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Lefu la Raw Cetilistat (282526-98-1)

Peso ea Cetilistate ke inhibitor ea pancreatic lipase e hlahisoang ke Alizyme bakeng sa ho phekola botenya le ho kopantsoe li-co-morbidity ...


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Tlhaloso

Phala ea Raw Cetilistat (282526-98-1) video

Raw Cetilistat phofo (282526-98-1) Tlhaloso

Pula ea Raw Cetilistat ke buka ea pancreatic lipase inhibitor e qapiloeng ke Alizyme bakeng sa phekolo ea botenya le lefu la tsoekere le maloetse a mang. E sebetsa ka ho thibela pancreatic lipase, e leng enzyme e senyang triglycerides ka mateng. E thibela mafura (triglycerides) lijo hore a se ke a sebelisoa hantle 'me a fetoloa mahala a mafura a acids a ka kenngoa ke' mele. Raw Cetilistat phofo haholo fokotswa boima ka 'me e ne e molemo mamella ho feta orlistat.

Raw Cetilistat phofo (282526-98-1) Lintlha

Name Product Raw Cetilistat phofo
Lebitso la lik'hemik'hale Mofuta oa Raw Cetilistat (Alt-962); Xinliorlistat; Mafura a Raw Cetilistat (282526-98-1)
Brand Name Khamente kapa Oblean
Sehlopha sa Lithethefatsi Meriana e thibelang botenya
Nomoro ea CAS 282526-98-1
InChIKey MVCQKIKWYUURMU-UHFFFAOYSA-N
limolek'hule Formula C25H39NO3
limolek'hule Wtse robeli 401.58
Masapo a monoisotopic 401.293 g / mol
Ho qhibiliha Poli 72.0 ho 76.0 ° C
Fho tsosolosa Poli 74 ° C
Likokoana-hloko tsa Half-Life Ha ho letsatsi le fumanehang
Color Crystal e ntle-ntle
Sho khoneha Ho qhibiliha ka DMSO, eseng metsing
Storage Tmocheso -20 ° C
Aho latela Sebelisa ho tšoara botenya ka mathata

Lefu la Raw Cetilistat (282526-98-1)

Cetilistat, eo hape e tsejoang e le ATL-962, ke buka ea inhibitor ea pancreatic lipase e hlahisoang ke Alizyme bakeng sa ho phekola botenya le likamano tse amanang le li-co-morbidity, ho kenyelletsa le mofuta oa 2 lefu la tsoekere. E sebetsa ka tsela e tšoanang le ea khale ea lithethefatsi kapa orlistat (Xenical) ka ho thibela pancreatic lipase, e leng enzyme e senyang triglycerides ka maleng. Ntle le enzyme ena, triglycerides ho tloha lijong e thibela ho haelloa ke hydrolyzed hore e fumanehang mahala mafura acid 'me ba excreted ungested. Meriana ena e lokela ho nkoa ka lijo tse fokolang mafura le boithaopo bo bongata ba ho ikoetlisa ho finyella liphello tse ntle ka ho fetisisa.

Litlhaselong tsa batho, cerealtilat phofo e ne e bontšoa ho hlahisa tahlehelo ea boima bo tšoanang ho orlistat, empa e boetse e hlahisitse litla-morao tse tšoanang le tse oli, likoloto tse hlephileng, ho se tsitse ha fecal, ho itšoara ka makhetlo a mangata, le ho thella. Ho ka 'na ha e-ba le mehato e tšoanang ea ho itšireletsa e ka sebelisoang ha mavithamine a mangata a nang le mafura le limatlafatsi tse ling tse nang le mafura a mangata a ka thibeloa, a hloka hore li-supplement tse nang le mafura li sebelisoe ho qoba ho fokolloa.

Peso ea Cetilistat e ile ea amoheloa ke Mokhatlo oa Maiketsetso oa Bongaka oa Meriana oa Japane (PMDA) ka September 20, 2013. E qapiloe ke Norgine le Takeda, ebe ba rekisoa e le Oblean® ka Takeda Japane.

Peso ea Cetilistate (282526-98-1) Mokhoa oa Ketso

Peso ea Cetilistate ke tahlehelo ea boima ba phofo e sebelisitsoeng hammoho le lijo tse tlaase tsa k'halori. Cetilistat ke gastrointestinal lipase inhibitor, e sebetsa ka ho thibela mafura a mangata ho tloha ho fumanoa le ho kenngoa 'meleng. Phofo ena ea tahlehelo ea boima ba 'mele e hlalosoa e le lipase inhibitor mme e sebetsa ka kotloloho tsamaisong ea lijo ea' mele moo e thibelang liketso tsa enzyme ea lipolytic e bitsoang lipase. Li-lipases ke seo 'mele o se sebelisang ho cheka mafura. Leha ho le joalo, ha meriana ena e tsamaisoa haufi le lijo, e tlama lipases, e ba thibela ho senya mafura. Lihlahisoa tse sa sebelisetsoeng ha hydrolyzed li e-na le libaka tse hlahisang lihlahisoa, li fella ka ho eketseha ha mafura a mafura le ho fokotseha mafura a mafura. Ha li sebelisoa hammoho le lijo tse fokotsehileng tsa khalori, li ka thusa ho ntlafatsa boima ba 'mele le ho etsa hore ho be bonolo hore bakuli ba fetang boima ba' mele ba khutlele sebōpeho, kahoo ba matlafatse menyetla ea ho lahleheloa ke boima ba 'mele. Tsela ea eona ea ho sebelisa e tšoana le phofo ea oldlistat ka ho thibela pancreatic lipase.

melemo e ea photilistat phofo (282526-98-1)

▪ Kalafo ea botenya

▪ Ho fokotsa boima ba 'mele

▪ Kalafo ea lefu la tsoekere

▪ Ho mamelloa hantle ha ho bapisoa le lithethefatsi tse ling

Ho khothalletsoa phofo ea Cetilistat (282526-98-1) Palo

Peso ea Cetilistat e fumaneha joaloka letlapa bakeng sa tšebeliso ea molomo, e nang le 120 mg ea Cetilistat e sa lefelloeng. Moriana o khothalletsoang ke 120 mg ka makhetlo a mararo ka letsatsi hang ka mor'a lijo. Meriana e nkoa ka lijo ho etsa bonnete ba hore e ka sebetsa ha lijo li ntse li chekoa, e le hore mafura a tsoang lijong a ka fokotsoa ka katleho.

Litla-morao ea photilistat phofo (282526-98-1)

Bakuli ba etsoang kalafo bakeng sa botenya haholo le phofo ea Cetilistat ba ka ba le litla-morao. U tlameha ho tsebisa ngaka ea hau haeba sena se etsahala. Ho na le litla-morao tse ling tsa ho buoa:

Letlalo ka setulo

Karolo ea mpa

Flatus le ho tsoa

Ho sheba mafura ka mafura

Ho se khone ho itšireletsa

Flatulence

Bohloko ba mpa

Letšollo

Litebelisoa tse bonolo

Ho ferekanngoa ke metsi

Ho ikarabella khafetsa

Bohloko bo ka mpeng

Ho senya kapa ho hlatsa

Sehlōhō

Molomo o omileng

Ho tepella

Ho otlolla pelo ho sa tloaelehang

Ho khathala ho sa tloaelehang kapa bofokoli

Le hoja hangata liketso tse bonolo li nkoa e le tse tloaelehileng, liketsahalo tse mpe tse tebileng li ka boela tsa etsahala. Botsa ngaka ea hao hang-hang haeba sena se etsahala.


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Litlhaloso le lihlahisoa tsa lihlahisoa

Ke hobane'ng ha Sibutramine e tumme hakaale ho lahleheloa ke boima ba 'mele?

References

  • Botenya: Epidemiology, Pathophysiology, le Thibelo, Debasis Bagchi, Harry G. Preuss, leqepheng la 205-2012.
  • HCL ea Sibutramine: Boima bo botenya, W. Philip James, Eleanor Bull, Ian Campbell, Communications ea CSF ea Bongaka, 2004, leqepheng la 1-44
  • Textbook of Therapeutics: Tsamaiso ea lithethefatsi le mafu, Richard A. Helms, David J. Quan, khaolo ea 57.

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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