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Sulforaphane (4478-93-7)

Sulforaphane, e tsejoang hape e le "dl-sulforaphane", ke semela sa tlhaho se fumanehang merohong e mengata e kholo e kang …… ..


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Tlhaloso

Sulforaphane Slitšobotsi

Name Product Sulforaphane
Lebitso la lik'hemik'hale Sulforafan
DL-Sulforaphane
1-Isothiocyanato-4- (methylsulfinyl) butane
D, L-Sulforaphane
Brand Name N / A
Sehlopha sa Lithethefatsi Melao; Bahlahisi ba Enzyme le Li-Inhibitors;
Nomoro ea CAS 4478-93-7
InChIKey SUVMJBTUFCVSAD-UHFFFAOYSA-N
limolek'hule Formula C6H11NOS2
limolek'hule Wtse robeli 177.3 g / mol
Masapo a monoisotopic 177.028206 g / mol
Sebaka se belang 125-135 ° C
Fho tsosolosa Poli N / A
Likokoana-hloko tsa Half-Life N / A
Color mosehla
Sho khoneha DMSO: qhibilihang 40 mg / mL
Storage Tmocheso -20 ° C
Aho latela Sulforaphane phofo e sebetsa haholo ho tlatsetso.

Sulforaphane ke eng?

Sulforaphane, e tsejoang hape e le "dl-sulforaphane", ke semela sa tlhaho se fumanehang merohong e mengata e nang le sefapano joaloka broccoli, k'habeche, kholifulawa le Kale.

Ke antioxidant e tloaelehileng le sejalo se sebetsang sa semela se fumanehang merohong. Sulforaphane ha e na ts'ebetso e matla ea anti-kankere feela, empa hape e na le bokhoni bo matla ba ho thibela oxidation. E tsejoa e le e 'ngoe ea lihlahisoa tsa tlholeho tse nang le litlamorao tse khahlanong le mofets'e le botle.

Sulforaphane e hlahisoa ha enzyme myrosinase e fetola glucoraphanin, glucosinolate, ho etsa sulforaphane holim'a tšenyo ea semela (joalo ka ho tsoa ho hlafuna), e lumellang metsoako ena e 'meli ho kopanya le ho etsa joalo. Lihlahisoa tse nyane tsa broccoli le cauliflower li na le glucoraphanin le sosforaphane haholo-holo.

Sulforaphane (SFN) ke isothiocyanate, motsoako o nang le sebabole o nang le sebabole.Sulforaphane e na le antioxidant, antimicrobial, anticancer, anti-inflammatory, anti-botsing, neuroprotective, le anti-diabetes.

Sulforaphane melemo e

Melemo ea Bophelo bo Botle ba Sulforaphane

Li-supplement tsa Sulforaphane ha li amoheloe ke FDA bakeng sa tšebeliso ea bongaka mme ka kakaretso ha li na lipatlisiso tse tiileng tsa kliniki. Melao e ba behela litekanyetso tsa tlhahiso empa ha e tiise hore e bolokehile kapa e ea sebetsa.

  • ho ntšetsa pele phetisetso
  • boost boko
  • ho thusa mmele ho theha metsoako e loantsanang le mofets'e
  • e ts'ehetsa ts'ebetso ea pelo e phetseng hantle
  • glutathione e ntse e eketseha ka ho ba sebapali sa Nrf2
  • ho phahamisa boima ba mmele
  • ho fokotsa botsofe ka ho sebelisa liprotheine tse tšosang mocheso
  • boost mosebetsi oa sebete
  • ho fokotsa ho ruruha le bohloko
  • ho emisa le ho khutlisa moriri o lahlehang.
  • Sulforaphane e ka fokotsa cholesterol ea LDL
  • lefu la tsoekere

Ho hlaha ha Broccoli ho ntlafatsa likarolo tse ngata tsa lefu la tsoekere. Ho mofuta oa 2 diabetes, ho ja li-broccoli ho ile ha eketsa matla a antioxidant ea mali le cholesterol ea HDL, le ho fokotsa khatello ea oxidative, triglycerides, insulin, insulin, le CRP.

  • Tšenyo ea Letlalo

Sulforaphane e ka fana ka ts'ireletso khahlanong le ts'oaetso ea UVA le UVB, ho chesoa ke letsatsi le tšenyo ea letlalo.

  • Sulforaphane E fokotsa Matšoao a Autism

Sulforaphane e ka kenya tšebetsong mefuta e meng e sirelletsang lisele khahlanong le khatello ea oxidative, ho ruruha le tšenyo ea DNA, tseo kaofela li amanang le lefu la Autism spectrum disorder.

  • Ts'ebetso ea Tlosa Matla

Sulforaphane o bontšitse ts'ebetso ea antivir ha lisele tse nang le tšoaetso li pepesoa ka kotloloho

Litlamorao tsa Sulforaphane le polokeho.

Sulforaphane e bolokehile ha e sebelisoa ka bongata bo fumanoang lijong. Empa ha ho na tlhahisoleseling e lekaneng ho tseba hore na ho bolokehile hore o ka e nka molomo joalo ka moriana.

Sulforaphane o sebelisa le ho sebelisa

-Sulforaphane e ka sebelisoa bakeng sa ho hlakola libaktheria tse mpe tsa matšoafo.

-Sulforaphane e na le ts'ebetso ea ho thibela ho ruruha le ho imolla bohloko ho ramatiki.

-Sulforaphane e ka qala ka potlako ts'ebetso ea pholiso ea 'mele, tsamaiso ea detoxation, e nang le litho tse hlano tsa ka hare, tekano, tokiso ea litho tse senyehileng, sulforaphane e na le phello ea thibelo le kalafo ea gout.

-Sulforaphane e ka sebelisoa bakeng sa anti-cancer. Sulforaphane e ka thibela lefu la ka mpeng, gritis ea atrophic gancer

-Sulforaphane e sebelisoa tšimong ea lijo, sulforaphane ke mofuta oa lijo tse tala tse tala ho fokotsa boima;

-Sulforaphane e sebelisoa tšimong ea lihlahisoa tsa bophelo bo botle, celery e ka tsitsisa mohopolo mme ea tlosa ho se utloane;

-Sulforaphane e sebelisoa tšimong ea meriana, ho phekola rheumatism le gout e na le litholoana tse ntle.

Hape Research

Sulforaphane phofo ka Kankere ea Prostate ho etsa lipatlisiso

Sulforaphane (ka sebopeho sa monokotšoai oa broccoli) o fana ka bopaki bo matla ba tleliniki bakeng sa karolo ea thibelo ea mofets'e oa mofetše oa senya le maano a botsamaisi a ho thibela ho phetoa hape hoa mofetše oa senya.

Lithutong tse ngata tsa kliniki, banna ba nang le mofetše oa kankere ea senya ea methapo ea kutlo ea 60 mg ka letsatsi ba ne ba e-na le antigen (PSA, letšoao le neng le tloaetse ho lekanya tsoelo-pele ea mofetše oa kankere ea senya) ho feta ba sa kang ba etsa sulforaphane.

Ho boleloa joalo, FDA ha e lumellane le sofforaphane bakeng sa thibelo ea phetoho ea mofetše oa mofetše.

Reference:

  • Dietary Sulforaphane ho Cancer Chemoprevention: Karolo ea Epigenetic Regulation le HDAC Inhibition Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis Antioxid Redox Signal. 2015 Jun 1; 22 (16): 1382-1424. Doi: 10.1089 / ars.2014.6097 Sulforaphane e laola litsela tse amanang le phallo le litumellano tse amanang le tsoelo-pele le li-synergis tse nang le lisplatin ho hatella mofets'e oa batho ba nang le mofets'e Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. 2018 Nov; 42 (5): 2447–2458. E phatlalalitsoe marang-rang 2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
  • Bioavailability of Glucoraphanin and Sulforaphane from High ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Mol Nutr Food Res. 2018 Sep; 62 (18): 1700911. E phatlalalitsoe marang-rang 2018 Mar 8. doi: 10.1002 / mnfr.201700911
  • Thibelo ea Kankere ea Molomo ea Carcinogen-E susumetsoa ke Sulforaphane Julie E. Bauman, Yan Zang, Senabaka oa Malabika, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler , Daniel E. Johnson Cancer Prev Res (Phila) mongolo o ngotsoeng; e fumaneha ho PMC 2017 Jul 1. E phatlalalitsoe ka foromo e hlophisitsoeng ea hoqetela e le: Cancer Prev Res (Phila). 2016 Jul; 9 (7): 547-557. E phatlalalitsoe online 2016 Jun 23 doi: 10.1158 / 1940-6207.CAPR-15-0290
  • Boithuto ba karolo ea bobeli ba li-broccoli tse nang le lera le lengata la sforforaphane le tsoa ho banna ba nang le mofets'e oa mehleng ea khale oa Josaf J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis R. Koop, Angela Gibbs, Lina Gao, Jason F. Flamiatos, Erin Tucker, Richard Kleinschmidt, Motomi Mori Invest New Lithethefatsi. Sengoloa se ngotsoeng; e fumaneha ho PMC 2016 Apr 1. E phatlalalitsoe ka foromo e hlophisitsoeng ea hoqetela e le: Jala lithethefatsi tse ncha. 2015 Apr; 33 (2): 480-489. E phatlalalitsoe marang-rang 2014 Nov 29 Doi: 10.1007 / s10637-014-0189-z

TLHOKOMELISO LE TLHALOSO:

Boitsebiso bona bo rekisetsoe tšebeliso ea lipatlisiso. Lipehelo tsa thekiso Etsa kopo. Eseng molemong oa tšebeliso ea batho, kapa bongaka, bongaka ba liphoofolo kapa lisebelisoa tsa lapeng.


Video

Sulforaphane (4478-93-7) video

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Litlhaloso le lihlahisoa tsa lihlahisoa

Reference:

  • Dietary Sulforaphane ho Cancer Chemoprevention: Karolo ea Epigenetic Regulation le HDAC Inhibition Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis Antioxid Redox Signal. 2015 Jun 1; 22 (16): 1382-1424. Doi: 10.1089 / ars.2014.6097 Sulforaphane e laola litsela tse amanang le phallo le litumellano tse amanang le tsoelo-pele le li-synergis tse nang le lisplatin ho hatella mofets'e oa batho ba nang le mofets'e Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. 2018 Nov; 42 (5): 2447–2458. E phatlalalitsoe marang-rang 2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
  • Bioavailability of Glucoraphanin and Sulforaphane from High ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Mol Nutr Food Res. 2018 Sep; 62 (18): 1700911. E phatlalalitsoe marang-rang 2018 Mar 8. doi: 10.1002 / mnfr.201700911
  • Thibelo ea Kankere ea Molomo ea Carcinogen-E susumetsoa ke Sulforaphane Julie E. Bauman, Yan Zang, Senabaka oa Malabika, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler , Daniel E. Johnson Cancer Prev Res (Phila) mongolo o ngotsoeng; e fumaneha ho PMC 2017 Jul 1. E phatlalalitsoe ka foromo e hlophisitsoeng ea hoqetela e le: Cancer Prev Res (Phila). 2016 Jul; 9 (7): 547-557. E phatlalalitsoe online 2016 Jun 23 doi: 10.1158 / 1940-6207.CAPR-15-0290
  • Boithuto ba karolo ea bobeli ba li-broccoli tse nang le lera le lengata la sforforaphane le tsoa ho banna ba nang le mofets'e oa mehleng ea khale oa Josaf J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis R. Koop, Angela Gibbs, Lina Gao, Jason F. Flamiatos, Erin Tucker, Richard Kleinschmidt, Motomi Mori Invest New Lithethefatsi. Sengoloa se ngotsoeng; e fumaneha ho PMC 2016 Apr 1. E phatlalalitsoe ka foromo e hlophisitsoeng ea hoqetela e le: Jala lithethefatsi tse ncha. 2015 Apr; 33 (2): 480-489. E phatlalalitsoe marang-rang 2014 Nov 29 Doi: 10.1007 / s10637-014-0189-z