Tadalafil e mafura a mafura (171596-29-5)

October 20, 2018

Raw Tadalafil phofo tlasa lebitso la Cialis e sebelisetsoa ho sebetsana le ho se sebetse (ho hloka matla) le matšoao a prostatic benign ………


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1190kg / khoeli

Setšoantšo sa Tadalafil

 

Boitsebiso ba Base

Name Product Tadalafil powder
Lebitso la lik'hemik'hale (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name Cialis, Adcirca
Sehlopha sa Lithethefatsi PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors
Nomoro ea CAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
limolek'hule Formula C22H19N3O4
limolek'hule Wtse robeli 389.4
Masapo a monoisotopic 389.138 g / mol
Ho qhibiliha Poli  298-300 ° C
Fho tsosolosa Poli 2 ° C
Likokoana-hloko tsa Half-Life dihora tse 17.5
Color Ho soeufala ho fihlela ho se soeufalitsoe ke Cyrstalline e tiileng
Sho khoneha  Qhibilihang ka har'a DMSO (78 mg / ml ho 25 ° C), methanol, metsi (<1 mg / ml ho 25 ° C), dichloromethane, le ethanol (<1 mg / ml ho 25 ° C)
Storage Tmocheso  Boloka mocheso oa kamoreng lipakeng tsa 59 ° F le 86 ° F (15 ° C le 30 ° C). Se ke oa boloka meriana ena libakeng tse mongobo kapa tse mongobo.
Tadalafil Aho latela Li-tablets tsa mafura tsa Tadalafil, li-candy tsa thobalano, kofi ea thobalano, joalo-joalo.

 

Tlhaloso

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6, 3,4] pyrido [1,4-b] indole-5-dione (Cialis), ke mofuta oa PDE5 inhibitor le sethethefatsi se fanoang ka molomo. Ke sehlahisoa sa b-carboline mme e arohane ka sebopeho sa vardenafil (Levitraw) le sildenafil (Viagraw), tseo ka bobeli e leng li-PDE171596 inhibitors tse ipapisitseng le sebopeho sa mantlha sa pyrimidine. Tadalafil powder (CAS 29-5-2003) e eketsa phallo ea mali ka har'a corpus cavernosum ka ho phomotsa mesifa ea methapo ea mali, mme sena se nolofalletsa monna ho fihlela tsoho. Tadalafil phofo e ile ea amoheloa ke Tsamaiso ea Lijo le Lithethefatsi ea United States (US) ho XNUMX bakeng sa kalafo ea ho se sebetse hantle (ED), mme ea rekisoa lefatšeng ka bophara tlasa lebitso la Cialis. E boetse e sebelisetsoa ho alafa pulmonary arterial hypertension le benign prostatic hyperplasia, e leng boemo boo tšoelesa ea senya e holisoang, e bakang mathata ka ho ntša metsi.

Karolo e khethollang ea pharmacologic ea Tadalafil ke halofo ea bophelo ba eona (lihora tse 17.5) ha e bapisoa le Viagra le Levitra (lihora tse 4-5). Nako ena e telele ea bophelo e fella ka nako e telele ea ts'ebetso mme, karolo e 'ngoe, e ikarabella bakeng sa lebitso la bosoasoi la Cialis la "pilisi ea beke". Nako ena e telele ea bophelo hape ke motheo oa lipatlisiso tsa hajoale bakeng sa ts'ebeliso ea tadalafil ho pulmonary arterial hypertension e le kalafo ea hanngoe ka letsatsi.

Mokhoa oa Khato

Ho tsosoa ha maikutlo nakong ea ho kopanela liphate ho finyelloa ke ho phomola ha methapo ea penile le methapo e tsitsitseng ea mafu, e leng se lebisang ho eketsehileng ha mali ho phalla. Phomolo ena e lumella ho phahama ha mali ka methapo ea penile, ha mali ana a tlatsa likamore tse peli ka har'a penis e bitsoang corpora cavernosa. Ha likamore li tlatsa mali, botona bo ntse bo hōla. Ho khaotsa ho felisoa ha konteraka ea mesifa le mali a bokellaneng a ka phalla ka methapong ea penile.

Karabelo ena e buelloa ke ho lokolloa ha nitric oxide (NO) ho tsoa litsing tsa methapo le lisele tsa endothelial, tse hlohlelletsang ho qaptjoa ha cGMP liseleng tse boreleli tsa mesifa ebe li laola ho phahama le ho honyela ha methapo ea mali e tsamaisang mali ho ea le botoneng. Cyclic GMP e baka phomolo e boreleli ea mesifa le ho eketsa phallo ea mali ka har'a corpus cavernosum, mme e nyenyefatsoa ke mofuta oa cGMP o khethehileng oa phosphodiesterase mofuta oa 5 (PDE5) ho corpus cavernosum e haufi le botona. Tadalafil e thibela PDE5 mme ka hona e ntlafatsa ka ho eketsa palo ea cGMP e fumanehang. Tadalafil e emisa PDE5 ho senya cGMP ebe e eketsa cGMP e fumanehang ho fihlela ts'ebetso mme e etsa hore erection e tšoarelle nako e telele.

Leha ho le joalo, ha halofo ea bophelo ba Tadalafil e le khutšoane, phello ea eona ea fela matsatsing a 2 a etsang hore PDE5 e khutle mme bophelo ba hau ba thobalano bo mpefala. U kanna ua hloka ho nka nako e teletsana ho fihlela sephetho seo u se batlang, joalo ka matla a tlase a Cialis matsatsi a 4-5 matsatsi a 4-5.

kopo

  • Erectile ho se sebetse (ED)
  • Pulmonary arterial hypertension
  • Benign Prostatic hyperplasia
  • Analgesic
  • Norepinephrine e thibela ho thibela
  • Mo-opiod receptor agonist

Tadalafil ea phofshoana ea phofo e khothalletsoang

Cialis e hlaha ka matlapa a mosehla, a koahetsoeng ka filimi le a almonde ka litekanyo tsa 5, 10 le 20 milligram (mg). Tekanyo e khothalletsoang ea ho qala ea Cialis phofo bakeng sa ts'ebeliso ha ho hlokahala ho bakuli ba bangata ke 10 mg, e nkuoeng pele ho thobalano e lebelletsoeng.

Moriana oa pele ke li-milligrams tsa 10 (mg) bonyane metsotso ea 30 pele ho thobalano. Lethal dose e ka eketseha ho isa ho 20 mg kapa ea fokotseha ho ea 5 mg, ho itšetlehile ka katleho ea motho ka mong le ho mamella. Empa, boholo ba 20 mg e le tekanyo e le 'ngoe. Maqhubu a holimo a khothalletsoang hangata ka nako e le 'ngoe ho bakuli ba bangata. ha ea lokela ho nka litekanyetso tse fetang tse le 'ngoe lihora tsa 24. Bakuli ba lebeletseng ho kopanela liphate bonyane ka makhetlo a mabeli ka beke ba ka nka tekanyo ea letsatsi le letsatsi ea 5 mg, mme sena se ka fokotsoa ho 2.5 mg hang ka letsatsi, ho itšetlehile ka tsela eo motho a itšoarang ka eona.

Cialis phofo bakeng sa ts'ebeliso kamoo e hlokahalang e ile ea bontšoa ho ntlafatsa ts'ebetso ha e bapisoa le placebo ho fihlela lihora tsa 36 ka mor'a dosing. Ka hona, ha u eletsa bakuli ka tšebeliso e nepahetseng ea phofo ea Cialis, sena se lokela ho nahaneloa.

Ho bohlokoa ho tseba hore moriti o ke ke oa hlaha ka ho nka pilisi. 'Me u se ke ua nka Cialis bakeng sa ho se sebetse letho haeba u nka Adcirca bakeng sa khatello ea mali ea methapo ea mali. Beside, Tadalafil bakeng sa khatello ea kelello e sebelisoa feela ke batho ba baholo ba nang le lilemo tse 18 le ho feta.

melemo e

Adala Tadalafil phofo e ka thusa ho khatholla mesifa ea senya le senya. Sena se ka thusa ho ntlafatsa matšoao a hau a BPH.

Ho ntlafatsa matšoao a ED, tadalafil powder e thusa ho eketsa phallo ea mali botoneng. Sena se ka u thusa ho fumana le ho boloka erection. Bakeng sa phofo ea tadalafil ho u thusa ho emisoa, o hloka ho tsosa takatso ea thobalano.

Bakeng sa PAH, tadalafil powder e sebetsa ho ntlafatsa bokhoni ba hau ba ho ikoetlisa ka ho phomotsa methapo ea mali matšoafong a hao. Sena se eketsa phallo ea mali.

Litla-morao

Hammoho le liphello tsa eona tse hlokahalang, moriana o ka baka liphello tse ling tse sa batleheng. Le hoja ho se na litla-morao tsena kaofela tse ka 'nang tsa etsahala, haeba li ka etsahala li ka' na tsa hloka tlhokomelo ea bongaka. Ka kopo sheba liphello tse latelang tsa tadalafil powder:

Litla-morao tse tloaelehileng

▪ hlooho

▪ e halefisitsoe ke mpa

▪ bohloko bo bohloko

▪ mahlaseli a mesifa

▪ ho hlatsoa (letlalo le khubelu)

▪ letheba kapa lesoba le leholo

▪ letšollo

Litla-morao tse mpe empa tse tebileng 

Erection e telele e ka lebisang tšenyo ho botona, mathata a pono, le tahlehelo ea kutlo.

Haeba liphello tsena li le bonolo, li ka 'na tsa tloha ka mor'a matsatsi a seng makae kapa libeke tse' maloa. Haeba ba le matla haholo kapa ba sa tsamaee, buisana le ngaka kapa setsebi sa metsoako.

Batho ba nang le maemo ana a latelang ha baa lokela ho nka Cialis phofo ntle le hore ngaka e lumellane:

Mathata a lipelo tsa pelo, angina, kapa mofuta ofe kapa ofe oa lefu la pelo

Khatello ea mali e phahameng kapa e tlaase

Ho senyeha pelo ha pelo kapa ho otloa ha pelo nakong ea likhoeli tsa ho qetela tsa 6, kapa ho fokotsa likokoana-hloko nakong ea likhoeli tsa ho qetela tsa 3

Boloetse ba mali bo bakoang ke lefu la lisele, lefu la myeloma e mengata, hemophilia, kankere ea mali, kapa lefu le leng la mali

Lefu kapa lefu la liphio

Matšoafo a mala

Retinitis pigmentosa

Ho holofala hoa sebopeho sa botona, joalo ka lefu la Peyronie

Boemo bofe kapa bofe ba bophelo boo ba eletsoeng hore ba se ke ba kopanela liphate

Tšebelisano ea Tadalafil

Ha o sebelisa tadalafil, ho ka 'na ha e-ba le lithethefatsi tse ling tse ka amanang le lithethefatsi, tse ka lebisang litlamong. Litšebelisano le lithethefatsi li ka fetola kamoo meriana ea hau e sebetsang kateng kapa eketsa kotsi ea litla-morao tse tebileng.

Tadalafil e na le phello e itekanetseng ea ts'ebetso ea nitrate e bakoang ke ho fokotsa khatello ea mali. Tadalafil e ka baka lerotholi le matla la khatello ea mali ha le sebelisoa le nitrate, e ka lebisang ho ba le botenya, ho fokolloa, le ho ba le khaello ea pelo hangata kapa ho otloa ke stroke. U se ke ua sebelisa tadalafil ka tse ling tse latelang: lithethefatsi tse ling tse sebelisetsoang ho tšoara lefu la sefuba / angina (nitrate e kang nitroglycerin, isosorbide), lithethefatsi tsa boithabiso tse bitsoang "poppers" tse nang le amyl kapa butyl nitrite.

Haeba u boetse u nka meriana ea li-alpha blocker (e kang doxazosin, tamsulosin) ho tšoara prostate e atolositsoeng / BPH kapa khatello e phahameng ea mali, khatello ea mali ea hao e ka 'na ea theoha haholo e ka lebisang ho ba le botenya kapa ho fokotseha. Ngaka ea hau e ka qala kalafo ka tekanyo e tlaase ea tadalafil kapa fetola meriana ea hao ea li-alpha blocker ho fokotsa kotsi ea khatello ea mali e tlaase.

Lithutong tsa kliniki, litekanyetso tsa bohlokoa tsa karabelo li tlalehiloe ho fihlela 36 h ka mor'a ho ts'oaroa ke lithethefatsi. Tadalafil e hlahisoa ka bongata sebeteng ka CYP3A4 ho liphutheloana tse sa sebetseng khahlano le PDE5 mme e hlahisoa haholo-holo e le metabolites ka har'a maro le urine. Li-pharmacokinetics tsa tadalafil ha li angoe ke lintlha tse kang ho ja lijo le joala, botsofali, boteng ba lefu la tsoekere, le khaello e fokolang ea hepatic kapa e leka-lekaneng. Liketsahalo tse mpe tse atileng haholo tse amanang le lithethefatsi ke hlooho, bohloko ba mokokotlo, dyspepsia le myalgia. Ho tekanyetso ea 10 le 20 mg, Tadalafil ha e na phello e kholo khatello ea mali le lebelo la pelo ebile ha e hlahise maemo a eketsehang a infraction ea myocardial. Litlaleho tse sa tloaelehang tsa li-erections tsa nako e telele ho feta 4 h le tsa pele li hlokometsoe ka ts'ebeliso ea tadalafil. Ho tsepamisa mohopolo, haeba ho sa tšoaroe hantle, ho ka baka tšenyo e ke keng ea fetoloa lithong. Bakuli ba nang le erection e kholo ho feta 4 h ba eletsoa ho batla tlhokomelo ea bongaka ea tšohanyetso. Ho bakuli ba lefu la tsoekere, ntlafatso ea ts'ebetso ka tadalafil ha e khetholle mofuta oa lefu la tsoekere le mofuta oa kalafo ea lefu la tsoekere.

Meriana e meng e ka ama ho tlosoa ha tadalafil 'meleng oa hau, e ka' nang ea ama tsela eo tadalafil e sebetsang ka eona. Mehlala e kenyelletsa li-antifungals tsa azole (tse kang itraconazole, ketoconazole), lithibela-mafu tse kang macrolide (joaloka clarithromycin, erythromycin), HIV protease inhibitors (e kang fosamprenavir, ritonavir), kokoana-hloko ea hepatitis C protease inhibitors (e kang boceprevir, telaprevir), rifampin .

Se ke oa nka meriana ena ka sehlahisoa leha e le sefe se nang le tadalafil kapa meriana e meng e tšoanang e sebelisetsoang ho phekola dysfunction-ED kapa pulmonary hypertension (joalo ka sildenafil, vardenafil).

Mabapi le puisano ea tadalafil le lithethefatsi tse ling li ntse li e-na le lintho tse ngata, haeba u batla ho sebelisa lithethefatsi ka tadalafil powder (CAS 171596-29-5), qala ho hopola ho buisana le ngaka ea hau 'me o tla u fa keletso ea setsebi le e ka tšeptjoang.

Lintlha tse ling hape

Tadalafil powder, sildenafil powder, le vardenafil powder kaofela li sebetsa ka ho thibela enzyme ea PDE5, empa lithethefatsi tsena li boetse li thibela li-enzyme tsa PDE 6, 1 le 11 ka mekhahlelo e fapaneng. Mohlala, Sildenafil le vardenafil ba thibela PDE6, enzyme e fumanoang ka leihlong, ho feta tadalafil. Basebelisi ba bang ba sildenafil ba bona tinge e putsoa 'me ba na le kutloisiso e phahameng ea leseli ka lebaka la thibelo ea PDE6. Ntle le moo, Sildenafil le vardenafil le tsona li thibela PDE1 ho feta tadalafil. PDE1 e fumanoa bokong, pelong le mesifa e boreleli ea methapo. Ho nahanoa hore thibelo ea PDE1 ke sildenafil le vardenafil e lebisa ho vasodilation, flushing le tachycardia.

Ha li bapisoa le ts'ebetso ea PDE6 le PDE1, tadalafil e iketsetsa haholo PDE11. PDE11 e hlahisoa ka mesifa ea masapo, prostate, sebete, liphio, lesela la pituitary le litlhahlobo. Leha ho le joalo, liphello tsa 'mele oa ho thibela PDE11 ha li tsejoe.