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Mofuta o moholo oa Tianeptine (66981-73-5)

Peso ea tianeptine ke nootropic le serotonin e khethollang serotonin e ntseng e tsoela pele ho ntlafatsa (SSRE). Hangata e ......


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Palesa e mafura ea Tianeptine (66981-73-5) video

Mofuta o moholo oa Tianeptine (66981-73-5)

Mofuta o motenya oa Tianeptine ke moemeli ea nang le bothata ba ho imeloa kelellong o nang le phihlelo ea morao-rao ea mali. Raw Tianeptine phofo ha e bonahale eka e amahanngoa le ho ba le tsebo e sa utloiseng, ea maikutlo, ea ho robala, ea pelo kapa ea 'mele ea' mele 'me e na le tšusumetso e tlaase ea tlhekefetso. Mafura a Raine Tianeptine a na le phihlelo e ntle ea pharmacokinetic. Ha e sebetsane le metabolism e tsitsitseng ea pele, e na le bothata bo phahameng ba ho ba le bioava le ho aroloa ho fokolang, 'me e felisoa ka potlako. Le hoja sena se fana ka melemo bakeng sa phofo e mafura ea Tianeptine ka li-tricyclic tse hlekefetsang maikutlo ka lebaka la ho ba le maqiti a maholo, liphetoho tsa kalafo le mekhoa e ka sebelisanang le lithethefatsi, ho felisoa ha eona ka potlako ho etsa hore litlhophiso tsa meriana e be tsa bohlokoa haholo. Mafura a mafura a Tianeptine a fapana le a mangata a ho imeloa kelellong kahobane ha a khone ho ts'oaroa ke mokhoa oa hepatic cytochrome P450, o bonts'a monyetla o monyenyane oa ho sebelisana ha lithethefatsi; sena ke sa bohlokoa haholo ho bakuli ba hōlileng.

Mofuta o moholo oa Tianeptine (66981-73-5) Lintlha

Name Product Phofo e mafura ea Tianeptine
Lebitso la lik'hemik'hale Phofo e mafura ea Tianeptine; 66981-73-5; 72797-41-2; Metsoako a mafura a Tianeptine; Phofo e mafura ea Tianeptine
Brand Name Yocon
Sehlopha sa Lithethefatsi liketsahalo tse nyahamisang
Nomoro ea CAS 66981-73-5
InChIKey JICJBGPOMZQUBB-UHFFFAOYSA-N
limolek'hule Formula C21H25ClN2O4S
limolek'hule Wtse robeli 436.951 g / mol
Masapo a monoisotopic 436.122 g / mol
Ho qhibiliha Poli 148
Boiling Point 609.2
Likokoana-hloko tsa Half-Life Ha ho letsatsi le fumanehang
Color Tšoeu ho ea phofo e tšoeu
Sho khoneha Ha ho letsatsi le fumanehang
Storage Tmocheso Sehatsetsi
Aho latela Ke lithethefatsi tse sebelisetsoang ho sebetsana le matšoao a maholo a nyahamisang (bonolo, a itekanetseng, kapa a matla).

Mofuta o moholo oa Tianeptine (66981-73-5) Tlhaloso

Peso ea Tianeptine ke sethethefatsi se sebelisetsoang haholo ho ntlafatsa matšoao a lefu le tebileng la ho tepella maikutlo (MDD). E boetse e sebelisitsoe ho thusa lefu le bohloko la 'mele le asthma. Ka mokhoa o hlophisitsoeng, o hlalosoa e le tricyclic e loantšang maikutlo (TCA), leha ho le joalo, e na le mefuta e fapaneng ea thepa ea meriana ho feta e tloaelehileng ea tricyclic ea ho tepella maikutlo. Tianeptine e ile ea sibolloa 'me ea e-na le patentishene ke sechaba sa Mafora sa Lipatlisiso tsa Bongaka ho 1960s. Mabitso a marang-rang a kenyeletsa Stablon, Coaxil. Tatinol, Tianeurax, le Salymbra.

Phofo ea tianeptine ha e bonahale eka e amahanngoa le bothata bo botle ba kelello, boikutlo ba kelello, boroko, maikutlo a pelo kapa 'mele o bobebe' me bo na le matla a tlaase a ho hlekefetsoa. Mafura a Raine Tianeptine a na le phihlelo e ntle ea pharmacokinetic. Ha e sebetsane le metabolism e tsitsitseng ea pele, e na le bothata bo phahameng ba ho ba le bioava le ho aroloa ho fokolang, 'me e felisoa ka potlako. Le hoja sena se fana ka melemo bakeng sa phofo e mafura ea Tianeptine ka li-tricyclic tse hlekefetsang maikutlo ka lebaka la ho ba le maqiti a maholo, liphetoho tsa kalafo le mekhoa e ka sebelisoang ke lithethefatsi, ho felisoa ha eona ka potlako ho etsa hore litemana tsa litekanyetso e be tsa bohlokoa haholo. Mafura a mafura a Tianeptine a fapana le a mangata a ho imeloa kelellong kahobane ha a khone ho ts'oaroa ke mokhoa oa hepatic cytochrome P450, o bonts'a monyetla o monyenyane oa ho sebelisana ha lithethefatsi; sena ke sa bohlokoa haholo ho bakuli ba hōlileng.

Haufinyane, Tianeptine e fumaneha linaheng tsa Europe, Asia le Amerika Boroa. E thibetsoe United Kingdom 'me ha e phekoloe ke lingaka United States.

Peso ea Tianeptine (66981-73-5) Mokhoa oa Ketso

Liphuputso tsa morao-rao li bontša hore li-tianeptine li sebetsa joaloka agonist e feletseng ka mofuthu oa opioid receptor (MOR). Hona joale li-receptor tse fumanehang li-opioid li ntse li ithutoa e le sepheo se sebetsang sa phekolo ea meriana ea ho imeloa kelellong. Ho lumeloa hore liphello tsa kliniki tsa tianeptine li na le molato oa ho feto-fetoha ha li-receptor tsena. Ho phaella liketsong tsa eona ho receptor ea opioid, lithuto tsa pele li entse hore ketso ea eona e be le phello ho li-receipton serotonin receptor dopamine (D2 / 3) le li-receptor tsa glutamate.

Peso ea Tianeptine ke meriana e ikhethang ea ho imeloa kelellong le ea khatello ea kelello e susumetsang ho fumanoa ke serotonin (5-hydroxytryptamine; 5-HT), le 5-hydroxyindoleacetic acid (5-HIAA) liphateng tsa boko.

Le hoja serotonin ea monoamineric serotonin (5-HT), noradrenaline (NA) le dopamine (DA) e pakoa hore e amahanngoa le bothata ba ho tepella maikutlo, hona joale e hlokometse hore ho haelloa ke monoamine ha ho lekane ho hlalosa mokhoa oa ketso ea ho tepella maikutlo meriana.

Tšebeliso ea phofo ea Tianeptine (66981-73-5)

▪ Tianeptine e ntlafatsa matšoao a lefu le tebileng la ho tepella maikutlo (MDD)

▪ Tianeptine e thusa ho tšoaroa ke lefu la masapo le lefu la "astmma"

▪ Tianeptine e ntlafatsa maikutlo le ho kokobetsa matšoenyeho.

▪ Tianeptine e eketsa hore na serotonin e bokella bokae

▪ Tianeptine e ntlafatsa tšusumetso, ho tsepamisa mohopolo le kutloisiso, ho thibela matšoenyeho, ho tsosolosa le ho fokotsa mokhathala oa kutloisiso.

Tlhahiso ea Tianeptine e khothalletsoang (66981-73-5) Nako

Hangata phofo ea tianeptine e behiloe ka tekanyo ea 12.5 mg mme e nkoa ka makhetlo a mararo ka letsatsi. Ho fapana le li-TCA tse ling le serotonin reuptake inhibitors (SSRIs), lithielo tsa tianeptine ha li hlokahale hore li eketsehe hanyane ka hanyane mme taper ha meriana e khaolloa e sa hlokeha.

Litla-morao tsa phofo ea Tianeptine (66981-73-5)

Litla-morao tsa phofo ea tianeptine li makatsa haholo. Ha li bapisoa le li-TCA tse ling esita le sehlopha sa SSRI sa ho itšireletsa maikutlo, phofo ea tianeptine e batla e se na litla-morao. Ho sa tsotellehe boemo ba eona bo bonolo bo bobebe, ke habohlokoa hore u se ke ua kopanya tianeptine le monoamine oxidase inhibitors kapa tse ling tse nang le bothata ba ho imeloa kelellong kaha likamano li ka beha bophelo kotsing. Tianeptine ha ea lokela hape e tsoakane le anesthetics 'me tšebeliso ea eona e lokela ho khaotsa 24-48 pele ho kenngoa phekolo e hlokang ho anesthetics kapa hypnotics. Tse ling tsa litla-morao tse tloaelehileng tse amanang le tianeptine ke tsena.

Ho tlosoa ha 'mele

Letšollo

Boitšoaro

Ho otla

Molomo o omileng

Mokhathala

lefu la ho hlobaela

Liphetoho tsa takatso ea lijo

Sehlōhō

Ho tepella maikutlo ka ho hema

Ho robala

Pono e fosahetseng

Ho fokotsa likamano tsa thobalano

Hlooho ea hlooho

Ho hlatsoa


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Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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