Phofo ea cycloastragenol

April 17, 2020

Cycloastragenol ke motsoako oa phepelo ea lijo o khahlanong le botsofali 'marakeng.

Cycloastragenol phofo (78574-94-4) video

Cycloastragenol phofo Slitšobotsi

Name Product Phofo ea cycloastragenol
Lebitso la lik'hemik'hale N / A
Li-synonyms lenangpheng

cyclogalegigenin

GRN510

CAG

Sehlopha sa Lithethefatsi N / A
Nomoro ea CAS 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
limolek'hule Formula C30H50O5
limolek'hule Wtse robeli 490.7 g / mol
Masapo a monoisotopic 490.365825 g / mol
Sebaka se belang  N / A
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life N / A
Color ho tšoeu ho beige
Sho khoneha  DMSO: 10 mg / mL, hlakileng
Storage Tmocheso  2-8 ° C
Aho latela Cycloastragenol ke activator ea matla ea telomerase. Hape, e ka hokahana le anti-botsofe ho moriana oa setso oa chinese.

Overview

Cycloastragenol ke motsoako oa phepelo ea lijo o khahlanong le botsofe 'marakeng. E sebelisoa hape ka mekhoa e metle ea skincare le litlolo. Cycloastragenol e ile ea rekisoa ka lekhetlo la pele ho lisebelisoa tsa phepo e nepahetseng USA ka 2007 tlasa lebitso la TA-65, ke ka lebaka lena TA 65 kapa TA65 e ntseng e le lebitso le tsebahalang haholo la cycloastragenol.

Cycloastragenol ke eng?

Cycloastragenol ke molek'hule e nkiloeng ka setlama sa Astragalus membranaceus. Setlama sa Astragalus se sebelisitsoe litlhare tsa China lilemo tse makholo. Machaena o ile a re Astragalus e ka lelefatsa bophelo, 'me e' nile ea e sebelisa ho phekola mokhathala, lefu la sefuba, sefuba, lefu la pelo le lefu la tsoekere.

Cycloastragenol ke e 'ngoe ea metsoako e sebetsang ho Astragalus. Cycloastragenol e na le sebopeho se tšoanang sa lik'hemik'hale se tšoanang le molek'hule ea Astragaloside IV, empa e nyane ebile e kholo haholo ka bioavavage, e nolofalletsang ho nooa litekanyetso tse tlase. E se e sebelisoa e le immunostimulant ka lebaka la bokhoni ba eona ba ho eketsa proliferation ea T lymphocyte. Leha ho le joalo, ke thepa ea eona e khahlano le ho tsofala e khahlang sechaba sa mahlale.

Cycloastragenol e hlohlelletsa ho lokisoa ha tšenyo ea DNA ka ho kenya ts'ebetsong telomerase, enzyme ea nucleoprotein e etsang hore khalase e be teng le kholo ea DNA ea telomeric. Li-telomere li entsoe ka likhoele tse tšesaane 'me li fumanoa lintlheng tsa li-chromosome. Ho boloka botsitso ba tsona ho nolofalletsa lisele hore li qobe ho itšireletsa le ho ata ho sa feleng ho feta 'moeli oa Hayflick'. Li-telomere li khutsufatsa ka potoloho e ngoe le e ngoe ea karohano ea sele, kapa ha e le tlas'a khatello ea mali. Ho fihlela joale, ona esale e le mokhoa o ke keng oa qojoa oa botsofali.

Mekhoa ea ts'ebetso ea cycloastragenol

Palo e kholo ea lithuto e bontšitse hore ho khutsufatsa ho tsoelang pele ha li-telomeres ho amana haufi le mafu a mangata a amanang le lilemo (lefu la pelo, ts'oaetso, joalo-joalo) mme hape le ponelopele ea lefu la pele ho nako lithutong tsa maqheku. Telomeres e khutsufatsa ka potoloho e 'ngoe le e' ngoe ea karohano ea sele, kapa ha e le tlas'a khatello ea oxidative. Ho fihlela joale, ona e bile mokhoa o ke keng oa qojoa oa botsofaling.

Telomerase ke enzyme ea nucleoprotein e thusang ho hlophisa ho hola le ho hola ha telomeric DNA hape e tsosetsang ho lokisoa ha ts'abo ea DNA.

Cycloastragenol e sebetsa le ho tsosa enzyme ena, ka hona e fokotsa ho khutsufatsoa ha li-telomeres hape e eketsa palo ea bona. Ka tsela ena, e lumella bolelele ba li-telomeres, ka lebaka leo, e phahamisa nako ea bophelo ea sele.

Ka lebaka la boima ba eona bo tlase ba limolek'hule, Cycloastragenol e feta habonolo ka leboteng la mala. Ho hlaphoheloa ka nepo ho lumella katleho e phahameng, leha e le ka tekanyo e tlase. Tlatsetso ea letsatsi le letsatsi ebang e ka boeona, kapa e kopane kapa e kopana le, astragaloside IV, ka hona e tla thusa ho thibela ho tsofala le ho eketsa nako ea bophelo ea tlhaho.

Cycloastragenol melemo e

Astragalus membranaceus ke e 'ngoe ea litlama tsa mantlha nalaneng ea Tloaelo ea Machaena ea Machaena e le litlhare tsa tlholeho ho phekola mokhathala, ho kula, liso, mofetše, feberu, seterouku, bophelo bo bolelele jj. Leha ho le joalo, melemo ea mantlha ea phofo ea cycloastragenol e joalo ka litlamorao tsa ho loants'a botsofali le boits'ireletso.

Cycloastragenol le ts'ehetso ea 'mele

Cycloastragenol e ka sebelisoa ho sireletsa sesole sa 'mele, li-antibacterial, le antiinflammatory, bakeng sa ho qoba sefuba se tloaelehileng le tšoaetso e kaholimo ea tsamaiso ea methapo. E sebelisitsoe joalo ka matlafatso ea 'mele ea ho itšireletsa mafung hobane e khona ho nyolla ts'oaetso ea T lymphocyte ea T. Empa, seo sechaba sa mahlale se ntseng se se thahasella le ho feta ke ho hanyetsa ha sona botsofaling. Cycloastragenol e khothaletsa DNA ho lokisa tšenyo ka ho qala telomerase le ho lumella protheine ea nyutlelie e ts'oarisang ho hola le ho hola ha telomere DNA.

Cycloastragenol le anti-botsofali

Ho khaotsa ho tsofala ke molemo o hlakileng haholo oa cycloastragenol. Cycloastragenol ha e liehise botsofaling ba batho feela, empa ka ho eketsehileng e ntlafalitse ho itšireletsa mafung, ho senya chefo, ho sireletsa lisele tsa pelo, haholoholo ho tsoa ho hydrolaloside (Astragaloside Ⅳ) hydrolysis.

Melemo e meng ea Cycloastragenol

  1. cycloastragenol phofo e na le phello ea ho imolla khatello ea maikutlo le ho sireletsa 'mele khahlanong le likhatello tse fapaneng, ho kenyelletsa khatello ea maikutlo, ea kelello kapa ea maikutlo;
  2. cycloastragenol phofo e na le li-antioxidants, tse sirelletsang lisele khahlano le tšenyo e bakiloeng ke li-radicals tsa mahala;
  3. cycloastragenol phofo e na le phello ea ho theola khatello ea mali, ho phekola lefu la tsoekere le ho sireletsa sebete.

Cycloastragenol litlamorao tsa phofo

Ho fihlela hajoale, ha ho na tlaleho kapa litlhahlobo tsa phello e mpe kapa ho hanyetsa ho nka cycloastragenol supplement.

Cycloastragenol tlatsetsa litekanyetso

Cycloastragenol e ncha ha e bapisoa le lihlahisoa tse tlatsetsang 'marakeng,' me ha ho na lethaliti le khothalletsoang le fumanehang. Ho latela boiphihlelo ba rona, litekanyetso li fapana ka sepheo se fapaneng, lilemo. Ehlile cycloastragenol e matla ho feta Astragaloside IV eo lethalinyana la eona le khothalletsoang ke 50mg ka letsatsi. Ha o le cycloastragenol, ho nka 10mg ho isa ho 50mg ho lokile. Tlhokahalo ea khale ea ho nka ho feta batho ba baholo ba lilemo li mahareng. Ba bang ba fana ka tlhahiso ea ho qala ka 5mg ka letsatsi, ebe u eketsa butle butle. Kaha cycloastragenol ke khetla ea tlhaho, ho ka nka nako ho bona litlamorao, tse ka bang likhoeli tse tšeletseng.

Cycloastragenol sebakeng se sireletsehileng

Cycloastragenol e phatlalalitsoe ke ba bang e le moemeli oa khahlanong le botsofali. Boithuto ba pele bo bonahala bo ts'episa, ho bonts'a bo na le bokhoni ba ho eketsa bolelele ba telomere, leha ho le joalo ho na le khaello ea lipatlisiso tse ntlafalitsoeng ke lithaka. Ntle le moo, ho na le matšoenyeho a hore ho nka Cycloastragenol ho ka eketsa kotsi ea kankere e itseng. Leha ho le joalo, lithuto tsa lipatlisiso ha li a khona ho hlahisa kotsi efe kapa efe ea mofets'e e amanang le ts'ebeliso ea cycloastragenol.

Cycloastragenol e shebahala joalo ka ntho e ts'episang ho thibela botsofali. Le ha ho sa netefatsoa hore e eketsa nako ea bophelo leha ho le joalo ho bonts'itsoe ho fokotsa li-biomarker tse amanang le lilemo. Ho tlatselletsa ho bonts'itsoe ho fokotsa matšoao a botsofali joalo ka mela e metle le makhopho. E kanna ea fokotsa le menyetla ea mafu a fokolisang a kang Alzheimer's, Parkinson's, retinopathies, le cataract.

Cycloastragenol Tšebeliso ea phofo le ts'ebeliso

Cycloastragenol e sebelisetsoa kalafo, taolo, thibelo le ntlafatso ea maloetse le maemo a latelang:

  • Ho ruruha
  • Apoptosis
  • Litšitiso tsa lapeng
  • Cycloastragenol le eona e ka sebelisoa bakeng sa merero e sa thathamisitsoeng mona.

Bulk cycloastragenol phofo e sebelisitsoe karolong e ka tlase ea ts'imo:

  1. E sebelisoa tšimong ea lijo, hangata e sebelisoa e le tlatsetso ea lijo;
  2. E sebelisoa tšimong ea lihlahisoa tsa bophelo bo botle, tlhahiso ena e thusa 'mele oa motho;
  3. E kenngoa ka lebaleng la litlolo, joalo ka mofuta oa lisebelisoa tse tala, e ka kopanya litlolo tsa tlhaho.

Reference:

  • Lihlahisoa tse khahlanong le botsofali tsa cycloastragenol tse hlahisoang ke biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. doi: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: Mokhethoa ea monate oa lipale tsa mafu a amanang le lilemo. Yu Y et al. Exp Ther Med. (2018) Lihlahisoa tse khahlano le botsofali tsa cycloastragenol tse hlahisoang ke biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. doi: 10.1080 / 14786419.2019.1662011
  • Cycloastragenol e ka nyatsa ts'ebetso ea STAT3 le ho khothaletsa apltapisiti e bakoang ke "paclitaxel" liseleng tsa mofets'e oa motho. Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Jun
  • Astragaloside VI le cycloastragenol-6-O-beta-D-glucoside li khothaletsa pholiso ea leqeba ho vitro le vivo.Lee SY et al. Phytomedicine. (2018)