Nikotinamide adenine dinucleotide (53-84-9) video
Nicotinamide adenine dinucleotide (53-84-9) Slitšobotsi
| Name Product | Nicotinamide adenine dinucleotide (NAD +) |
| Lebitso la lik'hemik'hale | Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride; |
| Nomoro ea CAS | 53-84-9 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| Smile | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| Molecular Formula | C21H27N7O14P2 |
| Boima ba 'mele | 663.4 g / mol |
| Masapo a monoisotopic | 663.109123 g / mol |
| Melting Point | 160 ° C (320 ° F; 433 K) |
| Color | White |
| Stempage temp | 2-8 ° C |
| Solubility | H2O: 50 mg / mL |
| kopo | Lijo tsa bophelo bo botle, litlolo, motsoako o matlafatsang |
ke eng Nikotinamide adenine dinucleotide(NAD +)?
Nicotinamide adenine dinucleotide (NAD) ke cofactor e thusang metabolism e fumanoang liseleng tsohle tse phelang. E fumaneha ka mefuta e 'meli, oxidized (NAD +) mme e fokotsehile (NADH).
Coenzyme NAD +, mofuta oa oxidised oa NAD, e qalile ho fumanoa ka 1906 ke litsebi tsa biochemists tsa Borithane Arthur Harden le William John Young. NAD + e entsoe ka litsela tse peli tsa metabolic, tse ka hlahisoang ho tsoa tseleng ea de novo amino acid, kapa e ka hlahisoa ka ho lokisa likarolo tse entsoeng pele (tse kang nicotinamide) ho khutlela tseleng ea pholoso ea NAD +. Ke ea bohlokoa pyridine nucleotide mme e sebetsa e le cofactor ea bohlokoa le substrate bakeng sa lits'ebetso tse ngata tsa bohlokoa tsa cellular tse kenyelletsang phosphorylation ea oxidative le tlhahiso ea ATP, tokiso ea DNA, taolo ea epigenetic ea polelo ea gene, intracellular calcium signaling le mosebetsi oa Immunological.
NAD + ke molek'hule e ka sehloohong e amohelang elektrone ho oxidation ea biological. E amohela lielektrone ho tsoa limolek'hule tse ling 'me ea fokotsoa. E boetse e sebetsa e le coenzyme ea phetisetso ea hydride le substrate e jang polane ea NAD (+), 'me e theha coenzyme redox para ka β-nicotinamide adenine dinucleotide (NADH). NAD (R) ke "ribP" ea AdP-ribose donor unit e fumanehang ho ADP-A. Hape ke selelekela sa cyclic ADP-ribose (ADP-ribosyl cyclase).
Joaloka oxidant ka metabolism ea sele, NAD (R) le eona e bapala karolo ea adenosine diphosphate (ADP) -e fetisa liphetoho tse amang diadenylate (ADP-ribose) polymerase le lits'ebetso tse ling tse ngata tsa enzymatic. E ka thibela NAD ho thibela kapa ho fokotsa lefu la tsoekere, mofetše le mafu a mang a amanang le lilemo. Hape, li-boost tsa NAD + li ka sebetsa ka mokhoa o lumellanang le li-supplement tse kang resveratrol ho thusa ho nchafatsa mitochondria le ho loants'a maloetse a tsofalang.
Nikotinamide adenine dinucleotide(NAD +) melemo
Ha e le oxidant e sebetsang, Nikotinamide adenine dinucleotide e bonts'a melemo e meng e metle mesebetsing ea motho.
Im Ntlafatsa ts'ebetso ea hau ea lisele,
Eketsa matla a hau ka tlhaho;
Ntlafatsa ts'ebetso ea boko, tsepamiso le mohopolo;
Ost Matlafatsa metabolism ea hau;
Rove Ntlafatsa boroko;
♦ Ho matlafatsa ts'ebetso ea sirtuin ea lefats'e;
♦ Ntlafatsa katleho ea antioxidant;
Fokotsa ho ruruha;
Ho ntlafatsa botsitso, maikutlo, pono le kutlo;
Nicotinamide adenine dinucleotid le eona ke sepheo se tobileng sa moriana isoniazid, o sebelisetsoang ho phekola lefuba, tšoaetso e bakoang ke Mycobacterium lefuba. Tekong e le 'ngoe, litoeba tse fuoeng NAD ka beke e le' ngoe li ntlafalitse puisano ea nyutlelie-mitochrondrial.
Ntle le moo, Nikotinamide adenine dinucleotide (NAD +) e boetse e na le thibelo le kalafo ea ho thiba ha pelo, sinus node function le anti-potlako ea liteko tsa liteko, nicotinamide e ka ntlafatsa haholo sekhahla sa pelo le atriove ntricular block e bakoang ke verapamil.
Nikotinamide adenine dinucleotide(NAD +) e sebetsa joang:
- Tsebiso ea ho hlapela lihlahisoa tse tala, liteko tsa boithuto ba mahlale.
- Lijo tsa bophelo bo botle, litlolo, motsoako o matlafatsang
- Tlhahiso ea API
Hape Nikotinamide adenine dinucleotide(NAD +) lipatlisiso
Li-enzyme tse etsang le ho sebelisa NAD + le NADH li bohlokoa ho pharmacology ka bobeli le ho etsa lipatlisiso kalafo ea nako e tlang bakeng sa mafu. Coenzyme NAD + ha e sebelisoe hajoale e le kalafo ea lefu lefe kapa lefe. Leha ho le joalo, e ntse e ithutoa bakeng sa ts'ebeliso ea eona ea kalafo ea mafu a methapo e kang lefu la Alzheimer's and Parkinson.
Tlhaloso:
- Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism in health and disease" (PDF). Mekhoa ea Likokoana-hloko. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. E bolokiloe ho tsoa ho ea pele (PDF) ka la 4 Phupu 2009. E khutlisitsoe ka la 23 Tšitoe 2007.
- Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Ho khetholla morali oa lipalangoang oa NAD + ho Saccharomyces cerevisiae". J. Biol. Khem. 281 (3): 1524 - doi: 10.1074 / jbc.M510425200. PMID 16291748.
- Lin SJ, Guarente L (Mphalane 2003). "Nicotinamide adenine dinucleotide, taolo ea metabolic ea sengoloa, bophelo bo bolelele le mafu". Mokotla. Opin. Cell Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
- Williamson DH, Lund P, Krebs HA (1967). "Boemo ba redox ba mahala nicotinamide-adenine dinucleotide ho cytoplasm le mitochondria ea sebete sa rat". Likokoana-hloko. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
- Foster JW, Moat AG (1 Hlakubele 1980). "Nicotinamide adenine dinucleotide biosynthesis le pyridine nucleotide cycle metabolism ka likokoana-hloko". Microbiol. Tšen. 44 (1): 83– PMC 373235. PMID 6997723.
- Sefora SW. Binging e sa foleng ea joala e lematsa sebete le litho tse ling ka ho fokotsa maemo a NAD⁺ a hlokahalang bakeng sa ts'ebetso ea sirtuin's deacetylase. Tlhaloso ea Mol Pathol. 2016 Mphalane; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
- Kane AE, Sinclair DA. Sirtuins le NAD + ho Nts'etsopele le Phekolo ea Maloetse a Metabolic le Cardiovascular. Potoloho ea Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.
