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Anandamide (AEA) (94421-68-8)

Anandamide, eo hape a tsejoang e le N-arachidonoylethanolamine (AEA), ke mafura a 'mala oa methapo e tsoang ho …… ..


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Tlhaloso

Anandamide (AEA) (94421-68-8) Slitšobotsi

Name Product Anandamide (AEA)
Lebitso la lik'hemik'hale Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

Nomoro ea CAS 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Smile CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Molecular Formula C22H37NO2
Boima ba 'mele 347.53
Masapo a monoisotopic 347.282429 g / mol
Melting Point N / A
Boiling Point 522.3 ± 50.0 ° C (E boletsoe esale pele)
segokanyipalo 0.92 g / mL ho 25 ° C (mat.)
Color mosehla o bobebe
Stempage temp -20 ° C
Solubility ethanol: qhibilihang
kopo E sebelisoa bakeng sa mohopolo, tšusumetso, ts'ebetso ea kelello, taolo ea ho sisinyeha, taolo ea bohloko, takatso ea takatso le boiqapelo.

Anandamide (AEA) ke eng?

Anandamide, e tsejoang hape e le N-arachidonoylethanolamine (AEA), ke mafura a 'mele a nang le acid e nang le metabolic e tsoang holimo ea acid e nang le acid e nang le sebopeho se tšoanang le tetrahydrocannabinol, karolo e sebetsang ea cannabis. e silafalitsoe ka ho khetheha ke enzyme ea mafura acid amide hydrolase (FAAH), e fetolang anandamide ho ethanolamine le arachidonic acid, Qetellong, Anandamide e kopantsoe le neuron ka karohano ea methapo e etsahala pakeng tsa arachidonic acid le ethanolamine tlasa taolo ea calcium ion le cyclic monophosphate adenosidase. Ke selelekela sa sehlopha sa lintho tse sebetsang tsa 'mele (Prostamides) se etsang karolo ea mesebetsi e mengata ea' mele, ho kenyelletsa takatso ea lijo, ho hopola, bohloko, khatello ea maikutlo le boimana. Ntle le moo, Anandamide e boetse e thibela batho Ho eketseha ha lisele tsa mofetše oa matsoele.

Anandamide e teng libopuoa tse ngata, joalo ka urchin roe, likokoana-hloko tsa likolobe le li-mice livers, joalo-joalo, empa palo ea eona e nyane. Hape, bafuputsi ba boetse ba fumane Anandamide le lintho tse peli (N-oleoylethanolamine le N-Linoleylethanolamine) ka chokolete e lefifi. Anandamide e bile e fumaneha mehlolong e meng e sebetsitsoeng, (bohobe bo tšoeu), joala (ka ho khetheha, tšebeliso e sa foleng kapa ho itlopa joala), tsoekere e ntlafalitsoeng, mafura a Trans, Lijo tse halikiloeng ka oli ea meroho le lijo tse se nang mmele tse nang le chefo e bolaeang likokonyana.

E le karolo ea tsamaiso ea endocannabinoid (ECS), Anandamide e khethiloe e le molaoli oa homeostasis hammoho le sehlopha se seng sa "cannabis" se tšoanang le lik'hemik'hale tsa "cannabis" tse tšoanang le mmele. Sisteme ena e teng ho li-vertebrates tsohle. Anandamide e bapala karolo ea ho laola boitšoaro ba ho fepa le takatso ea neurogenic le thabo, ho boloka 'mele le likelello tsa rona li le tekong. Boithuto bo fumane hore maikutlo a rona, thabo, tšabo, matšoenyeho le bokhoni ba ho mamella khatello ea maikutlo kaofela li laoloa ke tsamaiso ea endocannabinoid, le mafu a fapa-fapaneng ho tloha ho schizophrenia ho isa khatello ea maikutlo a tsamaeang le maemo a sa tloaelehang a anandamide.

Anandamide, e ts'oanang le THC, ke agonist ea nakoana ea CB1R. E kanna ea baka ntlafatso e ka hlahisoang ke "ts'ebetso" e felletseng ea ts'ebetso ea boko. Ho bohlokoa ho hlokomela hore litlamorao tsena tsohle tsa Anandamide li bonahala li ntlafatsoa ke bo-rasaense ba thibelang ts'ilafalo ea metabolism ea eona. Ho sibolloa ha Anandamide ho ka lebisa nts'etsopele ea lelapa le lecha ka ho felletseng la meriana e phekolang.

Melemo ea Anandamide (AEA)

Anandamide, eo hape a tsejoang e le "bliss molecule", ke mohloli o ntlafatsang maikutlo, neurotransmitter le endocannabinoid, e nang le melemo e mengata ea bophelo bo botle le kelello:

Anandamide e fokotsa sebopeho sa lisele tsa mofetše kapele. Ka 1998, sehlopha sa bo-rasaense ba Italy se ile sa sibolla hore anandamide e ka khothaletsa neurogeneis le ho etsa lisele tse ncha tsa methapo, ka potlako ea theha / eketsa boleng ba lisele tsa mofetše oa matsoele.

Bokhoni ba Anandamide ba ho khothaletsa neurogeneis (sebopeho sa li-neuron tse ncha) li bapala karolo ea taolo ea boitšoaro ba ho fepa le ho hlahisa tšusumetso le thabo ho litoeba. Sena se thusa ho kokobetsa matšoao a khatello ea maikutlo le matšoenyeho. Phuputso e entsoeng ka 2015 ea batho le litoeba e fumane hore maemo a phahameng a anandamide a ka khothaletsa ntlafatso ea maikutlo le phokotso ea tšabo.

Ntle le moo, bokhoni ba anandamide ba ho ikamahanya le li-receptor tsa CB1 le CB2 le tsona li tla ama mekhoa e mengata ea 'mele, ho bontša melemo e meng ka mohopolo, ts'usumetso, ts'ebetso ea kelello, taolo ea motsamao, taolo ea bohloko, takatso ea takatso le thollo.

Mokhoa oa ho eketsa anandamide(AEA) maemo 'meleng oa motho?

Hobane anandamide e na le karolo ea ho sebetsa joaloka neurotransmitter, moemeli oa li-vasodilator le serum metabolite ea motho, le melemo ea bophelo bo botle le kelello bo bontšitsoeng, o kanna oa batla ho eketsa boemo ba anandamide 'meleng oa hau. Mona ke mekhoa e meng ea ho eketsa nakoana ea li-ananamide 'meleng oa motho:

- BoikoetlisoIng

Phuputso e fumane hore kamora metsotso e 30 feela ea ho matha, litaba tsa anandamide (AEA) tsa batho le lintja li eketsehile. Kahoo haeba u batla ho fumana molemo ka ho fetisisa, etsa boikoetliso bo matla ba moea hangata.

- Ho ja chokolete e lefifi

Chokolete e lefifi e na le karolo e phahameng ea theobromine ka chokolete e phetseng hantle, 'me theobromine e thusa ho eketsa tlhahiso ea anandamide bokong mme ka nakoana e liehise ho phatloha ha eona.

- Ho ja li-truffle tse ntšo

Furu e ntšo (fungus e ntšo) ka tlhaho e na le anandamide. Le ha fungus e sa khone ho sebelisa anandamide ka tsela efe kapa efe, bafuputsi ba lumela hore e sebelisetsoa ho hohela liphoofolo hore li e je le ho ikatisa hape.

- Ho tsepamisa maikutlo

Patlisiso e bonts'a hore ha motho a le naheng (e bitsoang "e phallang" kapa "sebakeng,") ea khatello e phahameng ea ts'ebetso, ts'ebetso, le ho tsepamisa maikutlo, ha se feela hore o tla ba le tlhahiso e ngata kapa ho theha mesebetsi e metle bokong ba hau hape e fana ka tlhahiso. palo e kholo ea lik'hemik'hale, tse kang serotonin, dopamine, endorphin le anandamide.

Ho feta moo, tee, coriander le celery le tsona li ka thusa ho eketsa tlhahiso ea anandamide.

Tlhaloso:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Mots'eanong 2001). "Anandamide le lijo: Ho kenyelletsoa ha lijo tsa arachidonate le docosahexaenoate ho lebisa mananeong a kelello a li-N-acylethanolamines tse lumellanang" li-piglets ". Likhatiso tsa Mokhatlo oa Sechaba oa Saense. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (Mmesa 2010). "Kamano pakeng tsa maemo a plasma ea endocannabinoid, anandamide, li-steroid tsa thobalano le gonadotrophins nakong ea khoeli". Mongobo. Steril. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; Okorokov, Andrei L .; Hill, Matthew N .; Bras, Jose T .; Lee, Monna-Cheung; Li, Shengnan; Gossage, Samuel J .; van Drimmelen, Marie; Morena, Maria (Hlakubele 2019). "Microdeletion ho pseudogene e khethiloeng ho mokuli ea nang le ho tsepamisa maikutlo ho tebileng le ho se utloe bohloko". Koranta ea Brithani ea Anesthesia. 123: e249- doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Mphalane 2007). "Endocannabinoid hedonic hotspot bakeng sa menyaka ea boithabiso: anandamide ka har'a nucleus e bokellanang likhetla li ntlafatsa" ho rata "moputso o monate". Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Tsela e sa sebetsoang e isang ho bokong ba tlhaho ba" cannabinoid ligands "," ancamides ". Ho Pertwee RG (ed.). Li-receptors tsa cannabinoid. Boston: Tlhahlobo ea litaba. maq. 233- ISBN 978-0-12-551460-6.
  • Mallet PE, Beninger RJ (1996). "" Endo native cannabinoid receptor agonist anandamide e senya memori ho likhoto ". Behavioural Pharmacology. 7 (3): 276- doi: 10.1097 / 00008877-199605000-00008.

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


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