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Mofuta o moholo oa Tianeptine letsoai la sodium (30123-17-2)

Sesepa sa letsoai sa sodium sa sodium ke tricyclic compound, ke motataisi ea khethiloeng oa 5-HT (serotonin; sc-201146) e kenang in vitro ....


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Motsoako oa Raine Tianeptine ea letsoai le phofo (30123-17-2) video

Tlhahiso e matla ea letsoai ea sianeptine ea sodium (30123-17-2) Lintlha

Name Product Mofuta o moholo oa Tianeptine letsoai la sodium
Lebitso la lik'hemik'hale Tianeptine sodium; Letsoai la sodium la tianeptine; 30123-17-2; Stablon; Coaxil;
Brand Name N / A
Sehlopha sa Lithethefatsi N / A
Nomoro ea CAS 30123-17-2
InChIKey HNTRDGDHBBFLPG-UHFFFAOYSA-M
limolek'hule Formula C21H24ClN2NaO4S
limolek'hule Wtse robeli 458.93
Masapo a monoisotopic 458.104 g / mol
Ho qhibiliha Poli 1800C
PhehaIng Poli 609.2 ° C ho 760 mmHg
Likokoana-hloko tsa Half-Life N / A
Color Tšoeu ho ea phofo e tšoeu
Sho khoneha DMSO: ≥20mg / mL
Storage Tmocheso Desiccate at RT
Aho latela Tianeptine letsoai la letsoai la sodium ke letsoai la Tianeptine.

Tianeptine e na le bothata ba ho tepella maikutlo.

Mofuta o motsoako oa Tianeptine oa letsoai la sodium (30123-17-2) Tlhaloso

Letsoai la sodium ea Tianeptine ke letsoai la Tianeptine. Tianeptine, e entsoeng ka tricyclic, ke motataisi ea khethollang 5-HT (serotonin; sc-201146) e kenang ka vitro le ka vivo. Ho phaella moo, Tianeptine e tlalehoa hore e sebetsa ka mokhoa o khethollang li-dopamine 'me e tšoana le amineptine. Tianeptine ha e na phello e hlakileng ea ho hlahisa monoamine. Phuputsong e sebelisang synaptosomes e hloekisitsoeng ho tloha boko ba rat, tianeptine e tlalehoa ho ntlafatsa tlhahiso ea serotonin libakeng tsa boko. Li-synaptosomone tse hloekisitsoeng li ile tsa fumanoa likotong 'me tsa kenngoa ka tritium-e ngotsoeng ka 5-HT le Tianeptine in vitro. Ka nako eo synaptosomes e ile ea hlahlojoa bakeng sa ho ts'oaroa le ho lokolloa ha 5-HT ka k'hamphani ea metsi e hlahisang metsi.

Mofuta o moholo oa Tianeptine letsoai la letsoai ke sesebelisoa se sa tloaelehang se nang le mefuta e fapa-fapaneng, haholo-holo karolong ea glutamatergic. E thibela ho lokolloa ha glutamate le ho tsamaisa mosebetsi oa receptor ea AMPA.Tianeptine e boetse e sebetsa joaloka agonist ea receptor ea μ-opioid (EC50s = 194 le 641 nM bakeng sa li-receptor tsa batho le li-mouse, ka ho latellana). E sebetsa hantle joaloka fluoxetine tsamaisong ea lefu la khatello ea kelello ea morao-rao.

Letsoai la sodium la tianeptine le na le bokhoni ba nootropic mabapi le batho bao kamohelo ea bona e amehang hampe ke mathata a mehopolo 'me e na le bokhoni ba ho ntlafatsa ho tsepamisa mohopolo le ho tsepamisa mohopolo ho batho ba sa tsotelleng.

Tianeptine letsoai la letsoai la sodium (30123-17-2) Mokhoa oa bohato

Liphuputso tsa morao-rao li bontša hore li-tianeptine li sebetsa joaloka agonist e feletseng ka mofuthu oa opioid receptor (MOR). Tianeptine e phephetse khopolo ea monoaminergic ea ho tepella maikutlong, hammoho le mekhoa ea monoamineric e tšehetsoeng ka ho fetisisa eo liketso tse ngata tse tsejoang ka ho feteletseng ha li hlalosetsoe. Ka ho khetheha, lithethefatsi tsena li nahanoa hore li phehella ho fetola ho amoheloa ha glutamate ho phatloha ha synppse ea maiketsetso ea li-CA3 ea hippocampal. Phuputso ea morao tjena e fana ka maikutlo a hore tianeptine e hlahisa liphello tsa eona tse tepelletsang maikutlo ka ho feto-fetoha ha mesebetsi ea li-glutamate (ka mohlala, li-receptors tsa AMPA le li-receptors tsa NMDA) le ho ama ho lokolloa ha neurotrophic factor (BDNF) e fumanoeng ke boko, e leng se amang plastiki ea neural. Liphuputso tsa morao-rao ka ho tšehetsa karolo ea phekolo ea mantlha ho latela mokhoa oa glutaminergic ho amygdala, karolo ea maikutlo ea boko e amanang le likhopotso.

Tianeptine e fokotsa karabo ea hypothalamic-pituitary-adrenal khatello ea maikutlo, 'me e thibela mathata a boitšoaro a amanang le khatello ea kelello. Li-rodents, khatello ea kelello e matla e eketsa litekanyetso tsa extracellular tsa glutamate mokhoeng oa li-amygdala tse nang le phello e thibelitsoeng ke tianeptine. Ho thahasellisang ke hore SSRI fluoxetine e eketse litekanyetso tsa extracellular glutamate ho amygdala e tlase ho sa tsotellehe maemo a khatello. Litlaleho tsena li bontša hore mochine oa liketso tsa tianeptine o fapane le li-SSRI ebile o tšehetsa khopolo ea hore mechine ea liketso tsa tianeptine e amana le phetoho ea mesebetsi ea glutaminergic ho amygdala le hippocampus.

Ntle le mekhoa e ka holimo, tianeptine ke moriana o ikhethang oa ho imeloa kelellong le oa khatello ea kelello e susumelletsang ho fumanoa ke serotonin (5-hydroxytryptamine; 5-HT), le 5-hydroxyindoleacetic acid (5-HIAA) liphateng tsa boko.

Le hoja serotonin ea monoamineric serotonin (5-HT), noradrenaline (NA) le dopamine (DA) e pakoa hore e amahanngoa le bothata ba ho tepella maikutlo, hona joale e hlokometse hore ho haelloa ke monoamine ha ho lekane ho hlalosa mokhoa oa ketso ea ho tepella maikutlo meriana.

melemo e of Tianeptine letsoai la letsoai la sodium (30123-17-2)

  • Letsoai la sodium la tianeptine le ka tšoara lefu le tebileng la ho tepella maikutlo.
  • Letsoai la sodium la Tianeptine le na le litšobotsi tse khahlanong le ho tšoenyeha le ho tepella maikutlo le tsa nootropic.
  • Letsoai la sodium la tianeptine le ntlafatsa maikutlo le ho ntlafatsa maemo a kelello.
  • Letsoai la sodium la tianeptine le ka thibela litlhaselo tsa panic tse hlahang.
  • Letsoai la sodium la tianeptine le tšoara bohloko bo amanang le fibromyalgia.
  • Tianeptine sodium letsoai le sebelisetsoang ho phekola khatello ea maikutlo ho banna ba nang le bothata ba ho akheha.
  • Letsoai la sodium ea Tianeptine le na le katleho e bonolo bakeng sa ADHD.
  • Manyolo a sianeptine ea sesedium e boetse e khothalletsa batho hore ba se ke ba hlola ba e-ba teng.

Recommended Tianeptine letsoai la letsoai la sodium (30123-17-2) Nako

Sodium ea Tianeptine e na le halofo ea nako e khutšoanyane ka nako ea 2.5 hours14, mme e hloka ho khutlisetsoa habeli mantsiboea. Litekete tsa soaneine tsa sodium ke 12.5 mg e nkiloeng ka makhetlo a mararo ka letsatsi, bakeng sa kakaretso ea 37.5mg ka letsatsi.

U se ke ua feta 50mg ea Sodium ea Tianeptine ka letsatsi le le leng. Ho etsa joalo ho ka bula monyako oa ho hlekefetsoa le ho lemalla lithethefatsi.

Litla-morao ea Tianeptine letsoai la letsoai la sodium (30123-17-2)

Tianeptine letsoai la letsoai la sodium le kopana le likarolo tse ngata tsa boko ho kopanyelletsa le li-receptor tsa opiod, tse ka hlahisang phello ea lehlakoreng la thabo. Litla-morao tse ling tse nang le maqhubu a sa tšoaneng li kenyeletsa tse latelang:

Bohlooho-hlooho (ho fihlela ho 18%)

Mosikoane (ho fihlela 10%)

Ho tsieleha / ho tšosa bosiu (ho fihlela ho 20%)

Ho otsela (ho fihlela ho 10%)

Molomo o omileng (ho fihlela ho 20%)

Litla-morao tse ling li kenyeletsa lintho tse kang ho roala, ho nyeheloa ke pelo, ho tšoenyeha kapa sebete se kotsi. Matšoenyeho a mangata a kenyeletsa ho tlohela ka mora ho hlekefetsoa 'me ho hakanngoa hore 0.1 - 0.3% ea basebelisi ba tla ba le bothata bona. Joang ha u ntse u ka bona, litla-morao tsa letsoai la sodium ea Tianeptine li tla itšetleha ka motho ka mong le ka tlhaho ea likokoana-hloko.

Ke habohlokoa ho hlokomela hore:

Bakuli ba baholo ba lokela ho nka tekanyo e menyenyane ea letsoai la sodium la Tianeptine, joaloka ba nang le bothata ba ho hloleha ha lesea. Tekanyo ha e hloke ho fetoha ho bakuli ba nang le tahi kapa bokooa ba hepatic, kapa bakuli ba dialysis .Le hoja ho imeloa kelellong, joaloka tianeptine, ho ekelitse kotsi ea chefo ea sebete.


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