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Tadalafil e mafura a mafura (171596-29-5)

Raw Tadalafil phofo tlasa lebitso la Cialis e sebelisoa ho phekola bothata ba ho hlobaela (impotence) le matšoao a prostate ea benign ………


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1190kg / khoeli

Tlhaloso

Setšoantšo sa Tadalafil

Boitsebiso ba Base

Name Product Tadalafil powder
Lebitso la lik'hemik'hale (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name Cialis, Adcirca
Sehlopha sa Lithethefatsi PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors
Nomoro ea CAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
limolek'hule Formula C22H19N3O4
limolek'hule Wtse robeli 389.4
Masapo a monoisotopic 389.138 g / mol
Ho qhibiliha Poli 298-300 ° C
Fho tsosolosa Poli 2 ° C
Likokoana-hloko tsa Half-Life dihora tse 17.5
Color Ho soeufala ho fihlela ho se soeufalitsoe ke Cyrstalline e tiileng
Sho khoneha Ho qhibiliha ho DMSO (78 mg / ml ho 25 ° C), methanol, metsi (<1 mg / ml ho 25 ° C), dichloromethane, le ethanol (<1 mg / ml ho 25 ° C)
Storage Tmocheso Boloka mocheso oa motsoako pakeng tsa 59 ° F le 86 ° F (15 ° C le 30 ° C). U se ke ua boloka meriana ena sebakeng se mongobo kapa sa mongobo.
Tadalafil Aho latela Li-tablets tsa mafura tsa Tadalafil, li-candy tsa thobalano, kofi ea thobalano, joalo-joalo.

Tlhaloso

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4 -N] Cialis), ke mofuta oa PDE1,4 inhibitor le sethethefatsi se laetsoeng ka molao. Ke b-carboline e nkiloeng mme e hlophisitsoe ka mokhoa o fapaneng le vardenafil (Levitraw) le sildenafil (Viagraw), tseo ka bobeli e leng li-inhibitors tsa PDE5 tse ipapisitseng le sebopeho sa mantlha sa frit pyrimidine. Tadalafil phofo (CAS 5-171596-29) e eketsa phallo ea mali ka har'a corpus cavernosum ka ho phomotsa mesifa ea methapo ea mali, mme sena se nolofalletsa monna ho fihlela erection. Tadalafil phofo e amohetsoe ke United States (US) Food and Drug Administration (FDA) ho 5 bakeng sa kalafo ea dysfunction (ED), mme e rekisoa lefatšeng ka bophara tlasa lebitso la brand Cialis. E boetse e sebelisetsoa ho phekola khatello ea methapo ea methapo ea methapo ea methapo ea methapo le mothapo o mong oa mothapo o moholo oa tšoelesa ea senya.

Tšebetso ea pharmacologic e khethollang Tadalafil ke nako ea halofo ea nako (lihora tsa 17.5) ha e bapisoa le Viagra le Levitra (lihora tsa 4-5). Hona halofo ea bophelo e fella ka nako e teletsana ea liketso 'me karolo e' ngoe e na le boikarabello ba lebitso la bososello la Cialis la "pilisi ea beke ea beke." Sena se halofo ea bophelo bo boetse e le motheo oa lipatlisiso tsa morao-rao bakeng sa tšebeliso ea tadalafil ka lefu la methapo ea mali phekolo ea hang-hang.

Mokhoa oa Khato

Ho tsosoa ha maikutlo nakong ea ho kopanela liphate ho finyelloa ke ho phomola ha methapo ea penile le methapo e tsitsitseng ea mafu, e leng se lebisang ho eketsehileng ha mali ho phalla. Phomolo ena e lumella ho phahama ha mali ka methapo ea penile, ha mali ana a tlatsa likamore tse peli ka har'a penis e bitsoang corpora cavernosa. Ha likamore li tlatsa mali, botona bo ntse bo hōla. Ho khaotsa ho felisoa ha konteraka ea mesifa le mali a bokellaneng a ka phalla ka methapong ea penile.

Karabelo ena e kopantsoe le ho lokolloa ha nitric oxide (NO) litsing tsa methapo ea kutlo le lisele tsa endothelial, e tsosang pherekano ea cGMP liseleng tsa mesifa e boreleli ebe e laola ho fokotseha le ho ts'oaroa ha methapo ea mali e tsamaisang mali ho ea le ho tsoa botoneng. Cyclic GMP e baka boikhathollo ba mesifa le ho eketseha ha phallo ea mali ka har'a corpus cavernosum, 'me e silafalitsoe ke mofuta oa "cGMP" phosphodiesterase mofuta oa 5 (PDE5) ka har'a cous cavernosum e haufi le penis. Tadalafil inhibits PDE5 mme ka tsela eo e eketsa ka ho eketsa palo ea cGMP e fumanehang. Tadalafil e emisa PDE5 ho senya cGMP ebe e eketsa cGMP e fumanehang ho fihlela ts'ebetso mme e etsa hore kopane e tšoarelle nako e telele.

Leha ho le joalo, ha halofo ea bophelo ea Tadalafil e le khutšoanyane, phello ea eona e fela nakong ea matsatsi a 2 a etsa hore PDE5 e khutlele 'me bophelo ba hao ba thobalano - bo mpefala. Ho ka 'na ha hlokahala hore u nka nako e teletsana ho finyella phello eo ue batlang, e kang matsatsi a tlase a matla a Cialis 4-5 bakeng sa matsatsi a 4-5.

kopo

  • Erectile ho se sebetse (ED)
  • Pulmonary arterial hypertension
  • Benign Prostatic hyperplasia
  • Analgesic
  • Norepinephrine e thibela ho thibela
  • Mo-opiod receptor agonist

Tadalafil ea phofshoana ea phofo e khothalletsoang

Cialis e na le matlapa a mahlahahlaha a mahlaseli a mahlaku a mahlaku a 5, a 10 le a 20 milligram (mg). Mokhoa o khothalletsoang oa ho qala oa pholi ea Cialis bakeng sa ho sebelisoa ha ho hlokahala ho bakuli ba bangata ke 10 mg, e nkiloeng pele ho lebelloa ho etsa thobalano.

Moriana oa pele ke li-milligrams tsa 10 (mg) bonyane metsotso ea 30 pele ho thobalano. Lethal dose e ka eketseha ho isa ho 20 mg kapa ea fokotseha ho ea 5 mg, ho itšetlehile ka katleho ea motho ka mong le ho mamella. Empa, boholo ba 20 mg e le tekanyo e le 'ngoe. Maqhubu a holimo a khothalletsoang hangata ka nako e le 'ngoe ho bakuli ba bangata. ha ea lokela ho nka litekanyetso tse fetang tse le 'ngoe lihora tsa 24. Bakuli ba lebeletseng ho kopanela liphate bonyane ka makhetlo a mabeli ka beke ba ka nka tekanyo ea letsatsi le letsatsi ea 5 mg, mme sena se ka fokotsoa ho 2.5 mg hang ka letsatsi, ho itšetlehile ka tsela eo motho a itšoarang ka eona.

Cialis phofo bakeng sa ts'ebeliso kamoo e hlokahalang e ile ea bontšoa ho ntlafatsa ts'ebetso ha e bapisoa le placebo ho fihlela lihora tsa 36 ka mor'a dosing. Ka hona, ha u eletsa bakuli ka tšebeliso e nepahetseng ea phofo ea Cialis, sena se lokela ho nahaneloa.

Ho bohlokoa ho tseba hore moriti o ke ke oa hlaha ka ho nka pilisi. Mme o seke oa nka Cialis bakeng sa ho se sebetse letho haeba o nka Adcirca bakeng sa khatello ea mali ea methapo ea mali. Beside, Tadalafil bakeng sa khatello ea kelello e sebelisoa feela ke batho ba baholo ba nang le lilemo tse 18 le ho feta.

melemo e

• Tadalafil powder e ka thusa ho phutholoha mesifa ea prostate le senya. Sena se ka thusa ho ntlafatsa matšoao a hau a BPH.

• Ho ntlafatsa matšoao a ED, tadalafil powder e thusa ho eketsa tšelo ea mali ho pholiseng. Sena se ka u thusa ho fumana le ho boloka erection. Bakeng sa tadalafil powder ho u thusa hore u hlahe, u lokela ho tsosoa ka thobalano.

♦ Bakeng sa PAH, tadalafil powder e sebetsa ho ntlafatsa bokhoni ba hau ba ho ikoetlisa ka ho phutholoha methapo ea mali matšoafong a hau. Sena se eketsa tšollo ea mali.

Litla-morao

Hammoho le liphello tsa eona tse hlokahalang, moriana o ka baka liphello tse ling tse sa batleheng. Le hoja ho se na litla-morao tsena kaofela tse ka 'nang tsa etsahala, haeba li ka etsahala li ka' na tsa hloka tlhokomelo ea bongaka. Ka kopo sheba liphello tse latelang tsa tadalafil powder:

Litla-morao tse tloaelehileng

▪ hlooho

▪ e halefisitsoe ke mpa

▪ bohloko bo bohloko

▪ mahlaseli a mesifa

▪ ho hlatsoa (letlalo le khubelu)

▪ letheba kapa lesoba le leholo

▪ letšollo

Litla-morao tse mpe empa tse tebileng

Erection e telele e ka lebisang tšenyo ho botona, mathata a pono, le tahlehelo ea kutlo.

Haeba liphello tsena li le bonolo, li ka 'na tsa tloha ka mor'a matsatsi a seng makae kapa libeke tse' maloa. Haeba ba le matla haholo kapa ba sa tsamaee, buisana le ngaka kapa setsebi sa metsoako.

Batho ba nang le maemo ana a latelang ha baa lokela ho nka Cialis phofo ntle le hore ngaka e lumellane:

Mathata a lipelo tsa pelo, angina, kapa mofuta ofe kapa ofe oa lefu la pelo

Khatello ea mali e phahameng kapa e tlaase

Ho senyeha pelo ha pelo kapa ho otloa ha pelo nakong ea likhoeli tsa ho qetela tsa 6, kapa ho fokotsa likokoana-hloko nakong ea likhoeli tsa ho qetela tsa 3

Boloetse ba mali bo bakoang ke lefu la lisele, lefu la myeloma e mengata, hemophilia, kankere ea mali, kapa lefu le leng la mali

Lefu kapa lefu la liphio

Matšoafo a mala

Retinitis pigmentosa

Bothata ba sebōpeho sa penis, joaloka lefu la Peyronie

Boemo bofe kapa bofe ba bophelo boo ba eletsoeng hore ba se ke ba kopanela liphate

Tšebelisano ea Tadalafil

Ha o sebelisa tadalafil, ho ka 'na ha e-ba le lithethefatsi tse ling tse ka amanang le lithethefatsi, tse ka lebisang litlamong. Litšebelisano le lithethefatsi li ka fetola kamoo meriana ea hau e sebetsang kateng kapa eketsa kotsi ea litla-morao tse tebileng.

Tadalafil e na le phello e itekanetseng ea ts'ebetso ea nitrate e bakoang ke ho fokotsa khatello ea mali. Tadalafil e ka baka lerotholi le matla la khatello ea mali ha le sebelisoa le nitrate, e ka lebisang ho ba le botenya, ho fokolloa, le ho ba le khaello ea pelo hangata kapa ho otloa ke stroke. U se ke ua sebelisa tadalafil ka tse ling tse latelang: lithethefatsi tse ling tse sebelisetsoang ho tšoara lefu la sefuba / angina (nitrate e kang nitroglycerin, isosorbide), lithethefatsi tsa boithabiso tse bitsoang "poppers" tse nang le amyl kapa butyl nitrite.

Haeba u boetse u nka meriana ea li-alpha blocker (e kang doxazosin, tamsulosin) ho tšoara prostate e atolositsoeng / BPH kapa khatello e phahameng ea mali, khatello ea mali ea hao e ka 'na ea theoha haholo e ka lebisang ho ba le botenya kapa ho fokotseha. Ngaka ea hau e ka qala kalafo ka tekanyo e tlaase ea tadalafil kapa fetola meriana ea hao ea li-alpha blocker ho fokotsa kotsi ea khatello ea mali e tlaase.

Lithutong tsa kliniki, litekanyetso tsa bohlokoa tsa karabelo li tlalehiloe ho fihlela 36 h ka mor'a ho ts'oaroa ke lithethefatsi. Tadalafil e tšelisitsoe ka bongata sebeteng ka CYP3A4 ho liphutheloana tse sa sebetseng khahlano le PDE5 mme e hlahisoa haholo-holo e le metabolites ka har'a maro le urine. Li-pharmacokinetics tsa tadalafil ha li angoe ke lintlha tse kang ho ja lijo le joala, ho tsofala, ho ba teng ha lefu la tsoekere, le khaello e fokolang ea hepatic kapa e leka-lekaneng. Liketsahalo tse mpe tse atileng haholo tse amanang le lithethefatsi ke hlooho, bohloko ba mokokotlo, dyspepsia le myalgia. Ho tekanyetso ea 10 le 20 mg, Tadalafil ha e na phello e kholo khatello ea mali le lebelo la pelo mme ha e hlahise maemo a eketsehang a infraction ea myocardial. Litlaleho tse sa tloaelehang tsa li-erections tsa nako e telele ho feta 4 h le tsa pele li hlokometsoe ka ts'ebeliso ea tadalafil. Ho tsepamisa mohopolo, haeba ho sa tšoaroe hantle, ho ka baka tšenyo e ke keng ea fetoloa lithong. Bakuli ba nang le erection e kholo ho feta 4 h ba eletsoa ho batla tlhokomelo ea bongaka ea tšohanyetso. Ho bakuli ba lefu la tsoekere, ntlafatso ea ts'ebetso ka tadalafil ha e khetholle mofuta oa lefu la tsoekere le mofuta oa kalafo ea lefu la tsoekere.

Meriana e meng e ka ama ho tlosoa ha tadalafil 'meleng oa hau, e ka' nang ea ama tsela eo tadalafil e sebetsang ka eona. Mehlala e kenyelletsa li-antifungals tsa azole (tse kang itraconazole, ketoconazole), lithibela-mafu tse kang macrolide (joaloka clarithromycin, erythromycin), HIV protease inhibitors (e kang fosamprenavir, ritonavir), kokoana-hloko ea hepatitis C protease inhibitors (e kang boceprevir, telaprevir), rifampin .

Se ke oa nka meriana ena ka sehlahisoa leha e le sefe se nang le tadalafil kapa meriana e meng e tšoanang e sebelisetsoang ho phekola dysfunction-ED kapa pulmonary hypertension (joalo ka sildenafil, vardenafil).

Mabapi le puisano ea tadalafil le lithethefatsi tse ling li ntse li e-na le lintho tse ngata, haeba u batla ho sebelisa lithethefatsi ka tadalafil powder (CAS 171596-29-5), qala ho hopola ho buisana le ngaka ea hau 'me o tla u fa keletso ea setsebi le e ka tšeptjoang.

Lintlha tse ling hape

Tadalafil powder, sildenafil powder, le vardenafil ka phofo kaofela ba nka khato ka ho thibela enzyme ea PDE5, empa lithethefatsi tsena li boetse li thibela lik'hemik'hale tsa PDE 6, 1 le 11 ka mefuta e sa tšoaneng. Ka mohlala, Sildenafil le vardenafil ba thibela PDE6, enzyme e fumanoang leihlo, ho feta tadalafil. Basebedisi ba bang ba sildenafil ba bona binge ya bluish mme ba ba le kutloisiso e khanyang ka lebaka la ho thibela PDE6. Ntle ho moo, Sildenafil le vardenafil ba boetse ba thibela PDE1 ho feta tadalafil. PDE1 e fumanoa bokong, pelo le mesifa e boreleli. Ho nahanoa hore thibelo ea PDE1 ka sildenafil le vardenafil e lebisa ho ts'oaetso, ho tsuba le tachycardia.

Ha li bapisoa le ts'ebetso ea PDE6 le PDE1, tadalafil e iketsetsa haholo PDE11. PDE11 e hlahisoa ka mesifa ea masapo, prostate, sebete, liphio, lesela la pituitary le litlhahlobo. Leha ho le joalo, liphello tsa 'mele oa ho thibela PDE11 ha li tsejoe.


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Litlhaloso le lihlahisoa tsa lihlahisoa

References

  • 1.National Centre bakeng sa Boitsebiso ba Biotechnology, US. Library ea Sechaba ea Meriana, Tadalafil, Pubchem Sehlopha 1-10.
  • 2.Evelyn C. Cortez, CIALIS (Tadalafil): Mesebetsi, Nako, Liphello Tse Ntle Le Boitsebiso le Moo U ka se Rekisang Generic Cialis (Tadalafil), Viagra (Sildenafil), le Meriana e Molemo ka ho fetisisa e Theko e tlaase le e sireletsehileng Inthaneteng, e hatisitsoeng, 13 Dec 2017, leqepheng la 5-3
  • 3.James Lee Anderson, Cialis, Tadalafil: E sebetsana le ho se sebetse ha Erectile, Matšoao a Benign Prostatic Hyperplasia, le Pulmonary Arterial Hypertension, CreatSpace Independent Publishing Platform, 26 Mar 2015, leqepheng la 5-47.

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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