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Phofshoana e matla ea Lorcaserin HCL (846589-98-8)

Raw Lorcaserin hydrochloride powder ke serotonin 2C (5-HT2C) e amohelang likokoana-hloko le meriana e sebelisoang ka molomo e khothalletsang ....


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 25kg / Drum
Bokhoni: 1380kg / khoeli

Tlhaloso

Molumo oa phofo ea Lorcaserin HCL (846589-98-8) video

Ho hlahisa phofo ea Lorcaserin HCL (846589-98-8) Lintlha

Name Product Raw Lorcaserin Hydrochloride powder
Lebitso la lik'hemik'hale Phofshoana e khōlō ea Lorcaserin HCL, Lorcaserin
Brand Name BELVIQ
Sehlopha sa Lithethefatsi 5-HT2C receptor inhibitor
Nomoro ea CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
limolek'hule Formula C11H15Cl2N
limolek'hule Wtse robeli 232.15
Masapo a monoisotopic 231.058154899
Ho qhibiliha Poli Ha ho dintlha tse fumanehang
Fho tsosolosa Poli Ha ho dintlha tse fumanehang
Likokoana-hloko tsa Half-Life Bophelo ba halofo ea lorcaserin e ka ba lihora tse ka bang 11.Ka phofo ea mokokotlo e felisoa haholo-holo mokokotlong (92%) le lijong tse ling (2.2%)
Color Pula e tšoeu
Solubility Metsoako a metsi: 0.0709 mg / mL
Storage Tmocheso -20 ° C.
Aho latela Serotonin 2C (HT2C) e amohelang batho ba amohelang boima ba 'mele.

Raw Lorcaserin Hcl phofo (846589-98-8) Tlhaloso

Raw Lorcaserin hydrochloride powder ke hydrochloride e fumanoeng ka phofo ea lorcaserin e nang le e lekanang le ea hydrochloric acid. E sebelisoa e le lithethefatsi tse khahlanong le botenya. Lorcaserin Hydrochloride ke 5HT2c receptor agonist e bontšitsoeng bakeng sa ho sebelisoa ho batho ba baholo ba nang le BMI ≥30, kapa ba nang le BMI ≥27 le bonyane boemo bo amanang le boima bo kang khatello ea meriana, mofuta oa lefu la 2 kapa dyslipidemia.Lorcaserin Hydrochloride powder e sebetsa ka ho thibela takatso ea lijo le e etsa hore motho a ikutloe a sa thaba, 'me ho nahanoa hore o lokela ho qoba boemo ba lefu la pelo ea valvular e amanang le ts'ebetso ea li-receptor tsa 5-HT2B, sebaka sa boko bo tsebahalang hore se phetha karolo ea bohlokoa ho laola tlala le ho ja lijo. Ka ho kenya li-receptor tsena, phofo ea Lorcaserin hydrochloride e ka fokotsa ho sebelisoa ha lijo ka ho fokotsa takatso ea lijo le ho etsa hore motho a ikutloe a khotsofetse esita le ka mor'a ho ja lijo tse seng kae ho feta tloaelo. e amoheletsoe kajeno ke FDA ka qeto e ikhethang ka mor'a lilemo tse 2 tsa ho hlahlojoa.

Lorcaserin hydrochloride powder e hlalosoa ka ho khetheha e le mokhoa o fokolang oa ho ja lijo tse nang le lik'hilojule le ho eketseha ka tsela ea 'mele bakeng sa ho laola boima ba' mele ho batho ba baholo haholo (BMI ea 30 kg / m2 kapa e kholo) le batho ba baholo ba fetang boima ba 'mele (BMI ea 27 kg / m2 kapa e kholo) bonyane boemo bo bong bo amanang le boima bo amanang le boima.

Lorcaserin hydrochloride powder e sebelisoa hammoho le ho ja le ho ikoetlisa ho phekola botenya. Ka linako tse ling ho sebelisoa ho phekola botenya bo ka 'nang ba amana le lefu la tsoekere, k'holeseterole e phahameng kapa khatello ea mali e phahameng.

Lorcaserin hydrochloride e ke ke ea sebetsana le boemo leha e le bofe ba bophelo bo botle (joalo ka lefu la pelo, lefu la tsoekere, khatello e phahameng ea mali). Tsoela pele ho noa meriana efe kapa efe eo ngaka eo ue laetseng hore e phekole maemo ana.

Lorcaserin Hcl phofo (846589-98-8) Mokhoa oa Ketso

Le hoja mokhoa o sa tsejoeng o sa tsejoe, ho lumeloa hore ho na le li-receptor tsa 5-HT2C tse khethollang li-anorexigic pro-opiomelanocortin neurons mokokotlong oa arpothalamus. Sena se fella ka ho fokotseha ho ja lijo le ho fokotsa lijo ka ho khothalletsa ho lokolloa ha alpha-melanocortin e susumetsang hormone, e sebetsang ka melanocortin-4 receptors.

Lorcaserin hydrochloride powder e sebetsa ka ho laola takatso ea lijo-haholo-holo ka ho etsa hore boko bo amohelehe bakeng sa serotonin, e leng neurotransmitter e etsang hore motho a ikutloe a sa khotsofala. Ho kenngoa ha lijo ho laoloa ke setsi sa satiety, se nucleus of hypothalamus le tlala centre hona joale ka lateral hypothalamus. Lithuto tse sa tšoaneng tse tsoang litsing tse phahameng le lipampitšana tsa meno li fetoha mokokotlo, moo ho nang le mefuta e 'meli ea li-neurone tse laolang lijo. Ntlha ea pele, sehlopha sa tlhahiso ea lijo se hlahisang liprotheine tse amanang le agouti le neuropeptide Y; 'me ea bobeli, sehlopha sa ho ja lijo tse nang le cocaine le amphetamine (CART) le pro-opiomelanocortin (POMC) neurons. POMC e na le li-receptor tsa 5-HT 2C, tseo ha li hlahisa li-hormone (stimulating hormone) (alfa-MSH). Motsoako oa paraventricular o na le li-receptor melanocyte 4 (MC4R) tse thibelang takatso ea lijo meriking ea phekolo ea lorcaserin hydrochloride powder e sebetsa e le 5-HT 2C agonist e khethollang POMC neurons, e leng eona e bakang alfa MSH. Ho feta alfa MSH e sebetsana le MC4R mokokotlong o ka sehloohong oa hypothalamus, e leng ho etsang hore ho fokotsehe takatso ea lijo. Maemong a supratherapeutic, lorcaserin hydrochlorider e boetse e sebetsa ka 5-HT 2B le 5-HT 2A receptors.

melemo e ea Lorcaserin Hcl powder (846589-98-8)

  • Phofo ea Lorcaserin HCL ke khetho ea 5-HT2C e amohelang batho ba nang le bokooa e nkoang e fokotsa lijo tse kenang ka har'a mokhoa oa POMC. Litlhoko tsa phofo tsa Lorcaserin HCL:
  • Lorcaserin HCL phofo e sebelisitsoe hammoho le ho ja le ho ikoetlisa ho phekola botenya.
  • Ka linako tse ling phofo ea Lorcaserin HCL e sebelisoa ho phekola botenya bo ka amanang le lefu la tsoekere, k'holeseterole e phahameng kapa khatello ea mali e phahameng.
  • Lorcaserin HCL phofo e ke ke ea tšoara boemo leha e le bofe ba bophelo bo botle (tse kang lefu la pelo, lefu la tsoekere, khatello e phahameng ea mali).

Khothalletso ea Lorcaserin Hcl (846589-98-8) Palo

Lorcaserin HCL phofo e kena ka setolanka 'me e nkoa hangata ka 1-2 linako tse ling ka letsatsi, ka ntle kapa ntle le lijo. Lorcaserin e tlameha ho sebelisoa hammoho le lijo tse fokotsehileng tsa khalori le moralo oa ho ikoetlisa.

Palo e khothalletsoang ea lorcaserin hcl powder ke 10 mg e tsamaisoang ka molomo habeli ka letsatsi. Lorcaserin e ka nkoa ntle ho lijo. Lorcaserin hcl e lokela ho khaotsa ho bakuli ba hlōlehang ho finyella bonyane 5% ho lahleheloa ke boima ka beke 12 ha bakuli bana ba sa khone ho ba le tahlehelo ea boima ba 'mele le phekolo e tsoelang pele.

Litla-morao ea Lorcaserin Hcl powder (846589-98-8)

Phororo ea Lorcaserin Hcl e sebelisetsoa ho phekoloa ho laola boima ba 'mele ho batho ba baholo ba nang le boima ba' mele (BMI) ea 30 kapa e kholoanyane (e bobebe) e le ho ekelletsa ho lijo tse fokotsehileng tsa khalori le ho ikoetlisa. E boetse e lumelloa ho sebelisoa ke batho ba baholo ba nang le BMI ea 27 kapa e kholoanyane (ho feta boima ba 'mele) le bao bonyane ba amanang le boima ba mali bo kang khatello e phahameng ea mali (khatello ea mali), kapa k'holeseterole e phahameng (dyslipidemia). Leha ho le joalo, e ka ba le litla-morao tse ling. E ka tlaase mona:

Tlitla-morao tse tloaelehileng haholo:

  • -Ke hlahlamang,
  • -Boiketsi,
  • -Fatigue,
  • -Ba baka,
  • -Khala molomo,
  • -Constipation, le
  • -Hygoglycemia (tsoekere e tlaase ea mali).

Litla-morao tse ling tse tloaelehileng empa tse tebileng tse amanang le lorcaserin li kenyelletsa:

  • -Bala mathata a li-valve,
  • -Ka ho ela hloko kapa ho hopola,
  • Mathata a kelello,
  • -Khatello kapa maikutlo a ho ipolaea,
  • -Ke likhetho tse ntle,
  • -Ka otla pelo,
  • -A theohela palo ea lisele tsa mali, le
  • -Ka eketseha ha hormone, prolactin.


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Litlhaloso le lihlahisoa tsa lihlahisoa

FDA ea Approved Lorcaserin HCL bakeng sa Tlhahlobo ea Botenya

References

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., le al .: Ts'ireletso ea lefu la pelo ea Lorcaserin le ho feta ho feta boima ba meriana, The New England Journal of Medicine, 2018
  2. Tsamaiso ea lithethefatsi le lithethefatsi, Meriana e laolang taolo ea nako e telele, Inthaneteng, e hatisitsoeng 17 July 2012
  3. Ashley Gustafson, Cammile King, Jose AR, Setsi sa Sechaba sa Boitsebiso ba Biotechnology, PMC Lihlooho, MediMedia, USA Lorcaserin (Belviq), Inthaneteng, September 2013

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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