Cycloastragenol phofo (78574-94-4)

April 17, 2020

Cycloastragenol ke motsoako oa phepelo ea lijo o khahlanong le botsofali 'marakeng.

Cycloastragenol phofo (78574-94-4) video

Cycloastragenol phofo Slitšobotsi

Name Product Phofo ea cycloastragenol
Lebitso la lik'hemik'hale N / A
Li-synonyms astramembrangenin

cyclogalegigenin

GRN510

CAG

Sehlopha sa Lithethefatsi N / A
Nomoro ea CAS 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
limolek'hule Formula C30H50O5
limolek'hule Wtse robeli 490.7 g / mol
Masapo a monoisotopic 490.365825 g / mol
Sebaka se belang N / A
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life N / A
Color ho tšoeu ho beige
Sho khoneha DMSO: 10 mg / mL, hlakileng
Storage Tmocheso 2-8 ° C
Aho latela Cycloastragenol ke activator ea matla ea telomerase. Hape, e ka hokahana le anti-botsofe ho moriana oa setso oa chinese.

Overview

Cycloastragenol ke motsoako oa phepelo ea lijo o khahlanong le botsofe 'marakeng. E sebelisoa hape ka mekhoa e metle ea skincare le litlolo. Cycloastragenol e ile ea rekisoa ka lekhetlo la pele ho lisebelisoa tsa phepo e nepahetseng USA ka 2007 tlasa lebitso la TA-65, ke ka lebaka lena TA 65 kapa TA65 e ntseng e le lebitso le tsebahalang haholo la cycloastragenol.

Cycloastragenol ke eng?

Cycloastragenol ke molek'hule e nkiloeng ka setlama sa Astragalus membranaceus. Setlama sa Astragalus se sebelisitsoe litlhare tsa China lilemo tse makholo. Machaena o ile a re Astragalus e ka lelefatsa bophelo, 'me e' nile ea e sebelisa ho phekola mokhathala, lefu la sefuba, sefuba, lefu la pelo le lefu la tsoekere.

Cycloastragenol ke e 'ngoe ea metsoako e sebetsang ho Astragalus. Cycloastragenol e na le sebopeho se tšoanang sa lik'hemik'hale se tšoanang le molek'hule ea Astragaloside IV, empa e nyane ebile e kholo haholo ka bioavavage, e nolofalletsang ho nooa litekanyetso tse tlase. E se e sebelisoa e le immunostimulant ka lebaka la bokhoni ba eona ba ho eketsa proliferation ea T lymphocyte. Leha ho le joalo, ke thepa ea eona e khahlano le ho tsofala e khahlang sechaba sa mahlale.

Cycloastragenol e hlohlelletsa tokiso ea ts'enyo ea DNA ka ts'ebetso ea telomerase, e leng encyme ea nucleoprotein e thusang ho hlophisa le ho hola ha telomeric DNA. Li-Telomeres li entsoe ka lifilimi tse tšesaane 'me li fumaneha ho likeletso tsa chromosomes. Ho boloka botsitso ba tsona li thusa lisele ho qoba ho ikatisa le ho eketseha ho sa feleng ho feta moeli oa "Hayflick". Telomeres e khutsufatsa ka potoloho e 'ngoe le e' ngoe ea karohano ea sele, kapa ha e le tlas'a khatello ea oxidative. Ho fihlela joale, ona e bile mokhoa o ke keng oa qojoa oa botsofaling.

Mekhoa ea ts'ebetso ea cycloastragenol

Palo e kholo ea lithuto e bontšitse hore ho khutsufatsa ho tsoelang pele ha li-telomeres ho amana haufi le mafu a mangata a amanang le lilemo (lefu la pelo, ts'oaetso, joalo-joalo) mme hape le ponelopele ea lefu la pele ho nako lithutong tsa maqheku. Telomeres e khutsufatsa ka potoloho e 'ngoe le e' ngoe ea karohano ea sele, kapa ha e le tlas'a khatello ea oxidative. Ho fihlela joale, ona e bile mokhoa o ke keng oa qojoa oa botsofaling.

Telomerase ke enzyme ea nucleoprotein e thusang ho hlophisa ho hola le ho hola ha telomeric DNA hape e tsosetsang ho lokisoa ha ts'abo ea DNA.

Cycloastragenol e sebetsa le ho tsosa enzyme ena, ka hona e fokotsa ho khutsufatsoa ha li-telomeres hape e eketsa palo ea bona. Ka tsela ena, e lumella bolelele ba li-telomeres, ka lebaka leo, e phahamisa nako ea bophelo ea sele.

Ka lebaka la boima ba eona bo tlase ba limolek'hule, Cycloastragenol e feta habonolo ka leboteng la mala. Ho hlaphoheloa ka nepo ho lumella katleho e phahameng, leha e le ka tekanyo e tlase. Tlatsetso ea letsatsi le letsatsi ebang e ka boeona, kapa e kopane kapa e kopana le, astragaloside IV, ka hona e tla thusa ho thibela ho tsofala le ho eketsa nako ea bophelo ea tlhaho.

Cycloastragenol melemo e

Astragalus membranaceus ke e 'ngoe ea litlama tsa mantlha nalaneng ea setso ea Machaena a China e le litlhare tsa tlhaho tsa ho phekola mokhathala, ho kula, liso, kankere, feberu ea feberu, lefu la ho chesoa ka morao-rao, ho phela nako e telele joalo ka "cycloastragenol" ke molek'hule e tlisoang ke limela tsa limela tsa "Astragalus membranaceus". Leha ho le joalo, melemo ea bohlokoa ea phofo ea cycloastragenol e tšoana le litlamorao tsa ts'ehetso ea botsofali le boits'ireletso ba mmele.

Cycloastragenol le ts'ehetso ea 'mele

Cycloastragenol e ka sebelisoa ho sireletsa sesole sa 'mele, li-antibacterial, le antiinflammatory, bakeng sa ho qoba sefuba se tloaelehileng le tšoaetso e kaholimo ea tsamaiso ea methapo. E sebelisitsoe joalo ka matlafatso ea 'mele ea ho itšireletsa mafung hobane e khona ho nyolla ts'oaetso ea T lymphocyte ea T. Empa, seo sechaba sa mahlale se ntseng se se thahasella le ho feta ke ho hanyetsa ha sona botsofaling. Cycloastragenol e khothaletsa DNA ho lokisa tšenyo ka ho qala telomerase le ho lumella protheine ea nyutlelie e ts'oarisang ho hola le ho hola ha telomere DNA.

Cycloastragenol le anti-botsofali

Ho khaotsa ho tsofala ke molemo o hlakileng haholo oa cycloastragenol. Cycloastragenol ha e liehise botsofaling ba batho feela, empa ka ho eketsehileng e ntlafalitse ho itšireletsa mafung, ho senya chefo, ho sireletsa lisele tsa pelo, haholoholo ho tsoa ho hydrolaloside (Astragaloside Ⅳ) hydrolysis.

Melemo e meng ea Cycloastragenol

  1. cycloastragenol phofo e na le phello ea ho imolla khatello ea maikutlo le ho sireletsa 'mele khahlanong le likhatello tse fapaneng, ho kenyelletsa khatello ea maikutlo, ea kelello kapa ea maikutlo;
  2. cycloastragenol phofo e na le li-antioxidants, tse sirelletsang lisele khahlano le tšenyo e bakiloeng ke li-radicals tsa mahala;
  3. cycloastragenol phofo e na le phello ea ho theola khatello ea mali, ho phekola lefu la tsoekere le ho sireletsa sebete.

Cycloastragenol litlamorao tsa phofo

Ho fihlela joale, ha ho na tlaleho kapa litlhahlobo tsa phello e mpe kapa ea contraindication e nkang tlatsetso ea cycloastragenol.

Cycloastragenol tlatsetsa litekanyetso

Cycloastragenol e ncha ha e bapisoa le lihlahisoa tse tlatsetsang 'marakeng,' me ha ho na lethaliti le khothalletsoang le fumanehang. Ho latela boiphihlelo ba rona, litekanyetso li fapana ka sepheo se fapaneng, lilemo. Ehlile cycloastragenol e matla ho feta Astragaloside IV eo lethalinyana la eona le khothalletsoang ke 50mg ka letsatsi. Ha o le cycloastragenol, ho nka 10mg ho isa ho 50mg ho lokile. Tlhokahalo ea khale ea ho nka ho feta batho ba baholo ba lilemo li mahareng. Ba bang ba fana ka tlhahiso ea ho qala ka 5mg ka letsatsi, ebe u eketsa butle butle. Kaha cycloastragenol ke khetla ea tlhaho, ho ka nka nako ho bona litlamorao, tse ka bang likhoeli tse tšeletseng.

Cycloastragenol sebakeng se sireletsehileng

Cycloastragenol e phatlalalitsoe ke ba bang e le moemeli oa khahlanong le botsofali. Boithuto ba pele bo bonahala bo ts'episa, ho bonts'a bo na le bokhoni ba ho eketsa bolelele ba telomere, leha ho le joalo ho na le khaello ea lipatlisiso tse ntlafalitsoeng ke lithaka. Ntle le moo, ho na le matšoenyeho a hore ho nka Cycloastragenol ho ka eketsa kotsi ea kankere e itseng. Leha ho le joalo, lithuto tsa lipatlisiso ha li a khona ho hlahisa kotsi efe kapa efe ea mofets'e e amanang le ts'ebeliso ea cycloastragenol.

Cycloastragenol e shebahala e le karolo e tšepisang ea ho thibela botsofali. Le ha ho e-so fumanoe hore e eketsa nako ea bophelo empa e bontšitsoe ho fokotsa mefuta e fapaneng ea li-biomarkers tse amanang le lilemo. Ntle le moo ho bontšitsoe ho fokotsa mats'oao a botsofali a joalo ka mela e metle le likhohlano. Ho kanna ha fokotsa le monyetla oa mafu a ho fokola joaloka Alzheimer's, Parkinson's, retinopathies le lefu la mahlo.

Cycloastragenol Tšebeliso ea phofo le ts'ebeliso

Cycloastragenol e sebelisetsoa kalafo, taolo, thibelo, le ntlafatso ea maloetse a latelang, maemo le matšoao:

  • Ho ruruha
  • Apoptosis
  • Litšitiso tsa lapeng
  • Cycloastragenol le eona e ka sebelisoa bakeng sa merero e sa thathamisitsoeng mona.

Bulk cycloastragenol phofo e sebelisitsoe karolong e ka tlase ea ts'imo:

  1. E sebelisoa tšimong ea lijo, hangata e sebelisoa e le tlatsetso ea lijo;
  2. E sebelisoa tšimong ea lihlahisoa tsa bophelo bo botle, tlhahiso ena e thusa 'mele oa motho;
  3. E kenngoa ka lebaleng la litlolo, joalo ka mofuta oa lisebelisoa tse tala, e ka kopanya litlolo tsa tlhaho.

Reference:

  • Lintho tse khahlanong le botsofali tsa cycloastragenol tse hlahisoang ke biotransfform.Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G.Nat Prod Res. 2019 Sep 9: 1-6. Doi: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: Mokhethoa oa lipale tse monate tse monate oa maloetse a amanang le lilemo.Yu Y et al. Exp Ther Med. (2018) Lintho tse tlisoang ke ho tsofala tsa cycloastragenol tse hlahisoang ke biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. Doi: 10.1080 / 14786419.2019.1662011
  • Cycloastragenol e ka nyenyefatsa ts'ebetso ea "STAT3" ea ts'ebetso le ho phahamisa apoptosis ea lisele tsa mofetše oa lefu la setho.Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Jun
  • Astragaloside VI le cycloastragenol-6-O-beta-D-glucoside li khothaletsa pholiso ea leqeba ho vitro le vivo.Lee SY et al. Phytomedicine. (2018)