Urolithin A.

April 8, 2021

Urolithin A e bontšitsoe e le ho hlasimolla mitophagy le ho ntlafatsa bophelo bo botle ba mesifa liphoofolong tsa khale le mefuteng ea botsofe. Ho sa le joalo, ho boetse ho bonts'itsoe hore e tšela tšitiso ea boko ba mali, mme e kanna ea ba le litlamorao tsa ts'ireletso khahlanong le Lefu la Alzheimer's.

Video ea Urolithin A (1143-70-0)

Urolithin A (1143-70-0)songolo

Name Product Urolithin A phofo
Lebitso la lik'hemik'hale 3,8-dihydroxy-6H-benzo [c] chromen-6-e le 'ngoe;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-ngoe;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-ngoe;

6H-Dibenzo [b, d] pyran-6-ngoe, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

Nomoro ea CAS 1143-70-0
InChIKey RIUPDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
limolek'hule Formula C13H8O4
limolek'hule Wtse robeli 228.2 g / mol
Masapo a monoisotopic 228.042259 g / mol
Ntlha e qhibilihisang 340-345 ° C
Sebaka se belang  527.9 ± 43.0 ° C (E boletsoe esale pele)
Flash point 214.2ºC
Likokoana-hloko tsa Half-Life Urolithin A e teng morotong ho fihlela lihora tse 48 kamora ts'ebeliso ea lero la kharenate.
Color E tšoeu ho beige
Sho khoneha  DMSO: 20 mg / mL, hlakileng
Storage Tmocheso  2-8 ° C
Aho latela E sebelisoa e le tlatsetso ea lijo le sehlahisoa se khahlanong le botsofali, e ka sebelisoa ho fokotsa ho ruruha le ho loantša mofetše;

 

Tlhaloso:

[1] Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Phello ea Metabolic ea Ellagitannins: Litlamorao ho Bophelo bo Botle, le Lits'ebetso tsa Patlisiso bakeng sa Lijo Tse Sebetsang Tse Sebetsang". Litlhahlobo tse Bohlokoa ho Saense ea Lijo le Phepo e Ntle. 54 (12): 1584–1598. doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. le al. Urolithin A e fokotsa mitophagy mme e lelefatsa bophelo ba motho ho C. elegans mme e eketsa ts'ebetso ea mesifa litoeba. Nat. Med. 22, 879-888 (2016).

[3] "Tsebiso ea FDA GRAS ea GRN ea 791: urolithin A". Tsamaiso ea Tsamaiso ea Lijo le Lithethefatsi ea US. La 20 Tšitoe 2018. E khutlisitsoe ka la 25 Phato 2020.

[4] Singh, A .; Andreux, P.; Blanco-Bose, W.; Ryu, D .; Aebischer, P.; Auwerx, J .; Rinsch, C. (2017-07-01). "Urolithin A e fanoang ka molomo e bolokehile ebile e hlophisa li-biomarker tsa mesifa le mitochondrial ho batho ba tsofetseng". Ntlafatso ea botsofaling. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Tekolo ea polokeho ea urolithin A, metabolite e hlahisoang ke microbiota ea motho ka mpeng ha ho jeoa limela tse nkiloeng ke ellagitannins le ellagic acid". Lijo le Lik'hemik'hale Toxicology. EA-108-Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.