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Raw RAD140 phofo (1182367-47-0)

RAD140 phofo e nkoa e le e 'ngoe ea li-SARM tse ntle ka ho fetisisa tsa ho haha ​​mashome a mane moo. Ntho e kholo ka SARMS ke hore ...... ..


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Tlhaloso

Phala e kholo ea RAD140 (1182367-47-0) video

Raw RAD140 phofo (1182367-47-0) Tlhaloso

RAD140 phofo e boima e tsejoang hape e le Testolone (Raw RAD140 powder), ke khetho ea androgen receptor modulator (SARM) e hlahisoang ke khamphani ea meriana ea Radius bakeng sa ho phekola kankere ea matsoele le ho senyeha ha mesifa ho basali ba postmenopausal. Testolone e ncha haholo marakeng oa khoebo ka ho fumanoa ha eona pele ho 2010.

Raw RAD140 phofo e le sekhetho sa "androgen receptor modulator" (SARM). E susumetsa li-receptor tsa androgen masapong le mesifa ka kamano e matla haholo ho feta litho tsa litho tsa botona. Moriri o moholo oa RAD140 o tumme har'a basebetsi ba 'mele le baatlelete ba batlang ho eketsa mesifa ea' mele.

Raw RAD140 phofo (1182367-47-0) Slitšobotsi

Name Product Raw RAD140 phofo
Lebitso la lik'hemik'hale 2-Chloro-4-(((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile
Brand Name Testolone
Sehlopha sa Lithethefatsi khetha androgen receptor modulator (SARM)
Nomoro ea CAS 1182367-47-0
InChIKey XMBUPPIEVAFYHO-KPZWWZAWSA-N
limolek'hule Formula C20H16ClN5O2
limolek'hule Wtse robeli 393.831 g / mol
Masapo a monoisotopic 393.099 g / mol
Ho qhibiliha Poli Ha ho dintlha tse fumanehang
Fho tsosolosa Poli Ha ho dintlha tse fumanehang
Likokoana-hloko tsa Half-Life Ha ho dintlha tse fumanehang
Color Pula e tšoeu
Solubility Metsi a Matsoeliso 0.153 mg / mL
Storage Tmocheso Boloka licheteng
Raw RAD140 phofo Aho latela Palesa e kholo ea RAD140 ke mokhoa oa lipatlisiso o khethiloeng ke androgen receptor modulator (SARM) bakeng sa phekolo ea maemo a kang ho senyeha ha mesifa le kankere ea matsoele.

Motsoako o moholo oa RAD140 powder (1182367-47-0) Tlhaloso

RAD140, eo hape e tsejoang e le Testolone hangata e bitsoa SARM e matla ka ho fetisisa. E ntse e ntse e batlisisoa ke k'hamphani ea meriana e bitsoang Radius Health.

Li-electro-receptor modulators (SARM) tse khethiloeng ke Selective ke tsona tse nkoang e le tse ling tse bolokehileng ho steroids.

Ke eng e etsang hore e be e khethehileng haholo?

Hantle, Maroa ana a khetha ntho e 'ngoe le e' ngoe eo a e etsang. Ka ho tlama melaetsa ea androgen ka tsela e khethollang, u tla fumana melemo ntle le ho tšoenyeha ka litla-morao.

Litsela tse tsamaisang lik'hemik'hale tsena li fapane ka ho fapaneng ho feta tse ngata tse ntlafatsang ts'ebetso.

SARM tse kang Testolone (RAD140) li na le litla-morao tse fokolang haholo ha li bapisoa le li-steroid ke hore na ke hobane'ng ha li atisa ho sebelisoa ke litho tsa 'mele.

Boholo ba basebelisi ba bolela hore sena se khethiloeng ke androgen receptor modulator (SARM) ke ntho e haufi ka ho fetisisa ho li-steroids. Sena se bolela hore u ka lebella ho eketseha ho hoholo ha mesifa le mesifa e boima. U ka ba ua lahleheloa ke mafura a mang ha u ntse u haha ​​mesifa, eo ba bang ba reng ha e khone ho e etsa.

Hobane SARM ena e matla haholo, o ka lebella liphetho tse kholo. Kahobane e e-na le kamano e phahameng e tlamang le ba amohelang li-androgen, karolo ena e nkoa e le e 'ngoe ea matla ka ho fetisisa.

Ho beha lintho ka tsela e nepahetseng, phofo e tala ea RAD140 e na le anabolic: karolelano ea androgenic ea 80: 1.

Lik'hemik'hale tse nang le karolelano e phahameng ea anabolic li tsejoa e le lihahi tse khōlō tsa boima. U ka apara habonolo 10lbs ea mesifa ea mesifa ha e ntse e etsa lipatlisiso ka SARM ena.

Raw RAD140 phofo (1182367-47-0) Mokhoa oa Ketso

RAD140 e sebetsa ka ho khetha ho amohela li-androgen receptors 'meleng. E kenyeletsa li-receptors ka mesifa le masapo 'me li na le phello e fokolang likarolong tsa ho ikatisa.

Matla a khethollang a SAR ha a utloisisoe ka botlalo. Ba ka 'na ba sebetsa ka ho khetha liprotheine tse sa tšoaneng ho feta testosterone. Sena se fella feela ka li-receptors tse itseng feela-haholo-holo ka mesifa-e ntse e sebelisoa, ha e ntse e qobella ba bang.

Sebopeho sa RAD140 se boetse se fapane le sebopeho sa li-hormone tsa steroid tse kang testosterone. Sena se bolela hore 'mele ha o khone ho fetola RAD140 phofo e tala ho li-hormone tse ling tse kang estrogen e ka ba le liphello tse sa rateheng.

Sehlopha sena se boetse se susumelletsa mesifa ho hōla ka ho khothalletsa ntshetsopele ea lisele le liprotheine.

E itšetlehile ka thuto ho likhoto, polase e kholo ea RAD140 e amohelang li-receptors libakeng tsa boko bo lemetseng. Sena se etsa hore ho be le letšoao le bitsoang tsela ea MAPK e thusang ho sireletsa lisele.

melemo e ea mafura a RAD140 phofo (1182367-47-0)

◆ Ho eketsa mesifa ea mesifa

RAD140 e tloaelehile mokhatlong oa ho haha ​​'mele bakeng sa liphetoho tsa mesifa. Ho tšoana le li-SARM tse ling, li fana ka mokhoa oa ho eketsa mesifa ea mmele ntle le liphello tse sa batleheng tsa steroid tse tloaelehileng.

Ho sa tsotellehe botumo bona, bopaki ba saense ka mor'a hore RAD140 phofo e tala e fokotsehe haholo.

Hona joale, ho na le thuto e le 'ngoe feela ea lifofane e ileng ea hlahloba phello ea RAD140 ka ho hōla ha mesifa. Phuputsong, bafuputsi ba ile ba hlahloba litekanyo tse sa tšoaneng ka litšoene tsa 9. Ba fumane hore RAD140 e eketsa mesifa ea mesifa e boima ka mor'a matsatsi a 28 feela a sebelisoang.

Thuto ea batho ea RAD140 ha e e-s'o etsoe hona joale. Leha ho le joalo, teko ea meriana ea SARM e fapaneng e bitsoang Ostarine e fumane hore e ntlafatsa boima ba mesifa le boima ba 'mele ho batho ba hōlileng.

◆ Kankere ea matsoele

RAD140 e bontša liphello tse tšepisang tsa kankere ea matsoele.

Sebopeho se tloaelehileng sa kankere ea matsoele se bitsoang androgen le estrogen receptor positive (AR / ER +) se na le li-hormone. Meriana e amang li-receptor tsena, joaloka SARM, e ka 'na ea e-ba le bokhoni ba ho loantša kankere.

Ha u ntse u etsa lipatlisiso tsa sele, pola e tala ea RAD140 e emisa ho hōla ha lisele tsa kankere tsa matsoele tsa AR / ER + ka ho thibela liphello tsa estrogen.

Ka ho khetheha, RAD140 e bonahala eka e thibela thepa ea ESR1. Lefu lena le ikarabella ho bōpa li-receptor tsa estrogen. Ntle le li-receptor tse lekaneng, estrogen e ka 'na ea sala e se na matla ebile e sa sebetse.

◆ Liphello tsa Bongo

Androgens e boetse e phetha karolo ea bohlokoa ho sireletsa boko. Li ka eketsa khōlo ea lisele tsa boko, ntlafatsa mohopolo, le ho fokotsa ho bokella ha beta ea amyloid. Ho lumeloa hore li-proteine ​​tse nang le li-beta tse nang le majoe a mangata ke tsona tse bakang lefu la Alzheimer.

Phuputsong ea likhoto, litsebe tsa RAD140 li sirelelitsoe kelellong khahlanong le kotsi ho tloha ho amyloid beta. Ho phaella moo, RAD140 le testosterone li ne li sebetsa hantle ha li sireletsa khahlanong le li-neurotoxin.

Ho thahasellisang ke hore basebelisi ba bang ba RAD140 ba tlaleha boroko bo botle, empa ha ho na lithuto tsa ho khutlisa sena. Same e ea bakeng sa litlaleho tsa bokhoni ba eona ba ho ntlafatsa ts'ebetso ea thobalano-le hoja sena se ka etsahala hore se lumellane le liphello tsa testosterone.

◆ Tahlehelo ea boima ba 'mele

Maroa a tsebahala ho eketsa mesifa le ho fokotsa mafura a 'mele.

Thuto e le 'ngoe feela ka litšoene e ile ea sheba liphello tsa RAD140 ho mesifa le mafura. Le hoja e ile ea eketsa mesifa e boima, phello ea mafura a 'mele e ne e sa hlaka.

Leha ho le joalo, thuto e fumane hore RAD140 e ntlafatsa maemo a k'holeseterole. Ho phaella moo, boima ba mesifa bo phahameng bo ka eketsa tšebeliso ea matla ho ntlafatsa tahlehelo ea mafura.

Khothalletsoang Raw RAD140 phofo (1182367-47-0) Palo

Basebelisi ba bangata ha ba fete 20mg ka letsatsi. Ke SARM e matla kahoo ha ho hlokahale ho nka ho fetang ho buelloa.

Boholo ba potoloho le RAD140 phofo e tala e tla lula kae kapa kae ho tloha ho 6 ho ea ho libeke tsa 8. Hape, bafuputsi ba nang le phihlelo ba ka 'na ba qobella libeke tse 10.

Litla-morao ea mafura a RAD140 phofo (1182367-47-0)

RAD140 ke ntho e ncha ea lipatlisiso. Tšireletseho ea eona le litla-morao tsa eona ha li e-s'o hlahlojoe ka bongaka.

E itšetlehile ka hore na SARM e sebetsa joang, RAD140 e lokela ho baka liphello tse seng kae tse sa batleheng ho feta testosterone. Seo se boletse, RAD140 e ntse e na le bokhoni ba ho baka litla-morao tse amanang le testosterone. Tsena li kenyeletsa:

  • Boea ba botona / kholo ea banna
  • Ho hōla ha moriri o sa tloaelehang oa mmele ho basali
  • Liphetoho tsa ho khanna thobalano
  • Tsela ea banna ba lahleheloang ke moriri / ho lahleheloa ke moriri
  • Ho feto-fetoha ha maikutlo le ho tšoenyeha / ho tepella maikutlong
  • Nosea le ho hlatsa

Baetsi ba 'mele hangata ba tlaleha ho lahleheloa ke moriri e le phello e lehlakoreng, e fetoletsoeng ha ba khaotsa ho nka RAD140.


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Litlhaloso le lihlahisoa tsa lihlahisoa

RAD140 (Testolone): Hlahloba & Sebelisa & Likotsi

References

  1. Pier Giorgio Righetti; '' Capillary Electrophoresis ea Analytical Biotechnology: Tsela e Lekaneng ea Khopolo ''
  2. John J. Qu, Wei Gao, Menas Kafatos, Robert E. Murphy, Vincent V. Salomonson; '' Lefats'e la lefats'e la lefats'e la lits'ebeletso tsa libaka tse fokolang libaka tsa maoto: Vol.1: Saense le lisebelisoa ''
  3. Mokhatlo oa Amerika oa Phuputso ea Kankere; '' AACR 2017 Proceedings: Tse ling tsa 3063-5947 ''

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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