho ba baholo ba ho feta boima ba 'mele, lilemo tsa 18 le ho feta, ha li sebelisoa hammoho le khalori e fokotsehileng le lijo tse fokolang mafura.
Pula e monate ea Orlistat ke lithethefatsi tse etselitsoeng ho phekola botenya. Mosebetsi oa eona o ka sehloohong ke ho thibela mafura a tsoang ho lijo tsa batho, ka tsela eo ho fokotsa lijo tsa caloric. Moriana o moholo oa Orlistat o sebetsa ka ho thibela pancreatic lipase, e leng enzyme e senyang triglycerides ka maleng. Ntle le enzyme ena, triglycerides ho tloha lijong e thibela ho haelloa ke hydrolyzed hore e fumanehang mahala mafura acid 'me ba excreted ungested. Palo e ngotsoeng ka letsoho ea Orlistat e sebelisoang ka molao e sebelisoa ho batho ba fetang boima ba 'mele ba nang le khatello ea mali e phahameng, lefu la tsoekere, k'holeseterole e phahameng kapa lefu la pelo. Katleho ea phofo ea Raw Orlistat e matlafatsang ho lahleheloa ke boima ba 'mele ke e tobileng empa e itekanetse. Lintlha tse arohaneng tse tsoang litekong tsa meriana li fana ka maikutlo a hore batho ba fuoe phofo ea Raw Orlistat ho phaella ho phetoho ea bophelo, e kang ho ja le ho ikoetlisa, ba lahleheloa ke lik'hilograma tse 2-3 (4.4-6.6 lb) ho feta ba sa sebeliseng lithethefatsi ka nako ea selemo. Moriana o monate oa Orlistat o boetse o fokotsa khatello ea mali 'me o bonahala o thibela ho qala ha mofuta oa lefu la tsoekere la 2, ebang ke oa boima ba' mele kapa liphello tse ling. E fokotsa ts'oaetso ea lefu la tsoekere la mofuta oa II ho batho ba nang le boima bo bongata ba palo e lekanang ea liphetoho tsa bophelo.
Orlistat phofo (96829-58-2) Mehato ea Ketso
Orlistat phofo ke mofuta oa lipase o thibelang tahlehelo ea boima ba 'mele ebile ke sehlahisoa sa hydrated sa lipostatin. Orlistat ka katleho le ka mokhoa o khethiloeng e thibela mala lipase le lipancreatic lipase, ha e sa na tšusumetso ho li-enzyme tse ling tse silang lijo (joalo ka amylase, trypsin le chymotrypsin) le phospholipase, ebile ha e ame ho monya lik'habohaedreite, liprotheine le phospholipids. Meriana ena ha e monye le ha e le ka mpeng 'me e na le tšitiso e ka khutlisetsoang ho lipase. Orlistat e thibela li-enzyme ka ho tlama ka covalent ho masala a serine libakeng tse sebetsang tsa mpa le pancreatic lipase. Sena se thibela mafura a lijong hore a se ke a theoleloa mafura a mafura le diacylglycerol, ka hona e ke ke ea kenella, ea theola ho ja ha kalori mme ka hona ea laola boima ba 'mele. Meriana ena ha e hloke hore e kenngoe ke 'mele oohle hore e sebetse. Ts'ebetso ea meriana ea Orlistat e ipapisitse le tekanyetso: tekanyetso ea kalafo ea Orlistat (120mg / d, tid, e nkuoeng le lijo), e kopantsoeng le phepo e tlase ea khalori, e ka fokotsa ho fihlela ho 30% ea monya mafura. Phuputsong e bapisang baithaopi ba tloaelehileng le ba nonneng, Orlistat e ne e sa ananeloe ke mmele ho hang mme e na le khatello ea mali e tlase haholo. Kamora tekanyo e le 'ngoe ea molomo (e kholo ka ho fetisisa e le 800mg), khatello ea mali ea Orlistat lihoreng tse latelang tsa 8 e ne e le <5 ng / ml. Ka tloaelo, tekanyetso ea kalafo ea Orlistat e monya mmele hanyane feela mme e ke ke ea ipokellela nakong e khuts'oane ea kalafo. Tekong ea in vitro, sekhahla se tlamang sa Orlistat le liprotheine tse ling tsa serum se feta 99% (liprotheine tse tlamiloeng e ne e le lipoprotein le albin), 'me sekhahla sa eona se tlamang le lisele tse khubelu tsa mali se ne se le tlase haholo.
Melemo ea phofo ea orlistat (96829-58-2)
▪ Orlistat e fokotsa boima ba 'mele ka ho feta 20% ka litšenyehelo tsa mafura a' mele
▪ Orlista e u thusa ho ithuta ho bala lik'halori
▪ Orlista eu fa maikutlo a boiketlo
▪ Orlista e na le litholoana tse ntle tse fanang ka boits'epo le thabo ho basebelisi
▪ Orlista e fana ka liphetho tsa nako e telele tse tšoarellang
▪ Orlista e fokotsa ho teba ha mafu a kang hypotension, lefu la tsoekere, atherosclerosis le
k'holeseterole.
E khothalletsoa Orlistat phofo (96829-58-2) Palo
Palo e khothalletsoang ea Orlistat phofo ke sesebelisoa se le seng sa 120-mg ka makhetlo a mararo ka letsatsi le lijo tse ka sehloohong tse nang le mafura (nakong ea nako kapa ho fihlela ho 1 hora ka mor'a lijo). Mokhoa o ka holimo ho 120 mg ka makhetlo a mararo ka letsatsi ha oa bontšoa hore o fana ka molemo o eketsehileng.
Batho ba lokela ho ja lijo tse nang le phepo e nepahetseng, tse fokotsehileng tse nang le lik'hilograma tse ka bang 30% tsa mafura. Ho ja mafura, lik'habohaedreite le liprotheine letsatsi le leng le le leng ho lokela ho abeloa lijo tse tharo tse ka sehloohong. Haeba lijo li sa hlokomeloe kapa ha li na mafura, phofo ea Orlistat e ka tlosoa.
Hobane phofo ea Orlistat e bonts'itsoe ho fokotsa ho monya li-vithamine tse qhibilihang mafura le betacarotene, batho ba lokela ho eletsoa ho nka li-multivitamin tse nang le livithamini tse qhibilihang mafura ho netefatsa phepo e nepahetseng. Ntle le moo, tlatsetso ea vithamine e lokela ho nkuoa bonyane lihora tsa 2 pele kapa kamora tsamaiso ea phofo ea Orlistat, joalo ka ha u robala.
Litla-morao tsa phofo ea Orlistat (96829-58-2)
Ho tloaelehile ho bona litla-morao tsa phofo ea Orlistat hang ha ue sebelisa. U ka ba le litla-morao tse ling kapa eseng feela ka mor'a ho noa meriana efe kapa efe. Boholo ba liphello tse tlisoang ke tšebeliso ea phofo ea Orlistat li amana le tsela eo e sebetsang ka eona tsamaisong ea hau ea lijo. Hangata li bonolo ebile lia etsahala hang ha o qala kalafo. Li boetse li etsahala ka mor'a hore u nke lijo tse mafura haholo. Ka lehlohonolo, bongata ba bona boa tsamaea ha phekolo e ntse e tsoela pele le ka mor'a ho ja lijo tse nepahetseng.
Tse latelang ke tse ling tsa litla-morao tse tloaelehileng:
▲ Hlooho ea hlooho
▲ Matšoao a mpeng
▲ Phallo ea oli
▲ Lijo tse nyenyane
▲ Phofshoana ea letlalo
▲ Bohloko bo khutlang
Ntle ho moo, haeba u feta leha e le efe ea litla-morao tsena, u lokela ho e nka e le boemo bo potlakileng 'me u bitse ngaka hang-hang. Ke;
▲ Bohloko bo bohloko ba mpa bo sa tsamaeeng.
▲ Li-hives kapa ho hlatsoa ho feteletseng
▲ Bothata bo ho metsa
▲ Ho phefumoloha ho thata
