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Letswai la disodium la NADP (24292-60-2)

Nicotinamide adenine dinucleotide phosphate (NADP +) ke cofactor e sebelisoang ho arabela ka anabolic. Nic-Nicotinamide adenine ……


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salt-Nicotinamide adenine dinucleotide phosphate disodium letsoai (NADP letsoai la letsoai) Slitšobotsi

Name Product salt-Nicotinamide adenine dinucleotide phosphate disodium letsoai (letsoai la disodium la NADP)
Lebitso la lik'hemik'hale Disodium ea NADP; Nadide phosphate disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium letsoai;
Nomoro ea CAS 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
Smile C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
Molecular Formula C21H26N7Na2O17P3
Boima ba 'mele 787.37
Masapo a monoisotopic 787.039342 g / mol
Melting Point 175-178 ° C
Color Yellow
Stempage temp -20 ° C
metsi Solubility > 50 g / L
kopo Coenzyme ka li-oxidations tsa aerobic le anaerobic

Β-Nicotinamide adenine dinucleotide phosphate disodium letsoai (letsoai la NADP disodium) ke eng?

Nicotinamide adenine dinucleotide phosphate (NADP +) ke cofactor e sebelisoang ho arabela ka anabolic. salt-Nicotinamide adenine dinucleotide phosphate disodium letsoai la letsoai la NADP +, ke coenzyme e hlokahalang bakeng sa phepelo ea joala ea tsoekere le kholofalo ea oxidative ea lintho tse ling. 'Me e etsahala haholo linthong tse phelang, haholo-holo ka har'a sebete.

Nicotinamide adenine dinucleotide phosphate (NADP) le NADPH ba etsa mofuta oa redox. Tekanyo ea NADPH / NADP e laola bokhoni ba redox ea intracellular, haholo-holo karabelo ea anaerobic, ka hona e ama karabelo ea metabolic 'meleng. Mehlala ke lipid le syntic acid synthesis. NADP hape ke li-coenzyme tse peli ka har'a li-system tse fapaneng tsa cytochrome P450 le oxidase / reductase reaction system tse kang thioredoxin reductase / thioredoxin system.

NADPH e fana ka phokotseho e lekanang ea karabelo ea biosynthetic hape e fana ka litlamorao tsa redox ho thibela kotsi ea mefuta ea oksijene e sebetsang (ROS), ka hona e nchafatsa glutathione (GSH). E boetse e sebelisoa litseleng tsa anabolic tse kang cholesterol synthesis le ho eketsoa ha mafura a acid.

Ntle le moo, Sisteme ea NADPH e boetse e ikarabella bakeng sa ho hlahisa li-radicals tsa mahala liseleng tsa 'mele tsa ho itšireletsa mafung ka NADPH oxidase. Li-radicals tsena tsa mahala li sebelisetsoa ho senya likokoana-hloko ka mokhoa o bitsoang phefumoloho. Ke phapang e lekanang le mohloli oa li-aromatics tsa cytochrome P450 hydroxylated, li-steroid, li-alcohols le lithethefatsi.

kopo ea β-Nicotinamide adenine dinucleotide phosphate disodium letsoai

Nicotinamide adenine dinucleotide phosphate (NADP) le NADPH ba etsa mofuta oa redox. NADP / NADPH ke coenzyme e tšehetsang maikutlo a redox ka ho tsamaisa lielektrone ka bongata ba lits'ebetso, haholo-holo karabelo ea anaerobic e kang lipid le syntic acid synthesis. NADP / NADPH ke banyalani ba Coenzyme ka har'a li-system tse fapaneng tsa cytochrome P450 le oxidase / reductase reaction system, joalo ka thioredoxin reductase / thioredoxin system.

Li-enzyme tse ling tse sebelisang NADP joalo ka coenzyme ke: Alcohol dehydrogenase: NADP e itšetlehileng ka eona; Adomatic ADH: Ho latela NADP; Ffereoxin-NADP reductase; L-Fucose dehydrogenase; Sebaka sa polokelo ea litaba; Galactose-1-phosphate uridyl e fetisoang; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP e ikhethang; Isocitric dehydrogenase; Li-enzyme tsa Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase le Succinic semialdehyde dehydrogenase.

Tlhaloso:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism e Tšehetsa Leseli le Nang le Boemo ba Li-NADP Limeleng. Mofuta oa Semela oa Front. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Mofuta oa lefuba ke chefo ea NAD + le NADP + glycohydrolase e nang le thepa e ikhethang ea enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Distribution, Evolution, Catalytic Mechanism, le Mesebetsi ea 'mele ea Flavin-based Electron-Bifurcating NADH-Dependent Feduoxin: NADP + Oxidoreductase. Bokapele ba Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. "Sebopeho le ts'ebetso ea NAD kinase le NADP phosphatase: li-enzymes tsa bohlokoa tse laolang tekanyo e tsitsitseng ea NAD (H) le NADP (H)". Bioscience, Biotechnology le Biochemistry 72 (4): 919–30. Doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. "Tlhokomelo ea likhakanyo tsa Enzyme-Coenzyme ka FAD le NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme". Tlaleho ea Phetohelo ea Limolek'hule. 85 (5-6): 205-218. Bibcode: 2017JMolE..85..205H. Doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

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