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Phofo e matla ea Synephrine (97-07-5)

Synephrine ka tlhaho e teng limela tsa li-citrus tse tsoang malapeng a Rutaceae, ke alkaloid sympathomimetic. Synephrine o na le tse tharo tse fapaneng ......


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Tlhaloso

Pono ea Raw Synephrine (97-07-5) video

Phofo e matla ea Synephrine (97-07-5)

Raw Synephrine phofo ke lik'hemik'hale tse tloaelehileng tseo baatlelete ba li batlang le ba batlang ho theola 'mele ka lebaka la liphello tsa' mele oa tlhahiso ea matla. Leha ho le joalo, motsoako ona o ka boela oa sebetsa joaloka antioxidant le anti-inflammatory agent mme o ka ba le melemo e meng ea bohlokoa ea bophelo bo botle.

Moriana o moholo oa Synephrine ke amine ea biogenic. E fumanoa ka litsela tse phahameng lifateng tsa limela tsa citrus, joaloka li-orange tse matla kapa Seville orange (Citrus aurantium). Lihlahisoa tse tsoang litholoana kapa lipepele tsa limela tsena li 'nile tsa sebelisoa meriana ea setso ea Chaena ho tšoara mathata a mala le ho kula ha makholo a lilemo.

Mafura a Raw Synephrine (97-07-5) Lintlha

Name Product Raw ea Synephrine phofo
Lebitso la lik'hemik'hale Synephrine; Oxedrine; P-Synephrine ;; Parasympatol; Sympaethamine
Brand Name Yocon
Sehlopha sa Lithethefatsi Mafura aa lahleha
Nomoro ea CAS 97-07-5
InChIKey YRCWQPVGYLYSOX-UHFFFAOYSA-N
limolek'hule Formula C9H13NO2
limolek'hule Wtse robeli 167.208 g / mol
Masapo a monoisotopic 167.095 g / mol
Ho qhibiliha Poli 162 ho 164 ° C
Boiling Point 295.79 ° C (tekanyo e boima)
Likokoana-hloko tsa Half-Life Ha ho letsatsi le fumanehang
Color Tšoeu ho ea phofo e tšoeu
Sho khoneha Ha ho letsatsi le fumanehang
Storage Tmocheso Sehatsetsi
Aho latela Ha ho pelaelo hore ke mafura a atlehang ka ho fetisisa a tukang

Phofo e matla ea Synephrine (97-07-5) Tlhaloso

Synephrine, e boetse e bitsoa, ​​p-synephrine, e hlahisa alkaloid ka tlhaho. Karolo e kholo ea agrenists ea adrenergic ke p-synephrine, mme e ngotsoe pharmacopoeia ho tsoa Europe Leboea le Jeremane.Ia teng lihlahisoa tsa lithethefatsi tse amohelehang e le neo-synephrine, analog ea m-substituted. p-synephrine le m-synephrine ba tsejoa ka liphello tsa bona tse telele tse etsang li-adrenergic ha li bapisoa le norepinephrine. E ka sebelisoa kalafo ea meriana ea phallo ea bronchial, hypotension, ho oa, ho tšoha, le hypotension orthostatic hypotension; ho ntlafatsa metabolism; le kalafo ea mathata a ho ja lijo tse kang indigestion, ho ruruha ha sebete, phlegm le ptosis.

Linaheng tsa linaheng tse ling, phofo e tala ea synephrine e 'nile ea batloa ke baatlelete le ba batlang ho theola' mele ka lebaka la liphello tsa matla a 'mele. Synephrine e sebelisoa bakeng sa ho phekola botenya ka ho eketsa khalori e sebelisoang le ho noa ha mafura, hammoho le ho fokotsa khatello ea maikutlo e bakoang ke botenya. Leha ho le joalo, motsoako ona o ka boela oa sebetsa joaloka antioxidant le anti-inflammatory agent mme o ka ba le melemo e meng ea bohlokoa ea bophelo bo botle.

Mofuta o moholo oa Synephrine ke amine ea biogenic. E fumanoa litekanyetsong tse phahameng lifateng tsa limela tsa limela tsa citrus, tse kang lamunu ea Orange kapa Seville orange (Citrus aurantium). Lihlahisoa tse tsoang litholoana kapa lipepele tsa limela tsena li 'nile tsa sebelisoa meriana ea setso ea Chaena ho tšoara mathata a mala le ho kula ha makholo a lilemo. Hona joale, p-synephrine e sebelisoa ka ho fetisisa merianeng ea meriana, lijo, seno le tse ling.

Peso ea Synephrine (97-07-5) Mokhoa oa Ketso

Matšoao a pelo a li-ligands a amahanngoa le adrenergic receptor e tlamang. Ka kakaretso, ha li-ligands li ikamahanya le li-receptor tsa α-adrenergic, vasoconstriction e hlaha, mme ha e tlamella li-receptor tsa β1-adrenergic, likonteraka tsa pelo le ho eketseha ha lebelo la pelo. Liphuputso li bontša hore phofo ea synephrine e tlama li-receptor tsa β3-adrenergic, e leng se fellang ka ho eketsa bokhoni ba 'mele ba ho senya mafura. Ho khomarela li-receptor tsa β3-adrenergic ha li susumetse lebelo la pelo kapa khatello ea mali. Hape, hobane synephrine e na le likarolo tse nyane kapa tse se nang letho ho li-α1-, β2-, le β1-adrenergic receptors 'me ha li bonahale eka li na le liphello tse sa hlakang tsa li-adrenergic, liphello tsa pelo, tse kang ho eketseha ha sekhahla sa pelo le khatello ea mali, ha li tse nang le menyetla e tloaelehileng e sebelisoang, ho fapana le tse ling tse ngata tsa phenylethylamine le li-derivative phenylpropanolamine. Liphetoho tse nyenyane tsa mohaho li fella ka phapang e kholo ea recerenor receptor e tlamang 'me hamorao e khona ho hlahisa liphello tsa pelo.

Synephrine e boetse e eketsa 'mele oa lik'habohaedreite ka ho hlahisa matla a mangata ka sebōpeho sa ATP.49-52 E nolofalletsa ho kenngoa ha cellular liseleng tsa mesifa, hammoho le glycogenolysis, gluconeogenesis, glycolysis le phetoho ea oksijene. Ho ameha ha motone oa khalsiamo le k'hamphani le li-receptor tsa adrenergic ho bontšitsoe hore li ameha ho mekhoa ena ea lik'hemik'hale, e bontšang ho ameha ha mekhoa e mengata.

Ntle ho moo, tšebeliso ea phofo ea Synephrine e tla thibela ho sebelisoa ha NF-kB. Ntho ena ke senotlolo ho bakang mafu a ho ruruha a kang asthma. Tšebeliso ea Synephrine e fumanoe e ama liketso tsa hormone ea eotaxin-1 haholo. Sena se thibela phetoho ea eosinophil sebakeng se chesang.

Le hoja e sa bontšoa hantle ka liteko, tšebeliso ea phofo ea Synephrine e fumanoe e thibela ketso ea acetylcholinesterase. Khemik'hale ena e tsejoa ho baka lefu la Alzheimer.

Ts'ebeliso ea phofo ea Synephrine (97-07-5)

▪ Ho ntlafatsa tshebetso ea ho ikoetlisa

▪ Ho Phekola lefu la tsoekere

▪ Thuso ea ho theola boima ba 'mele

▪ Ho fokotsa tšabo pele ho buuoa

▪ Ho phekola tšoaetso ea letlalo la fungal joaloka leqeba, leoto la moatlelete le jock itch.

▪ Ntlafatsa Maemo a Moodlo le Matla

Nako e khothalletsoang ea Synephrine powder (97-07-5)

Meriana e tloaelehileng ea phofo ea Synephrine ke 50-100mg letsatsi ka leng le metsotso ea 30-40 pele ho mosebetsi. Hape, ho molemo ho nkoa ntho ea pele hoseng kapa 15 - 30 metsotso pele u ikoetlisa. Phofo ea Synephrine e lokela ho nkoa ka metsi pele e ikoetlisa.

Melemo ea phofo ea Synephrine (97-07-5)

• Tlhahlobo (DB-RCT) ea banna ba 12 e bontšitse hore phofo ea synephrine e nkiloe ka metsotso ea 45 pele ho ikoetlisa e eketsa palo ea ho pheta-pheta le boima bo boima ba boima ha li etsa li-squats ho bapisoa le placebo.

♦ Phuputso ea pele e bontša hore ho noa tee e tsoang makhasi a Indian snakeroot le litholoana tsa lamunu e bohloko bakeng sa likhoeli tsa 4 ho bonahala ho fokotseha tsoekere ea mali ho batho ba nang le lefu la tsoekere.

• Ho kopanya synephrine, caffeine le St. John's wort ho ka thusa ho fokotseha ha boima ha o sebelisoa ka lijo tse tlaase tsa lik'halori le boikoetliso.

• Tlhahlobo (DB-RCT) ea lihlooho tsa 10 tse fuoeng 50 mg ea synephrine e bontšitse hore litaba li chesa lik'halori tsa 65 ho feta barupeluoa ba fuoeng sebaka sa sebaka sa metsotsoana ea pele ea 75 ka mor'a hore ba nke tlatsetso.

♦ Phuputso e fana ka maikutlo a hore ho noa li-Orange tse peli pele ho opereishene ho fokotsa ho tšoha.

♦ Oli e bohloko ea lamunu, e nang le synephrine ho phaella litsong tse ling tse sebetsang, ho ithutela ka bang bakuli ba 60, ho fokolisa maloetse a letlalo la maoto (maoto, 'mele kapa letlalo) kapa libeke tse 2 ho feta 3% ea barupeluoa.

• Litoeba tse nang le matšoao a khale a ho tepella maikutlo, ho kenyelletsa mathata a boroko le liphetoho tsa mekhoa ea ho ja, etsa ho hobe ho feta likarolong tse sithabetsang, joaloka ho qobelloa ho sesa, ho feta litoeba tse phetseng hantle. Phuputso e 'ngoe e bontšitse hore litoeba tse fepehileng tsa synephrine powderwere li khona ho sesa nako e teletsana, e bontšang matla a phahameng le a maikutlo a maikutlo

• Phuputso e 'ngoe ea laboratori e bontšitse hore phofo ea synephrine e thibela ho hōla ha libaktheria tse kang E. coli, tse ka bakang chefo ea lijo, hammoho le Staphylococcus aureus, e ka bakang mafu a letlalo.

♦ Phuputso e entsoeng ho sebelisa likolobe e bontšitse hore synephrine e fokolitse likaroloana tsa mesifa e boreleli ka tseleng, e leng letšoao le amanang le ho khohlela. Synephrine e boetse e fokotsa matšoao a asthma a ileng a etsahala ha liphoofolo li ne li fuoa histamines.

♦ Ho litoeba tse nang le kotsi ea matšoafo, synephrine e fokolitse palo ea lisele tsa ho ruruha le li-cytokines tse chesang TNF-alpha le IL-6, ha li ntse li eketsa IL-10 e khahlanong le ho ruruha.


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Shangke Chemical ke setsi se phahameng sa theknoloji se ikhethileng ka li-intermediate tse sebetsang tsa meriana (APIs). Ho laola boleng nakong ea tlhahiso, litsebi tse ngata tse nang le phihlelo, lihlahisoa tsa tlhahiso ea pele le li-laboratori ke lintlha tsa bohlokoa.

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