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Palesa e kholo ea AICAR (2627-69-2)

Pula ea AICAR, e tsejoang hape e le AICA, e na le pele-pele ea purine e nang le tšebetso ea antineoplastic le activator ea AMP-activated ...... ..


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Tlhaloso

Video e kholo ea AICAR (2627-69-2) video

Palesa e kholo ea AICAR (2627-69-2) Tlhaloso

Palesa e kholo ea AICAR e tsejoang hape e le ZMP ke analog ea AMP e khonang ho susumetsa mosebetsi oa protein kinase (AMPK) o itšetlehileng ka AMP. Palesa e kholo ea AICAR ke karolo ea moloko oa inosine monophosphate. Phofo e kholo ea AICAR e sebelisoa ho phekola le ho itšireletsa khahlanong le kotsi ea pelo, e ka kenya lisele tsa pelo ho thibela adenosine kinase le adenosine deaminase. E eketsa lebelo la nucleotide re-synthesis ho eketsa moloko oa adenosine ho tswa ho adenosine monophosphate feela nakong ea maemo a li-cardiovascular ischemia. Phofo e kholo ea AICAR e eketsa phekolo ea tsoekere ka ho fetisetsa phetoho ea GLUT4 le / kapa ka ho sebelisa tsela ea p38 MAPK. Hona joale, lithethefatsi li boetse li bontšoa e le phekolo ea lefu la tsoekere ka ho eketsa ts'ebetso ea lik'hemik'hale tsa lik'hemik'hale ka ho fetola sebōpeho sa 'mele oa mesifa.

Palesa e kholo ea AICAR (2627-69-2) Slitšobotsi

Name Product Palesa e kholo ea AICAR
Lebitso la lik'hemik'hale 1-ribosyl-4-carboxamido-5-aminoimidazole, ARA 100, ARA-100, ARA100, GP 1 110, 5-aminoimidazole-4-carboxamide 1-ribofuranoside, 5-aminoimidazole-4-carboxamide riboside, acadesine, AICA ribofuranoside, AICA lebōpong la leoatle, aminoimidazole carboxamide ribonucleoside, arasine, Z-riboside
Brand Name Ha ho data e fumanehang
Sehlopha sa Lithethefatsi SARM
Nomoro ea CAS 2627-69-2
InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N
limolek'hule Formula C9H14N4O5
limolek'hule Wtse robeli 258.23
Masapo a monoisotopic 258.096 g / mol
Ho qhibiliha Poli 214-215 ° C
Fho tsosolosa Poli 214 ° C
Likokoana-hloko tsa Half-Life E khutšoanyane haholo
Color emelana
Sho khoneha H2O:> 10 mg / mL
Storage Tmocheso -20 ° C
Palesa e kholo ea AICAR Aho latela Mokhatelli oa AMPK

Palesa e kholo ea AICAR (2627-69-2)

Palesa e kholo ea AICAR e tsejoang hape e le ZMP ke analog ea AMP, ke e kentsoeng ke Cell-permmeable, ea sebelisang li-allosteric ea AMP-activated protein kinase (AMPK). E khona ho susumetsa tšebetso ea AMPK ts'ebetsong ea AMP, e fokotsa ho ata, ho khetholla le ho fokotseha ha lisele tsa osteoblastic MC3T3-EI le ho thibela maikutlo a susumelitsoeng ke kelello ea proinflammatory cytokines le iNOS ka astrocytes.

Palesa e kholo ea AICAR ke karolo ea moloko oa inosine monophosphate. Phofo e kholo ea AICAR e sebelisoa ho phekola le ho itšireletsa khahlanong le kotsi ea pelo, e ka kenya lisele tsa pelo ho thibela adenosine kinase le adenosine deaminase. E eketsa lebelo la nucleotide re-synthesis ho eketsa moloko oa adenosine ho tswa ho adenosine monophosphate feela nakong ea maemo a li-cardiovascular ischemia. Phofo e kholo ea AICAR e eketsa phekolo ea tsoekere ka ho fetisetsa phetoho ea GLUT4 le / kapa ka ho sebelisa tsela ea p38 MAPK. Hona joale, lithethefatsi li boetse li bontšoa e le phekolo ea lefu la tsoekere ka ho eketsa ts'ebetso ea lik'hemik'hale tsa lik'hemik'hale ka ho fetola sebōpeho sa 'mele oa mesifa.

AICAR ke pele-pele ea purine e nang le tšebetso ea likokoana-hloko. Ke habohlokoa ho phekola maloetse a ts'oaetsanoang a mofuta oa lefu la tsoekere ea 2 hammoho le phekolo ea mefuta e sa tšoaneng ea kankere.

Peso ea AICAR (2627-69-2) Mokhoa oa Ketso

Foromo ea nucleoside ea AICAR, acadesine, ke analog ea adenosine e kenang liseleng tsa pelo ho thibela adenosine kinase le adenosine deaminase. E eketsa lebelo la nucleotide re-synthesis ho eketsa moloko oa adenosine ho tswa ho adenosine monophosphate feela nakong ea maemo a li-cardiovascular ischemia. Myocyte ea pelo, acadesine ke phosphorylated ho AICAR ho kopa AMPK ntle le ho fetola litekanyetso tsa nucleotides. AICAR e khona ho kenya tsela ea synthesis ea noevo bakeng sa adenosine synthesis ho thibela adenosine deaminase e baka ho eketseha ha maemo a ATP le maemo a adenosine.

Tšebeliso ea phofo ea AICAR (2627-69-2)

▪ Antineoplastic

▪ Ho sebelisa lithethefatsi tse matlafatsang

▪ Ho ba le tsoekere e tsosang takatso

▪ Mokhatlalatsi oa AMPK

▪ Mathata a metsolic

▪ Lefu la mali le bitsoang acute lymphoblastic leukemia

Recommended Peso ea AICAR (2627-69-2) Palo

Litekanyo tsa AICAR li ka tloha ho 150 mg letsatsi le leng le le leng, haeba u li tšela ka GW, ho ea ho 500 mg ka letsatsi ha u e sebelisa u le mong. Hangata botlolo e 'ngoe le e' ngoe e fihla meleng ea 50 mg, kahoo ho hlakile hore e theko e boima. Ka lebaka lena, hoa utloahala ho e sebelisa libeke tse 'nè pele ho letsatsi la tlhōlisano.

Melemo ea ho AICAR phofo (2627-69-2)

♦ AICAR ke mohato oa pele oa purine o sebetsang ka matla. Ke habohlokoa ho phekola maloetse a ts'oaetsanoang a mofuta oa lefu la tsoekere ea 2 hammoho le phekolo ea mefuta e sa tšoaneng ea kankere.

♦ Kopo ea AICAR ea ho phekola mathata a metsolic.

♦ AICAR e na le bokhoni ba ho phekola mafu a meriana ao microglia e sebetsanang le 'ona e phetha karolo ea bohlokoa.

♦ AICAR e thusa ho ntlafatsa motlakase, mokhoa oa ho hopola le ho sebetsa ka boko

♦ AICAR e sebelisoa ka ho fetisisa e le ho kenngoa ho stack ea mamello. Baatlelete ba boetse ba e sebelisa bakeng sa ts'ebetso e ntlafatsang lipapaling moo ba hlokang mamello.

♦ AICAR ke nucleoside analogue e khonang ho kenya matamo a nucleoside 'me e khona ho eketsa haholo likarolo tsa adenosine nakong ea ho senyeha ha ATP. Li-agent tse laolang li-Adenosine (ARAs) li 'nile tsa hlokomeloa bakeng sa matla a phekolo ea mericardial ischemia.

♦ AICAR e sebelisetsoa ho phekola kankere ea mali e matla 'me e tlalehoa hore e na le liphello tsa pelo.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.