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Nicotinamide adenine dinucleotide (53-84-9)

Nicotinamide adenine dinucleotide (NAD) ke cofactor e thusang metabolism e fumanoang liseleng tsohle tse phelang. E teng ka mefuta e 'meli …….


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Nicotinamide adenine dinucleotide (53-84-9) Slitšobotsi

Name Product Nicotinamide adenine dinucleotide (NAD +)
Lebitso la lik'hemik'hale Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
Nomoro ea CAS 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
Smile C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Molecular Formula C21H27N7O14P2
Boima ba 'mele 663.4 g / mol
Masapo a monoisotopic 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
Color White
Stempage temp 2-8 ° C
Solubility H2O: 50 mg / mL
kopo Lijo tsa bophelo bo botle, litlolo, motsoako o matlafatsang

ke eng Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) ke cofactor e thusang metabolism e fumanoang liseleng tsohle tse phelang. E fumaneha ka mefuta e 'meli, oxidized (NAD +) mme e fokotsehile (NADH).

Coenzyme NAD +, mofuta oa oxidised oa NAD, e qalile ho fumanoa ka 1906 ke litsebi tsa biochemists tsa Borithane Arthur Harden le William John Young. NAD + e entsoe ka litsela tse peli tsa metabolic, tse ka hlahisoang ho tsoa tseleng ea de novo amino acid, kapa e ka hlahisoa ka ho lokisa likarolo tse entsoeng pele (tse kang nicotinamide) ho khutlela tseleng ea pholoso ea NAD +. Ke ea bohlokoa pyridine nucleotide mme e sebetsa e le cofactor ea bohlokoa le substrate bakeng sa lits'ebetso tse ngata tsa bohlokoa tsa cellular tse kenyelletsang phosphorylation ea oxidative le tlhahiso ea ATP, tokiso ea DNA, taolo ea epigenetic ea polelo ea gene, intracellular calcium signaling le mosebetsi oa Immunological.

NAD + ke molek'hule e ka sehloohong e amohelang elektrone ho oxidation ea biological. E amohela lielektrone ho tsoa limolek'hule tse ling 'me ea fokotsoa. E boetse e sebetsa e le coenzyme ea phetisetso ea hydride le substrate e jang polane ea NAD (+), 'me e theha coenzyme redox para ka β-nicotinamide adenine dinucleotide (NADH). NAD (R) ke "ribP" ea AdP-ribose donor unit e fumanehang ho ADP-A. Hape ke selelekela sa cyclic ADP-ribose (ADP-ribosyl cyclase).

Ha e le oxidant ho metabolism ea sele, NAD (R) e bapala karolo ea adenosine diphosphate (ADP) -pielo phetiso e kenyelletsang polymerase ea diadenylate (ADP-ribose) le lits'ebetso tse ling tse ngata tsa enzymatic. E ka fa NAD pele ho tšitiso ho thibela kapa ho fokotsa lefu la tsoekere, mofetše le mafu a mang a amanang le lilemo. Hape, li-boost tsa NAD + li ka sebetsa ka mokhoa o kopaneng le li-supplements tse kang resveratrol ho thusa ho nchafatsa mitochondria le ho loants'a mafu a botsofaling.

Nicotinamide adenine dinucleotide(NAD +) melemo

Ha e le oxidant e sebetsang, Nikotinamide adenine dinucleotide e bonts'a melemo e meng e metle mesebetsing ea motho.

♦ Sebelisa mesebetsi ea hau ea mobile

Eketsa matla a hau ka tlhaho;

♦ Ntlafatsa ts'ebetso ea bokong, ho tsepamisa mohopolo le ho hopola;

Ost Matlafatsa metabolism ea hau;

Ntlafatsa boroko;

Ost Ho eketsa ts'ebetso ea lefats'e la Sirtuin;

♦ Ntlafatsa katleho ea antioxidant;

Fokotsa ho ruruha;

Balance Tekano e ntlafalitsoeng, maikutlo, pono le kutlo;

Nicotinamide adenine dinucleotid le eona e lebisitsoe ka kotloloho ho lithethefatsi isoniazid, se sebelisoang ho kalafo ea lefu la ho bolaoa ke lefu la tšoaetso, lefu le bakoang ke lefuba la Mycobacterium. Thutong e le 'ngoe, litoeba tse fuoeng NAD bakeng sa beke e le ngoe li ntlafalitse puisano ea nyutlelie ka nyutlelie.

Ntle le moo, Nikotinamide adenine dinucleotide (NAD +) e boetse e na le thibelo le kalafo ea ho thiba ha pelo, sinus node function le anti-potlako ea liteko tsa liteko, nicotinamide e ka ntlafatsa haholo sekhahla sa pelo le atriove ntricular block e bakoang ke verapamil.

Nicotinamide adenine dinucleotide(NAD +) e sebetsa joang:

  1. Tsebiso ea ho hlapela lihlahisoa tse tala, liteko tsa boithuto ba mahlale.
  2. Lijo tsa bophelo bo botle, litlolo, motsoako o matlafatsang
  3. Tlhahiso ea API

Hape Nicotinamide adenine dinucleotide(NAD +) lipatlisiso

Li-enzyme tse etsang le ho sebelisa NAD + le NADH li bohlokoa ho pharmacology le lipatlisisong tsa kalafo ea nako e tlang bakeng sa maloetse. Coenzyme NAD + ha e sebelisoe hona joale e le kalafo ea lefu lefe kapa lefe. Leha ho le joalo, e ntse e ithutoa bakeng sa tšebeliso ea eona e ka bang teng kalafong ea mafu a neurodegenerative joalo ka lefu laAlzheimer's andParkinson.

Tlhaloso:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism ho bophelo bo botle le bokuli" (PDF). Mekhoa ea Biochem. Saense 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. E bolokiloe ho tloha ea mantlha (PDF) ka 4 Phupu 2009. E khutlisitsoe ka la 23 Pherekhong 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). Tsebiso ea transporter ea mitochondrial NAD + ho Saccharomyces cerevisiae ”. J. Biol. Khemo. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Mmesa 2003). "Nicotinamide adenine dinucleotide," metabolic control of transcript, nako e telele le lefu ". Borr. Opin. Cell Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Sebaka sa" redox "sa" nicotinamide-adenine dinucleotide "setsing sa cytoplasm le mitochondria ea" sebete ". Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Qobella JW, Moat AG (1 Hlakubele 1980). "Nicotinamide adenine dinucleotide biosynthesis le pyridine nucleotidejikele metabolism ka lits'ebetsong tsa likokoana-hloko". Microbiol. Tshenolo 44 (1): 83– PMC 373235. PMID 6997723.
  • French SW. Ho itlopa joala ho sa feleng ho lematsa sebete le litho tse ling ka ho fokotsa maemo a NAD⁺ a hlokahalang bakeng sa ts'ebetso ea sirtuin deacetylase. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. Doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins le NAD + ho Nts'etsopele le Phekolo ea Maloetse a Metabolic le Cardiovascular. Potoloho ea Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


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