Video
songolo
| Name Product | Phororo e khōlō ea Nicotinamide Mononucleotide (NMN) |
| Mabitso a tšoanang ka moelelo le mabitso | NAMN, β-NMN, β-Nicotinamide Mononucleotide kapa Beta Nicotinamide Mononucleotide; NMN;
beta-NMN |
| Sehlopha sa Lithethefatsi | Phepo ea lijo |
| Nomoro ea CAS | 1094-61-7 |
| InChIKey | DAYLJWODMCOQEW-TURQNECASA-N |
| Foromo ea Limolek'hule | C11H15N2O8P |
| Boima ba limolek'hule | 334.22 g / mol |
| Masapo a monoisotopic | 334.056602 g / mol |
| Qhibiliha Point | 166 ° C (Hlakubele) |
| Leqhoa | N / A |
| Likokoana-hloko tsa Half-Life | N / A |
| Color | Bosoeu bo bosoeu bo bosoeu |
| Solubility | Beta-NMN e fanoa e le sekontiri se tiileng. Beta-NMN e qhibiliha hanyane ka hanyane ho li-solvent tse nang le ethanol, DMSO le dimethyl formamide. Bakeng sa liteko tsa baeloji, re fana ka maikutlo a hore litharollo tsa metsi tse se nang metsi tse tsoang ho Beta-NMN li lokisoe ka ho qhala ka kotloloho sekontiri se matla ka har'a li-buffers tse nang le metsi. Boreleli ba Beta-NMN ho PBS, pH 7.2, e ka ba 10 mg / ml. Ha re khothaletse ho boloka tharollo ea metsi matsatsi a fetang le le leng. |
| Mocheso oa polokelo | Temperatur ea kamore;
Boloka ho -20 ° C ho fihlela lilemo tse 2. |
| kopo | Lijo tse thibelang botsofali li tlatsetsa |
Nalane ea NMN
Nicotinamide mononucleotide (foromo ea limolek'hule: C11H15N2O8P, nomoro ea CAS: 1094-61-7, e tsejoang hape e le NMN, beta-Nicotinamide mononucleotide kapa β-NMN) ke vithamine B3 metabolite [1], eo ka tlhaho e fumanoang 'meleng oa motho,' me ka ho tšoana lijo tse kang broccoli le k'habeche ka chelete e nyane [2].
NMN e qalile ho fumana phaello e le tlatsetso ea phepo e ntle ho 2013, kamora phuputso e atlehileng e entsoeng ke bo-rasaense ba Harvard ho litoeba [3,4].
NMN e hlahisitsoe ka lekhetlo la pele e le tlatsetso bakeng sa batho ka 2015 [5], empa e ne e le theko e phahameng haholo ho e etsa, ho fihlela mekhoa e ntlafatsoa ho fokotsa litšenyehelo tsa tlhahiso le ho eketsa bohloeki ho 2018 [6], ka nako eo lilaboratori tse ikemiselitseng tlhahiso ea bongata li qalile tla inthaneteng.
Phofo ea NMN ke eng?
Nicotinamide mononucleotide (foromo ea limolek'hule: C11H15N2O8P, nomoro ea CAS: 1094-61-7, e tsejoang hape e le NMN, beta-Nicotinamide mononucleotide kapa β-NMN) ke vithamine B3 metabolite [1], eo ka tlhaho e fumanoang 'meleng oa motho,' me ka ho tšoana lijo tse kang broccoli le k'habeche ka chelete e nyane [2].
Nicotinamide Mononucleotide (NMN) ke motsoako o hlahang ka tlhaho o leng o monyane 'meleng oa motho hammoho le lijo tse ling. NMN ha e fumanehe ka molomo, 'me ha e nkuoa ka molomo e ka ts'ehetsa maemo a NAD + kahare ho lisele tsa sebete le mesifa.
Liphuputso tsa morao-rao li bontšitse hore NMN e ka ts'ehetsa bophelo bo botle ba pelo, tlhahiso ea matla, bophelo bo botle ba kelello, le bophelo bo botle ba 'mele le masapo. Sephetho se seng se khahlisang haholo sa lipatlisiso tsa NMN ke hore e ka khothaletsa tokiso ea DNA le ho ts'ehetsa ts'ebetso ea liphatsa tsa lefutso tsa SIRTUIN tseo ho nahanoang hore li ka nka karolo ho tsofaleng hantle.
E sebetsa joang?
NMN ke selelekela sa molek'hule ea NAD +; 'mele oa motho o hloka NMN ho iketsetsa NAD + ea ona.
NAD + ke mofuta o nang le oxidized oa NAD (Nicotinamide adenine dinucleotide), molek'hule e fumanoeng ka lekhetlo la pele ho 1906, mme e fumanoe liseleng tsohle tse phelang [7].
Ho tlatselletsa ka NAD + ka boeona ha se khetho ea ho matlafatsa maemo a NAD, hobane e kholo haholo hore e ka tšela lisele tsa lisele habonolo ho kena liseleng, ka hona e ke ke ea khona ho ama metabolism [8] hantle.
Melemo ea NMN.
Tsela e 'ngoe eo re ka matlafatsang maemo a phetseng hantle a NAD + ke ka ho tlatselletsa' mele ea rona ka selelekela sa eona, nicotinamide mononucleotide (NMN).
Patlisiso ea hajoale e bonts'a hore phetoho ena lipakeng tsa NR le NMN e tlameha ho etsahala bakeng sa ho kena mefuteng e 'maloa ea lisele. Sena se etsa hore bafuputsi ba lumele hore ha e le hantle, NMN ke e 'ngoe ea mekhoa e potlakileng ho feta ea ho susumetsa tlhahiso ea NAD. Leha ho le joalo, Nicotinamide mononucleotide powder le eona e paka hore e na le melemo ea eona e khahlanong le botsofali ho feta ea tlhahiso ea NAD feela.
Ntle le tsela ea metabolic ea NAD, phofo ea NMN e ka eketsoa ka kotloloho liseleng ntle le ho fetohela NAD. Ketsahalo ena e etsoa hore e khonehe ke liprotheine tse sa tsoa sibolloa tsa lipalangoang tse eketsang palo kamora hore maemo a NAD a theohe. Ka sebopeho sena, NMN e kenya letsoho ho matla a sele mme e lumella e 'ngoe le e' ngoe ea thepa e khahlano le botsofe e boletsoeng pejana e khothalletsoang ke lisele tse nang le bokhoni bo lekaneng ba ho hola le ho nchafatsa.
Khetha ho tlatsetsa ka phofo ea NMN hammoho le NAD e fana ka tsela e tobileng haholoanyane ea ho khothalletsa metabolism ea lisele 'me kahoo ke mokhoa o potlakileng oa ho etsa se tšoanang. Ho phaella moo, Nicotinamide mononucleotide phofo e fumanoe e ntlafatsa mosebetsi oa insulin le tlhahiso, e leng se hlahisang melemo e eketsehileng ea metabolism hammoho le mamello ea tsoekere. Haholo-holo, li-supplement tsa NMN li ka thusa ho sebetsa ho fokotsa maemo a metabolism a kang lefu la tsoekere, lefu la sebete sa mafura, le botenya. [11]
Melemo e meng e ka bang teng ea NMN
- E khothalletsa bophelo bo botle ba methapo le phallo ea mali. [11]
- E ntlafatsa mamello ea mesifa le matla
- E Sireletsa Khahlanong le Mafu a Pelo
- Ho fokotsa kotsi ea botenya. [10]
- E ntlafatsa tokiso ea tokiso ea DNA
- E eketsa mosebetsi oa Mitochondrial. [9]
Mokhoa oa ho fumana NMN e tsitsitseng, e hloekileng, e bolokehileng?
Bakeng sa ho tseba hore na sehlahisoa se tsitsitseng, sa 'nete, se hloekileng le se bolokehileng se ka fihlelleha joang, letoto la liteko le tlhahlobo li ile tsa etsoa. Ho ka fanoa ka litlaleho tsa COA, HPLC le HNMR.
Botsitso bo ntlafetseng
Ka ho sekaseka sebopeho sa Nicotinamide mononucleotide le ho sebelisa mokhoa oa phetisetso ea litefiso le in-situ FTIR, ho ile ha sibolloa hore NMN e na le sebopeho se le seng sa letsoai le kahare le letsoele la ka hare ke lona lebaka la bohlokoa la ho se tsitse ha NMN. Metsi, joalo ka molek'hule e le 'ngoe ea pola, a tla baka phetisetso ea motlakase ka har'a NMN e ka senyang masapo a letsoai a ka hare a NMN. Haeba ho joalo, NMN e tla bonts'a sebopeho sa phetoho se fetohang habonolo se silafatsang habonolo, e leng litaba tsa metsi sehlahisoa le limolek'hule tsa metsi tse sa lefelloeng moeeng li tla senya ka kotloloho ntlha ea motlakase ea letsoai le kahare le ho theola bohloeki ba NMN. Ena ke khatelo-pele e kholo lipatlisisong tsa botsitso ba phofo ea NMN, e tla ba qalo e le 'ngoe ea ho ntlafatsoa.
Ho ntlafatsa botsitso ba phofo ea NMN kahare, bafuputsi ka boqhetseke ba hlahisitse phofo e ncha ea NMN ka tlhophiso le tlhophiso e nyane ea microscopic.
Ho tsitsa ho matla, ho phela nako e telele
Phcoker NMN phofo e hlophisehile ebile e sebetsa hantle, e thibela ho ikopanya le metsi a mahala moeeng, e eketsa haholo botsitso ba NMN le ho lelefatsa bophelo ba sehlahisoa. Ho fapana le nalane ea NMN ea microscopic, moloko oa pele oa sawtooth o bonts'a ho hloka taolo le ho se sebetse hantle, ka hona molek'hule e ngoe le e ngoe e tla pepesehela moea le ho monya metsi a mangata.
Palo e phahameng, litekanyetso tse tsitsitseng le ho hlophisoa habonolo.
Phofo ea NMN e nang le tlhophiso e hlophisehileng le e nyane e na le letsoalo le phahameng le bongata, e qobang litekanyo tse sa tsitsang ka lebaka la ho phahamisa lerōle nakong ea boitokiso. Ho feta moo, e tla ama litekanyo tse tšoanang tsa li-capsules. Ho sa le joalo, kaha e na le mokelikeli o betere, phofo ea rona ea NMN e ka thusa ho fokotsa nako ea tlhahiso le litšenyehelo tsa tlhahiso nakong ea tlhahiso.
E netefalitsoe boleng bo holimo ebile e hloekile
Litlaleho tsa liteko tsa laboraka tsa motho e mong li lokela ho hlokahala ho netefatsa boits'oaro le bohloeki ba NNM. Sehlopha se seng le se seng sa thepa e tala se tlameha ho itlhahloba ka thata le tlhahlobo ea motho oa boraro. Litlaleho tsa tlhahlobo ea HNMR le HPLC li ka tiisa bonnete ba eona, boleng bo holimo le bohloeki ba NMN.
Phcoker ke moetsi oa phofo oa Nicotinamide mononucleotide (NMN)
Ka feme eo e leng ea hao, tlhahiso ea rona ea phofo ea NMN ea khoeli le khoeli e fihlela lithane tse 2.
kopo
Litlolo tse tala:
NMN ke ntho ea 'mele ea lisele,' me NMN ke molek'hule ea monomer, e khahlanong le botsofali e totobetse, ka hona e ka sebelisoa linthong tse tala tsa litlolo.
Lihlahisoa tsa tlhokomelo ea bophelo:
Phofo ea NMN e ka etsoa ka ho belisoa ha tomoso, tšebetso ea lik'hemik'hale kapa in vitro enzymatic catalysis.
Phofo ea NMN e sebelisoa haholo indastering ea tlhokomelo ea bophelo.
Tlhaloso:
[1] Mononucleotide ea Nicotinamide. Ho tsoa Wikipedia, encyclopedia ea mahala.
[2] Tsamaiso ea Nako e Telele ea Nicotinamide Mononucleotide e Fokotsa Phokotso ea Physiological e Amanang le Lilemo ho Litoeba. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Dec 13.
[3] Ho fokotsa NAD + ho baka Pseudohypoxic State ho senya puisano ea nyutlelie le mitochondrial nakong ea botsofali. Gomes AP, Theko NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Sele. 2013 Phato 19; 155 (7): 1624-38. doi: 10.1016 / j.cell.2013.11.037.
[4] Ntho e Ncha le e ka Fetohang — Lebaka la ho Tsofala. David Cameron. Sekolo sa Bongaka sa Harvard, Litaba le Patlisiso, la 19 Tšitoe 2013
[5] Mokotla o bolokiloeng oa NAD + o laolang likamano tsa protheine le protheine nakong ea botsofali Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Saense. Ka 2017 Mar 24; 355 (6331): 1312-1317. doi: 10.1126 / science.aad8242.
[6] Mokhoa oa ho Qhelelletsa Boholo ba Chromatography bakeng sa Tlhoekiso ea Nicotinamide Mononucleotide (NMN) ho Lisele tsa Baktheria. George Cătălin Marinescu, Roua-Gabriela Popescu le Anca Dinischiotu. Scientific Reportsvolume 8, Nomoro ea sengoloa: 4433 (2018).
[7] Nicotinamide adenine dinucleotide. Ho tsoa Wikipedia, encyclopedia ea mahala. 2019.
[8] Boitsebiso ba morali oa mitochondrial NAD + ho Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Pherekhong 20; 281 (3): 1524-31. Epub 2005 Pherekhong 16.
[9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Khatello ea Kelello ea Oxidative le Sisteme ea Kynurenine, e shebaneng le botsofe le tšireletso ea mali. Limolek'hule, 2018; DOI: 10.3390 / limolek'hule23010191.
[10] Tlatsetso ea Nicotinamide mononucleotide (NMN) e ntlafatsa phello ea botenya ba bakhachane ho litoeba: papiso le boikoetliso. Oddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.
[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, NAD + ea Bohlokoa, e Tšoara Pathophysiology ea Lijo le Lefu la Ts'oaetso le Ts'oeroang ke Lilemo ho Litoeba. Cell Metab, 2011; ETSAHALA: 10.1016 / j.cmet.2011.08.014.
[12] Lithethefatsi tsa morao-rao tsa ho tsofala: Nicotinamide Mononucleotide (NMN)
