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Raw YK-11 phofo (431579-34-9)

YK-11 phofo ke ea sehlopha sa li-androgen receptor modulators (SARM) tse khethiloeng. Ha e le hantle, seo YK11 se se khethang ke sefe ......


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1470kg / khoeli

Tlhaloso

Raw YK-11 phofo (431579-34-9) video

Raw YK-11 phofo (431579-34-9) Tlhaloso

YK11, e tsejoang hape e le Myostine, e nkoa e le e 'ngoe ea li-SAR tse matla ka ho fetisisa marakeng. Ke e entsoeng ka steroidal e khetha androgen receptor modulator. Meriana ena e na le mesebetsi ea anabolic in vitro ho C2C12 myoblasts 'me e bontša matla a fetang a dihydrotestosterone (DHT) tabeng ena. YK11 hape ke Myostatin inhibitor. li ka u thusa ho fumana mesifa le ho lahla mafura.

Raw YK-11 phofo (431579-34-9) Slitšobotsi

Name Product Raw YK-11 phofo
Lebitso la lik'hemik'hale YK11, (17a, 20E) -17,20 - [(1-Methoxyethylidene) bis (oxy)] - 3-oxo-19-norpregna- 4,20-diene-21-carboxylic Acid Methyl Ester; YK11 ((17A, 20E) -17,20 - [(1-methoxyethylidene) bis- (oxy)] - 3-oxo-; DNA (Terrabacter strain YK11 16S rRNA gene fragment); GenBank AB070463
Brand Name Ha ho data e fumanehang
Sehlopha sa Lithethefatsi SARM
Nomoro ea CAS 431579-34-9
InChIKey KCQHQCDHFVGNMK-DEIKBOPOSA-N
limolek'hule Formula C25H34O6
limolek'hule Wtse robeli 430.53386
Masapo a monoisotopic 430.236 g / mol
Ho qhibiliha Poli 190-200 ° C
Fho tsosolosa Poli Ha ho data e fumanehang
Likokoana-hloko tsa Half-Life Lihora tsa 6-10, ho itšetlehile ka motho ka mong
Color Tšepe e tšoeu
Sho khoneha Propylene Glycol, DMSO, Ethanol
Storage Tmocheso Mocheso oa kamore
Raw YK-11 phofo Aho latela Selection Androgen Receptor Modulator, Myostatin Inhibitor

Raw Raw YK-11 phofo (431579-34-9) Tlhaloso

Basebedisi ba bangata ba nahana hore YK11 ke senotlolo sa ho bula bokhoni ba 'mele o phethahetseng le ho finyella ka katleho ea mesifa e nang le litla-morao tse seng kae. YK11 e bonahala eka ke e kholo-SARM e itšetlehileng ka litlhaloso, ha e le hantle, lithethefatsi ena ha e na SARM e tloaelehileng. Sehlooho sena se senya saense le litlhaloso ho u fa khopolo e hlakileng ea seo u lokelang ho se lebella ho tsoa lebiseteng lena la SARM-steroid, ka likotsi le litla-morao.

Hape e boletse hore YK11 e na le bokhoni ba ho fokotsa mosebetsi oa myostatin, ho etsa hore e be myostatin inhibitor. YK-11 sarm ke e 'ngoe ea tse matla ka ho fetisisa moo. U ke ke ua bapisa YK le LGD-4033 kapa SARM efe kapa efe ka ho feletseng ka lebaka la hore na e matla hakae.

Leha ho le joalo, le hoja phofshoana e kholo ea YK-11 e le matla ka mokhoa o tsotehang hopola hore ho bile le lithuto tse 'maloa feela tse entsoeng ka sehlopha sena. Ena ke lona lebaka le ka sehloohong la batho ba bangata ba bonahalang ba e-na le SARM e kang Ostamuscle, RAD-140 kapa GW-501516.

YK11 e fumana thahasello ho litho tsa 'mele ka lebaka la bokhoni ba eona ba ho haha ​​mesifa ka potlako le litla-morao tse fokolang, haholo joaloka SARM tse sa tšoaneng. Sebopeho sa YK11 se ikhetha. Molek'hule ea YK e arolelana li-steroid ho feta li-SARM, le hoja hangata li kenngoa ka phoso leboteng le tšoanang le SARM e meng kaofela e seng steroidal.

Thuto e 'ngoe ea lisele e bontša hore YK11 e eketsa mesifa ea mesifa. Bafuputsi ba fumane hore ho eketsa protheine ea follyatin follistatin (a myostatin inhibitor).

YK11 e ka boela ea eketsa bophelo bo botle ba masapo. Phuputsong ea masapo a masapo, YK11 e ile ea eketsa litekanyetso tsa liprotheine tsa ho haha ​​masapo.

Ba bang ba 'mele ba ileng ba leka YK11 ba tlaleha melemo e mengata ea mesifa le tahlehelo ea mafura le liphello tse fokolang. Leha ho le joalo, hona joale ha ho na liphoofolo kapa lithuto tsa batho tsa YK11 le tšireletseho ea eona e sa hlaka.

Raw YK-11 phofo (431579-34-9) Mokhoa oa Ketso

YK11 e na le lik'hemik'hale tse tšoanang le tsa DHT 'me sena se bontšoa ka tsela eo e tlamang li-receptor tsa androgen. 'Mele o hlahisa DHT ka tlhaho ka morero oa ho khothalletsa bophelo bo botle ba prostate, kholo ea moriri, le tsoelo-pele e loketseng ea bokhachane.

Haeba re ne re ka kena sehlopheng sa YK11 re le SARM joale e ne e tla ba eona e matla le e matla ka ho fetisisa 'marakeng. Ke hobane feela e etsa hore li-androgen li amohelehe ka tsela e itseng, e leng se etsang hore mosebetsi oa li-androgenic oa ho thunya marulelong. Ho feta moo, YK11 e tsejoa e le myostatin inhibitor.

Bafuputsi ba ile ba etsa phuputso ea sele ho fumana hore na e sebetsa joang ho haha ​​mesifa. Liphetho li bontša hore e ikemiselitse ho eketsa maemo a follistatin. Follistatin ke e 'ngoe ea protheine e tloaelehileng' meleng oa motho e thusang ho boloka myostatin ho hlahloba. Myostatin ke hormone eo mosebetsi oa eona e leng ho fokotsa mesifa e sa tsitsang.

Ho fihlela joale, feela YK11 phofo e tala e na le matla a ho thibela myostatin.

Bopaki bo bong bo fana ka maikutlo a hore YK11 e ka boela ea khothalletsa kholo ea bone ka ho kena-kenana le monyako o sebetsang joaloka DHT.

melemo e ea Raw YK11 phofo (431579-34-9)

E eketsa boholo ba mesifa

Le hoja YK11 e se SARM ka hohle, e na le bokhoni bo hlollang ba ho susumelletsa mesifa ho hōla. Ho boleloa hore e matla joaloka S23.

Ke hobane ka tlhaho ho eketsa menyetla ea follistatin eo hape e ntlafatsang bokhoni ba 'mele oa hao oa ho hlahisa lisele tsa mesifa. Follistatin e boetse e na le boikarabello ba ho thibela myostatin, ka tsela eo ho u bula ho fihlela monyetla oa ho ba le mesifa e sa felleng. Empa haeba liphello tsa follistatin li thibeloa ka tsela leha e le efe, joale ho thibela myostatin ho ke ke ha etsahala, e leng ho ka etsang hore YK11 e se ke ea atleha.

Hase ho utloahala joaloka tlaleho e robehileng empa ha ho na lithuto tsa batho kapa tsa liphoofolo ho khutlisetsa boitsebiso boemong bona.

Sohle seo re nang le sona ke bopaki ba anecdotal bo thehiloeng ho liphuputso tsa 'mele ka liforomo tsa inthanete. Seo ba re bolellang sona ke hore ba khonne ho fokotseha haholo mafura le li-lbs tsa 15 tsa bohlokoa tsa mesifa e boima ka nako e khutšoanyane.

E Matlafatsa Likere

Li-hormone tsa thobalano ke tsa bohlokoa bakeng sa ho boloka masapo a matla le a phetseng hantle. Bopaki bo fumanehang bo bontša hore YK11 phofo e tala e ka eketsa matla a bone ka ho itlama ho li-receptor tsa androgen, tse tšoanang le tseo SARM tse ngata li li etsang.

YK11 e ka boela ea eketsa boholo ba PKB (protein kinase B) e fumanehang lisele tsa 'mele tse thusang ho hōla ha lisele tsa masapo.

A re se keng ra lebala hore o batla ho ba le mesifa le masapo a matla, a phetseng hantle ho qoba fractures. E ka 'na ea khona ho thusa tabeng ena hape hobane e atleha haholo ho haha ​​mesifa, ho tšehetsa bophelo bo botle ba masapo le ho fokotsa liphello tsa lesapo la masapo.

Motsoako o motsoako oa YK-11 (431579-34-9).

Basebetsi ba sebelisang YK11 phofo e tala ba re ho e noa meleng ea 10 ho 15 mg ka letsatsi e sebetsa hantle bakeng sa bona. Ba bang ba tlalehile liphello tse ntle ho 5 mg ka letsatsi. Boholo ba basebelisi ba e fetisetsa bakeng sa 4 ho libeke tse 8. U tla boela u fumane basebelisi ba nang le li-SAR tse fapaneng hammoho.

Litla-morao ea Raw YK-11 phofo (431579-34-9)

▲ Hona joale, lithuto tsa lisele feela li 'nile tsa khannoa ka YK11.

Ha ho na bopaki ba bongaka kapa esita le lithuto tsa liphoofolo ho khutlisa lipolelo tse ling tse ntseng li etsoa ka moriana.

Sena se lokela ho etsa hore o nahane ka makhetlo a mabeli ka lipatlisiso ka likarolo tsena. Mohlomong u lokela ho hlahloba lik'hemik'hale tse sa tšoaneng tse kang Ostarine le Ligandrol. Ba na le boitsebiso bo bongata le lipatlisiso tse teng.

Ho boleloa hore YK11 e ka ba chefo ho sebete. Ha e bua ka mokhoa oa ho itlhakisa, e ka ama kholo ea moriri, khoele ea mantsoe, bophelo ba senya le likarolo tse ling tsa bohlokoa 'meleng.


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Litlhaloso le lihlahisoa tsa lihlahisoa

Kakaretso ea YK-11 le Phihlelo Tlhahiso e tsoang ho Basebelisi ba Sebele

References

  1. Thevis, M., Piper, T., Dib, J., Lagojda, A., Kühne, D., Packschies, L., ... & Schänzer, W. (2017). Mokhoa oa ho bonahatsa lipono tse hlahisang metsoako ea androgen receptor modulator (SARM) YK-11 bakeng sa merero ea ho laola doping. Rapid Communications In Mass Spectrometry, 31(14), 1175-1183.
  2. Kanno, Y., Ota, R., Someya, K., Kusakabe, T., Kato, K., & Inouye, Y. (2013). Selekhegen e amohelang androgen receptor modulator, YK11, e laola phapang ea myogenic ea C2C12 myoblasts ke polelo ea follistatin. Likokoana-hloko le Meriana Bulletin, 36(9), 1460-1465.
  3. Piper, T., Dib, J., Putz, M., Fusshöller, G., Pop, V., Lagojda, A., ... & Thevis, M. (2018). Liphuputso tse hlahang ka vivi metabolism ea SARM Y1K11: Ho khetholla le ho khetholla metabolites tse ka sebelisoang bakeng sa ho laola doping. Ho hlahloba lithethefatsi le tlhahlobo, 10(11-12), 1646-1656.

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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