Meclofenoxate (Centrophenoxine) (51-68-3)

March 11, 2020
SKU: 541-15-1
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Meclofenoxate (Centrophenoxine), e rekisitsoeng ka lebitso la brand Lucidril, ke e 'ngoe ea pele le e ithutoang haholo ....


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Meclofenoxate (Centrophenoxine) (51-68-3) video

Meclofenoxate (Centrophenoxine) phofo Slitšobotsi

Name Product Meclofenoxate (Centrophenoxine) (51-68-3)
Lebitso la lik'hemik'hale Clophenoxate;
Meclophenoxate;
Clofenoxin;
Proseryl;
2- (dimethylamino) ethyl 2- (4-chlorophenoxy) acetate
Brand Name N / A
Sehlopha sa Lithethefatsi Li-antigen-Allergic Agents, Li-Ainets tsa Antineoplastic, Age ea Antiparasitic
Nomoro ea CAS 51-68-3
InChIKey XZTYGFHCIAKPGJ-UHFFFAOYSA-N
limolek'hule Formula C12H16ClNO3
limolek'hule Wtse robeli 257.71 g / mol
Masapo a monoisotopic 257.081871 g / mol
Sebaka se belang 345.941 ° C ho 760 mmHg
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life dihora tse 2-4
Color o mosoeu
Sho khoneha Solubility ea Metsi: 2.9 mg / mL
Storage Tmocheso -20 ° C
Aho latela Centrophenoxine phofo e sebelisitse litlatsetso tsa tlhabollo ea lithethefatsi tsa nootropics.

Kakaretso ea kakaretso ea Meclofenoxate (Centrophenoxine)

Meclofenoxate (Centrophenoxine), e rekisitsoeng ka lebitso la brand Lucidril, ke se seng sa lithethefatsi tsa pele ho fetisisa tse ithutoang haholo ka litlolo kapa tse bitsoang li "bohlale". Ke nootropic e tsebahalang le e hlomphuoang e ipakile e le lilemo tse fetang mashome a mahlano ts'ebeliso ea tlhahlobo ea kliniki.

Qaleho e qaliloe ka 1959 ke bo-rasaense Setsing sa Patlisiso ea Saense ea Fora e le kalafo bakeng sa lefu la Alzheimer, phallo e sa lekanang ea mali ho ea bokong, decline le ho fokotseha hoa kelello ho amanang le lilemo, setlhare sena se sebelisitsoe haholo ho phekola mafu a amanang le lilemo tsa boko, le Alzheimer's le 'dementia' E boetse e sebelisoa ke batho ba phetseng hantle ho matlafatsa ts'ebetso ea ho hopola le ho lemoha le ho ntlafatsa bophelo bo botle ba kelello.

Patlisiso e bontšitse phofo ea centrophenoxine ho ba moemeli ea matla oa ho hopola le ho hanela botsofali.

Europe, e laetsoe kalafo ea tahlehelo ea memori e amanang le lilemo, empa e fumaneha ka lebaka la morekisi e le tlatsetso ea lijo Amerika le Canada, moo e sebelisoang khafetsa bakeng sa thepa ea eona e ntlafatsang ea kelello.

Meclofenoxate (Centrophenoxine) ke eng?

Centrophenoxine e sebelisitsoe e le tlatsetso ea ho ja bakeng sa bokhoni ba eona ba ho ntlafatsa mohopolo.

Centrophenoxine ke motsoako oa lik'hemik'hale tse peli:

Dimethyl-aminoethanol (DMAE), e leng ntho ea tlhaho e fumanoang lijong tse ling (tlhapi, lijo tsa leoatleng) le ka bongata bokong. Ke mohloli oa choline hape o na le litlamorao tse susumetsang kelello.

Parachlorphenoxyacetic acid (pCPA), mofuta oa maiketsetso oa lihormone tsa kholo ea limela tse bitsoang "auxins".

DMAE ke karolo ea mantlha e sebetsang setsing sena sa lithethefatsi. DMAE ha e tšele mekoallo ea mali le bokong hantle. Leha ho le joalo, ka har'a centrophenoxine, e ka fetela ka har'a mokoallo oa mali 'me ea kena bokong hantle

Hang ha e kenelletse 'meleng, karolo ea centrophenoxine e robeha ho DMAE le pCPA ka har'a sebete. DMAE e ntan'o fetoloa hore e be choline, athe Centrophenoxine e setseng e potoloha le 'mele kaofela.

Melemo ea Meclofenoxate (Centrophenoxine)

Centrophenoxine e ka thusa ho loantša mofetše.

Centrophenoxine e kanna ea thusa matšoao a dyskinesia ea nakoana.

Centrophenoxine e ntlafatsa mohopolo le ho ithuta, e ka ntlafatsa mohopolo ho bakuli ba 'dementia'.

Centrophenoxine e bontšitsoe ho ntlafatsa sebopeho, polokelo, le ho khutlisa mehopolo. Moralo oa memori oa ntlafatsoa ha re na le maemo a holimo a acetylcholine. Ka lebaka la hore Centrophenoxine e ntlafatsa mesebetsi e fapaneng ea cholinergic, e 'ngoe ea lintho tse hlahisoang ke choline, har'a li-phospholipids tse ling tse fapaneng.

Mesebetsi e Ntlafetseng ea Kelello

Centrophenoxine e ka sebelisoa e le DMAE prodrug 'me sena se bohlokoa haholo, kaha molek'hule ena e sebetsa hantle haholo ho fokotsa molek'hule e meng e kotsi kahare ho boko e ka bakang phokotso e kholo ea mesebetsi ea kelello. Ha limolek'hule tsena li tlositsoe, batho ba baholo ba ka fokotsa botsofali ba bona le ho khutlisetsa litlamorao ho botsofaling.

Centrophenoxine e na le thepa ea ho tsofala le ho se tsofale

Centrophenoxine e bontšitsoe ho eketsa nako ea bophelo ea likhoto ho fihlela ho 50%.

Centrophenoxine e ntlafatsa Mood le ho susumetsa, e ka thusa ho kokobetsa ho tšoenyeha.

Boithuto ba liphoofolo bo supa hore centrophenoxine e na le matla a ho leka-lekanya ho loants'a ho tšoenyeha .‍

Meclofenoxate (Centrophenoxine) metabolism

Centrophenoxine e sebetsa haholo ka ho lopolla le ho ntlafatsa liketso tsa choline. Choline ke selelekela sa acetylcholine, neurotransmitter ea bohlokoa le e se nang moeli e amanang haholo le cuity acuity, plasticity, le memori. Ha ho hlake hore na hantle-ntle li-centrophenoxine li eketsa maemo a choline le acetylcholine joang, empa ho nahanoa hore ka tlhaho e ikhula ho choline kapa e fetoha phospholipid e bohareng ebe e sebelisoa ho hlahisa acetylcholine. Ho sa tsotelehe tsela e kholo, ke bokhoni ba cholinergic bo etsang hore centrophenoxine e joalo e matla ea potentiator nootropic ka tokelo ea eona.

Ntle le ntlafatso ea tlhahiso ea acetylcholine, centrophenoxine e boetse e tsejoa e le sefutho se matla sa neuro se matlafatsang ts'ebetso ea boko ka botlalo ka ho ntlafatsa ho monya ha glucose le ho phahamisa phetoho ea oksijene. Ka ho etsa joalo, centrophenoxine e etsa hore kelello e sebetse hantle, ka hona e ntlafatsa mohopolo, ho tsepamisa mohopolo, le ho hlaka mehopolo, ho tlosa ntho eo ho thoeng ke moholi oa kelello. Ha e le antioxidant e matla, e theola maqhubu a mahala, e ntša chefo le ho nka karolo ho lokiseng lisele tse senyehileng. Qetellong, e khutlisetsa botsofaling ba kelello ka ho fokotsa kapa ka ho felisa ho hahuoa ha lihlahisoa tsa litšila tsa metabolic tseo ho nkoang e le "liaparo tse senyehileng" le "."

Litla-morao tsa Meclofenoxate (Centrophenoxine) le polokeho.

Centrophenoxine ka kakaretso e nkuoa e sireletsehile ebile e se chefo. E sebelisitsoe lilemo tse ka bang 50 ntle le litla-morao tse kholo tse boletsoeng.

Ho boleloa hore ke setlhare se mamellehang ho batho ba baholo ba phetseng hantle le senile se nang le bothata ba ho lebala.

Leha ho le joalo, basebelisi ba bang ba bile le litlamorao tse bobebe le tse nyane, ho kenyelletsa ho nyekeloa, ho opeloa ke hlooho, mathata a ka mpeng, le ho hloka boroko.‍

Centrophenoxine ha e eletsoe basali ba baimana ka lebaka la litaba tsa DMAE.

Meclofenoxate (Centrophenoxine) Litekanyetso tsa phofo

Centrophenoxine e fumaneha ka holim'a mochini ho likhabapo tse nang le 200-300 mg ka ngoe. Liteko tsa kliniki tse ileng tsa leka litlamorao tsa centrophenoxine mesebetsing ea kelello li sebelisitse tekanyetso ea letsatsi le letsatsi ea

1,200 mg ho batho ba baholo ba phetseng hantle le tekanyetso ea ho fihlela ho 2,000 mg ho bakuli ba 'dementia'.

Ho pata

Centrophenoxine ke mohloli o motle oa choline, o ka e fumana mekotleng e mengata ea nootropic - e meng ea eona e atileng haholo ke Noopept le Racetams.

Centrophenoxine le Aniracetam Stack

Mona ke mohlala oa "stroprophenoxine stack" e kenyeletsang racetam aniracetam e tsebahalang ea ho holisa ho boloka mohopolo, maikutlo, boqapi, ha o ntse o fokotsa letsoalo.

1-2x ka letsatsi

250 mg Centrophenoxine

750 mg Aniracetam

Centrophenoxine le Noopept Stack

Mona ke mohlala oa stack ea centrophenoxine e nang le Noopept, stack ena e ka ntlafatsa mohopolo le ho ithuta, ha e ntse e fana ka thepa ea methapo.

1-2x ka letsatsi

250 mg Centrophenoxine

20 mg Noopept

Reference:

  • Karolong ea intracellular physicochemistry ho palo ea liphatsa tsa lefutso nakong ea botsofali le phello ea centrophenoxine. Tlhahlobo. Zs-Nagy I et al. Arch Gerontol Geriatr. (1989)
  • Moriana oa cholinergic bakeng sa dyskinesia ea antipsychotic-ikiwa. Tammenmaa-Aho I, Asher R, Soares-Weiser K, Bergman H. Cochrane Database Syst Rev. 2018 Mar 19
  • Ts'ebetso ea Cytotoxic ea li-alkylating agents ka boteng ba Centrophenoxine le lihlahisoa tsa eona tsa hydrolysis. Sladek NE. J Theracol Exp Ther. 1977 Dec
  • Potentiation ea mosebetsi oa antitumor oa cyclophosphamide ke centrophenoxine. Kanzawa F, Hoshi A, Tsuda S, Kuretani K. Gan. 1972 Aug
  • Centrophenoxine: litlamorao ho bokong ba botsofe ba mammary. Nandy K et al. J Ke Geriatr Soc. (1978)
  • Litlamorao tse fapaneng tsa meclofenoxate mabapi le tahlehelo ea memori ho batho ba tsofetseng. Marcer D et al. Botsofe. (1977)

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.