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Palesa e meholo ea Orlistat (96829-58-2)

Pula e tala ea Orlistat ke lithethefatsi tse sebelisoang ho phekola botenya. Mosebetsi oa eona o ka sehloohong o thibela ho fumana mafura a lijo tsa motho ....


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Tlhaloso

Palesa e tala ea Orlistat (96829-58-2) video

Palesa e meholo ea Orlistat (96829-58-2)

Pula e mafura ea Orlistat e ka sehlopheng sa meriana e bitsoang lipase inhibitors e sebetsang ka ho thibela ho kenngoa ha 25% ea mafura a lijo le ho sebelisoa ho fokotsa boima ba batho ba baholo ba ho feta boima ba 'mele, lilemo tsa 18 le ho feta, ha li sebelisoa hammoho le khalori e fokotsehileng le lijo tse fokolang mafura. Pula e monate ea Orlistat ke lithethefatsi tse etselitsoeng ho phekola botenya. Mosebetsi oa eona o ka sehloohong ke ho thibela mafura a tsoang ho lijo tsa batho, ka tsela eo ho fokotsa lijo tsa caloric. Moriana o moholo oa Orlistat o sebetsa ka ho thibela pancreatic lipase, e leng enzyme e senyang triglycerides ka maleng. Ntle le enzyme ena, triglycerides ho tloha lijong e thibela ho haelloa ke hydrolyzed hore e fumanehang mahala mafura acid 'me ba excreted ungested. Palo e ngotsoeng ka letsoho ea Orlistat e sebelisoang ka molao e sebelisoa ho batho ba fetang boima ba 'mele ba nang le khatello ea mali e phahameng, lefu la tsoekere, k'holeseterole e phahameng kapa lefu la pelo. Katleho ea phofo ea Raw Orlistat e matlafatsang ho lahleheloa ke boima ba 'mele ke e tobileng empa e itekanetse. Lintlha tse arohaneng tse tsoang litekong tsa meriana li fana ka maikutlo a hore batho ba fuoe phofo ea Raw Orlistat ho phaella ho phetoho ea bophelo, e kang ho ja le ho ikoetlisa, ba lahleheloa ke lik'hilograma tse 2-3 (4.4-6.6 lb) ho feta ba sa sebeliseng lithethefatsi ka nako ea selemo. Moriana o monate oa Orlistat o boetse o fokotsa khatello ea mali 'me o bonahala o thibela ho qala ha mofuta oa lefu la tsoekere la 2, ebang ke oa boima ba' mele kapa liphello tse ling. E fokotsa ts'oaetso ea lefu la tsoekere la mofuta oa II ho batho ba nang le boima bo bongata ba palo e lekanang ea liphetoho tsa bophelo.

Palesa e meholo ea Orlistat (96829-58-2) Lintlha

Name Product Palesa e meholo ea Orlistat
Lebitso la lik'hemik'hale Tetrahydrolipstatin, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
Brand Name Alli, Xenical
Sehlopha sa Lithethefatsi lipase inhibitors
Nomoro ea CAS 96829-58-2
InChIKey AHLBNYSZXLDEJQ-FWEHEUNISA-N
limolek'hule Formula C29H53NO5
limolek'hule Wtse robeli 495.745 g / mol
Masapo a monoisotopic 495.392 g / mol
Ho qhibiliha Poli <50 ° C
Fho tsosolosa Poli Ha ho letsatsi le fumanehang
Likokoana-hloko tsa Half-Life E itšetlehile ka boitsebiso bo lekanyelitsoeng, halofo ea bophelo ea phofo ea Raw Orlistat e nkiloeng e le ka har'a 1 ho ea ho lihora tsa 2.
Color Pula e tšoeu
Solubility DMSO: 19 mg / mL
Storage Tmocheso nako ea ho boloka. 2-8 ° C
Aho latela Sebelisa ho tšoara botenya.

Raw Orlistat phofo (96829-58-2) Tlhaloso

Pula e mafura ea Orlistat e ka sehlopheng sa meriana e bitsoang lipase inhibitors e sebetsang ka ho thibela ho kenngoa ha 25% ea mafura a lijo le ho sebelisoa ho fokotsa boima ba batho ba baholo ba ho feta boima ba 'mele, lilemo tsa 18 le ho feta, ha li sebelisoa hammoho le khalori e fokotsehileng le lijo tse fokolang mafura.

Pula e monate ea Orlistat ke lithethefatsi tse etselitsoeng ho phekola botenya. Mosebetsi oa eona o ka sehloohong ke ho thibela mafura a tsoang ho lijo tsa batho, ka tsela eo ho fokotsa lijo tsa caloric. Moriana o moholo oa Orlistat o sebetsa ka ho thibela pancreatic lipase, e leng enzyme e senyang triglycerides ka maleng. Ntle le enzyme ena, triglycerides ho tloha lijong e thibela ho haelloa ke hydrolyzed hore e fumanehang mahala mafura acid 'me ba excreted ungested. Palo e ngotsoeng ka letsoho ea Orlistat e sebelisoang ka molao e sebelisoa ho batho ba fetang boima ba 'mele ba nang le khatello ea mali e phahameng, lefu la tsoekere, k'holeseterole e phahameng kapa lefu la pelo. Katleho ea phofo ea Raw Orlistat e matlafatsang ho lahleheloa ke boima ba 'mele ke e tobileng empa e itekanetse. Lintlha tse arohaneng tse tsoang litekong tsa meriana li fana ka maikutlo a hore batho ba fuoe phofo ea Raw Orlistat ho phaella ho phetoho ea bophelo, e kang ho ja le ho ikoetlisa, ba lahleheloa ke lik'hilograma tse 2-3 (4.4-6.6 lb) ho feta ba sa sebeliseng lithethefatsi ka nako ea selemo. Moriana o monate oa Orlistat o boetse o fokotsa khatello ea mali 'me o bonahala o thibela ho qala ha mofuta oa lefu la tsoekere la 2, ebang ke oa boima ba' mele kapa liphello tse ling. E fokotsa ts'oaetso ea lefu la tsoekere la mofuta oa II ho batho ba nang le boima bo bongata ba palo e lekanang ea liphetoho tsa bophelo.

Orlistat phofo (96829-58-2) Mehato ea Ketso

Pula ea Orlistat ke mofuta oa lipase ho thibela boima ba lithethefatsi 'me ke motsoako oa hydrated oa lipostatin. Orlistat e thibela ka botlalo le lipase lipase le pancreatic lipase, ha li sa na tšusumetso ho li-enzyme tse ling tsa 'mele (tse kang amylase, trypsin le chymotrypsin) le phospholipase, ebile ha e ama ho kenngoa ha lik'habohaedreite, liprotheine le phospholipids. Lithethefatsi tsena ha lia kenngoa le hoja ho na le tšoaetso ea moriana 'me e na le phello e tsitsitseng ea lipase lipase. Orlistat e thibela li-enzyme ka ho kopanya li-covalent ho li-restine tsa serine libakeng tse sebetsang tsa mala le ka pancreatic lipase. Sena se thibela mafura a lijo hore a se ke a theohela ka mafura a mafura a acids le diacylglycerol, kahoo a ke ke a kenngoa, a theola boima ba caloric mme kahoo a laola boima ba 'mele. Meriana ena ha e hlokahale hore e kenyelletsoe ke 'mele oohle hore o sebetse. Mosebetsi oa Orlistat oa phekolo ea meriana ke ho itšetleha ka menyetla: tekanyo ea kalafo ea Orlistat (120mg / d, tid, e nkiloeng ka lijo), e kopantsoeng le lijo tse tlaase tsa khalori, e ka fokotsa ho fihlela ho 30% ea mafura a mafura. Phuputsong e bapisang baithaopi ba tloaelehileng le ba mahlahahlaha, Orlistat ha e le hantle e ne e sa amehe ka 'mele leha e le efe' me e na le mahloriso a tlaase a mali. Ka mor'a tekanyo e le 'ngoe ea molomo (e leng 800mg e kholo ka ho fetisisa), mahlaseli a mali a Orlistat lihora tse latelang tsa 8 e ne e le <5 ng / ml. Ka tloaelo, tekanyo ea kalafo ea Orlistat e nkoa ke 'mele feela' me e ke ke ea bokella ka nako e khutšoanyane ea phekolo. Ka tekanyo ea in vitro, likhaello tsa Orlistat le liprotheine tse ling tsa serum li feta 99% (liprotheine tse koetsoeng li ne li le lipoproteins le albin), 'me tekanyo ea eona ea ho kopanya ka lisele tse khubelu ea mali e ne e le tlase haholo.

Melemo ea phofo ea orlistat (96829-58-2)

▪ Orlistat e fokotsa 'mele ka ho feta 20% ka litšenyehelo tsa mafura a' mele

▪ Orlista e thusa ho ithuta ho bala lik'hilojule

▪ Orlista e etsa hore u ikutloe u phela hantle

▪ Orlista e na le liphello tse ntle tse etsang hore basebelisi ba be le tšepo le thabo

▪ Orlista e fana ka liphello tse tšoarellang nako e telele

▪ Orlista e fokotsa ho teba ha mafu a kang hypotension, lefu la tsoekere, atherosclerosis le

k'holeseterole.

E khothalletsoa Orlistat phofo (96829-58-2) Palo

Palo e khothalletsoang ea Orlistat phofo ke sesebelisoa se le seng sa 120-mg ka makhetlo a mararo ka letsatsi le lijo tse ka sehloohong tse nang le mafura (nakong ea nako kapa ho fihlela ho 1 hora ka mor'a lijo). Mokhoa o ka holimo ho 120 mg ka makhetlo a mararo ka letsatsi ha oa bontšoa hore o fana ka molemo o eketsehileng.

Batho ba lokela ho ja lijo tse nang le phepo e nepahetseng, tse fokotsehileng tse nang le lik'hilograma tse ka bang 30% tsa mafura. Ho ja mafura, lik'habohaedreite le liprotheine letsatsi le leng le le leng ho lokela ho abeloa lijo tse tharo tse ka sehloohong. Haeba lijo li sa hlokomeloe kapa ha li na mafura, phofo ea Orlistat e ka tlosoa.

Hobane phofo ea Orlistat e bontšitsoe ho fokotsa ho kenngoa ha livithamine tse nang le mafura le botacarotene, batho ba lokela ho eletsoa ho nka multivithamine tse nang le livithamine tse nang le mafura a mafura ho etsa bonnete ba phepo e nepahetseng. Ntle le moo, vithamine ea tlatsetso e lokela ho nkoa bonyane lihora tsa 2 pele kapa ka mor'a ho tsamaisoa ha phofo ea Orlistat, e kang nakong ea ho robala.

Litla-morao tsa phofo ea Orlistat (96829-58-2)

Ho tloaelehile ho bona litla-morao tsa phofo ea Orlistat hang ha ue sebelisa. U ka ba le litla-morao tse ling kapa eseng feela ka mor'a ho noa meriana efe kapa efe. Boholo ba liphello tse tlisoang ke tšebeliso ea phofo ea Orlistat li amana le tsela eo e sebetsang ka eona tsamaisong ea hau ea lijo. Hangata li bonolo ebile lia etsahala hang ha o qala kalafo. Li boetse li etsahala ka mor'a hore u nke lijo tse mafura haholo. Ka lehlohonolo, bongata ba bona boa tsamaea ha phekolo e ntse e tsoela pele le ka mor'a ho ja lijo tse nepahetseng.

Tse latelang ke tse ling tsa litla-morao tse tloaelehileng:

Hlooho ea hlooho

Matšoao a mpeng

Phallo ea oli

Lijo tse nyenyane

Phofshoana ea letlalo

Bohloko bo khutlang

Ntle ho moo, haeba u feta leha e le efe ea litla-morao tsena, u lokela ho e nka e le boemo bo potlakileng 'me u bitse ngaka hang-hang. Ke;

Bohloko bo bohloko ba mpa bo sa tsamaeeng.

Li-hives kapa ho hlatsoa ho feteletseng

Bothata bo ho metsa

Ho phefumoloha ho thata


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Litlhaloso le lihlahisoa tsa lihlahisoa

Orlistat bakeng sa boima ba 'mele: E ka tlosa mafura ka potlako joang?

Reference

  1. Ho ja lijo le ho kenngoa ha lijo, ho hlophisitsoeng ke Armand B. Christophe, Stephanie R. De Vriese, Stephanie DeVriese, leqepheng la 426- 437.
  2. Khatelo-pele ea Boikoetliso bo Botenya: 9, e hlophisitsoeng ke Geraldo Madeiros-Neto, Alfredo Halpern, Claude Bouchard, leqepheng la 1046.
  3. Botenya le Boima ba Boima Boemong bo ka Sehloohong-Ka Colin Waine, Nick Bosanquet, leqepheng la 68-71.

Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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