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Pfu ea Raw Synephrine HCL (5985-28-4)

Synephrine HCL phofo ke tlhaho li etsahala alkaloid lik'hemik'hale komponeng fumanoa limela le ntšitsoeng bakeng sa ho sebelisoa e le tlatsetsa ho ...... ..


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Tlhaloso

Video ea Raw Synephrine HCL (5985-28-4) video

Mahlaseli a Raw Synephrine HCL (5985-28-4)

Name Product Raw Synephrine HCL
Lebitso la lik'hemik'hale Synephrine hydrochloride; 5985-28-4; 4- (1-Hydroxy-2- (methylamino) ethyl) phenol, hydrochloride;
Brand Name Yocon
Sehlopha sa Lithethefatsi Mafura aa lahleha
Nomoro ea CAS 5985-28-4
InChIKey COTCEGYSNTWJQV-UHFFFAOYSA-N
limolek'hule Formula C9H14ClNO2
limolek'hule Wtse robeli 203.666 g / mol
Masapo a monoisotopic 203.071 g / mol
Ho qhibiliha Poli 147-150 ° C
Boiling Point 341.10 ° C. @ 760.00 mm Hg (ke)
Likokoana-hloko tsa Half-Life Ha ho letsatsi le fumanehang
Color Tšoeu ho ea phofo e tšoeu
Sho khoneha Ha ho letsatsi le fumanehang
Storage Tmocheso Sehatsetsi
Aho latela Ha ho pelaelo hore ke mafura a atlehang ka ho fetisisa a tukang

Raw Synephrine hcl phofo (5985-28-4) Tlhaloso

Raw Synephrine HCL e hlahisitsoeng ke tlhaho ea alkaloid lik'hemik'hale e fumanehang limela le e nkiloe bakeng sa ho sebelisoa e le tlatsetso. Ka linako tse ling Synephrine e bitsoa "lamunu e bohale" kaha e tsoa linthong tse nyenyane tsa li-orang. Ha e le hantle, ke ka tlhaho ho fumanoang ntlheng ea lamunu, ke ka lebaka leo e tsejoang e le e bohloko ea lamunu. Hona joale ho na le lithethefatsi tse bohloko tse sebelisetsoang lipotso tse tšoanang le mathata a mang a kajeno a kang ho lahleheloa ke boima ebile e le thuso ntoeng ea mohanyetsi oa maoto. ke e 'ngoe ea metsoako e kholo ea lamunu le e nahannoang hore ke motheo oa litšobotsi tsa pholiso ea Raw Synephrine HCL, ha ho pelaelo hore mafura a chesang ka ho fetisisa a chesang metsoako.Synephrine e fumanoa li-orang,' me hang ha u e-na le eona, u ka khona rua molemo hohle ka litsela tse sa tšoaneng.

Joaloka sesebelisoa sa phepo ea lijo, synephrine HCL phofo e ka sireletseha ho batho ba baholo ha e sebelisoa hantle. Leha ho le joalo, ho na le liphello tse bohloko tse bonolo har'a basebelisi ba ntseng ba nka synephrine hcl haholo. Synephrine ke ntho e susumetsang, kahoo ke habohlokoa ho qala tekanyo e tlaase ho hlahloba mamello. Ho feteletseng ha synephrine HCL ho ka baka ho eketseha ka potlako khatello ea mali, methapo ea pelo ea pelo, ho tsuba ha letlalo, ho lula fatše, ho hloka botsitso, khatello ea maikutlo, mathata a ho hema, tsoekere ea mali, ho tšoaroa ke hlooho, bohloko ba mpa, ho nyeheloa ke pelo le letšollo, haholo-holo ho kopantsoe le tse ling tse susumetsang.

Synephrine hcl phofo (5985-28-4) Mehato ea Ketso

Matšoao a pelo a li-ligands a amahanngoa le adrenergic receptor e tlamang. Ka kakaretso, ha li-ligands li ikamahanya le li-receptor tsa α-adrenergic, vasoconstriction e hlaha, mme ha e tlamella li-receptor tsa β1-adrenergic, likonteraka tsa pelo le ho eketseha ha lebelo la pelo. Liphuputso li bontša hore poone ea synephrine hcl e tlama ho li-receptor tsa β3-adrenergic, e leng se etsang hore ho eketseha ha matla a 'mele a ho senya mafura. Ho khomarela li-receptor tsa β3-adrenergic ha li susumetse lebelo la pelo kapa khatello ea mali. Hape, hobane synephrine e na le likarolo tse nyane kapa tse se nang letho ho li-α1-, β2-, le β1-adrenergic receptors 'me ha li bonahale eka li na le liphello tse sa hlakang tsa li-adrenergic, liphello tsa pelo, tse kang ho eketseha ha sekhahla sa pelo le khatello ea mali, ha li tse nang le menyetla e tloaelehileng e sebelisoang, ho fapana le tse ling tse ngata tsa phenylethylamine le li-derivative phenylpropanolamine. Liphetoho tse nyenyane tsa mohaho li fella ka phapang e kholo ea recerenor receptor e tlamang 'me hamorao e khona ho hlahisa liphello tsa pelo.

Synephrine Hcl powder e boetse e eketsa 'mele oa lik'habohaedreite ka ho hlahisa matla a mangata ka mokhoa oa ATP.49-52 E thusa ho fetisoa ha cellular ka lisele tsa mesifa, hammoho le glycogenolysis, gluconeogenesis, glycolysis le phetoho ea oksijene. Ho ameha ha motone oa khalsiamo le k'hamphani le li-receptor tsa adrenergic ho bontšitsoe hore li ameha ho mekhoa ena ea lik'hemik'hale, e bontšang ho ameha ha mekhoa e mengata.

Ntle ho moo, tšebeliso ea poone ea Synephrine hcl e tla thibela ho sebelisoa ha NF-kB. Ntho ena ke senotlolo ho bakang mafu a ho ruruha a kang asthma. Tšebeliso ea phofo ea Synephrine e fumanoe e ama liketso tsa hormone ea eotaxin-1 haholo. Sena se thibela phetoho ea eosinophil sebakeng se chesang.

Le hoja e sa bontšoa hantle ka liteko, tšebeliso ea poone ea Synephrine hcl e fumanoe ho thibela ketso ea acetylcholineterase. Khemik'hale ena e tsejoa ho baka lefu la Alzheimer.

melemo e ea Synephrine hcl phofo (5985-28-4)

  • Synephrine hcl bakeng sa tahlehelo ea boima ba 'mele
  • Synephrine hcl thusa ho lahleheloa ke takatso ea lijo
  • Synephrine Hcl e eketsa ts'ebetso e ntle ea tsoekere ea mesifa
  • Synephrine Hcl lithuso tse sa ntlafateng tsa glycogenesis
  • Synephrine hcl thusa ho laola lefu la tsoekere
  • Synephrine hcl ntlafatsa ts'ebetso
  • Synephrine hcl e fokotsa ho tšoha pele ho buuoa
  • Synephrine hcl e ntlafatsa maemo le matla a matla
  • Synephrine hcl thusa ho laola libaktheria tse kotsi
  • Synephrine hcl thusa ho fokotsa ho ruruha

E khothalletsoa Synephrine hcl phofo (5985-28-4) Palo

Nako e tloaelehileng haholo ea Synephrine hcl e ka bang 100mg ka letsatsi. Sena se nkoa e le tekanyo e lekaneng ea ho fokotsa boima ba 'mele. Leha ho le joalo, chelete e khothalletsoang hore esita le basebelisi ba boemo bo sa lokelang ho feta ke 200mg ka letsatsi. Ntho efe kapa efe e ka holim'a letšoao lena e nkoa e le chefo 'me e tla beha motho ka kotsing ea ho ba le litla-morao tsa litla-morao tse bolaeang tse amanang le ts'ebeliso e sebelisang. Ho eletsa, ho qala, 10 ho 20mg ho netefatsa hore poone ea Synephrine hcl e lumellana hantle le 'mele oa hao. Ka mor'a hore u nke tekanyo ena ea pele, u lokela ho nka nako ea ho hlahloba karabo ea 'mele ho tlatsetso. Haeba tsohle li le hantle, tekanyo ea bobeli ea 20mg e ka etsoa ka mor'a lihora tse peli. Ntle ho moo, nako e sireletsehileng ea litekanyetso e nka Synephrine Hcl powder hang ka lihora tse peli.

Litla-morao ea Synephrine hcl phofo (5985-28-4)

Tšebeliso ea Synephrine e boetse e tsamaea le litla-morao feela joaloka lithethefatsi leha e le life tse ling. Ha e mong le e mong a se a sebelisa synephrine hcl hammoho le cafeineine. hape e na le litla-morao tse ling. Tse latelang ke tse ling tsa litla-morao tse tloaelehileng:

  • Khatello ea mali e phahameng.
  • Boloetse ba pelo.
  • Ho otloa ha pelo ho sa tloaelehang.
  • Ho bolaoa ha ho sebelisoa litekanyetso tse phahameng pele ho buuoa.
  • Hallucinations / psychosis
  • Likhalase tsa Coronary le thrombosis
  • Litšitiso tsa molumo oa pelo (fibrillation ea ventricular)
  • Ho fokotseha ha boholo ba mesifa (rhabdomyolysis)
  • Ho hloleha ha liphio
  • Tšelo ea mali
  • Tšenyo ea methapo ka lebaka la khatello e eketsehileng ea mesifa (malapa a mabeli a likarolo tse ling)
  • Mahlaba a sefuba (angina e fapaneng)
  • leqeba


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Litlhaloso le lihlahisoa tsa lihlahisoa

Synephrine HCL e Sebetsa Joang Molaleng oa Hao?

References

  1. Akhlaghi, M., Shabanian, G., Rafieian-Kopaei, M., Parvin, N., Saadat, M, le Akhlaghi, M. Citrus ba hlahisa lithunthung le ho tšoenyeha pele. Rev Bras.Anestesiol. 2011; 61 (6): 702-712.
  2. Bent, S., Padula, A., le Neuhaus, J. Ts'ireletseho le katleho ea citrus aurantium bakeng sa tahlehelo ea boima ba 'mele. Am.J.Cardiol. 11-15-2004; 94 (10): 1359-1361
  3. Campbell-Tofte, JI, Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, SH, Cornett, C., Mu, H., Richter, EA, Petersen, H, Norregaard, JC, le Winther, Tlhahlobo ea lipilisi ea lifofane tsa K. Randomized le tse peli tse foufalitsoeng ka tekanyo ea tšireletso le ea lefu la tsoekere ea tee ea Rauvolfia-Citrus, e sebelisoang meriana ea setso ea Nigeria. J Ethnopharmacol. 1-27-2011; 133 (2): 402-411.
  4. R. Costa, MBA Glória, ka Encyclopedia of Food Sciences le Nutrition (Khatiso ea Bobeli), 2003
  5. Ghanim H, Sai CL, Upadhyay M. et al a. Jusi ea Orange ha e amohele liphello tse hlahisoang ke oli e ngata haholo, e nang le lik'habohaedreite le ho thibela ho eketseha ha endotoxin le polelo ea ho amohela li-receptor. Mokelikeli oa Amer J Clin. 2010; 91: 940-949
  6. SJ. Tlhahlobo ea litlaleho tse bohloko tsa ketsahalo tse amanang le Citrus aurantium(e bolila ba lamunu) ho tloha ka April 2004 ho fihlela ho October 2009.
  7. Dragull K, Breksa AP, Kaine B. Synephrine dikahare tsa lero ho tswa ho Satsuma mandarins (Citrus unshiuMarcovitch). J Agric.Food Chem. 2008; 56: 8874-8878
  8. Roman MC, Betz JM, Hildreth J. Ho iketsetsa ha synephrine ka lintho tse bohloko tse bolila tsa lamunu, lihlahisoa tse ling, le lisebelisoa tsa lijo tse nang le lik'hemik'hale tse nang le lisele tse nang le mahlaseli a kotsi: laboratori e le 'ngoe ea laboratory. J Amer Chem Chemistry Int. 2007; 90: 68-81
  9. Mercolini L, Mandrioli R, Trere T. et al a. Fast CE tlhahlobo ea adrenergic amine likarolong tse fapaneng tsa Citrus aurantiumlitholoana le lijo tse ling tsa lijo. J Sep Sci. 2010; 32: 1-8
  10. Haaz S, Fontaine KR, Cutter G, Limdi N. et al a. Citrus aurantiumle synephrine alkaloids ho phekola ho feta tekanyo e feteletseng le botenya: tlhahiso-pele. Obesity Rev. 2006; 7: 79-88
  11. Higgins, JP, Tuttle, TD, le Higgins, CL Matla a linotsi: dikahare le polokeho. Mayo Clin Proc. 2010; 85 (11): 1033-1041.
  12. Kaats, GR, Miller, H., Preuss, HG, le Stohs, SJ A 60day thuto e sirelelitsoeng ka bobeli e nang le bokooa bo bongata bo nang le bokooa bo akarelletsang Citrus aurantium (e bolila ba lamunu). Li-Chem Toxicol ea Lijo. 2013; 55: 358-362.
  13. Lynch B. Tlhahlobo ea polokeho ea p-synephrine le caffeine. Tlaleho ea Intertek-Cantox, 2013; 1-20.
  14. Tlhahlobo ea bophelo ea lipapali le ho lahleheloa ke lisebelisoa tse nang le synephrine le caffeine BfROpinion No. 004 / 2013, ea 16 November 2012

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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