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Sodium ea Monosialotetrahexosylganglioside (GM1) boko ba kolobe (37758-47-7)

GM1 phofo e 'nile ea sebelisoa haholo ho sebetsana le kotsi ea bongo ea kelello ea lefu la bongoana, lefu la Parkinson ...


Boemo: Ka Phatlalatso ea Mesebetsi
E hlophisitsoeng le e rarahaneng e fumaneha
Bokhoni: 1277kg / khoeli

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Sodium ea Monosialotetrahexosylganglioside (GM1) boko ba kolobe (37758-47-7) video

Sodium ea Monosialotetrahexosylganglioside (GM1) boko ba kolobe (37758-47-7) Tlhaloso

Bokopi ba kolobe ea Monosialotetrahexosylganglioside (1-37758-47), lebitso le lekhutšoanyane le ka fetoha GM7, le ntšitsoeng ke boko ba kolobe 'me e le setho sa sehlopha sa gangliosides sa ganglio se nang le masala a sialic a le mong.

GMl e ka kgothaletsa ho hlaphoheloa ha methapo ea pelo ka mor'a ho lematsa tsamaiso ea methapo e kholo ea lisosa tse fapaneng, ho khothalletsa ho fokola ha pelo. Liteko li bontša kotsi ea boko ba 'mele ea GMl, boko bo bohloko ba ho tsosolosa lisele tsa methapo mokokotlong oa mokokotlo bo na le phello e sireletsang le ho ntšetsa pele karolo ea sele.

Karolo ea pele ea liteko tsa tlhokomelo ea meriana ea boipheliso e bontšitse, e ka fokotsa lefu la neurotoxicity (OIN) ea oxaliplatin. Empa ha ea ka ea tiisetsoa ka nyeoe ea phase III. Tlhahlobo ea mohato oa III e hlokeha ho etsa lipatlisiso ka phello le ts'ireletseho ea khanya ea sodium ea monosialotetrahexosylganglioside bakeng sa thibelo ea OIN ha motho a tšoeroe ke lefu la kankere.

Sodium ea Monosialotetrahexosylganglioside (GM1) boko ba kolobe (37758-47-7) Specifilitente

Name Product Sodium ea Monosialotetrahexosylganglioside (GM1) boko ba kolobe
Lebitso la lik'hemik'hale Sodium ea Monosialotetrahexosylganglioside (Porcine boko)

Kapa GM1

Ho latellana /
Brand Name Shenjie
Sehlopha sa Lithethefatsi Sphingolipids
Nomoro ea CAS 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
limolek'hule Formula C73H134N4O31
limolek'hule Wtse robeli 1563.85
Masapo a monoisotopic 1563.85
Ho qhibiliha Poli N / A
Likokoana-hloko tsa Half-Life /
Color Off-white lyophilized phofo
Solubility chloroform / methanol (9: 1): 10 mg / mL, e hlakileng, e se nang mebala
Storage Tmocheso -20 ° C
Aho latela Li-receptors tse khethehileng bakeng sa chefo ea k'holera e bokellang bokong qetellong ea infantile lipidosis.
Lintho tsa teko Ka tlung Mokhoa oa Boitšoaro
Character Pente e tšoeu kapa e mosoeu; ho nkhang hamonate, ha ho na letho; metsi. Sehlahisoa sena se qhibiliha metsing, se qhibilihisoa hanyenyane ka methanol, hoo e ka bang e sa tšolohe ka har'a ethanol ea anhydrous.
Boitsebiso
Mokhoa oa ho fetola mebala 1 Fumana tharollo ea 0.2ml tlas'a boits'oaro ba motsoako, eketsa metsi 2ml, ebe o kenya Hydroquinone Hydrochloric acid solution (hydroquinone 0.2g, eketsa metsi 10ml qhibiliha, eketsa metsi a hydrochloric acid 90ml, eketsa 0.1mol / L Copper sulfate tharollo 0.25ml, ho boloka sehatsetsing) 2ml, metsi a futhumetseng a metsi bakeng sa metsotsoana ea 15, tharollo e le 'mala o moputsoa le o pherese, o se nang joala 5ml ho tlosoa hoa metsi, le joala bo bobebe.
Mokhoa oa ho fetola mebala 2 Nka sehlahisoa sena ka 20mg, kenyelletsa lekhasi la acaltic acid 1ml, metsi a futhumetseng a futhumatsang ka ho feletseng a qhibiliha ka ho feletseng, eketsa marotholi a mararo a chloride test fluid 1, ka metsi a chesang a batang haufi le lerako la pipe butle-butle eketsa sulfuric acid 1ml, e le hore tharollo e be likarolo tse peli , li-interface tse peli tse metsi li lokela ho ba sootho
Letsoai la sodium Mokhoa oa ho tseba ha sodium ea letsoai sehlabelong sena (Chinese Pharmacopoeia khatiso ea 2015 ea 0301).
Li-chromatography ea metsi (LC) Khaleng ea chromatographic e tlalehiloeng tlas'a boikemisetso ba litaba, nako ea ho boloka ntlha ea tlhōrō e kholo ea tharollo ea teko e lokela ho lumellana le nako ea ho boloka ntlha ea tlhōrō e kholo ea tharollo ea taolo.
Litlhahiso-pono-pono tse fosahetseng 'Mapa o kenyang mahlaseli oa khanya ea mochine ona o lokela ho lumellana le' mapa oa sehlahisoa sa taolo (Chinese Pharmacopoeia khatiso ea 2015 ea 0402).
Hlahloba
PH 5.0 ~ 6.5
Ho hlaka le mebala ea tharollo E lokela ho hlakisoa ka mebala; haeba e le koahetsoeng, e ke ke ea e-ba matla ho feta tekanyo e tloaelehileng ea sekhahla sa 1th; Haeba ho hlahisa 'mala ha hoa lokela ho ba tebileng ho feta tharollo ea Yellow No 1th colorimetric.
Boikemisetso bo phahameng ba khatello E felile tharollo e lokela ho ba e hlakileng le e hlakileng ka mor'a hore phahameng mocheso, ha ho lebese leseli, ha ho precipitation
Sensitizing factor (Li-protein tse sa tšoaneng) ≤50000
Kakaretso ea sialic acid Ho ea ka sehlahisoa se ommeng, mashala a nang le acid e lokela ho ba 19.0 ~ 21.0%
Lintho tse amanang Sialic acid ≤0.3%; GD3, GD1a, litšila tse sa tsejoeng ke ≤ 0.5%; litšila le ≤2.0%
Protein ≤1.0%
Boholo ba molek'hule bo boima ba 'mele ≤0.5%
Li-solvents tsa nakoana Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
metsi ≤4.0%
Mahlaseli a tukang ≤5.0%
Sesebelisoa se matla ≤20ppm
Chefo e sa tloaelehang Lumellana le Melao
Lintho tse nang le likokoana-hloko E lokela ho latela tumellanong le melao (tsamaiso e mengata ea tsamaiso)
Pyrogen E lokela ho latela tumellanong le melao (tsamaiso e mengata ea tsamaiso)
Meeli ea microbial Palo eohle ea baktheria ea aerobic e lokela ho ba <100cfu / g, 'me palo eohle ea hlobo le mefuta e lokela ho ba <50cfu / g
E tobileng ≥98.0%

Raw MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) phofo (37758-47-7) Tlhaloso

Sodium Monosialotetrahexosylganglioside (37758-47-7), lebitso le lekhutšoanyane le ka fetoha GM1, le ntšitsoeng ke boko ba kolobe 'me le setho sa sehlopha sa gangliosides sa ganglio se nang le masala a sialic a le mong.

GM1 e ka kgothaletsa ho hlaphoheloa ha methapo ea pelo ka mor'a ho lematsa tsamaiso ea methapo e kholo ea lisosa tse fapaneng, ho khothalletsa ho fokola ha pelo. Lipatlisiso li bontša kotsi ea boko boko bo bong ba GM1, boko bo bohloko ba ho tsosolosa lisele tsa methapo ka mokokotlo oa mokokotlo bo na le tšireletso le ho ntšetsa pele karolo ea sele.

Karolo ea pele ea liteko tsa tlhokomelo ea meriana ea boipheliso e bontšitse, e ka fokotsa lefu la neurotoxicity (OIN) ea oxaliplatin. Empa ha ea ka ea tiisetsoa ka nyeoe ea phase III. Tlhahlobo ea mohato oa III e hlokeha ho etsa lipatlisiso ka phello le ts'ireletseho ea khanya ea sodium ea monosialotetrahexosylganglioside bakeng sa thibelo ea OIN ha motho a tšoeroe ke lefu la kankere.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) phofo (37758-47-7) Mokhoa oa liketso?

GM1 (monosialotetrahexosylganglioside) "sebopeho" sa ganglioside, ke setho sa sehlopha sa gangliosides se nang le setseng e le 'ngoe ea acid. GM1 e na le lintho tsa bohlokoa tsa 'mele le liphello tsa polasetiki ea neuronal le mokhoa oa ho lokisa, le ho lokolloa ha li-nerurotrophins bokong. Ntle le ts'ebetso ea eona lefats'eng la boko, GM1 e sebetsa e le sebaka sa ho tlamella chefo ea k'holera le E. coli mocheso-labile enterotoxin (letšollo la baeti).

melemo e of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) phofo (37758-47-7)

Ganglioside GM1 ke setho sa lelapa la ganglioside se 'nileng sa sebelisoa linaheng tse ngata' me le nkoa e le phekolo e 'ngoe e tšepisang e ka tšeptjoang bakeng sa ho thibela maloetse a mangata a methapo ea pelo, ho kenyelletsa le ho tsoa kotsi ha kelello ea senyesemane. Litholoana tsa phekolo ea GM1 li pakelitsoe ka bobeli le ho batho ba baholo ka mor'a ho senyeha ha kelello ea kelello.

Recommended MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) phofo (37758-47-7) Tekanyo

Meriana e ne e fanoa ka tekanyo ea 20-40 letsatsi le leng le le leng ka ente e kenang ka hare kapa e butle-butle ho latela litaelo tsa ngaka. Karolong e matla ea liphetoho tsa patholose: Meriana e ne e sebelisetsoa tekanyo ea 100 letsatsi le leng le le leng ka ente ea 'mele; Ka mor'a libeke tsa 2-3, hangata li boloka meriana ea 20-40 letsatsi le leng le le leng bakeng sa libeke tse tšeletseng, tekanyo ea pele ea 500-1000 mg e ne e tsamaisoa ke ho phunyeha ha lefu la Parkinson; ho tloha letsatsing la bobeli, lithethefatsi li ne li sebelisoa le tekanyo ea 200 letsatsi le leng le le leng ka ente e entsoeng ka tlaase, e entramuscular kapa e entsoeng ka methapo ea libeke tsa 18 hangata. ha lithethefatsi tsena li ne li tsamaisoa ke ente e ka tlaase kapa e se nang methapo, e lokela ho qhibiliha ebe e hloekisoa ka metsing bakeng sa ente ho fihlela mokokotlo oa 10 mg / ml ha; ha ho senyeha ha moriana, lithethefatsi li ne li sa ratoe 'me li hloekiselitsoe ho 0.9% serodium chloride kapa 5% ente ea tsoekere.

Litla-morao of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) phofo (37758-47-7)

Phello e lehlakoreng ea GM1 phofo ke haholo-holo ho potlakela ho arabela ka mor'a hore e sebelisoe.


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