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Mofuta o moholo oa SR9009 (1379686-30-2)

Moriana o moholo oa SR9009 o tloaelehile ho bitsoa Stenabolic mme ha e le hantle ke lithethefatsi tse entsoeng ka morero oa ......


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Tlhaloso

Phala e kholo ea SR9009 (1379686-30-2) video

Mofuta o moholo oa SR9009 (1379686-30-2) Tlhaloso

SR-9009 ke REV-ERB agonist. SR-9011 e 'nile ea bontšoa hore e kotsi haholo ho lisele tsa kankere le lisele tse nang le boikutlo bo hlakileng bo entsoeng ka oncogene, ho akarelletsa le melanocytic naevi,' me ha e na phello ho pheleng ea lisele tse tloaelehileng kapa lisele.

E ile ea bontšoa ho matlafatsa mamello, ho fokotsa ho tšoenyeha, le ho fokotsa k'holeseterole, boima le ho ruruha litoeba. Liphello tsena, haeba li pakoa ho batho, li ne li tla pheta tse ling tsa liphello tse atlehang tse amanang le 'mele ea rona' me kahoo, ntlafatsa bophelo ba rona. Li-SR9009 tse nang le litla-morao tse bohloko li ntse li sa tsejoe. Bala ho bala ho eketsehileng ka phofo e kholo ea SR9009.

Phala e kholo ea SR9009 (1379686-30-2) Slitšobotsi

Name Product Phala e kholo ea SR9009
Lebitso la lik'hemik'hale 1-Pyrrolidinecarboxylic acid, 3 - ((((4-chlorophenyl) methyl) ((5-nitro-2-thienyl) methyl) amino) methyl) - ethyl ester
Brand Name Ha ho dintlha tse fumanehang
Sehlopha sa Lithethefatsi Ha ho dintlha tse fumanehang
Nomoro ea CAS 1379686-30-2
InChIKey MMJJNHOIVCGAAP-UHFFFAOYSA-N
limolek'hule Formula C20H24ClN3O4S
limolek'hule Wtse robeli 437.939 g / mol
Masapo a monoisotopic 437.118 g / mol
Ho qhibiliha Poli Ha ho dintlha tse fumanehang
Fho tsosolosa Poli Ha ho dintlha tse fumanehang
Likokoana-hloko tsa Half-Life Ha ho dintlha tse fumanehang
Color Pente e tšoeu e tsoeu
Solubility Metsoako a metsi: 0.00162 mg / mL
Storage Tmocheso Boloka licheteng
Phala e kholo ea SR9009 Aho latela ho matlafatsa mamello, ho fokotsa ho tšoenyeha, le ho fokotsa k'holeseterole, boima le ho ruruha litoeba.

Mofuta o moholo oa SR9009 phofo (1379686-30-2) Tlhaloso

Karolo ea SR9009 ha e matleng a malapa a SARM. Ke karolo e thahasellisang haholo, ntumelle hore ke hlalose.

'Mele oa motho o sebetsa ho latela molumo oa circadian. Sena sohle se etsahala fensetereng ea lihora tsa 24. Ntho e thahasellisang ke hore mekhoa ea lits'ebeletso e ikarabella ho boloka pina ea circadian. Sena se laola tsela eo liphatsa tsa lefutso li bulehileng ka eona.

Ka mohlala, ha liphatsa tsa lefutso tsa CLOCK le BMAL1 li fetoha, li iketsa eka ke PER and CRY. PER le CRY, hape, tlosa MBAL1 le CLOCK ho tsosolosa potoloho ea lihora tsa 2.

BMAL1 e koetsoe ke li-proteine ​​tse tsejoang e le REV-ERBs. Ba na le boikarabello ba ho leka-lekanya nako ea ka hare ea 'mele. Li-REV-ERBs li bakoa ke sehlopha sa heme se entsoeng ka metsoako e menyenyane e nang le tšepe.Hona ho ka fumanoa ho pholletsa le 'mele. Li hlaha ka mefuta e fapaneng ho kenyeletsa lisele tse khubelu tsa mali.

SR9009 phofo e tsejoa ka matla a eona a ho ntlafatsa mosebetsi oa REV-ERBs 'me e na le bioavailability e ntle.

Phala e kholo ea SR9009 (1379686-30-2) Mokhoa oa Khato

Ka lebaka la bokhoni ba eona ba ho ama REV-ERBA (NR1D1, NR1D2) 'meleng, pono ea SR9009 e bontša melemo e mengata ea bophelo bo botle. Ho itšetlehile ka lipatlisiso tse entsoeng ka litoeba, REV-ERB e susumetsa tšebetso ea lipina tsa circadian ka ho tlosoa ha BMAL1 ho fetola mokhoa oa ho robala le mosebetsi oa kakaretso.

Ho phaella moo, REV-ERB e boetse e bontšitsoe ho susumetsa likarolo tse ling tse ngata tsa tlhahiso ea matla.

Hona mohlomong hobane REV-ERB e tsoa sebeteng, mesifa le mafura a mafura:

Sebete: Har'a liphatsa tsa 900 tse laoloang ke molumo oa mouse, e ka bang 90% e ka angoa ke REV-ERB. Hang ha e qala ho sebetsa, sena se etsa hore liphatsa tsa lefutso tse hlahisoang ke lefu la glucose li hlahe ha li ntse li siea kutloisiso ea insulin. Ka nako e ts'oanang, e fokotsa karabo ea 'mele ea ho ruruha ha e ntse e etsa hore ho thehoe lisele tse ncha tsa mafura.

Matšoao: REV-ERB e matlafatsa mosebetsi oa mitochondria ka nako e le 'ngoe ha e ntse e fokotsa ts'oaetso ea khale ea mitochondria. Ts'ebetso ena e potlakisa ho chesa mafura.

Lisele tsa Mafura: REV-ERB e ka boela ea thibela liphatsa tsa lefutso tsa mafura, tse fokotsang tlhahiso ea triglycerides.

Lithuto tsa liphoofolo le tsa sele tse entsoeng ka SR9009 li bontša hore:

▪ E atisa ho sebelisoa ha oksijene

▪ E fokotsa tlhahiso ea lisele tse ncha tsa mafura sebeteng

▪ Li-acid tse ngata le tlhahiso ea k'holeseterole li fokotsehile haholo

▪ Ho na le palo e kholoanyane ea mitochondria ka mesifa

▪ Masifa a sebelisa tekanyo e phahameng ea tsoekere le mafura a acids

▪ Ho na le mafura a seng makae a bolokiloeng mesifa

melemo e ea SR9009 phofo e kholo (1379686-30-2)

◆ Ho fokotsa tšoaetso ea mali ea cholesterol

◆ Ho Eketsa Mamello

◆ Ho fokotsa ho ruruha

◆ Ho Sireletsa Mafu a Pelo

◆ Ho U fa Matla

◆ o Thusa ka Matšoenyeho

◆ Ho fokotsa Tšenyo ea Matšoao (Fibrosis)

Khothalletso ea Rax SR9009 e khothalletsoang (1379686-30-2) Palo

Ho ea ka liforomo tsa marang-rang, Inthanete e lokela ho e nka ka litekanyetso tsa 10 ho 40 mg 3 ho linako tse 4 ka letsatsi.

Litla-morao ea SR9009 phofo e kholo (1379686-30-2)

Hona joale ha ho na litla-morao tse tsebahalang tsa SR9009. Liphetho tsa lipatlisiso tsa litoe ha li bontše matšoao a sebete sa sebete, empa ba bang ba tlalehile linyeoe tsa ho hlobaela. Ha e kena-kenane le li-hormone tsa tlhaho tsa 'mele oa hao kahoo ho ke ke ha e-ba le khatello leha e le efe.

Sena se bolela hore u ke ke ua batla PCT leha e le efe le MK677 le Cardarine.


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Litlhaloso le lihlahisoa tsa lihlahisoa

Lisebelisoa tsa SARM ho Top 10: SR9009 (1379686-30-2)

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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