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Nko e tala ea Nicotinamide Mononucleotide (NMN) (1094-61-7)

Nono e makhaola-khang ea Nicotinamide Mononucleotide (NMN) e hatelitsoeng lilemo tse ngata tse amanang le boima ba 'mele ......


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Nko e kholo ea Nicotinamide Mononucleotide (NMN) powder (1094-61-7) video

Nko e kholo ea Nicotinamide Mononucleotide (NMN) (1094-61-7) Tlhaloso

Phofo e khōlō ea Nicotinamide Mononucleotide ("NMN" le "β-NMN") ke nucleotide e nkiloeng ho ribose le nicotinamide. Joaloka nicotinamide riboside, NMN ke tsoa ho nicin, 'me batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide (NADH).

Hobane NADH ke motsoako oa lik'hemik'hale bakeng sa mekhoa e ka hare ho mitochondria, bakeng sa li-siretu, le bakeng sa PARP, NMN e 'nile ea ithutoa ka mehlape ea liphoofolo e le moemeli ea nang le tšoaetso ea mali le ea tsofetseng. Lik'hamphani tsa tlatsetso ea lijo li 'nile tsa rekisa lihlahisoa tsa NMN ka mokhoa o mabifi tse bolelang melemo eo, le hoja ho se na thuto ea meriana ea batho e hatisitsoeng.

Nko e makhaola-khang ea Nicotinamide Mononucleotide (NMN) (1094-61-7) Lintlha

Name Product Phororo e khōlō ea Nicotinamide Mononucleotide (NMN)
Lebitso la lik'hemik'hale Beta-nicotinamide ribose monophosphate; Phofo e khōlō ea Nicotinamide Mononucleotide; AC1Q6RVF; AC1L23AN; NMN (+); SCHEMBL6858129
Brand Name Mirailabo
Sehlopha sa Lithethefatsi Phepo ea lijo
Nomoro ea CAS 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
limolek'hule Formula C11H15N2O8P
limolek'hule Wtse robeli 334.22
Masapo a monoisotopic 335.229 g / mol
Ho qhibiliha Poli > 96 ° C
Fho tsosolosa Poli Ha ho letsatsi le fumanehang
Likokoana-hloko tsa Half-Life Kahoo, joalokaha ho bontšitsoe setšoantšong sa 3, nicotinamide e ile ea nyamela mali le halofo ea lihora tsa 5.3, athe halofo ea bophelo ea nicotinic acid e ne e le hora ea 1.1.
Color Tšoeu ho ea phofo e tšoeu
Sho khoneha Methanol (hanyenyane), metsi (hanyenyane)
Storage Tmocheso Hygroscopic, -20˚C Freezer, Tlas'a Sebaka sa Inert
Aho latela E le hore o phethe karolo ea ho eketsa bophelo le ho phekola lefu la tsoekere

Monotucleotide e khōlō ea Nicotinamide (NMN) phofo (1094-61-7) Tlhaloso

Phofo e khōlō ea Nicotinamide Mononucleotide ("NMN" le "β-NMN") ke nucleotide e nkiloeng ho ribose le nicotinamide. Joaloka nicotinamide riboside, NMN ke tsoa ho nicin, 'me batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide (NADH).

Phuputso e ncha e fana ka maikutlo a hore NMN e ka tsosolosa metabolism ea cellular, 'me ea ba le liphello tse tebileng tse khahlanong le botsofali. Ho etsahalang ka tlhaho 'meleng, NMN (β-Nicotinamide mononucleotide) ke ea bohlokoa bakeng sa ho fetoha ha limatlafatsi ka matla. Ho tlatsetsa NMN e le karolo ea puso ea hau ea letsatsi le letsatsi e ka fana ka matla a ho tsosolosa matla, ho sireletsa botsofaling, le ho fokotsa kotsi ea mathata a pelo. NMN ke motsoako oa li-redox, e leng ts'ebetso e bohlokong ea ts'ebetso ea ts'ebetso ea motlakase ho thehoa ha ATP molek'hule e fanang ka matla e phahameng. NMN e na le motsoako o kenyang letsoho o khothalletsang ho nepahala ha metsoli le bophelo bo bolelele.

Tšebeliso ea Nicotinamide Mononucleotide (NMN) phofo (1094-61-7)

  1. Nicotinamide mononucleotide ka lisele tsa motho e phetha karolo ea bohlokoa ho hlahisa matla a matla, e kenngoa ka NAD ea methapola (nicotinamide adenine dinucleotide, cell energy conversion e bohlokoa coenzyme) synthesis, e sebelisetsoang ho hlola botsofali, ho oa ha tsoekere ea mali le meriana e meng ea tlhokomelo ea bophelo.
  2. Nicotinamide Mononucleotide ke vithamine e qhibilihisang metsi, Sehlahisoa se na le phofo e tšoeu ea kristalline, e sa nkhang hamonate kapa e batlang e le monko o bohloko, e nang le tatso e bohloko, e tsitsitseng ka bolokolohi metsing kapa ethanol, e qhibilihisitsoeng ka glycerin.
  3. Nicotinamide Mononucleotidepowderis e bonolo ho noa molomo, 'me e ka fetisoa ka hohle' meleng, metabolite e feteletseng kapa sebopeho se potlakileng se leleka mokokotlong. Nicotinamide ke karolo ea coenzyme I le coenzyme II e phethang karolo ea ha hydrogen e tsamaisoang ka khase ea likokoana-hloko ea phefumoloho, e ka khothalletsa mekhoa ea ho ts'ebetso ea likokoana-hloko le mesifa ea metabolism, ho boloka lisele tse tloaelehileng (haholo-holo letlalo, tšitiso ea lijo le tsamaiso ea methapo) botšepehi bo na le karolo ea bohlokoa.

Ho phaella moo, nicotinamide e na le thibelo le phekolo ea pelo e thibelang pelo, sebono sa sinus le mananeo a khahlanong le potlako a ho leka-lekana, nicotinamide e ka ntlafatsa haholo sekhahla sa pelo le sebopeho sa atrioventricular se bakoang ke verapamil.

melemo e ea Nicotinamide Mononucleotide (NMN) phofo (1094-61-7)

  • NMN e Matlafatsa Metabolism ea Matla-NAD + e thusa lijo tse senyehang joaloka tsoekere ka matla.
  • E khothaletsa Bokooa bo Botle le Mesebetsi ea Motlakase.
  • Ho lokisa DNA ea Anti-Aging - NAD + e sebelisetsoa ho lokisa lisebelisoa tsa DNA tse robehileng.
  • Moqapi oa SIRTUIN - NAD + e hlokahalang bakeng sa liphatsa tsa rona tsa nako e telele ho sebetsa.
  • NMN ke moqhaka o sebelisitsoeng ke Harvard Scientists ho fetola matšoao a mang a mahlahahlaha a tsofetseng litoeba tse qalileng ho potlakisa NAD.
  • Kalafo ea NMN e sireletsa khahlanong le kotsi e entsoeng ke boko bo entsoeng ke CICH
  • Tlhahlobo ea NMN e lopolla ho holofala ha maikutlo
  • Nicotinamide mononucleotide e thibela ts'ebetso ea JNK ho fetola lefu la Alzheimer
  • NMN e ka tsosolosa tlhokomelo ka likhoto tsa mohlala tsa AD

E khothalletsoa Nicotinamide Mononucleotide (NMN) phofo (1094-61-7) Tekanyo

Tekanyo e atisang ho kgothaletswa ya Nicotinamide Mononucleotide powder ke kae kapa kae pakeng tsa 250 - 1500 mg ka letsatsi.

NMN e kenngoa ka potlako haholo 'me e na le halofo ea bophelo bo khutšoanyane, kahoo ho boloka litekanyetso tsa NAD + li phahame ka nako e ngata kamoo ho ka khonehang ho buelloa ho nka capsule e le' ngoe ea 125 mg ka ho tsoha le e mong ka thapama ha u nka 250 mg ka letsatsi.

Litla-morao ea Nicotinamide Mononucleotide (NMN) phofo (1094-61-7)

Le hoja pholisi ea Nicotinamide mononucleotide (NMN) e le tlatsetso e ncha e hlophisitsoeng 'me lipatlisiso li ntse li tsoela pele, lithuto tse entsoeng ho fihlela joale li bontšitse hore li sireletsehile haholo ebile ha li na chefo.

Litla-morao ha li fumanehe hangata, empa bolutu, ho ba le botenya, ho fufuleloa le ho nyefoloha ho 'nile ha tlalehoa maemong a mang.


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Litlhaloso le lihlahisoa tsa lihlahisoa

2019 Meriana ea Anti-Aging e Ncha: Nicotinamide Mononucleotide (NMN)

References

  1. Mills, KF, Yoshino, J., Yoshida, S., le al. (2016). Tlhaloso ea nako e telele ea Nicotinamide Mononucleotide e fokotsa ho ba le mekhoa e fokolang ea mekhoa ea mefuta ea lilemo. Cell Metabolism.
  2. Yoshino, J., Mills, KF, Imai, SI, le Yoon, MJ (2011). Nicotinamide Mononucleotide, e leng senotlolo sa NAD + se Akaretsang, se sebetsana le Pathophysiology ea lefu la tsoekere le la lilemo-ngata tse fumanoang ke litoeba. Cell Metabolism.
  3. Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., le Sadoshima, J. (2014). Nicotinamide Mononucleotide, ea Bohareng ba NAD + Synthesis, e Sireletsa Pelo ho tloha Ischemia le Reperfusion.
  4. Sinclair, DA, Uddin, GM, Youngson, NA, le Morris, MJ (2016). Hlooho ea Hlooho ho Hlooho Ho Bapisoa le Phekolo ea nako e Khuts'oanyane le Nako-pele ea NAD + ea Nicotinamide Mononucleotide (NMN) le Libeke tse tšeletseng tsa ho ikoetlisa Meleng ea Bo-'mè ba Bo-'mè.
  5. Imai, S., Yoshino, J., Mills, KF, Grozio, A., le al. (2019) Slc12a8 ke Transotter ea Nicotinamide Mononucleotide. Tlhaho ea Metabolism.
  6. De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, le al. (2016). Nicotinamide Mononucleotide e furalla ho se sebetse ha li-Vascular le khatello ea kelello ea likokoana-hloko le litoeba tse tsofetseng.
  7. Yao, Z., Gao, Z., Yang, W., le Jia, P. (2017). Nicotinamide Mononucleotide e Thibela JNK Ho Etsa Hore ho Phekoloe Maloetse a Alzheimer.
  8. Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Tlatsetso e lekanyetsa litšobotsi tsa Alzheimer ea Key le DNA Litlhaselo Tlokotsing ka New AD Mouse Model ka Khaello ea DNA Repair Repair.

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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