L - (+) - Ergothioneine (EGT) (497-30-3)

March 15, 2020
SKU: 1010396-29-8
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Ergothioneine ke tlhaho ea amino acid ka tlhaho 'me e tsoa ho histidine, e nang le atom ea sebabole ho …… ..


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L - (+) - video ea Ergothioneine (EGT) (497-30-3)


L - (+) - Ergothioneine (EGT) phofo Slitšobotsi

Name Product L - (+) - Ergothioneine (EGT)
Lebitso la lik'hemik'hale ERGOTHIONEINE;

L-Ergothioneine;

Sympectothion;

l ergothioneine

Brand Name N / A
Sehlopha sa Lithethefatsi N / A
Nomoro ea CAS 497-30-3
InChIKey SSISHJJTAXXQAX-ZETCQYMHSA-N
limolek'hule Formula C9H15N3O2S
limolek'hule Wtse robeli 229.3 g / mol
Masapo a monoisotopic 229.088498 g / mol
Sebaka se belang N / A
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life N / A
Color Ho soeufetse kapa ho se soeu
Sho khoneha Soluble ka Metsing (ho fihlela 10 mg / ml)
Storage Tmocheso -20 ° C
Aho latela l ergothioneine phofo e sebelisitse litlhare tse phetseng hantle

L - (+) - Ergothioneine (EGT) (497-30-3) Kakaretso

Ergothioneine ke tlhaho ea amino acid ka tlhaho 'me e tsoa ho histidine, e nang le athomo ea sebabole ka selikalikoeng sa imidazole. Karolo ena e entsoe ka libōpuoa tse 'maloa, haholo-holo Actinobacteria, Cyanobacteria le fungus e itseng. Ergothioneine e hloka mofetoleli ea ikhethileng, EGT, eo hape a tsejoang e le OCTN1 (letšoao la gene SLC22A4), ho kena ka har'a lisele. Polelo ea EGT e netefalitsoe mefuteng ea sele ea batho le liphoofolo mme bokhoni ba eona ba ho tsamaisa ergothioneine bo tiisitsoe ho vivo.

L-ergothioneine ke tlhaho ea amino acid ka tlhaho 'me ke mofuta oa thiol / thione oa histidine. L-ergothioneine e fumanoa liphoofolong tse phahameng ka ho fetisisa li-mushroom le libaktheria le linthong tse tlase lijong tse ling ho kenyelletsa le crab, nama ea khomo, nama ea kolobe, konyana le khoho.

Leha ho na le boteng ba L-ergothioneine lijong tsa batho, biosynthesis ea bona e se e bonoe ho libaktheria le li-fungus tse itseng.

ke eng L - (+) - Ergothioneine (EGT) ?

L-Ergothioneine ke amino acid e fumanehang haholo ka har'a li-mushroom, empa hape le ka har'a crab, nama e tsoang liphoofolong tse jang joang bo nang le ergothioneine le lijo tse ling. Li-amino acid ke lik'hemik'hale tseo e leng lithunya tsa liprotheine. Ergothioneine e sebelisoa e le moriana.

Batho ba nka ergothioneine bakeng sa tšenyo ea sebete, likatse, lefu la Alzheimer's, lefu la tsoekere le lefu la pelo.

L - (+) - ERGOTHIO ke mofuta oa tlhaho oa chiral amino-acid antioxidant biosynthesized ho libaktheria tse itseng le fungi. Ke motsoako oa bohlokoa oa "biioactive" o sebelisitsoeng e le "scavenger" e matla haholo, sefahleho sa ray ea ultraviolet, molaoli oa litheolelo tsa phokotso ea oxidation le li-cellular bioenergetics, le cytoprotector ea 'mele.

L-Ergothioneine ka linako tse ling e kenngoa ka ho toba letlalong ho thibela makhopho, ho fokotsa matšoao a letlalo le tsofetseng le ho fokotsa tšenyo ea letsatsi.

L - (+) - Melemo ea Ergothioneine (EGT)

L-ergothioneine e ikhethile ka hore e ka fihla botebong ba lisele tse itseng tse kang li-erythrocyte, ho fapana le li-antioxidants tse ling tsa khale tse kang livithamini C le E. Ha e le hantle e na le mofuta oa liprotheine tsa protheine e tsamaisang, o nolofalletsang hore o nkeloe tokelo ea ho pelo ea lisele. Ka hona, ke antioxidant e ka bang matla a litheko tse ngata haholo, a bohlokoa joaloka L-glutathione. Ntle le moo, e boetse e bontšitsoe e le chelator e matla, e e nolofalletsang hore e tlamelehe litsong tse boima tse nang le chefo, ha e ntse e sireletsa lisele tsa mali mefuteng eohle ea tšenyo.

Ba khothalelitsoe ke thepa ea eona ea li-antioxidant, bafuputsi ba ile ba hlahlobisisa litlamorao tsa eona tse khahlanong le ho ruruha, hobane ergothioneine e sebetsa, hara tse ling, pro-inflammatory cytokine, interleukin. L - (+) - Ergothioneine (EGT) ka hona e na le thepa e ngata e sebetsang ka hare ho 'mele oa motho:

  • e thusa hore ho se sebetsane le khatello ea maikutlo ea oxidative le ho fokotsa tšenyo ho DNA ea mitochondrial, oxidation ea liprotheine le lipid peroxidation;
  • Chelates - kapa maraba - mekhoa e metle ea tšepe e fapaneng;
  • E ka kenya tšebetsong li-enzyme tsa antioxidant joalo ka glutathione peroxidase kapa SOD, ha e ntse e thibela li-enzyme tse hlahisang superoxide radical;
  • Fokotsa oxidation ea li-haemoprotein tse fapaneng tse kang hemoglobin le myoglobin;
  • E sireletsa mitochondria;
  • L-ergothioneinereducer litlamorao tse mpe tsa mahlaseli a UV, joalo ka ts'ireletso bakeng sa Tlhokomelo ea Letlalo.
  • E boloka le ho boloka maemo a li-antioxidants tse ling tse kang livithamini C le E, glutathione le SOD;
  • E sireletsa boko ho li-neurotoxins mme ka hona e bapala karolo ea thibelo khahlanong le ho theoha ha kelello;
  • E khothaletsa ho phefumoloha ka seleng le ho phahamisa lipolysis, kahoo ho eketsa matla le boikoetliso bakeng sa boikoetliso ba 'mele;
  • Ha e kopantsoe le hyaluronic acid, glucosamine, collagen, e ile ea bontšoa e fokotsa haholo bohloko ba manonyeletso le ho phahamisa motsamao o kopaneng, o amanang haholo le mekhoa e mebe ea mosebetsi oa postural, kamora ts'ebeliso ea libeke tse tšeletseng feela.

L - (+) - Ergothioneine (EGT) sebakeng se sireletsehileng

Le ha l-ergothioneine e arolelana lebitso mme e ka tsoa fungus ea ergot, ha e na chefo ka tsela efe kapa efe.

European Union e na le litekanyetso tse tlatselletsang ho feta United States mme e ikemiselitse hore li-supplement tsa l-ergothioneine li bolokehile 'me ha li na litlamorao ho batho ba baholo le bana ba fetang.

Panel on Dietetic Products bakeng sa Lekhotla la Ts'ireletso ea Lijo ea Europe e fumana hore meeli e bolokehileng ea letsatsi le letsatsi ea 2.82 mg / kg ea boima ba 'mele bakeng sa masea, 3.39 mg / kg bakeng sa bana ba banyenyane, le 1.31 mg / kg ho batho ba baholo, ho kenyelletsa basali baimana le ba anyesa.

L - (+) - Ergothioneine (EGT) phofo sebelisa khanya le kopo

Tlatsetso e nepahetseng le / kapa lijo tse ntlafalitsoeng ho kenyelletsa livithamini tse telele tse kang L-ergothioneine tlatsetsa li ka fokotsa kotsi e kholo ea lefu le sa foleng le ho tsofala pele ho nako.

L-ergothioneine phofo ke motsoako o motle oa foromo e ntle ea phepo e nepahetseng.

Patlisiso e fana ka maikutlo a hore ho ka ba le lintho tse ka 'nang tsa baka antioxidant e le anti-inflammatory ho sireletsa lisele khahlano le mafu a mmele le neurodegenerative.

  1. Ho ruruha

Patlisiso e bontša hore e le antioxidant, EGT e kanna ea sireletsa khahlanong le ts'oaetso.

Rheumatoid ramatiki ke lefu la autoimmune le tšoailoeng ke ho ruruha ho matla (mme hangata ho sa hlalosoang).

Ho ka etsahala hore EGT e ka fokotsa ho ruruha ho bakuli ba nang le ramatiki.

  1. Maloetse a Neurodegenerative

Ha e le cytoprotectant, EGT ke tlatsetso e tsebahalang har'a bakuli ba Alzheimer's le Parkinson.

EGT e ts'ehetsa sesole sa 'mele sa hau sa antioxidant sa tlhaho sa ts'ireletso mme se ka sireletsa lisele tsa boko ho tsoa tšenyo ea oxidative le khatello ea maikutlo ho tsoa ho li-radicals tsa mahala.

Ka ho sireletsa lisele tsa boko, ho hlakile hore ho ka thibela lefu la lisele tsa bokong le ho sireletsa khahlanong le mafu a neurodegenerative.

  1. Maloetse a Seoa

Ka lebaka la bokhoni ba eona ba cytoprotectant le antioxidant, EGT ke amino acid e ratehang ho bakuli ba nang le lefu la sebete.

  1. Ho tsofala ho ka hlahisa bokhoni

Khafetsa u tla fumana EGT lihlahisoa tse ngata tsa skincare ka lebaka la thepa ea eona ea cytoprotectant le antioxidant- e ka sirelletsang lisele tsa letlalo ho senyeha ha oxidative.

Tšenyo ea mahala ea khatello ea kelello le khatello ea maikutlo e tlatsetsa haholo ho tsofeng pele ho nako, letlalo le sa tsitsang le makhopho.

  1. Maloetse a Bofokoli

Lefapha la Ts'ireletso la Amerika le fane ka thuso ea $ 1.34 milione ho bafuputsi ba Univesithing ea Colorado ho ithuta ketso ea antioxidant ea EGT bakeng sa ho loants'a mafu a matšoafo ho loantseng li-veteran.

Reference:

  • Oumari M, et al. Nchafatso ea ergothioneine kamora karabelo ka oksijene ea singlet. Radic Biol Med ea mahala. 2019 Apr; 134: 498-504.
  • Cheah, LK, Halliwell, B. Ergothioneine; matla a antioxidant, ts'ebetso ea 'mele le karolo ea mafu, Biochim. Li-biophys. Acta 2012; (5): 784-793.
  • Genghof, DS Biosynthesis ea Ergothioneine le Hercynine ka. Fungi le Actinomycetales, J. Bacteriol., 1970; 103 (2): 475-478.
  • Pheta, JE, Elkins, ND Phello ea ergothioneine ka leqeba le bohloko la matšoafong le ho ruruha ho likhoto tsa "cytokine" tse se keng tsa fetoloa, Prev. Moedi 2012; (54): S79-S82.
  • Panel ea EFSA mabapi le Lihlahisoa tsa Li-Dietetic, Nutrition and Allergies (2017). "Polelo mabapi le polokeho ea maiketsetso a l-ergothioneine e le lijo tse fumanehang - tlhaiso e fumanehang ea lijo le tlhahlobo ea polokeho ea masea le bana ba banyenyane, basali baimana le ba anyang". Sengoloa sa EFSA. 15 (11): 5060. Doi: 10.2903 / j.efsa.2017.5060.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.