+ 86 (1812) 4514114 info@phcoker.com

Palesa e mafura a Flibanserin (167933-07-5)

Palesa e meholo ea Flibanserin ke lithethefatsi tse ngotsoeng kalafo e bontšitsoeng bakeng sa ho phekola basali ba pelehi ba nang le bothata ba ho kopanela liphate, ba nang le mekhoa e metle ea ho kopanela liphate ....


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1489kg / khoeli

Tlhaloso

Phala ea Raw Flibanserin (167933-07-5) video

Palesa e mafura a Flibanserin (167933-07-5)

Phofo e mafura a Flibanserin, e rekisoang tlas'a lebitso la khoebo Addyi, ke setho sa li-agonist le se khahlanong le serotonin tse ngata tse sebelisetsoang ho phekola basali ba pele-pele ba nang le boloetse ba takatso ea ho kopanela liphate (HSDD). Meriana e eketsa lenane la liketsahalo tse khotsofatsang tsa thobalano ka khoeli ka hoo e batlang e le halofo ea placebo ho tloha qalong ea hoo e ka bang tse peli ho isa ho tse tharo. Ka nako e ts'oanang, E na le karolo ea serotonergic agonist, mohanyetsi oa serotonergic le ea nang le bothata ba ho tepella maikutlo ..

Palesa e kholo ea Flibanserin (167933-07-5) Slitšobotsi

Name Product Palesa e meholo ea Flibanserin
Lebitso la lik'hemik'hale 1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one
Brand Name Addyi
Sehlopha sa Lithethefatsi Multi-functional serotonin agonist le mohanyetsi
Nomoro ea CAS 167933-07-5
InChIKey PPRRDFIXUUSXRA-UHFFFAOYSA-N
limolek'hule Formula C20H21F3N4O
limolek'hule Wtse robeli 390.41 g / mol
Masapo a monoisotopic 390.167 g / mol
Ho qhibiliha Poli 225 ° C
Boiling Point N / A
Likokoana-hloko tsa Half-Life ~ Lihora tse 11
Color Ho soeufala ho ea ho beige
Sho khoneha DMSO: soluble10mg / mL, hlakileng
Storage Tmocheso 2-8 ° C
Palesa e meholo ea Flibanserin Aho latela E thehiloe bakeng sa ho phekoloa bothata ba boikaketsi ba ho kopanela liphate ho ba basali

Palesa e kholo ea Flibanserin (167933-07-5) Tlhaloso

Flibanserin phofo ke eona lithethefatsi tsa pele tse lokelang ho amoheloa bakeng sa bothata ba ho ba le takatso ea ho kopanela liphate (HSDD) boemong ba basali ba pelehi ba FDA ka August 2015. Qalong e ile ea hlahisoa e le moriana o thibelang ho imeloa kelellong ke Boehringer Ingelheim, empa e bontša ho se sebetse hantle litsing 'me e ile ea ntlafatsoa ka ho fetisisa e le moriana oa boikaketsi oa ho kopanela liphate le sekhooa sa Sprout Pharmaceuticals. Mekhoa ea Flibanserin e bakoa ke hore e na le kamano e phahameng ea 5-HTA1 le 5-HTA2 e amohelang, e bontšang liketso tsa agonist ka 5-HTA1 le mohanyetsi oa 5-HTA2, e leng ho etsang hore ho theohe ha serotonin bokong hammoho le phello ho eketsa norepinephrine le dopamine neurotransmitters.

Phello ea Flibanserin (167933-07-5) Mokhoa oa Ketso

Mekhoa ea Flibanserin e bakoa ke hore e na le kamano e phahameng ea 5-HTA1 le 5-HTA2 e amohelang, e bontšang liketso tsa agonist ka 5-HTA1 le mohanyetsi oa 5-HTA2, e leng ho etsang hore ho theohe ha serotonin bokong hammoho le phello ho eketsa norepinephrine le dopamine neurotransmitters. Flibansetrin e na le kamano e phahameng ea batho ba amohelang serotonin bokong: e sebetsa joaloka mogonist ka 5-HT1A le mohanyetsi oa 5-HT2A. Ka vivo, flibanserin e tlama ka tsela e tšoanang le 5-HT1A le 5-HT2A receptors. Leha ho le joalo, tlas'a maemo a phahameng a bokooa 5-HT (ke hore, tlas'a khatello ea maikutlo), flibanserin e ka 'na ea amohela li-receptor tsa 5-HT2A tse phahameng ho feta 5-HT (1A). E ka boela ea loantša D4 (dopamine) receptors le 5-HT2B le 5-HTB2C. Mesebetsi ea eona ho li-receptor tsa neurotransmitter e ka tlatsetsa ho fokotsehang maemong a serotonin le ho eketseha ha litekanyetso tsa dopamine le norepinephrine, tseo kaofela li ka bapalang karolo ea ho sebetsa ha moputso. Flibanserin e rekisoa tlas'a lebitso la khoebo Addyi le ho bontšoa bakeng sa ho phekoloa ha basali ba pele ho mangeloi a nang le bothata ba ho kopanela liphate (HSDD) e fumanoeng, e tloaelehileng ea ho kopanela liphate (HSDD) e nang le takatso e tebileng ea ho kopanela liphate e bakang bothata bo tebileng ba ho kopanela liphate.

Ts'ebeliso ea phofo ea Flibanserin (167933-07-5)

Pfu ea Flibanserin ke mohanyetsi oa 5-HT1A le 5-HT2A e hanyetsanang bakeng sa phekolo ea bothata ba boikaketsi ba ho kopanela liphate ho basali (1,2).

Phofo e khothalletsoang ea Flibanserin (167933-07-5) Palo

100 mg ka molomo hang ka letsatsi nakong ea ho robala

Nako ea phekolo: Moriana ona o lokela ho emisoa ka mor'a libeke tsa 8 haeba mokuli a sa tlalehe ho ntlafatsa matšoao.

Litlhaloso: Meriana ena ha e bontšoe ho ntlafatsa tshebetso ea thobalano, 'me ha e bontšoe kalafo ho basali ba postmenopausal kapa banna.

Litla-morao tsa phofo ea Flibanserin (167933-07-5)

Liketsahalo tse bohloko li atile haholo ho basali ba ntseng ba nka phofo ea flibanserin. Boholo ba liketsahalo tse bohloko li ne li le bonolo ho isa boemong bo itekanetseng. Liketsahalo tse bohloko tse tlalehiloeng ka kakaretso li kenyeletsa ho ba le botenya, ho nyekeloa ke pelo, ho ikutloa u khathetse, ho robala le bothata ba ho robala.

Ho noa joala ha o ntse o e-na le phofo ea flibanserin ho ka baka khatello e matla ea mali (khatello e tlase ea mali e hlahisitseng matšoao ka mor'a likhalase tsa 2 tsa veine li hlahile 17%).


=

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

Contact